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GUEST EDITORIAL
Year : 2012  |  Volume : 3  |  Issue : 4  |  Page : 200-201  

Natural products derived from plants as a source of drugs

Ciddi Veeresham
Department of Pharmacy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India

Date of Web Publication14-Dec-2012

Correspondence Address:
Ciddi Veeresham
Department of Pharmacy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-4040.104709

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How to cite this article:
Veeresham C. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res 2012;3:200-1

How to cite this URL:
Veeresham C. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res [serial online] 2012 [cited 2023 Mar 28];3:200-1. Available from: https://www.japtr.org/text.asp?2012/3/4/200/104709

Nature, the master of craftsman of molecules created almost an inexhaustible array of molecular entities. It stands as an infinite resource for drug development, novel chemotypes and pharmacophores, and scaffolds for amplification into efficacious drugs for a multitude of disease indications and other valuable bioactive agents. Since time immemorial, natural products have been the backbone of traditional system of healing throughout the globe, and have also been an integral part of history and culture. Although the use of bioactive natural products as herbal drug preparations dates back hundreds, even thousands, of years ago, their application as isolated and characterized compounds to modern drug discovery and development started only in the 19 th century. It has been well documented that natural products played critical roles in modern drug development, especially for antibacterial and antitumor agents. Even though popularity of the synthetic products increased due to its production cost, time effectiveness, easy quality control, stringent regulation and quick effects, but their safety and efficacy was always remained questionable, resulting in the dependence on the natural products by more than 80% of the total population in the developing world, because of its time tested safety and efficacy. A huge number of natural product-derived compounds in various stages of clinical development highlighted the existing viability and significance of the use of natural products as sources of new drug candidates.

Until recently, plants were an important source of novel pharmacologically active compounds with many blockbuster drugs being derived directly or indirectly from plants. Despite the current preoccupation with synthetic chemistry as a vehicle to discover and manufacture drugs, the contribution of plants to disease treatment and prevention is still enormous. Even at the dawn of 21 st century, 11% of the 252 drugs considered as basic and essential by the WHO were exclusively of flowering plant origin.

Obviously natural products will continue to be extremely important as sources of medicinal agents. In addition to the natural products which have found direct medicinal application as drug entities, many others can serve as chemical models or templates for the design, synthesis, and semi synthesis of novel substances for treating humankind's diseases. Although there are some new approaches to drug discovery, such as combinatorial chemistry and computer-based molecular modeling design, and many drugs are made by synthetic chemistry, none of them can replaced the important role of natural products in drug discovery and development as most of the core structures or scaffolds for synthetic chemicals are based upon natural products.

According to Newman and Cragg 2012, the utility of natural products as sources of novel structures is still alive and well. Up to 50% the approved drugs during the last 30 years are from either directly or indirectly from natural products and in the area of cancer, over the time frame from around the 1940s to date, of the 175 small molecules 85 actually being either natural products or directly derived there from.

The use of plants as medicines has a long history in the treatment of various diseases. The plant-derived compounds have a long history of clinical use, better patient tolerance and acceptance. To date, 35,000-70,000 plant species have been screened for their medicinal use. Plants especially those with ethnopharmacological uses have been the primary sources of medicine for early drug discovery. Fabricant and Farnsworth, (2001) reported that, 80% of 122 plant derived drugs were related to their original ethnopharmacological purposes. Current drug discovery from plants mainly relied on bioactivity-guided fractionation and led to isolation of many important anticancer drugs such as paclitaxel, camptothecin etc.

The first commercial pure natural product introduced for therapeutic use is morphine marketed by Merck in 1826, and the first semi-synthetic pure drug aspirin, based on a natural product salicin isolated from Salix alba, was introduced by Bayer in 1899. This led to the isolation of early drugs such as cocaine, codeine, digitoxin, quinine and pilocarpine, of which some are still in use and several other recent plant derived compounds, which have undergone development and have been marketed as drugs which include Paclitaxel from Taxus brevifolia for lung, ovarian and breast cancer, Artemisinin from traditional Chinese plant Artemisia annua to combat multidrug resistant malaria, Silymarin extracted from the seeds of Silybum marianum for the treatment of liver diseases.

There is growing evidence that the old molecules are finding new applications through better understanding of molecular biology and clinical observations. For instance, the alkaloid, forskolin from Coleus forskohlii and phytochemicals from Stephania glabra, are now being rediscovered as adenylate cyclase and nitric oxide activators, which may help in preventing conditions including obesity and atherosclerosis.

During the last decade few plant derived drugs have been launched include Arteether, endoperoxide sesquiterpene lactone and semisynthetic natural product derived from Artemisinin used in malarial treatment, Nitisinone derived from natural product Leptospermone (Callistemon citrinus) is used in treatment of antityrosinaemia, galantamine is a natural alkaloid (obtained from Galanthus nivalis) for Alzhemer's, apomorphine is a semisynthetic compound derived from morphine (Papaver somniferum) used in Parkinson's disease, Tiotropium a derivative of atropine from Atropa belladonna in chronic obstructive pulmonary disease, Dronabinol and Cannabidiol obtained from cannabis plant (Cannabis sativa) and Capsaicin active compound from Capsicum annuum are used as pain relievers.

Natural products discovered so far have played a vital role in improving the human health and have been the drugs of choice despite facing a tough competition from compounds derived from computational and combinatorial chemistry, due to their safety and efficacy. The most striking feature of natural products in connection to their long lasting importance in drug discovery is their structural diversity that is still largely untapped.

Revitalization of the natural products is bringing newer challenges with respect to quality control and standardization along with cost effectiveness. The renewed interest in the development of natural products requires the confluence of the modern techniques and harmonization of regulations related to their research and development between various fields of science.

