Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 3  |  Issue : 3  |  Page : 171--175

Evaluation of Caesalpinia bonduc seed coat extract for anti-inflammatory and analgesic activity


Dayanand M Kannur1, Mukta P Paranjpe2, Lalit V Sonavane3, Prerana P Dongre1, Kishanchand R Khandelwal4 
1 Department of Pharmacognosy and Phytochemistry, SCES' Indira College of Pharmacy, Braunschweig, Germany
2 Department of Pharmacognosy and Phytochemistry, Institute for Pharmaceutical Technology, TU Braunschweig, Mendelssohnstr.1, 38106, Braunschweig, Germany
3 Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Sangli, India
4 Department of Pharmacognosy and Phytochemistry, JSPM, Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune, India

Correspondence Address:
Dayanand M Kannur
Associate Professor, Head, Department of Pharmacognosy and Phytochemistry, SCES«SQ»s, Indira College of Pharmacy, Tathawade, Pune, Maharashtra, India

In the present work, Caesalpinia bonduc seed coat extract (CBSCE) has been evaluated for anti-inflammatory and analgesic activity C. bonduc seeds have been attributed with anti-inflammatory and analgesic properties in the folklore medicine. Here in our study, we have tried to carry out the systematic evaluation of the seed coat extract of C. bonduc to substantiate these claims. C. bonduc seed coat was extracted with 95% ethanol and concentrated; further, the extract was screened for anti-inflammatory and analgesic activity. The studies were carried using Carrageenan-induced Paw Edema, Egg albumin-induced paw edema, Eddy«SQ»s Hot Plate Test, Tail Immersion Method so as to prove acclaimed properties. The data was analyzed statistically by Students«SQ» «SQ»t«SQ» test. The results indicate that seed coat extract has the ability to decrease the induced inflammation at varied doses in Carrageenan model as well as in the Egg albumin model in rats. The antinociceptive results indicate that the extract has the ability to increase the pain threshold of the animals and reduce the pain factor, thereby inducing analgesia. Thus, it can be concluded that CBSCE posses analgesic and anti-inflammatory activity.


How to cite this article:
Kannur DM, Paranjpe MP, Sonavane LV, Dongre PP, Khandelwal KR. Evaluation of Caesalpinia bonduc seed coat extract for anti-inflammatory and analgesic activity.J Adv Pharm Technol Res 2012;3:171-175


How to cite this URL:
Kannur DM, Paranjpe MP, Sonavane LV, Dongre PP, Khandelwal KR. Evaluation of Caesalpinia bonduc seed coat extract for anti-inflammatory and analgesic activity. J Adv Pharm Technol Res [serial online] 2012 [cited 2021 Oct 23 ];3:171-175
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2012;volume=3;issue=3;spage=171;epage=175;aulast=Kannur;type=0