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GUEST EDITORIAL
Year : 2012  |  Volume : 3  |  Issue : 4  |  Page : 200-201  

Natural products derived from plants as a source of drugs

Ciddi Veeresham
Department of Pharmacy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India

Date of Web Publication14-Dec-2012

Correspondence Address:
Ciddi Veeresham
Department of Pharmacy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-4040.104709

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How to cite this article:
Veeresham C. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res 2012;3:200-1

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Veeresham C. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res [serial online] 2012 [cited 2022 Dec 8];3:200-1. Available from: https://www.japtr.org/text.asp?2012/3/4/200/104709

Nature, the master of craftsman of molecules created almost an inexhaustible array of molecular entities. It stands as an infinite resource for drug development, novel chemotypes and pharmacophores, and scaffolds for amplification into efficacious drugs for a multitude of disease indications and other valuable bioactive agents. Since time immemorial, natural products have been the backbone of traditional system of healing throughout the globe, and have also been an integral part of history and culture. Although the use of bioactive natural products as herbal drug preparations dates back hundreds, even thousands, of years ago, their application as isolated and characterized compounds to modern drug discovery and development started only in the 19 th century. It has been well documented that natural products played critical roles in modern drug development, especially for antibacterial and antitumor agents. Even though popularity of the synthetic products increased due to its production cost, time effectiveness, easy quality control, stringent regulation and quick effects, but their safety and efficacy was always remained questionable, resulting in the dependence on the natural products by more than 80% of the total population in the developing world, because of its time tested safety and efficacy. A huge number of natural product-derived compounds in various stages of clinical development highlighted the existing viability and significance of the use of natural products as sources of new drug candidates.

Until recently, plants were an important source of novel pharmacologically active compounds with many blockbuster drugs being derived directly or indirectly from plants. Despite the current preoccupation with synthetic chemistry as a vehicle to discover and manufacture drugs, the contribution of plants to disease treatment and prevention is still enormous. Even at the dawn of 21 st century, 11% of the 252 drugs considered as basic and essential by the WHO were exclusively of flowering plant origin.

Obviously natural products will continue to be extremely important as sources of medicinal agents. In addition to the natural products which have found direct medicinal application as drug entities, many others can serve as chemical models or templates for the design, synthesis, and semi synthesis of novel substances for treating humankind's diseases. Although there are some new approaches to drug discovery, such as combinatorial chemistry and computer-based molecular modeling design, and many drugs are made by synthetic chemistry, none of them can replaced the important role of natural products in drug discovery and development as most of the core structures or scaffolds for synthetic chemicals are based upon natural products.

According to Newman and Cragg 2012, the utility of natural products as sources of novel structures is still alive and well. Up to 50% the approved drugs during the last 30 years are from either directly or indirectly from natural products and in the area of cancer, over the time frame from around the 1940s to date, of the 175 small molecules 85 actually being either natural products or directly derived there from.

The use of plants as medicines has a long history in the treatment of various diseases. The plant-derived compounds have a long history of clinical use, better patient tolerance and acceptance. To date, 35,000-70,000 plant species have been screened for their medicinal use. Plants especially those with ethnopharmacological uses have been the primary sources of medicine for early drug discovery. Fabricant and Farnsworth, (2001) reported that, 80% of 122 plant derived drugs were related to their original ethnopharmacological purposes. Current drug discovery from plants mainly relied on bioactivity-guided fractionation and led to isolation of many important anticancer drugs such as paclitaxel, camptothecin etc.

The first commercial pure natural product introduced for therapeutic use is morphine marketed by Merck in 1826, and the first semi-synthetic pure drug aspirin, based on a natural product salicin isolated from Salix alba, was introduced by Bayer in 1899. This led to the isolation of early drugs such as cocaine, codeine, digitoxin, quinine and pilocarpine, of which some are still in use and several other recent plant derived compounds, which have undergone development and have been marketed as drugs which include Paclitaxel from Taxus brevifolia for lung, ovarian and breast cancer, Artemisinin from traditional Chinese plant Artemisia annua to combat multidrug resistant malaria, Silymarin extracted from the seeds of Silybum marianum for the treatment of liver diseases.