 
   Authors Top

Prof. (Dr.) Ciddi Veeresham



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60 Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure–activity relationship
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Journal of Enzyme Inhibition and Medicinal Chemistry. 2022; 37(1): 1120
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61 Ayurveda-based phytochemical composition attenuates lung inflammation and precipitates pharmacokinetic interaction with favipiravir: an in vivo investigation using disease-state of acute lung injury
Abhishek Gour, Ashish Dogra, Mahendra K. Verma, Mahir Bhardwaj, Dilpreet Kour, Ashiya Jamwal, Bapi Gorain, Mukesh Kumar, Bhavna Vij, Ajay Kumar, Utpal Nandi
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62 Antimicrobial betalains
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63 Ethnobotanical study of medicinal plants of Pashat Valley, Bajaur, along Pakistan–Afghanistan border: a mountainous region of the Hindu Kush Range
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Nordic Journal of Botany. 2022;
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64 KCNQ Potassium Channels as Targets of Botanical Folk Medicines
Kaitlyn E. Redford, Geoffrey W. Abbott
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65 Phytochemical and biological activities of some Iranian medicinal plants
Salome Dini, Qihe Chen, Faezeh Fatemi, Younes Asri
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66 3ß-Acetoxy-21a-H-hop-22(29)ene, a novel multitargeted phytocompound against SARS-CoV-2: in silico screening
Simna Siddique, R. Pradeep Kumar
Journal of Biomolecular Structure and Dynamics. 2022; : 1
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67 Identification of novel natural product inhibitors of BRD4 using high throughput virtual screening and MD simulation
Soumen Barman, Snehasudha Subhadarsini Sahoo, Jyotirmayee Padhan, Babu Sudhamalla
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68 Qualitative and quantitative phytochemical screening of Nerium oleander L. extracts associated with toxicity profile
Nese Bakir Çilesizoglu, Emine Yalçin, Kültigin Çavusoglu, Selin Sipahi Kuloglu
Scientific Reports. 2022; 12(1)
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69 Coumarin-acetohydrazide derivatives as novel antiproliferative agents via VEGFR-2/AKT axis inhibition and apoptosis triggering
Lina M. A. Abdel Ghany, Nehad M. El-Dydamony, Amira A. Helwa, Sahar M. Abdelraouf, Rana M. Abdelnaby
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70 Isolation and Characterization of Rare Flavone Tetraglycosides from the Seeds of the Bioactive Plant: Peganum harmala L.
Nuriye Hilal Tastekin, Mehmet Atakay, Bekir Salih, A. Ahmet Basaran
Analytical Letters. 2022; : 1
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71 A Novel Compound Plumercine from Plumeria alba Exhibits Promising Anti-Leukemic Efficacies against B Cell Acute Lymphoblastic Leukemia
Aaheli Chatterjee, Amrita Pal, Santanu Paul
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72 In vitro antimycobacterial activity of medicinal plants Lantana camara, Cryptolepis sanguinolenta, and Zanthoxylum leprieurii
Naasson Tuyiringire, Ivan Taremwa Mugisha, Deusdedit Tusubira, Jean-Pierre Munyampundu, Claude Mambo Muvunyi, Yvan Vander Heyden
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases. 2022; 27: 100307
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73 In vitro antiplasmodial activity-directed investigation and UPLC–MS fingerprint of promising extracts and fractions from Terminalia ivorensis A. Chev. and Terminalia brownii Fresen.
Mariscal Brice Tchatat Tali, Darline Dize, Steven Collins Njonte Wouamba, Patrick Valere Tsouh Fokou, Rodrigue Keumoe, Cyrille Njanpa Ngansop, Michelle Sidoine Nguembou Njionhou, Cedric Derick Jiatsa Mbouna, Lauve Rachel Yamthe Tchokouaha, Vinesh Maharaj, Ndivhuwo Kevin Khorommbi, Dashnie Naidoo-Maharaj, Jean Claude Tchouankeu, Fabrice Fekam Boyom
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74 Experimental and clinical trial investigations of phyto-extracts, phyto-chemicals and phyto-formulations in the treatment of oral lichen planus: A systematic review
Alaka Sahoo, Ajaya K. Jena, Maitreyee Panda
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75 Ethnopharmacology and biological activities of the Aizoaceae
B. Kalicharan, Y. Naidoo, J. van Staden
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76 A systematic review on the materialistic use of Pithecellobium dulce in food formulations
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Materials Today: Proceedings. 2022;
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77 Inhibition of Inflammation Associated Corneal Neovascularization by Dalbergia sissoo and Catharanthus roseus Leaves Extracts in Animal Model
Munir Ahmed, Muhammad Umar Khayam Sahibzada, Hafiz Majid Rasheed, Taous Khan, Fazli Wahid, Umar Farooq, Ameer Khusro, Jalal Uddin, Sher Afzal, Ajmal Khan, Ahmed Al-Harrasi
South African Journal of Botany. 2022;
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78 Molecular mechanism of Ferula Asafoetida for the treatment of asthma: Network pharmacology and molecular docking approach
Muhammad Qasim, Muhammad Abdullah, Usman Ali Ashfaq, Fatima Noor, Nazia Nahid, Ahmad Alzamami, Norah A Alturki, Mohsin Khurshid
Saudi Journal of Biological Sciences. 2022; : 103527
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79 An overview of some important deliberations to promote medicinal plants cultivation
Preet Amol Singh, Neha Bajwa, Sampath Chinnam, Arun Chandan, Ashish Baldi
Journal of Applied Research on Medicinal and Aromatic Plants. 2022; : 100400
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80 Seasonality impact on the anti-inflammatory, antiproliferative potential and the lignan composition of Bursera microphylla
Heriberto Torres-Moreno, Julio César López-Romero, Max Vidal-Gutiérrez, Karen Lillian Rodríguez-Martínez, Ramón Enrique Robles-Zepeda, Wagner Vilegas, Gloria Mariana Velarde-Rodríguez
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81 Evaluation of the antibacterial and antifungal potentials of peptide-rich extracts from selected Nigerian plants
Emmanuel A. Agbebi, Olumuyiwa S. Alabi, Abraham O. Nkrumah, Omonike O. Ogbole
European Journal of Integrative Medicine. 2022; : 102163
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82 Bioprospecting Dodonaea viscosa Jacq.; a traditional medicinal plant for antioxidant, cytotoxic, antidiabetic and antimicrobial potential
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Arabian Journal of Chemistry. 2022; : 103688
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83 Identification of secondary metabolites from Crescentia cujete as promising antibacterial therapeutics targeting type 2A topoisomerases through molecular dynamics simulation
Jamiu Olaseni Aribisala, Rukayat Abiola Abdulsalam, Yamkela Dweba, Khumbulani Madonsela, Saheed Sabiu
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84 In vitro and in silico perspectives to explain anticancer activity of a novel syringic acid analog ((4-(1H-1, 3-benzodiazol-2-yl)-2, 6-dimethoxy phenol)) through apoptosis activation and NFkB inhibition in K562 leukemia cells
Srinivasulu Cheemanapalli, Chandrasekaran Palaniappan, Yeshwanth Mahesh, Yuvaraj Iyyappan, Suresh Yarrappagaari, Sekar Kanagaraj
Computers in Biology and Medicine. 2022; : 106349
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85 Ciliatoside A, isolated from Peristrophe japonica, inhibits HBsAg expression and cccDNA transcription by inducing autophagy
Ren Fang, Tan Ming, Jerome P.L. Ng, Wu An Guo, Yuan Si Yu, Zhang Hui, Ren Ji Hua, Cheng Sheng Tao, Zhang Juan, Lo Hang Hong, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Chen Juan
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86 Pharmacological effect of Heritiera fomes on Long Evans rats against Postprandial Hyperglycemia and $${\left(\varvec{C}{\varvec{H}}_{2}\varvec{O}\right)}_{\varvec{n}}$$ adsorption in vitro
Md. Iqbal Hossain Nayan, Md. Mohibul Alam, Md. Abrar Jamil, Md. Ismail Hossain, Iqramul Haq, J.M.A. Hannan
Journal of Diabetes & Metabolic Disorders. 2022;
