Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 1  |  Issue : 4  |  Page : 401--405

Synthesis and antimalarial evaluation of some 4-quinazolinone derivatives based on febrifugine


Debanjan Sen1, Anirban Banerjee2, Ashoke Kumar Ghosh3, Tapan Kumar Chatterjee4 
1 Bengal Institute of Pharmaceutical Sciences, Kalyani, Nadia, West Bengal, India
2 IT consultant, Schrödinger LCC, Moradabad, Uttar Pradesh - 244001, India
3 Pharmacy College, IFTM, Lodhipur Rajput, Moradabad, Uttar Pradesh - 244001, India
4 Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India

Correspondence Address:
Debanjan Sen
Bengal institute of Pharmaceutical Sciences SPLPM campus, Kalyani, Nadia, West Bengal
India

A series of 2-substituted and 2,3-substituted quinazolin -4(3H)-one derivatives were designed and synthesized based on the structure of febrifugine. The structures of the new compounds were confirmed by spectral analysis. The in vivo biological activity test results indicated that those compounds exhibited antimalarial activities against Plasmodium berghei in mice, at a dose of 5 mg/kg. Compared to Chloroquine and Artemisinin, these compounds have the advantages of shorter synthetic routes and consequently are highly cost effective in nature.


How to cite this article:
Sen D, Banerjee A, Ghosh AK, Chatterjee TK. Synthesis and antimalarial evaluation of some 4-quinazolinone derivatives based on febrifugine.J Adv Pharm Technol Res 2010;1:401-405


How to cite this URL:
Sen D, Banerjee A, Ghosh AK, Chatterjee TK. Synthesis and antimalarial evaluation of some 4-quinazolinone derivatives based on febrifugine. J Adv Pharm Technol Res [serial online] 2010 [cited 2020 Nov 24 ];1:401-405
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2010;volume=1;issue=4;spage=401;epage=405;aulast=Sen;type=0