There is growing evidence that the old molecules are finding new applications through better understanding of molecular biology and clinical observations. For instance, the alkaloid, forskolin from Coleus forskohlii and phytochemicals from Stephania glabra, are now being rediscovered as adenylate cyclase and nitric oxide activators, which may help in preventing conditions including obesity and atherosclerosis.

During the last decade few plant derived drugs have been launched include Arteether, endoperoxide sesquiterpene lactone and semisynthetic natural product derived from Artemisinin used in malarial treatment, Nitisinone derived from natural product Leptospermone (Callistemon citrinus) is used in treatment of antityrosinaemia, galantamine is a natural alkaloid (obtained from Galanthus nivalis) for Alzhemer's, apomorphine is a semisynthetic compound derived from morphine (Papaver somniferum) used in Parkinson's disease, Tiotropium a derivative of atropine from Atropa belladonna in chronic obstructive pulmonary disease, Dronabinol and Cannabidiol obtained from cannabis plant (Cannabis sativa) and Capsaicin active compound from Capsicum annuum are used as pain relievers.

Natural products discovered so far have played a vital role in improving the human health and have been the drugs of choice despite facing a tough competition from compounds derived from computational and combinatorial chemistry, due to their safety and efficacy. The most striking feature of natural products in connection to their long lasting importance in drug discovery is their structural diversity that is still largely untapped.

Revitalization of the natural products is bringing newer challenges with respect to quality control and standardization along with cost effectiveness. The renewed interest in the development of natural products requires the confluence of the modern techniques and harmonization of regulations related to their research and development between various fields of science.