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87 Investigating the ability of Securigera securidaca extract in biological synthesis of selenium nanoparticles, pancreatic a-amylase inhibition, antioxidant and phenolic capacity and in vivo studying the anti-diabetic effects of extract on pseudo-diabetic r
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Nanotechnology for Environmental Engineering. 2022; 7(1)
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88 Comparative Content, Biological and Anticancer Activities of Heracleum humile Extracts Obtained by Ultrasound-Assisted Extraction Method
Mustafa Ocal, Yasemin Celik Altunoglu, Simone Angeloni, Ahmed M. Mustafa, Giovanni Caprioli, Gokhan Zengin, Mehmet Yavuz Paksoy, Mehmet Cengiz Baloglu
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89 Anti-Inflammatory Potential of Compounds Isolated from Tunisian Lichens Species
Mohamed Mendili, Ayda Khadhri, Jouda Mediouni-Ben Jemâa, Anna Andolfi, Immacolata Tufano, Samira Aschi-Smiti, Marina DellaGreca
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90 Total Bioactive Contents, Metabolic Profiling, Docking Studies, Antioxidant and Enzyme Inhibition Activities of Convolvulus Arvensis L. and Multivariate Analysis to Unravel a Potential Herb as Natural Resource for Phar
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91 Antiviral activity of triptolide on herpes simplex virus in vitro
Nasrin Aliabadi, Marzieh Jamalidoust, Gholamreza Pouladfar, Atoosa Ziyaeyan, Mazyar Ziyaeyan
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92 Eight key rules for successful data-dependent acquisition in mass spectrometry-based metabolomics
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93 Prospects and Challenges of Developing Plant-Derived Snake Antivenin Natural Products: A Focus on West Africa
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94 Computational screening of natural compounds from Salvia plebeia R. Br. for inhibition of SARS-CoV-2 main protease
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95 Non-toxic nature of chebulinic acid on biochemical, hematological and histopathological analysis in normal Sprague Dawley rats
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96 Anti-Leishmania Effects of Volatile Oils and Their Isolates
Patrícia Fampa,Melissa Florencio,Raissa Couto Santana,Dayana Rosa,Deivid Costa Soares,Herbert Leonel de Matos Guedes,Anabela Cordeiro da Silva,Douglas Siqueira A. Chaves,Lucia H. Pinto-da-Silva
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97 Coumarins as Potential Antiprotozoal Agents: Biological Activities and Mechanism of Action
Elkin Jose Torres Sierra,Cleydson Finotti Cordeiro,Livia de Figueiredo Diniz,Ivo Santana Caldas,Jamie Anthony Hawkes,Diogo Teixeira Carvalho
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98 Natural Bioactive Compounds as Potential Browning Agents in White Adipose Tissue
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99 In Vitro Anthelmintic Efficacy of Sesbania sesban var. bicolor, Cyperus compressus and Asparagus racemosus Against Gastrothylax crumenifer (Trematoda)
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100 Optimization of ultrasound-assisted, microwave-assisted and Soxhlet extraction of bioactive compounds from Lagenaria siceraria: A comparative analysis
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101 Challenges and recent trends with the development of hydrogel fiber for biomedical applications
Reema Ansar,Sidra Saqib,Ahmad Mukhtar,Muhammad Bilal Khan Niazi,Muhammad Shahid,Zaib Jahan,Salik Javed Kakar,Bushra Uzair,Muhammad Mubashir,Sami Ullah,Kuan Shiong Khoo,Hooi Ren Lim,Pau Loke Show
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102 Therapeutic effects of medicinal plants on isoproterenol-induced heart failure in rats
Faeze Keihanian,Mohsen Moohebati,Amin Saeidinia,Seyed Ahmad Mohajeri,Saeid Madaeni
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103 Ex vivo and in vivo chemoprotective activity and potential mechanism of Martynoside against 5-fluorouracil-induced bone marrow cytotoxicity
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104 Chitosan-tripolyphosphate nanoparticles designed to encapsulate polyphenolic compounds for biomedical and pharmaceutical applications - A review
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105 Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging
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106 Camptothecinæs Journey from Discovery to WHO Essential Medicine: Fifty Years of Promise
Noura Khaiwa,Noor R. Maarouf,Mhd H. Darwish,Dima W.M. Alhamad,Anusha Sebastian,Mohamad Hamad,Hany A. Omar,Gorka Orive,Taleb H. Al-Tel
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107 Alkaloidal extract from Carica papaya seeds ameliorates CCl4-induced hepatocellular carcinoma in rats
Isaac Kyei-Barffour,Roselind Kyei Baah Kwarkoh,Desmond Omane Acheampong,Augustine Suurinobah Brah,Samuel Addo Akwetey,Benjamin Aboagye
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108 An insight into Verbascum bombyciferum extracts: Different extraction methodologies, biological abilities and chemical profiles
Simone Angeloni,Gokhan Zengin,Kouadio Ibrahim Sinan,Gunes Ak,Filippo Maggi,Giovanni Caprioli,Alevcan Kaplan,Muammer Bahsi,Ugur Çakilcioglu,Abdelhakim Bouyahya,Sharmeen Jugreet,Mohamad Fawzi Mahomoodally
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109 Combination of docosahexaenoic acid and Ginko biloba extract improves cognitive function and hippocampal tissue damages in a mouse model of Alzheimer’s disease
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110 Electrospun nanocarriers for delivering natural products for cancer therapy
Reza Mohammadinejad,Vijay Sagar Madamsetty,Anuj Kumar,Mohammad Varzandeh,Ali Dehshahri,Ali Zarrabi,Fariba Sharififar,Mehdi Mohammadi,Amir Fahimipour,Seeram Ramakrishna
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111 Antiglycation and enzyme inhibitory potential of salicylalazine isolated from Micromeria biflora (Buch.-Ham.ex D.Don) Benth
Abdur Rauf,Saud Bawazeer,Umer Rashid,Mohamed A. El-Esawi,Muhammad Humayun Khan,Syed Uzair Ali Shah,Mohammad S. Mubarak,Kannan RR Rengasamy
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112 Molecular docking and network pharmacology-based approaches to explore the potential of terpenoids for Mycobacterium tuberculosis
K. Kalaimathi,G. Thiyagarajan,S. Vijayakumar,K. Bhavani,K. Karthikeyan,J. Maria Jancyrani,K. Doss,J. Sureshkumar,S. Prabhu
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113 Evaluation of the antiulcerogenic activity of hydromethanol extracts of Solanum incanum L. (Solanaceae) leaves and roots in mice; single and repeated dose study
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114 Antiplasmodial diterpenoid alkaloid from Aconitum heterophyllum Wall. ex Royle: Isolation, characterization, and UHPLC-DAD based quantification
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115 Red laser-mediated alterations in seed germination, growth, pigments and withanolide content of Ashwagandha [Withania somnifera (L.) Dunal]
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Journal of Photochemistry and Photobiology B: Biology. 2021; : 112144
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116 Molecular pharming to support human life on the moon, mars, and beyond
Matthew J. McNulty,Yongao (Mary) Xiong,Kevin Yates,Kalimuthu Karuppanan,Jacob M. Hilzinger,Aaron J. Berliner,Jesse Delzio,Adam P. Arkin,Nancy E. Lane,Somen Nandi,Karen A. McDonald
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117 Linalool attenuates acquisition and reinstatement and accelerates the extinction of nicotine-induced conditioned place preference in male mice
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118 A Study on the Effect of Valeric Acid in Alzheimer's Induced Rats by the Estimation of Aß 1-42 Biomarker
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119 Glycine betaine-based ionic liquids and their influence on bacteria, fungi, insects and plants
Damian Krystian Kaczmarek,Daniela Gwiazdowska,Krzysztof Jus,Tomasz Klejdysz,Marta Wojcieszak,Katarzyna Materna,Juliusz Pernak
