Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 8  |  Issue : 4  |  Page : 138--142

The effect of adding ferrous sulfate to methylphenidate on attention-deficit/hyperactivity disorder in children


Gholamreza Panahandeh1, Bahareh Vatani2, Parvin Safavi3, Abolfazl Khoshdel1 
1 Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Clinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Department of Psychiatry, Shahrekord University of Medical Sciences, Shahrekord, Iran

Correspondence Address:
Parvin Safavi
Department of Psychiatry, Shahrekord University of Medical Sciences, Shahrekord
Iran

Attention deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children with several complications. This study was conducted to investigate the effect of adding ferrous sulfate to methylphenidate in decreasing ADHD symptoms. This study was a double-blind, randomized clinical trial. In this study, 42 nonanemic children with ADHD and serum ferritin below 30 mg/ml were enrolled according to convenience sampling and randomly assigned to two groups of 21 each, cases and controls. The two groups were matched for age and sex. The case group was administered with ferrous sulfate 5 mg/kg in addition to methylphenidate up to 1 mg/kg and the control group with methylphenidate alone. The scores on child symptoms inventory-4 (CSI-4) were recorded at baseline and after 2 months of treatment. Data were analyzed by t-test, Pearson's correlation coefficient, and repeated measures ANOVA in SPSS 16. The scores on CSI-4 decreased significantly at month 2 in both groups (P < 0.001). The scores on attention deficit and hyperactivity subscales of the CSI-4 were significantly lower in the case group than the control group (P < 0.05). The total score on CSI-4 decreased more markedly in the case group (P < 0.04). Use of ferrous sulfate plus methylphenidate can be effective in reducing ADHD symptoms in nonanemic children with low serum ferritin.


How to cite this article:
Panahandeh G, Vatani B, Safavi P, Khoshdel A. The effect of adding ferrous sulfate to methylphenidate on attention-deficit/hyperactivity disorder in children.J Adv Pharm Technol Res 2017;8:138-142


How to cite this URL:
Panahandeh G, Vatani B, Safavi P, Khoshdel A. The effect of adding ferrous sulfate to methylphenidate on attention-deficit/hyperactivity disorder in children. J Adv Pharm Technol Res [serial online] 2017 [cited 2021 Oct 22 ];8:138-142
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2017;volume=8;issue=4;spage=138;epage=142;aulast=Panahandeh;type=0