 
   Authors Top

Prof. (Dr.) Ciddi Veeresham



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Masyitah Zulkipli, Nuzum Mahbub, Ayesha Fatima, Stefanie Lim Wan-Lin, Teng-Jin Khoo, Tooba Mahboob, Mogana Rajagopal, Chandramathi Samudi, Gheetanjali Kathirvalu, Nor Hayati Abdullah, Ana Rita Pinho, Sonia M. R. Oliveira, Maria de Lourdes Pereira, Mohammed Rahmatullah, Anamul Hasan, Alok K. Paul, Mark S. Butler, Muhammad Nawaz, Polrat Wilairatana, Veeranoot Nissapatorn, Christophe Wiart
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64 Screening of phytochemicals, toxicities, and activities of three Dillenia species
Pornnarong Siripiyasing, Kittiya Silawong, Tikumporn Thooptianrat, Runglawan Sudmoon, Nelly Babayan, Lusine Khondkaryan, Lilit Apresyan, Tawatchai Tanee, Arunrat Chaveerach
Journal of Herbmed Pharmacology. 2022; 11(3): 339
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65 Bioassay standardization of drug dosage form prepared from hydroalcoholic extract of Dracocephalum kotschyi
Hassan Sadraei, Amir Hossein Rasouli-Amirabadi, Afsaneh Yekdaneh, Naser Tavakoli
Journal of Herbmed Pharmacology. 2022; 11(3): 435
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66 In-vitro Comparative study on blood clotting time of some Plants Extracts and Heparin when Infected with Snakebite
Khalid Abdulkareem Mohammad
Research Journal of Pharmacy and Technology. 2021; : 2915
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67 Pharmacognostical Investigation of Trapa natans L Leaves
Chandana Majee,Rupa Mazumder,Alka N. Choudhary
Research Journal of Pharmacy and Technology. 2021; : 4680
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68 Advanced Analytical Approaches for the Analysis of Polyphenols in Plants Matrices—A Review
Elena Roxana Chiriac,Carmen Lidia Chitescu,Elisabeta-Irina Geana,Cerasela Elena Gird,Radu Petre Socoteanu,Rica Boscencu
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69 Analytical Separation of Carcinogenic and Genotoxic Alkenylbenzenes in Foods and Related Products (2010–2020)
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Toxins. 2021; 13(6): 387
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70 SARS-CoV-2 Fears Green: The Chlorophyll Catabolite Pheophorbide A Is a Potent Antiviral
Guillermo H. Jimenez-Aleman, Victoria Castro, Addis Londaitsbehere, Marta Gutierrez-Rodríguez, Urtzi Garaigorta, Roberto Solano, Pablo Gastaminza
Pharmaceuticals. 2021; 14(10): 1048
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71 Bryo-Activities: A Review on How Bryophytes Are Contributing to the Arsenal of Natural Bioactive Compounds against Fungi
Mauro Commisso,Francesco Guarino,Laura Marchi,Antonella Muto,Amalia Piro,Francesca Degola
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72 Selective Anticancer Properties, Proapoptotic and Antibacterial Potential of Three Asplenium Species
Venelin Petkov,Tsvetelina Batsalova,Plamen Stoyanov,Tsvetelina Mladenova,Desislava Kolchakova,Mariana Argirova,Tsvetanka Raycheva,Balik Dzhambazov
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73 Elemental Analysis and In Vitro Evaluation of Antibacterial and Antifungal Activities of Usnea barbata (L.) Weber ex F.H. Wigg from Calimani Mountains, Romania
Violeta Popovici, Laura Bucur, Suzana Ioana Calcan, Elena Iulia Cucolea, Teodor Costache, Dan Rambu, Verginica Schröder, Cerasela Elena Gîrd, Daniela Gherghel, Gabriela Vochita, Aureliana Caraiane, Victoria Badea
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74 Cheminformatics-Based Identification of Potential Novel Anti-SARS-CoV-2 Natural Compounds of African Origin
Samuel K. Kwofie,Emmanuel Broni,Seth O. Asiedu,Gabriel B. Kwarko,Bismark Dankwa,Kweku S. Enninful,Elvis K. Tiburu,Michael D. Wilson
Molecules. 2021; 26(2): 406
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75 Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy
Cristina Adriana Dehelean,Iasmina Marcovici,Codruta Soica,Marius Mioc,Dorina Coricovac,Stela Iurciuc,Octavian Marius Cretu,Iulia Pinzaru
Molecules. 2021; 26(4): 1109
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76 Phytochemicals Targeting JAK–STAT Pathways in Inflammatory Bowel Disease: Insights from Animal Models
Sun Young Moon,Kwang Dong Kim,Jiyun Yoo,Jeong-Hyung Lee,Cheol Hwangbo
Molecules. 2021; 26(9): 2824
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77 Natural Xanthine Oxidase Inhibitor 5-O-Caffeoylshikimic Acid Ameliorates Kidney Injury Caused by Hyperuricemia in Mice
Dong Zhang, Mojiao Zhao, Yumei Li, Dafang Zhang, Yong Yang, Lijing Li
