Journal of Advanced Pharmaceutical Technology & Research

REVIEW ARTICLE
Year
: 2013  |  Volume : 4  |  Issue : 1  |  Page : 9--17

Nanoparticles laden in situ gelling system for ocular drug targeting


Divya Kumar, Nidhi Jain, Neha Gulati, Upendra Nagaich 
 Department of Pharmaceutics, School of Pharmacy, BIT, Meerut, Uttar Pradesh, India

Correspondence Address:
Divya Kumar
Department of Pharmaceutics, School of Pharmacy, BIT, Meerut, Uttar Pradesh
India

Designing an ophthalmic drug delivery system is one of the most difficult challenges for the researchers. The anatomy and physiology of eye create barriers like blinking which leads to the poor retention time and penetration of drug moiety. Some conventional ocular drug delivery systems show shortcomings such as enhanced pre-corneal elimination, high variability in efficiency, and blurred vision. To overcome these problems, several novel drug delivery systems such as liposomes, nanoparticles, hydrogels, and in situ gels have been developed. In situ-forming hydrogels are liquid upon instillation and undergo phase transition in the ocular cul-de-sac to form viscoelastic gel and this provides a response to environmental changes. In the past few years, an impressive number of novel temperature, pH, and ion-induced in situ-forming systems have been reported for sustain ophthalmic drug delivery. Each system has its own advantages and drawbacks. Thus, a combination of two drug delivery systems, i.e., nanoparticles and in situ gel, has been developed which is known as nanoparticle laden in situ gel. This review describes every aspects of this novel formulation, which present the readers an exhaustive detail and might contribute to research and development.


How to cite this article:
Kumar D, Jain N, Gulati N, Nagaich U. Nanoparticles laden in situ gelling system for ocular drug targeting.J Adv Pharm Technol Res 2013;4:9-17


How to cite this URL:
Kumar D, Jain N, Gulati N, Nagaich U. Nanoparticles laden in situ gelling system for ocular drug targeting. J Adv Pharm Technol Res [serial online] 2013 [cited 2021 Oct 23 ];4:9-17
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2013;volume=4;issue=1;spage=9;epage=17;aulast=Kumar;type=0