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  Indian J Med Microbiol
 

Figure 4: Mechanism of pylorus ligation and ethanol induced ulcer. Pylorus ligation causes accumulation of acid and pepsin, which leads to auto digestion of gastric mucosa and ulceration. On the other hand, ulcer due to ethanol is the result of reactive oxygen species generation, microvascular injury and release of infl ammatory mediators, which leads to increased vascular permeability, edema formation, and epithelial lifting resulting in necrotic lesions in the gastric mucosa

Figure 4: Mechanism of pylorus ligation and ethanol induced ulcer. Pylorus ligation causes accumulation of acid and pepsin, which leads to auto digestion of gastric mucosa and ulceration. On the other hand, ulcer due to ethanol is the result of reactive oxygen species generation, microvascular injury and release of infl ammatory mediators, which leads to increased vascular permeability, edema formation, and epithelial lifting resulting in necrotic lesions in the gastric mucosa