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78 Atheroprotective Properties of Costus spicatus (Jacq.) Sw. in Female Rats
Bethânia Rosa Lorençone,Lucas Pires Guarnier,Rhanany Alan Calloi Palozi,Paulo Vitor Moreira Romão,Aline Aparecida Macedo Marques,Lislaine Maria Klider,Roosevelt Isaias Carvalho Souza,Ariany Carvalho dos Santos,Cleide Adriane Signor Tirloni,Nadla Soares Cassemiro,Denise Brentan Silva,Jane Manfron Budel,Arquimedes Gasparotto Junior
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79 Antiviral Properties of Polyphenols from Plants
Katarzyna Chojnacka,Dawid Skrzypczak,Grzegorz Izydorczyk,Katarzyna Mikula,Daniel Szopa,Anna Witek-Krowiak
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80 Adjunctive Nutraceutical Therapies for COVID-19
Lalita Subedi,Stephanie Tchen,Bhakta Prasad Gaire,Bingren Hu,Kurt Hu
International Journal of Molecular Sciences. 2021; 22(4): 1963
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81 Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives
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82 Evaluation of the Effectiveness of Herbal Components Based on Their Regulatory Signature on Carcinogenic Cancer Cells
Fazileh Esmaeili, Tahmineh Lohrasebi, Manijeh Mohammadi-Dehcheshmeh, Esmaeil Ebrahimie
Cells. 2021; 10(11): 3139
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83 Deeper Insights on Alchornea cordifolia (Schumach. & Thonn.) Müll.Arg Extracts: Chemical Profiles, Biological Abilities, Network Analysis and Molecular Docking
Kouadio Ibrahime Sinan,Gunes Ak,Ouattara Katinan Etienne,József Jeko,Zoltán Cziáky,Katalin Gupcsó,Maria João Rodrigues,Luisa Custodio,Mohamad Fawzi Mahomoodally,Jugreet B. Sharmeen,Luigi Brunetti,Sheila Leone,Lucia Recinella,Annalisa Chiavaroli,Giustino Orlando,Luigi Menghini,Massimo Tacchini,Claudio Ferrante,Gokhan Zengin
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84 UPLC-ESI-Q-TOF-MS-Based Metabolite Profiling, Antioxidant and Anti-Inflammatory Properties of Different Organ Extracts of Abeliophyllum distichum
Tong-Kewn Yoo,Won Tae Jeong,Jun Gu Kim,Hyo Seong Ji,Min-A Ahn,Jong-Wook Chung,Heung Bin Lim,Tae Kyung Hyun
Antioxidants. 2021; 10(1): 70
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85 Usnic Acid and Usnea barbata (L.) F.H. Wigg. Dry Extracts Promote Apoptosis and DNA Damage in Human Blood Cells through Enhancing ROS Levels
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86 LC-MS Based Analysis and Biological Properties of Pseudocedrela kotschyi (Schweinf.) Harms Extracts: A Valuable Source of Antioxidant, Antifungal, and Antibacterial Compounds
Kouadio Ibrahime Sinan,Stefano Dall’Acqua,Irene Ferrarese,Adriano Mollica,Azzurra Stefanucci,Jasmina Glamoclija,Marina Sokovic,Marija Nenadic,Abdurrahman Aktumsek,Gokhan Zengin
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87 Optimization of PhysicoChemical Parameters for Production of Cytotoxic Secondary Metabolites and Apoptosis Induction Activities in the Culture Extract of a Marine Algal–Derived Endophytic Fungus Aspergillus sp.
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Frontiers in Pharmacology. 2021; 12
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88 Synthesis, Characterization and Bioactivity Profiling of Gold Nanoparticles of Trachyspermum ammi Crude Extract
Saud Bawazeer,Abdur Rauf,Humaira Naz,Syed Uzair Ali Shah,Dania Saad Waggas,Jawad Ali,Yahia N. Mabkhot,Yahia N. Faryal,Mohamed Fawzy Ramadan
Journal of Pure and Applied Microbiology. 2021; : 667
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89 PHARMACOGNOSTICAL STUDIES OF LEAVES OF ACACIA ETBAICA SUBSPECIES UNCINATA
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Asian Journal of Pharmaceutical and Clinical Research. 2021; : 76
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90 Antioxidant, Anti-Inflammatory and Cytotoxic Properties of Centaurea africana Lamk var. [Bonnet] M
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91 Green synthesis of silver nanoparticles using Tropaeolum majus: Phytochemical screening and antibacterial studies
Saud Bawazeer,Abdur Rauf,Syed Uzair Ali Shah,Ahmed M. Shawky,Yahya S. Al-Awthan,Omar Salem Bahattab,Ghias Uddin,Javeria Sabir,Mohamed A. El-Esawi
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92 Thymoquinone and its derivatives against breast cancer with HER2 positive: in silico studies of ADMET, docking and QSPR
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Journal of Basic and Clinical Physiology and Pharmacology. 2021; 32(4): 393