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120 Acute and sub-acute oral toxicity Lagerstroemia speciosa in Sprague-Dawley rats
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121 New 3-O-substituted xanthone derivatives as promising acetylcholinesterase inhibitors
Zi Han Loh,Huey Chong Kwong,Kok Wai Lam,Soek Sin Teh,Gwendoline Cheng Lian Ee,Ching Kheng Quah,Anthony Siong Hock Ho,Siau Hui Mah
Journal of Enzyme Inhibition and Medicinal Chemistry. 2021; 36(1): 627
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122 A Review on Pharmacological, Anti-oxidant Activities and Phytochemical Constituents of a Novel Lichen Parmotrema Species
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123 Pharmacological profile of Shiva Gutika: an uncharted and versatilepolyherbal drug
V. H. Pushpa, M. K. Jayanthi, Shashank M. Patil, Ramith Ramu
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124 Hesperidin-An Emerging Bioactive Compound against Metabolic Diseases and Its Potential Biosynthesis Pathway in Microorganism.
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125 Aerosol-based Pulmonary Delivery of Therapeutic Molecules from Food Sources: Delivery Mechanism, Research Trends, and the Way Forward
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126 Resveratrol impairs acquisition, reinstatement and precipitates extinction of alcohol-induced place preference in mice
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Neurological Research. 2021; : 1
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127 In-silico screening and identification of phytochemicals from Centella asiatica as potential inhibitors of sodium-glucose co-transporter 2 for treating diabetes
Mark Andrian B. Macalalad,Arthur A. Gonzales
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128 Herbal antioxidants in dialysis patients: a review of potential mechanisms and medical implications
Masoumeh Asgharpour,Amirhesam Alirezaei
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129 Recent development in biological activities and safety concerns of perillaldehyde from perilla plants: A review
Famous Erhunmwunsee,Chao Pan,Kunlong Yang,Yongxin Li,Man Liu,Jun Tian
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130 Nutraceuticals: unlocking newer paradigms in the mitigation of inflammatory lung diseases
Yinghan Chan,Venkata Sita Rama Raju Allam,Keshav Raj Paudel,Sachin K. Singh,Monica Gulati,Muralikrishnan Dhanasekaran,Piyush Kumar Gupta,Niraj Kumar Jha,Hari Prasad Devkota,Gaurav Gupta,Philip M Hansbro,Brian Gregory George Oliver,Dinesh Kumar Chellappan,Kamal Dua
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131 Evaluation of the Hypoglycemic Potential of Leaves Extract of Spondias pinnata (L.f.) Kurz. from Nepal
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132 Traditional Medicinal Vegetables in Northern Uganda: An Ethnobotanical Survey
Rebecca Nakaziba,Maxson Kenneth Anyolitho,Sharon Bright Amanya,Crispin Duncan Sesaazi,Frederick Byarugaba,Jasper Ogwal-Okeng,Paul E. Alele,Severino Matias de Alencar
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133 Antifungal and Antibacterial Activities of Apple Vinegar of Different Cultivars
Driss Ousaaid,Hassan Laaroussi,Meryem Bakour,Hayat Ennaji,Badiaa Lyoussi,Ilham El Arabi,Giuseppe Comi
International Journal of Microbiology. 2021; 2021: 1
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134 Evaluation of the Antidiarrheal and Antioxidant Effects of Some Chewing Sticks Commonly Used for Oral Hygiene in Ghana
Edward Ken Essuman,Adjoa Agyemang Boakye,Clement Okraku Tettey,Gaston Hunkpe,Nii Korley Kortei,Henrietta Kwansa-Bentum,Sayanika Davi Waikhom,Enoch Aninagyei,Harish Chandra
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135 Therapeutic potential and pharmacological activities of ß-eudesmol
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136 Transferring Ethnopharmacological Results Back to Traditional Healers in Rural Indigenous Communities – The Ugandan Greater Mpigi Region Example
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137 An in vitro study of an Artocarpus heterophyllus substance as a hepatitis C antiviral and its combination with current anti-HCV drugs
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138 Alkaloidal Extract From Carica papaya Seeds Ameliorates CCl 4-Induced Hepatocellular Carcinoma in Rats
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139 Phytochemistry, Traditional Uses and Pharmacological Properties of Enhydra fluctuans Lour: a Comprehensive Review
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140 Current Knowledge Regarding Pharmacological Profile and Chemical Constituents of Gynura procumbens
Ehfazul Haque, Mir Shahriar Kamal, Md. Rafat Tahsin, Raju Ahmed, Jakir Ahmed Choudhury, Abu Asad Choudhury, Shaila Kabir, Md. Shah Amran, Md. Sahab Uddin
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141 Antioxidant, Anti-Inflammatory and Cytotoxic Properties of Centaurea africana Lamk var. [Bonnet] M
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142 Green synthesis of silver nanoparticles using Tropaeolum majus: Phytochemical screening and antibacterial studies
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143 Thymoquinone and its derivatives against breast cancer with HER2 positive: in silico studies of ADMET, docking and QSPR
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144 Toxicological evaluations of betulinic acid and ursolic acid; common constituents of Houttuynia cordata used as an anthelmintic by the Naga tribes in North-east India
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145 The neuroprotective attribution of Ocimum basilicum: a review on the prevention and management of neurodegenerative disorders
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146 Sub-Acute Oral Toxicity Study of Ethanol Extract of Oroxylum Indicum Leafin C57BL/6 Mice
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147 COVID-19: Challenges, Preventive Measures and Remediation
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148 Isolation, Characterization of Active Constituent and Evaluation of Hepatoprotective Activity of Inula Racemosa Hook. F. Roots
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149 UPLC-ESI-Q-TOF-MS-Based Metabolite Profiling, Antioxidant and Anti-Inflammatory Properties of Different Organ Extracts of Abeliophyllum distichum
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150 Usnic Acid and Usnea barbata (L.) F.H. Wigg. Dry Extracts Promote Apoptosis and DNA Damage in Human Blood Cells through Enhancing ROS Levels
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151 LC-MS Based Analysis and Biological Properties of Pseudocedrela kotschyi (Schweinf.) Harms Extracts: A Valuable Source of Antioxidant, Antifungal, and Antibacterial Compounds
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152 PHARMACOGNOSTICAL STUDIES OF LEAVES OF ACACIA ETBAICA SUBSPECIES UNCINATA
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153 Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives
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154 Optimization of PhysicoChemical Parameters for Production of Cytotoxic Secondary Metabolites and Apoptosis Induction Activities in the Culture Extract of a Marine Algal–Derived Endophytic Fungus Aspergillus sp.
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155 Synthesis, Characterization and Bioactivity Profiling of Gold Nanoparticles of Trachyspermum ammi Crude Extract
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156 Deeper Insights on Alchornea cordifolia (Schumach. & Thonn.) Müll.Arg Extracts: Chemical Profiles, Biological Abilities, Network Analysis and Molecular Docking
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157 Cheminformatics-Based Identification of Potential Novel Anti-SARS-CoV-2 Natural Compounds of African Origin
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158 Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy
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159 Phytochemicals Targeting JAK–STAT Pathways in Inflammatory Bowel Disease: Insights from Animal Models
