Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 8  |  Issue : 4  |  Page : 150--155

Novel biorelevant dissolution medium as a prognostic tool for polysaccharide-based colon-targeted drug delivery system


Ankit Kumar Yadav1, Manik Sadora1, Sachin Kumar Singh1, Monica Gulati1, Peddi Maharshi1, Abhinav Sharma1, Bimlesh Kumar1, Harish Rathee1, Deepak Ghai1, Adil Hussain Malik1, Varun Garg1, K Gowthamrajan2 
1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India
2 Department of Pharmaceutics, J.S.S. College of Pharmacy, Ooty, Tamil Nadu, India

Correspondence Address:
Monica Gulati
Department of Pharmaceutics, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab - 144 402
India

To overcome the limitations of the conventionally used methods for evaluation of orally administered colon-targeted delivery systems, a novel dissolution method using probiotics has been recently reported. In the present study, universal suitability of this medium composed of five different probiotics is established. Different delivery systems – mini tablets, liquisolid compacts, and microspheres coated with different polysaccharides – were prepared and subjected to sequential dissolution testing in medium with and without microbiota. The results obtained from fluid thioglycollate medium (FTM)-based probiotic medium for all the polysaccharide-based formulations showed statistically similar dissolution profile to that in the rat and goat cecal content media. Hence, it can be concluded that the developed FTM-based probiotic medium, once established, may eliminate the need for further animal sacrifice in the dissolution testing of polysaccharide-based colon-targeted delivery system.


How to cite this article:
Yadav AK, Sadora M, Singh SK, Gulati M, Maharshi P, Sharma A, Kumar B, Rathee H, Ghai D, Malik AH, Garg V, Gowthamrajan K. Novel biorelevant dissolution medium as a prognostic tool for polysaccharide-based colon-targeted drug delivery system.J Adv Pharm Technol Res 2017;8:150-155


How to cite this URL:
Yadav AK, Sadora M, Singh SK, Gulati M, Maharshi P, Sharma A, Kumar B, Rathee H, Ghai D, Malik AH, Garg V, Gowthamrajan K. Novel biorelevant dissolution medium as a prognostic tool for polysaccharide-based colon-targeted drug delivery system. J Adv Pharm Technol Res [serial online] 2017 [cited 2022 Sep 28 ];8:150-155
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2017;volume=8;issue=4;spage=150;epage=155;aulast=Yadav;type=0