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93 Alkaloidal Extract From Carica papaya Seeds Ameliorates CCl 4-Induced Hepatocellular Carcinoma in Rats
Isaac Kyei-Barffour,Roselind Kyei Baah Kwarkoh,Desmond Omane Acheampong,Augustine Suurinobah Brah,Samuel Akwetey Addo,Benjamin Benjamin Aboagye,Alex Boye
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94 Phytochemistry, Traditional Uses and Pharmacological Properties of Enhydra fluctuans Lour: a Comprehensive Review
Antica Barua, Muhammad S. Alam, Md. Junaid, Yeasmin Akter, Syeda S. Afrose, Tania Sharmin, Rasheda Akter, S.M. Zahid Hosen
Current Pharmaceutical Biotechnology. 2021; 22(8): 1061
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95 Current Knowledge Regarding Pharmacological Profile and Chemical Constituents of Gynura procumbens
Ehfazul Haque, Mir Shahriar Kamal, Md. Rafat Tahsin, Raju Ahmed, Jakir Ahmed Choudhury, Abu Asad Choudhury, Shaila Kabir, Md. Shah Amran, Md. Sahab Uddin
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96 Toxicological evaluations of betulinic acid and ursolic acid; common constituents of Houttuynia cordata used as an anthelmintic by the Naga tribes in North-east India
Vijaya Mishra,Amar Deep Soren,Arun Kumar Yadav
Future Journal of Pharmaceutical Sciences. 2021; 7(1)
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97 The neuroprotective attribution of Ocimum basilicum: a review on the prevention and management of neurodegenerative disorders
Mohamed Ali Seyed,Siddiqua Ayesha,Norazrina Azmi,Fahad Mohamed Al-Rabae,Adel Ibrahim Al-Alawy,Othman Rashed Al-Zahrani,Yousef Hawsawi
Future Journal of Pharmaceutical Sciences. 2021; 7(1)
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98 Sub-Acute Oral Toxicity Study of Ethanol Extract of Oroxylum Indicum Leafin C57BL/6 Mice
Mohd Farhan Hanif Reduan,Mohammad Rasul Arif Mastika,Fathin Faahimaah Abdul Hamid,Noramalina Noralidin,Nur Athirah Abd Manaf,Rumaizi Shaari,Intan Noor Aina Kamaruzaman,Muhammad Luqman Nordin
Biomedical and Pharmacology Journal. 2021; 14(3): 1579
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99 COVID-19: Challenges, Preventive Measures and Remediation
Sameena Mehtab,Pragati Joshi,M. G. H. Zaidi,T. I. Siddiqui,Vivek K. Mishra
Oriental Journal Of Chemistry. 2021; 37(2): 285
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100 Isolation, Characterization of Active Constituent and Evaluation of Hepatoprotective Activity of Inula Racemosa Hook. F. Roots
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Oriental Journal Of Chemistry. 2021; 37(5): 1199
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101 An in vitro study of an Artocarpus heterophyllus substance as a hepatitis C antiviral and its combination with current anti-HCV drugs
Adita Ayu Permanasari,Chie Aoki-Utsubo,Tutik Sri Wahyuni,Lidya Tumewu,Myrna Adianti,Aty Widyawaruyanti,Hak Hotta,Achmad Fuad Hafid
BMC Complementary Medicine and Therapies. 2021; 21(1)
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102 Transferring Ethnopharmacological Results Back to Traditional Healers in Rural Indigenous Communities – The Ugandan Greater Mpigi Region Example
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Video Journal of Education and Pedagogy. 2021; 6(1): 1
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103 Evaluation of the Hypoglycemic Potential of Leaves Extract of Spondias pinnata (L.f.) Kurz. from Nepal
Kusum Sai,Sumit Bahadur Baruwal Chhetri,Shankar Raj Devkota,Deepa Khatri,Juei Tang Cheng
The Scientific World Journal. 2021; 2021: 1
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104 Traditional Medicinal Vegetables in Northern Uganda: An Ethnobotanical Survey
Rebecca Nakaziba,Maxson Kenneth Anyolitho,Sharon Bright Amanya,Crispin Duncan Sesaazi,Frederick Byarugaba,Jasper Ogwal-Okeng,Paul E. Alele,Severino Matias de Alencar
International Journal of Food Science. 2021; 2021: 1
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105 Antifungal and Antibacterial Activities of Apple Vinegar of Different Cultivars
Driss Ousaaid,Hassan Laaroussi,Meryem Bakour,Hayat Ennaji,Badiaa Lyoussi,Ilham El Arabi,Giuseppe Comi
International Journal of Microbiology. 2021; 2021: 1
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106 Evaluation of the Antidiarrheal and Antioxidant Effects of Some Chewing Sticks Commonly Used for Oral Hygiene in Ghana
Edward Ken Essuman,Adjoa Agyemang Boakye,Clement Okraku Tettey,Gaston Hunkpe,Nii Korley Kortei,Henrietta Kwansa-Bentum,Sayanika Davi Waikhom,Enoch Aninagyei,Harish Chandra