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160 Natural Xanthine Oxidase Inhibitor 5-O-Caffeoylshikimic Acid Ameliorates Kidney Injury Caused by Hyperuricemia in Mice
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161 Atheroprotective Properties of Costus spicatus (Jacq.) Sw. in Female Rats
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162 Evaluation of the Effectiveness of Herbal Components Based on Their Regulatory Signature on Carcinogenic Cancer Cells
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163 Antiviral Properties of Polyphenols from Plants
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164 Adjunctive Nutraceutical Therapies for COVID-19
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165 Advanced Analytical Approaches for the Analysis of Polyphenols in Plants Matrices—A Review
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166 Analytical Separation of Carcinogenic and Genotoxic Alkenylbenzenes in Foods and Related Products (2010–2020)
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167 SARS-CoV-2 Fears Green: The Chlorophyll Catabolite Pheophorbide A Is a Potent Antiviral
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168 Bryo-Activities: A Review on How Bryophytes Are Contributing to the Arsenal of Natural Bioactive Compounds against Fungi
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169 Selective Anticancer Properties, Proapoptotic and Antibacterial Potential of Three Asplenium Species
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170 Elemental Analysis and In Vitro Evaluation of Antibacterial and Antifungal Activities of Usnea barbata (L.) Weber ex F.H. Wigg from Calimani Mountains, Romania
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171 In-vitro Comparative study on blood clotting time of some Plants Extracts and Heparin when Infected with Snakebite
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173 Quality assessment of frequently available mother tinctures in the market by employing standard values
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174 Therapeutic uses of post-partum tissue-derived mesenchymal stromal cell secretome
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175 Factorial design-guided optimization of extraction of therapeutically active furanocoumarin khellin from Ammi majus L. fruits
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176 Lead Compounds in the Context of Extracellular Vesicle Research
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177 Phytochemicals and Enzyme Inhibitory Capacities of the Methanolic Extracts from the Italian Apple Cultivar Mela Rosa dei Monti Sibillini
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178 Genista tridentata L.: A Rich Source of Flavonoids with Anti-Inflammatory Activity
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179 Chelerythrine Chloride Downregulates ß-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma
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180 Untargeted Characterization of Chestnut (Castanea sativa Mill.) Shell Polyphenol Extract: A Valued Bioresource for Prostate Cancer Cell Growth Inhibition
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181 Synthesis and Properties of CurNQ for the Theranostic Application in Ovarian Cancer Intervention
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182 Phytochemicals as Anti-Inflammatory Agents in Animal Models of Prevalent Inflammatory Diseases
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183 Prevention of Oxidative Stress-Induced Pancreatic Beta Cell Damage by Broussonetia kazinoki Siebold Fruit Extract via the ERK-Nox4 Pathway
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184 Assessment of the Pharmacological Properties and Phytochemical Profile of Bruguiera gymnorhiza (L.) Lam Using In Vitro Studies, In Silico Docking, and Multivariate Analysis
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185 Punica granatum L. (Pomegranate): A Potential Anti-microbial Agent
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186 Traditional and Herbal Medicines: Understanding & Exploration (Part II)
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187 Investigation of the Biological Activities of Different Extracts from Dipsacus laciniatus Aerial Parts
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189 Antioxidant and in vivo hepatoprotective effects of Gardenia gummifera L.f. fruit methanol extract
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190 In vitro antimitotic and cytotoxic potential of plant extracts: a comparative study of Mucuna pruriens, Asteracantha longifolia and Sphaeranthus indicus
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191 Ethnobotanical survey of the medicinal flora of Harighal, Azad Jammu & Kashmir, Pakistan
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192 Therapeutic Potential of Medicinal Plant Proteins: Present Status and Future Perspectives
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193 Metabolism and Pharmacokinetics of Phytochemicals in the Human Body
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194 Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections
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195 RP-HPLC-UV Analysis of the Phenolic Compounds, Antimicrobial Activity Against Multi-Drug Resistant Bacteria and Antioxidant Activity of Fruit and Seed of Diospyros lotus L.ctivity of Fruit and Seed of Diospyros lotus L.
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196 Antioxidant Potential of Glycyrrhiza glabra L. roots: In-Vitro Evidences
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197 Ethnobotanical Description and Biological Activities of Senna alata
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198 In Silico Identification of New Targets for Diagnosis, Vaccine, and Drug Candidates against Trypanosoma cruzi
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199 Pharmacological Assessment of the Carvacrol Chemotype Essential Oil FromPlectranthus amboinicusGrowing in Cuba
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200 Inhibitory potential on key enzymes relevant to type II diabetes mellitus and antioxidant properties of the various extracts and phytochemical constituents from Rumex acetosella L
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201 Hepatoprotective and hematological effects of Justicia secunda Vahl leaves on carbon tetrachloride induced toxicity in rats
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202 Antimicrobial activity of Plumbago indica and ligand screening of plumbagin against methicillin-resistant Staphylococcus aureus
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203 Dark Classics in Chemical Neuroscience: An Evidence-Based Systematic Review of Belladonna
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204 cis-9-Hexadecenal, a Natural Compound Targeting Cell Wall Organization, Critical Growth Factor, and Virulence of Aspergillus fumigatus
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205 Antiproliferative activity of new pentacyclic triterpene and a saponin from Gladiolus segetum Ker-Gawl corms supported by molecular docking study
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206 A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids
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207 Antioxidant properties of the Lebanese plantIrisxgermanicaL. crude extracts and antagonism of chlorpromazine toxicity onSaccharomyces cerevisiae
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208 Bioassay-guided isolation of antiplasmodial and antimicrobial constituents from the roots of Terminalia albida
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209 Constituents of essential oil of Origanum minutiflorum and its in vitro antioxidant, scolicidal and anticancer activities
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219 Production of plant natural products through engineered Yarrowia lipolytica
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Biotechnology Advances. 2020; : 107555
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220 Generation of A Stable GFP-reporter Zika Virus System for High-throughput Screening of Zika Virus Inhibitors
