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ORIGINAL ARTICLE
Year : 2015  |  Volume : 6  |  Issue : 2  |  Page : 48-52

In vitro anti-inflammatory, mutagenic and antimutagenic activities of ethanolic extract of Clerodendrum paniculatum root


1 Public Health Sciences Programme, College of Public Health Sciences, Bangkok 10330, Thailand
2 Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
3 Public Health Sciences Programme, College of Public Health Sciences, Bangkok 10330; Department of Pharmacognosy, Faculty of Pharmacy, Rangsit University, Pathumthani 12000, Thailand

Correspondence Address:
Chanida Palanuvej
College of Public Health Sciences, Chulalongkorn University, Bangkok 10330
Thailand
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Source of Support: Mae Fah Luang University for the scholarship of Ph.D. programme and thankful of College of Public Health Sciences and Department of Pharmacology, Faculty of Medicine, Chulalongkorn University for providing facilities throughout the work, Conflict of Interest: None


DOI: 10.4103/2231-4040.154529

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Clerodendrum paniculatum L. (Family Verbenaceae) has been used as an antipyretic and anti-inflammatory drug in traditional Thai medicine. This present study investigated the in vitro anti-inflammatory, mutagenic and antimutagenic activities of the ethanolic extract of C. paniculatum (CPE) dried root collected from Sa Kaeo Province of Thailand. Murine macrophage J774A.1 cells were stimulated by lipopolysaccharide (LPS) to evaluate nitric oxide (NO), tumor necrosis factor-α (TNF-α) and prostaglandin E 2 (PGE 2 ) production in the anti-inflammatory test while the mutagenic and antimutagenic potential was performed by the Ames test. The outcome of this study displayed that the CPE root significantly inhibited LPS-induced NO, TNF-α, and PGE 2 production in macrophage cell line. In addition, the CPE root was not mutagenic toward Salmonella typhimurium strain TA98 and TA100 with and without nitrite treatment. Moreover, it inhibited the mutagenicity of nitrite treated 1-aminopyrene on both strains. The findings suggested the anti-inflammatory and antimutagenic potentials of CPE root.


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