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107 In-silico screening and identification of phytochemicals from Centella asiatica as potential inhibitors of sodium-glucose co-transporter 2 for treating diabetes
Mark Andrian B. Macalalad,Arthur A. Gonzales
Journal of Biomolecular Structure and Dynamics. 2021; : 1
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108 Therapeutic potential and pharmacological activities of ß-eudesmol
Bishwanath Acharya,Wanna Chaijaroenkul,Kesara Na-Bangchang
Chemical Biology & Drug Design. 2021;
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109 New 3-O-substituted xanthone derivatives as promising acetylcholinesterase inhibitors
Zi Han Loh,Huey Chong Kwong,Kok Wai Lam,Soek Sin Teh,Gwendoline Cheng Lian Ee,Ching Kheng Quah,Anthony Siong Hock Ho,Siau Hui Mah
Journal of Enzyme Inhibition and Medicinal Chemistry. 2021; 36(1): 627
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110 A Review on Pharmacological, Anti-oxidant Activities and Phytochemical Constituents of a Novel Lichen Parmotrema Species
Saparja Saha,Amrita Pal,Santanu Paul
Journal of Biologically Active Products from Nature. 2021; 11(3): 190
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111 Pharmacological profile of Shiva Gutika: an uncharted and versatilepolyherbal drug
V. H. Pushpa, M. K. Jayanthi, Shashank M. Patil, Ramith Ramu
All Life. 2021; 14(1): 215
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112 Hesperidin-An Emerging Bioactive Compound against Metabolic Diseases and Its Potential Biosynthesis Pathway in Microorganism.
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113 Aerosol-based Pulmonary Delivery of Therapeutic Molecules from Food Sources: Delivery Mechanism, Research Trends, and the Way Forward
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114 Molecular pharming to support human life on the moon, mars, and beyond
Matthew J. McNulty,Yongao (Mary) Xiong,Kevin Yates,Kalimuthu Karuppanan,Jacob M. Hilzinger,Aaron J. Berliner,Jesse Delzio,Adam P. Arkin,Nancy E. Lane,Somen Nandi,Karen A. McDonald
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115 Herbal antioxidants in dialysis patients: a review of potential mechanisms and medical implications
Masoumeh Asgharpour,Amirhesam Alirezaei
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116 Recent development in biological activities and safety concerns of perillaldehyde from perilla plants: A review
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117 Nutraceuticals: unlocking newer paradigms in the mitigation of inflammatory lung diseases
Yinghan Chan,Venkata Sita Rama Raju Allam,Keshav Raj Paudel,Sachin K. Singh,Monica Gulati,Muralikrishnan Dhanasekaran,Piyush Kumar Gupta,Niraj Kumar Jha,Hari Prasad Devkota,Gaurav Gupta,Philip M Hansbro,Brian Gregory George Oliver,Dinesh Kumar Chellappan,Kamal Dua
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118 Linalool attenuates acquisition and reinstatement and accelerates the extinction of nicotine-induced conditioned place preference in male mice
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The American Journal of Drug and Alcohol Abuse. 2021; : 1
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119 Glycine betaine-based ionic liquids and their influence on bacteria, fungi, insects and plants
Damian Krystian Kaczmarek,Daniela Gwiazdowska,Krzysztof Jus,Tomasz Klejdysz,Marta Wojcieszak,Katarzyna Materna,Juliusz Pernak
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120 Resveratrol impairs acquisition, reinstatement and precipitates extinction of alcohol-induced place preference in mice
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Neurological Research. 2021; : 1
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121 A Study on the Effect of Valeric Acid in Alzheimer's Induced Rats by the Estimation of Aß 1-42 Biomarker
Blessina Sugandhi Dulla, Bindhu S., Leena Pramod K.
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122 Antiglycation and enzyme inhibitory potential of salicylalazine isolated from Micromeria biflora (Buch.-Ham.ex D.Don) Benth
Abdur Rauf,Saud Bawazeer,Umer Rashid,Mohamed A. El-Esawi,Muhammad Humayun Khan,Syed Uzair Ali Shah,Mohammad S. Mubarak,Kannan RR Rengasamy
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123 Molecular docking and network pharmacology-based approaches to explore the potential of terpenoids for Mycobacterium tuberculosis