Jing-Wei Zhang,Han Wang,Jing Liu,Le Ma,Rong-Hong Hua,Zhi-Gao Bu
Virologica Sinica. 2020;
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221 Urolithin A Induces Brown-like Phenotype in 3T3-L1 White Adipocytes via ß3-adrenergic Receptor-p38 MAPK Signaling Pathway
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Biotechnology and Bioprocess Engineering. 2020;
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222 Phytochemicals and biological activities of species from the genus Maytenus
Lei Zhang,Ming-Yue Ji,Ming-Yue Bin Qiu,Qin-Yu Li,Ke-Yong Zhang,Ji-Cheng Liu,Lian-Sheng Dang,Min-Hui Li
Medicinal Chemistry Research. 2020;
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223 Anti-Cancer and Anti-Inflammatory Activities of Bromo- and Cyano-Substituted Azulene Derivatives
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Inflammation. 2020;
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224 Antifungal Activity of Essential Oils Against Candida Species Isolated from Clinical Samples
S. Córdoba,W. Vivot,W. Szusz,G. Albo
Mycopathologia. 2019;
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225 The genus Laggera (Asteraceae) – Ethnobotanical and Ethnopharmacological Information, Chemical Composition as well as Biological Activities of Its Essential Oils and Extracts: A Review
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Chemistry & Biodiversity. 2019;
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226 Essential oil yield estimation by Gas chromatography–mass spectrometry (GC–MS) after Methyl jasmonate (MeJA) elicitation in in vitro cultivated tissues of Coriandrum sativum L.
Muzamil Ali,Abdul Mujib,Basit Gulzar,Nadia Zafar
3 Biotech. 2019; 9(11)
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227 Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system
Aleksandra Golonko,Tomasz Pienkowski,Renata Swislocka,Ryszard Lazny,Marek Roszko,Wlodzimierz Lewandowski
European Journal of Medicinal Chemistry. 2019;
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228 Status and future scope of plant-based green hydrogels in biomedical engineering
Reza Mohammadinejad,Hajar Maleki,Eneko Larrañeta,André R. Fajardo,Amirala Bakhshian Nik,Amin Shavandi,Amir Sheikhi,Mansour Ghorbanpour,Mehdi Farokhi,Praveen Govindh,Etienne Cabane,Susan Azizi,Amir Reza Aref,Masoud Mozafari,Mehdi Mehrali,Sabu Thomas,João F. Mano,Yogendra Kumar Mishra,Vijay Kumar Thakur
Applied Materials Today. 2019; 16: 213
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229 Progress in the discovery of naturally occurring anti-diabetic drugs and in the identification of their molecular targets
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Fitoterapia. 2019; 134: 270
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230 Accessing to the Nicotiana tabacum leaf antimicrobial activity: In-silico and in-vitro investigations
Yanelis Capdesuñer,Jorge García-Brizuela,Hans Peter Mock,Karel Vives Hernández,Martha Hernández de la Torre,Cosme E. Santiesteban-Toca
Plant Physiology and Biochemistry. 2019;
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231 Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?
Reece G. Kenny,Celine J. Marmion
Chemical Reviews. 2019; 119(2): 1058
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232 In silico identification of mimicking molecule(s) triggering von Willebrand factor in human: a molecular drug target for regulating coagulation pathway
Garima Rana,Rajesh Kumar Pathak,Rohit Shukla,Mamta Baunthiyal
Journal of Biomolecular Structure and Dynamics. 2019; : 1
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233 Pharmacokinetics of thymoquinone in layer chickens following oral and intravenous administration
Sehrish Iqbal,Aqeel Javeed,Adeel Sattar,Rabia Tanvir
Journal of Veterinary Pharmacology and Therapeutics. 2019;
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234 Morelloflavone as a novel inhibitor of mitotic kinesin Eg5
Tomisin Happy Ogunwa,Kenichi Taii,Kei Sadakane,Yuka Kawata,Shinsaku Maruta,Takayuki Miyanishi
The Journal of Biochemistry. 2019;
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235 Protective Effects of Broussonetia kazinoki Siebold Fruit Extract against Palmitate-Induced Lipotoxicity in Mesangial Cells
Donghee Kim,Hyo-Jin Kim,Seon-Heui Cha,Hee-Sook Jun
Evidence-Based Complementary and Alternative Medicine. 2019; 2019: 1
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236 Pharmacotherapeutics and Molecular Mechanism of Phytochemicals in Alleviating Hormone-Responsive Breast Cancer
Shailima Rampogu,Chanin Park,Doneti Ravinder,Minky Son,Ayoung Baek,Amir Zeb,Rohit Bavi,Raj Kumar,Gihwan Lee,Shraddha Parate,Smita C. Pawar,Yohan Park,Seok Ju Park,Keun Woo Lee
Oxidative Medicine and Cellular Longevity. 2019; 2019: 1
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237 Cannabis medicinal, más que una encrucijada legal para el tratamiento de la epilepsia
Diana C. Riveros,Laura E. González-Valenzuela
Revista La Propiedad Inmaterial. 2019; (28): 259
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238 The Promising Role of Plant Tannins as Bioactive Antidiabetic Agents
Mohammed Ajebli,Mohamed Eddouks
Current Medicinal Chemistry. 2019; 26(25): 4852
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239 Use of Natural Components Derived from Oil Seed Plants for Treatment of Inflammatory Skin Diseases
Monika Styrczewska,Magdalena Zuk,Aleksandra Boba,Iwan Zalewski,Anna Kulma
Current Pharmaceutical Design. 2019; 25(20): 2241
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240 Medicinal Plant Compounds for Combating the Multi-drug Resistant Pathogenic Bacteria: A Review
Mulugeta Mulat,Archana Pandita,Fazlurrahman Khan
Current Pharmaceutical Biotechnology. 2019; 20(3): 183
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241 Oral Acute and Repeated-Doses Toxicity Study of Valepotriates from Valeriana glechomifolia (Meyer) in Mice
Tielle Moraes de Almeida,Gilsane Lino von Poser,Liz Girardi Müller,Paula Reis Pereira,Eduardo Cassel,Rubem Mario Figueiro Vargas,Nilson Junior da Silva Nunes,David Driemeier,Eliane Dallegrave,Stella de Faria Valle,Stela Maris Kuze Rates
Current Drug Discovery Technologies. 2019; 16(1): 96
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242 Isolation, Characterization and Assessment for Central Nervous System Effects of Novel Phytomolecule from Galphimia glauca Cav. Stems
VAISHNAVI VEERA REDDY,BHARGAVI THALLURI,BABA SHANKAR RAO GARIGE,RAM MOHAN MANDA,VASUDHA BAKSHI
Asian Journal of Chemistry. 2019; 31(6): 1230
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243 Crystal structure and in vitro antimicrobial activity studies of Robustic acid and other Alpinumisoflavones isolated from Millettia thonningii
Jerry Joe E.K. Harrison,Moscoh Daniel Ayine-Tora,Benjamin Appiagyei,Felix C. Mills-Robertson,William A. Asomaning,Daniel G. Achel,Hiroyuki Ishida,Robert Kingsford-Adaboh
Zeitschrift für Kristallographie - Crystalline Materials. 2019; 234(4): 229
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244 Inhibition of Aspergillus fumigatus Biofilm and Cytotoxicity Study of Natural Compound Cis-9-Hexadecenal
Shanu Hoda,Lovely Gupta,Harshita Agarwal,Gaurav Raj,Maansi Vermani,Pooja Vijayaraghavan
Journal of Pure and Applied Microbiology. 2019; 13(2): 1207
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245 Deciphering the Antibacterial Mode of Action of Alpha-Mangostin on Staphylococcus epidermidis RP62A Through an Integrated Transcriptomic and Proteomic Approach
Murugesan Sivaranjani,Katarzyna Leskinen,Chairmandurai Aravindraja,Päivi Saavalainen,Shunmugiah Karutha Pandian,Mikael Skurnik,Arumugam Veera Ravi
Frontiers in Microbiology. 2019; 10
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246 Larrea tridentata Extract Mitigates Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells
Karla Morán-Santibañez,Abimael H. Vasquez,Armando Varela-Ramirez,Veronica Henderson,Janae Sweeney,Valerie Odero-Marah,Karine Fenelon,Rachid Skouta
Antioxidants. 2019; 8(10): 427
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247 Cutting-Edge Search for Safer Opioid Pain Relief: Retrospective Review of Salvinorin A and Its Analogs
