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  Indian J Med Microbiol
 

Figure 3: Mechanism of castor oil and magnesium sulfate-induced diarrhea. Castor oil-induces diarrhea by: (1) Releasing nitric oxide and thereby increasing permeability of gastrointestinal membrane for calcium; (2) stimulating prostaglandin synthesis and thereby increasing fluid and electrolytes into the lumen of the bowel; and (3) increasing peristalsis. On the other hand, magnesium sulfate induces diarrhea by promoting cholecytokinin release from the duodenal mucosa preventing the reabsorption of sodium chloride and water from the lumen

Figure 3: Mechanism of castor oil and magnesium sulfate-induced diarrhea. Castor oil-induces diarrhea by: (1) Releasing nitric oxide and thereby increasing permeability of gastrointestinal membrane for calcium; (2) stimulating prostaglandin synthesis and thereby increasing fluid and electrolytes into the lumen of the bowel; and (3) increasing peristalsis. On the other hand, magnesium sulfate induces diarrhea by promoting cholecytokinin release from the duodenal mucosa preventing the reabsorption of sodium chloride and water from the lumen