K. Kalaimathi,G. Thiyagarajan,S. Vijayakumar,K. Bhavani,K. Karthikeyan,J. Maria Jancyrani,K. Doss,J. Sureshkumar,S. Prabhu
Pharmacological Research - Modern Chinese Medicine. 2021; : 100002
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124 Red laser-mediated alterations in seed germination, growth, pigments and withanolide content of Ashwagandha [Withania somnifera (L.) Dunal]
Sachin Ashok Thorat,Poornima Poojari,Arya Kaniyassery,Kodsara Ramachandra Kiran,Kapaettu Satyamoorthy,Krishna Kishore Mahato,Annamalai Muthusamy
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125 Acute and sub-acute oral toxicity Lagerstroemia speciosa in Sprague-Dawley rats
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126 Electrospun nanocarriers for delivering natural products for cancer therapy
Reza Mohammadinejad,Vijay Sagar Madamsetty,Anuj Kumar,Mohammad Varzandeh,Ali Dehshahri,Ali Zarrabi,Fariba Sharififar,Mehdi Mohammadi,Amir Fahimipour,Seeram Ramakrishna
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127 Antiplasmodial diterpenoid alkaloid from Aconitum heterophyllum Wall. ex Royle: Isolation, characterization, and UHPLC-DAD based quantification
Anmol, Surekha Kumari, Rakesh Kumar, Raman Singh, Gaurav Aggarwal, Prakhar Agrawal, Dinkar Sahal, Upendra Sharma
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128 Evaluation of the antiulcerogenic activity of hydromethanol extracts of Solanum incanum L. (Solanaceae) leaves and roots in mice; single and repeated dose study
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129 Eight key rules for successful data-dependent acquisition in mass spectrometry-based metabolomics
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130 Prospects and Challenges of Developing Plant-Derived Snake Antivenin Natural Products: A Focus on West Africa
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131 Computational screening of natural compounds from Salvia plebeia R. Br. for inhibition of SARS-CoV-2 main protease
Afraa Aqeel Zackria, Ramya Pattabiraman, T. P. Krishna Murthy, S. Birendra Kumar, Blessy Baby Mathew, Vinai George Biju
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132 Non-toxic nature of chebulinic acid on biochemical, hematological and histopathological analysis in normal Sprague Dawley rats
Khurram Aamir,Vaisnevee Sugumar,Hidayat Ullah Khan,Chung Yeng Looi,Rajesh Juneja,Muhammad Waqas,Aditya Arya
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133 Anti-Leishmania Effects of Volatile Oils and Their Isolates
Patrícia Fampa,Melissa Florencio,Raissa Couto Santana,Dayana Rosa,Deivid Costa Soares,Herbert Leonel de Matos Guedes,Anabela Cordeiro da Silva,Douglas Siqueira A. Chaves,Lucia H. Pinto-da-Silva
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134 Coumarins as Potential Antiprotozoal Agents: Biological Activities and Mechanism of Action
Elkin Jose Torres Sierra,Cleydson Finotti Cordeiro,Livia de Figueiredo Diniz,Ivo Santana Caldas,Jamie Anthony Hawkes,Diogo Teixeira Carvalho
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135 Natural Bioactive Compounds as Potential Browning Agents in White Adipose Tissue
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136 In Vitro Anthelmintic Efficacy of Sesbania sesban var. bicolor, Cyperus compressus and Asparagus racemosus Against Gastrothylax crumenifer (Trematoda)
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137 Camptothecinæs Journey from Discovery to WHO Essential Medicine: Fifty Years of Promise
Noura Khaiwa,Noor R. Maarouf,Mhd H. Darwish,Dima W.M. Alhamad,Anusha Sebastian,Mohamad Hamad,Hany A. Omar,Gorka Orive,Taleb H. Al-Tel
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138 Optimization of ultrasound-assisted, microwave-assisted and Soxhlet extraction of bioactive compounds from Lagenaria siceraria: A comparative analysis
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139 Challenges and recent trends with the development of hydrogel fiber for biomedical applications
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140 Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging
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141 Therapeutic effects of medicinal plants on isoproterenol-induced heart failure in rats
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142 Ex vivo and in vivo chemoprotective activity and potential mechanism of Martynoside against 5-fluorouracil-induced bone marrow cytotoxicity
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143 Chitosan-tripolyphosphate nanoparticles designed to encapsulate polyphenolic compounds for biomedical and pharmaceutical applications - A review