Jordan K. Zjawiony,Antônio S. Machado,Ricardo Menegatti,Paulo C. Ghedini,Elson A. Costa,Gustavo R. Pedrino,Scott E. Lukas,Octávio L. Franco,Osmar N. Silva,James O. Fajemiroye
Frontiers in Psychiatry. 2019; 10
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248 Phenolic Profiling and Biological Potential of Ficus curtipes Corner Leaves and Stem Bark: 5-Lipoxygenase Inhibition and Interference with NO Levels in LPS-Stimulated RAW 264.7 Macrophages
Catarina Andrade,Federico Ferreres,Nelson G. M. Gomes,Sutsawat Duangsrisai,Nattawut Srisombat,Srunya Vajrodaya,David M. Pereira,Angel Gil-Izquierdo,Paula B. Andrade,Patrícia Valentão
Biomolecules. 2019; 9(9): 400
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249 Evaluating Iso-Mukaadial Acetate and Ursolic Acid Acetate as Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase Inhibitors
Francis Opoku,Penny P. Govender,Ofentse J. Pooe,Mthokozisi B.C. Simelane
Biomolecules. 2019; 9(12): 861
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250 Casticin-Induced Inhibition of Cell Growth and Survival Are Mediated through the Dual Modulation of Akt/mTOR Signaling Cascade
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Cancers. 2019; 11(2): 254
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251 Phytochemical Profiling of Coryphantha macromeris (Cactaceae) Growing in Greenhouse Conditions Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
Emmanuel Cabañas-García,Carlos Areche,Juan Jáuregui-Rincón,Francisco Cruz-Sosa,Eugenio Pérez-Molphe Balch
Molecules. 2019; 24(4): 705
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252 At-Line Monitoring of the Extraction Process of Rosmarini Folium via Wet Chemical Assays, UHPLC Analysis, and Newly Developed Near-Infrared Spectroscopic Analysis Methods
Stefanie Delueg,Christian G. Kirchler,Florian Meischl,Yukihiro Ozaki,Michael A. Popp,Günther K. Bonn,Christian W. Huck
Molecules. 2019; 24(13): 2480
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253 Erythroxylum in Focus: An Interdisciplinary Review of an Overlooked Genus
J.C.A. Restrepo,J.C.A. Saenz,J.C.A. Jara-Muñoz,J.C.A. Calixto-Botía,J.C.A. Rodríguez-Suárez,J.C.A. Zuleta,J.C.A. Chavez,J.C.A. Sanchez,J.C.A. D’Auria
Molecules. 2019; 24(20): 3788
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254 Cytotoxic Potential and Phytochemical Profile of Extracts from Garcinia rubra Merr. Leaves
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International Journal of Cancer Research. 2019; 15(2): 38
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255 Effects of Hydroalcoholic Flower Extract of Marigold (Calendula officinalis) on the Biochemical and Histological Parameters in STZ-Induced Diabetic Rats
Esmaeel Ebrahimi,Alireza Kheirollah,Esrafil Mansouri,Hossein Babaahmadi-Razaei,Ghorban Mohammadzadeh
Jundishapur Journal of Natural Pharmaceutical Products. 2019; In Press(In Press)
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256 Natural Products Extraction of the Future—Sustainable Manufacturing Solutions for Societal Needs
Lukas Uhlenbrock,Maximilian Sixt,Martin Tegtmeier,Hartwig Schulz,Hansjörg Hagels,Reinhard Ditz,Jochen Strube
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257 Transcriptional Profiles of Secondary Metabolite Biosynthesis Genes and Cytochromes in the Leaves of Four Papaver Species
Dowan Kim,Myunghee Jung,In Ha,Min Lee,Seok-Geun Lee,Younhee Shin,Sathiyamoorthy Subramaniyam,Jaehyeon Oh
Data. 2018; 3(4): 55
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258 Effects of Mulberry Fruit (Morus alba L.) Consumption on Health Outcomes: A Mini-Review
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Antioxidants. 2018; 7(5): 69
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259 Evaluation of Manganese Chloride’s Effect on Biosynthetic Properties of In Vitro Cultures of Eschscholzia californica Cham.
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Molecules. 2018; 23(4): 971
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260 Molecular Targets Modulated by Fangchinoline in Tumor Cells and Preclinical Models
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Molecules. 2018; 23(10): 2538
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261 Antioxidant activity, antibacterial potential and characterization of active fraction of Dioscorea pentaphylla L. tuber extract collected from Similipal Biosphere Reserve, Odisha, India
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Brazilian Journal of Pharmaceutical Sciences. 2018; 53(4)
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262 Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities
Ammara Riaz,Azhar Rasul,Ghulam Hussain,Muhammad Kashif Zahoor,Farhat Jabeen,Zinayyera Subhani,Tahira Younis,Muhammad Ali,Iqra Sarfraz,Zeliha Selamoglu
Advances in Pharmacological Sciences. 2018; 2018: 1
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263 Isolation of anticancer constituents from Cucumis prophetarum var. prophetarum through bioassay-guided fractionation
Abdulrhman Alsayari,Lucas Kopel,Mahmoud Salama Ahmed,Hesham S. M. Soliman,Sivakumar Annadurai,Fathi T. Halaweish
BMC Complementary and Alternative Medicine. 2018; 18(1)
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264 Toxicity and Antigenotoxic Effect of Hispolon Derivatives: Role of Structure in Modulating Cellular Redox State and Thioredoxin Reductase
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ACS Omega. 2018; 3(6): 5958
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265 Recommended Medicinal Plants as Source of Natural Products: A Review
Henry Ivanz A. Boy,Alfred Joshua H. Rutilla,Kimbberly A. Santos,Allister Matthew T. Ty,Alicia I. Yu,Tooba Mahboob,Jitbanjong Tangpoong,Veeranoot Nissapatorn
Digital Chinese Medicine. 2018; 1(2): 131
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266 Bioactive Compounds Extracted from Mangrove Plants (Avicennia marina and Rhizophora mucronata): an Overview
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267 Alkaloid rich fraction of Datura alba Rumph. ex Nees leaves possesses antitumor and antimitotic activity
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South African Journal of Botany. 2018; 117: 282
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268 Toxic effect of Moringa peregrina seeds on histological and biochemical analyses of adult male Albino rats
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269 The Medicinal Uses, Toxicities and Anti-inflammatory Activity of Polyalthia Species (Annonaceae)
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Journal of Ethnopharmacology. 2018;
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270 Evaluation of Boerhavia erecta L. for potential antidiabetic and antihyperlipidemic activities in streptozotocin-induced diabetic Wistar rats
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Future Journal of Pharmaceutical Sciences. 2018;
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271 HPLC-DAD profiles and pharmacological insights of Onobrychis argyrea subsp isaurica extracts
Gokalp Ozmen Guler,Gokhan Zengin,Firat Karadag,Adriano Mollica,Carene Marie Nancy Picot,Mohamad Fawzi Mahomoodally
Computational Biology and Chemistry. 2018; 76: 256
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272 Optimization of extraction parameters of antioxidant activity of extracts from New Zealand and Chinese Asparagus officinalis L root cultivars
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Industrial Crops and Products. 2018; 119: 191
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273 Lotus aegaeus (Gris.) Boiss and Iberis sempervirens L.: Chemical fingerprints, antioxidant potential, and inhibition activities and docking on key enzymes linked to global health problems
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274 Phytochemical screening, free radical scavenging and antimicrobial potential of Chromolaena odorata leaf extracts against pathogenic bacterium in wound infections– a multispectrum perspective
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Biocatalysis and Agricultural Biotechnology. 2018;
