Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 1  |  Issue : 4  |  Page : 396--400

Synthesis and biological evaluation of formazan derivatives


Gurusamy Mariappan1, Rejaul Korim1, Nand Madhwa Joshi2, Faruk Alam1, Rajib Hazarika1, Deepak Kumar1, Tiewlasubon Uriah1 
1 Department of Medicinal Chemistry, Himalayan Pharmacy Institute, E. Sikkim, India
2 Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Correspondence Address:
Gurusamy Mariappan
Department of Medicinal Chemistry, Himalayan Pharmacy Institute, E. Sikkim-737136
India

The formazan derivatives (FM1-FM5) were synthesized by the reaction of benzaldehyde phenylhydrazone with substituted aromatic and hetero aromatic amines. The structures of the synthesized compounds were then elucidated using UV, IR, 1 H NMR and mass spectral data. The synthesized derivatives were screened for anticonvulsant, antibacterial and antiviral activities. All the compounds showed remarkable antibacterial activity at 250 μg/ml, but FM4 and FM3 did not show any inhibition on Staphylococcus aureus and Vibriocholera, respectively. All the compounds showed significant anticonvulsant effect at 100 mg/kg p.o. and the experimental data were statistically significant at P<0.001 level. But none of the compounds was effective against Japanese encephalitis virus.


How to cite this article:
Mariappan G, Korim R, Joshi NM, Alam F, Hazarika R, Kumar D, Uriah T. Synthesis and biological evaluation of formazan derivatives.J Adv Pharm Technol Res 2010;1:396-400


How to cite this URL:
Mariappan G, Korim R, Joshi NM, Alam F, Hazarika R, Kumar D, Uriah T. Synthesis and biological evaluation of formazan derivatives. J Adv Pharm Technol Res [serial online] 2010 [cited 2020 Dec 4 ];1:396-400
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2010;volume=1;issue=4;spage=396;epage=400;aulast=Mariappan;type=0