%A Aly, SAS
%T Detachment and recovery index: A new parameter measuring powder compressibility
%9 Original Article
%D 2010
%J Journal of Advanced Pharmaceutical Technology & Research
%R 10.4103/0110-5558.76440
%P 406-414
%V 1
%N 4
%U https://www.japtr.org/article.asp?issn=2231-4040;year=2010;volume=1;issue=4;spage=406;epage=414;aulast=Aly
%8 October 1, 2010
%X This investigation introduces a simple and reliable approach to measure the compressibility of some direct compression excipients in tablet systems made from compressible components. The claim made here is that: the total reduction, Δ*L *_{T} , in the thickness of a tablet batch due to compression at a confined machine settings is the integral sum of small reductions generated by the compressible components in the batch. The reduction value, Δ*L *_{E} , generated by a single or a blend of excipients in a batch could be calculated and was found to correlate to its concentration, C, by the relation: Δ*L *_{E} =*A *_{E}.*C *^{x}. The constants AE and x concern the reduction tendency, RT, of the excipient particles due to compression, and detachment and recovery index (DRI), respectively. Some physicomechanical parameters characterizing the compression behavior of an excipient in a tablet batch could be determined and were found to be functions of the determine DRI of the excipient in the batch.
%0 Journal Article
%I Wolters Kluwer Medknow Publications
%@ 2231-4040