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275 Comprehensive review of antimicrobial activities of plant flavonoids
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Phytochemistry Reviews. 2018;
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276 Effect of Synadenium grantii and its isolated compound on dysmenorrhea behavior model in mice
Flávia Werner da Rocha Jesuíno,Jaqueline Pavesi Reis,Juliana Cristina Pereira Whitaker,Adriana Campos,Maria Verônica Dávila Pastor,Valdir Cechinel Filho,Nara Lins Meira Quintão
Inflammopharmacology. 2018;
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277 Constituents of leaves from Bauhinia curvula Benth. exert gastroprotective activity in rodents: role of quercitrin and kaempferol
Ana Paula Beber,Priscila de Souza,Thaise Boeing,Lincon Bordignon Somensi,Luísa Nathália Bolda Mariano,Benhur Judah Cury,Ligia Moura Burci,Cristiane Bezerra da Silva,Euclésio Simionatto,Sérgio Faloni de Andrade,Luísa Mota da Silva
Inflammopharmacology. 2017;
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278 Antidiabetic plant-derived nutraceuticals: a critical review
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European Journal of Nutrition. 2017;
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279 Metal-Free trans -Aziridination of Zerumbone: Synthesis and Biological Evaluation of Aziridine Derivatives of Zerumbone
Greeshma Gopalan,Bhandara Purayil Dhanya,Jayaram Saranya,Thankappan Remadevi Reshmitha,Thekke Veettil Baiju,Murugan Thulasi Meenu,Mangalam S. Nair,Prakasan Nisha,Kokkuvayil Vasu Radhakrishnan
European Journal of Organic Chemistry. 2017; 2017(21): 3072
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280 Exploiting natural variation for accelerating discoveries in plant specialized metabolism
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Phytochemistry Reviews. 2017;
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281 Euclea undulata Thunb.: Review of its botany, ethnomedicinal uses, phytochemistry and biological activities
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Asian Pacific Journal of Tropical Medicine. 2017;
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282 A Novel DSC Approach for Evaluating Protectant Drugs Efficacy against Dementia
Silviya Abarova,Rumiana Koynova,Lyubka Tancheva,Boris Tenchov
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2017;
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283 Topical aqueous extract of Ephedra alata can improve wound healing in an animal model
Naim Kittana,Hanood Abu-Rass,Ruba Sabra,Lama Manasra,Hadeel Hanany,Nidal Jaradat,Fatima Hussein,Abdel Naser Zaid
Chinese Journal of Traumatology. 2017;
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284 Antinociceptive and anti-inflammatory effects of the methanolic stem bark extract of Antrocaryon klaineanum Pierre (Anacardiaceae) in mice and rat
Annie Laure Magne Fongang,Edwige Laure Nguemfo,Yolande Djouatsa Nangue,Calvin Bogning Zangueu,Yannick Fouokeng,Anatole Guy Blaise Azebaze,Eulogio José Llorent-Martínez,Maria Luisa Fernández-de Córdova,Alain Bertrand Dongmo,Wolfgang Vierling
Journal of Ethnopharmacology. 2017; 203: 11
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285 Antibacterial activity of medicinal plants from The Physicians of Myddvai, a 14th century Welsh medical manuscript
Charles Stephen Wagner,Jillian De Gezelle,Maureen Robertson,Keith Robertson,Mickey Wilson,Slavko Komarnytsky
Journal of Ethnopharmacology. 2017; 203: 171
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286 A polyphenolic extract from green tea leaves activates fat browning in high fat diet-induced obese mice
Audrey M. Neyrinck,Laure B. Bindels,Lucie Geurts,Matthias Van Hul,Patrice D. Cani,Nathalie M. Delzenne
The Journal of Nutritional Biochemistry. 2017;
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287 Bioavailability-enhanced Resveramax™ modulates quorum sensing and inhibits biofilm formation in Pseudomonas aeruginosa PAO1
H.S. Vasavi,H.V. Sudeep,H.B. Lingaraju,K. Shyam Prasad
Microbial Pathogenesis. 2017;
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288 Broadening our perspectives on complementary and alternative medicine for menopause: A narrative review
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Maturitas. 2017; 99: 79
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289 Biological activities of plant extracts from Ficus elastica and Selaginella vogelli : An antimalarial, antitrypanosomal and cytotoxity evaluation
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Saudi Journal of Biological Sciences. 2017;
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290 In vitro antimicrobial activity of the methanol extract and compounds from the wood of Ficus elastica Roxb. ex Hornem. aerial roots
J.E. Mbosso Teinkela,X. Siwe Noundou,S. Fannang,F. Meyer,J.C. Vardamides,E. Mpondo Mpondo,R.W.M. Krause,A.G.B. Azebaze,J.C.A. Nguedia
South African Journal of Botany. 2017; 111: 302
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291 Magnolol inhibits venous remodeling in mice
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Scientific Reports. 2017; 7(1)
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292 Molecular binding mechanism of 5-hydroxy-1-methylpiperidin-2-one with human serum albumin
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Journal of Biomolecular Structure and Dynamics. 2017; : 1
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293 Traditional Chinese herbal medicine and its effects on the quality of life of lung cancer patients: a meta-analysis
Amy Stewart
Bioscience Horizons: The International Journal of Student Research. 2017; 10
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294 The role of spices in nutrition and health: a review of three popular spices used in Southern Nigeria
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Food Quality and Safety. 2017;
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295 An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae
Syed Babar Jamal,Syed Shah Hassan,Sandeep Tiwari,Marcus V. Viana,Leandro de Jesus Benevides,Asad Ullah,Adrián G. Turjanski,Debmalya Barh,Preetam Ghosh,Daniela Arruda Costa,Artur Silva,Richard Röttger,Jan Baumbach,Vasco A. C. Azevedo,Alexandre G. de Brevern
PLOS ONE. 2017; 12(10): e0186401
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296 Bioactive Steroids and Saponins of the Genus Trillium
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Molecules. 2017; 22(12): 2156
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297 Optimizing the Maximum Recovery of Dihydromyricetin from Chinese Vine Tea, Ampelopsis grossedentata, Using Response Surface Methodology
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Molecules. 2017; 22(12): 2250
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298 Cytotoxicity of n-Butanol Extracts of Streptomyces Against Human Breast Cancer Cells
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International Journal of Pharmacology. 2017; 13(8): 969
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299 Therapeutic effect of an alkaloid-rich fraction of Abrus precatorius seed methanol extract on paracetamol-induced liver damage in rats
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African Journal of Biochemistry Research. 2017; 11(11): 72
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300 Phytochemicals as novel agents for the induction of browning in white adipose tissue
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301 Fraxinus xanthoxyloides leaves reduced the level of inflammatory mediators during in vitro and in vivo studies
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BMC Complementary and Alternative Medicine. 2016; 16(1)
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302 Preliminary assessment of free radical scavenging, thrombolytic and membrane stabilizing capabilities of organic fractions of Callistemon citrinus (Curtis.) skeels leaves
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319 Mucoadhesive microparticulate drug delivery system of curcumin against Helicobacter pylori infection: Design, development and optimization
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