Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 1  |  Issue : 1  |  Page : 22--29

In Vivo rodent micronucleus assay of Gmelina Arborea Roxb (Gambhari) extract


Rohit Sahu, Goli Divakar, Kalyani Divakar 
 Acharya & B.M. Reddy College of Pharmacy, Bangalore, India

Correspondence Address:
Rohit Sahu
Acharya & B.M. Reddy College of Pharmacy, Bangalore
India

Gmelina arborea Roxb (family Verbenaceae) commonly known as «SQ»Gambhari«SQ» tree, the various parts of the plants are widely used in diarrhoea, anti-pyretic, thirst, anemia, leprosy, ulcers, consumption, strangury, vaginal discharges. We tested the genotoxic potential of G. arborea in bone marrow cells obtained from Swiss albino mice using micronuclei formation as the toxicological endpoints. Aqueous extract of G. arborea (AEGA) was tested at the dose of 286 & 667 mg/kg body weight (b. w.). Cyclophosphamide (CPZ) 25 mg/kg b. w. was used as positive control in micronucleus test. The AEGA significantly increased the % micronucleated polychrometics at doses of 286mg/kg and 667mg/kg, after 24, 48 72h time interval. And also decreased the PCE/NCE ratio after 24, 48 and 72 h as compared to solvent control group. In this study, we investigated the effect of G. arborea on mammalian bone marrow cells using micronuclei formation to assess the genotoxicity of the herb.


How to cite this article:
Sahu R, Divakar G, Divakar K. In Vivo rodent micronucleus assay of Gmelina Arborea Roxb (Gambhari) extract.J Adv Pharm Technol Res 2010;1:22-29


How to cite this URL:
Sahu R, Divakar G, Divakar K. In Vivo rodent micronucleus assay of Gmelina Arborea Roxb (Gambhari) extract. J Adv Pharm Technol Res [serial online] 2010 [cited 2021 Oct 20 ];1:22-29
Available from: https://www.japtr.org/article.asp?issn=2231-4040;year=2010;volume=1;issue=1;spage=22;epage=29;aulast=Sahu;type=0