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144 Alkaloidal extract from Carica papaya seeds ameliorates CCl4-induced hepatocellular carcinoma in rats
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145 An insight into Verbascum bombyciferum extracts: Different extraction methodologies, biological abilities and chemical profiles
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146 Combination of docosahexaenoic acid and Ginko biloba extract improves cognitive function and hippocampal tissue damages in a mouse model of Alzheimer’s disease
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147 Quality assessment of frequently available mother tinctures in the market by employing standard values
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148 Therapeutic uses of post-partum tissue-derived mesenchymal stromal cell secretome
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149 Factorial design-guided optimization of extraction of therapeutically active furanocoumarin khellin from Ammi majus L. fruits
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150 Bioassay-guided isolation of antiplasmodial and antimicrobial constituents from the roots of Terminalia albida
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151 Resveratrol encapsulation in high molecular weight chitosan-based nanogels for applications in ocular treatments: Impact on human ARPE-19 culture cells
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152 Nanocapsules Containing Saussurea lappa Essential Oil: Formulation, Characterization, Antidiabetic, Anti-Cholinesterase and Anti-Inflammatory Potentials
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153 Production of plant natural products through engineered Yarrowia lipolytica
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154 Calotropis - A multi-potential plant to humankind: Special focus on its wound healing efficacy
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155 Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways
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156 Generation of A Stable GFP-reporter Zika Virus System for High-throughput Screening of Zika Virus Inhibitors
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157 Urolithin A Induces Brown-like Phenotype in 3T3-L1 White Adipocytes via ß3-adrenergic Receptor-p38 MAPK Signaling Pathway
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158 Phytochemicals and biological activities of species from the genus Maytenus
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159 Anti-Cancer and Anti-Inflammatory Activities of Bromo- and Cyano-Substituted Azulene Derivatives
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160 Therapeutic potential of sulfur-containing natural products in inflammatory diseases
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161 Anti-diabetic potential of plant alkaloids: Revisiting current findings and future perspectives
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162 Sugiol, a diterpenoid: Therapeutic actions and molecular pathways involved
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163 Davilla elliptica (Dilleniaceae) a. St.-Hil. Ethnomedicinal, phytochemical, and pharmacological aspects: A review
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164 Constituents of essential oil of Origanum minutiflorum and its in vitro antioxidant, scolicidal and anticancer activities
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165 Biochanin A: A novel bioactive multifunctional compound from nature
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166 Dark Classics in Chemical Neuroscience: An Evidence-Based Systematic Review of Belladonna
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167 cis-9-Hexadecenal, a Natural Compound Targeting Cell Wall Organization, Critical Growth Factor, and Virulence of Aspergillus fumigatus
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168 A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids
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169 Antiproliferative activity of new pentacyclic triterpene and a saponin from Gladiolus segetum Ker-Gawl corms supported by molecular docking study
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170 Antioxidant properties of the Lebanese plantIrisxgermanicaL. crude extracts and antagonism of chlorpromazine toxicity onSaccharomyces cerevisiae
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171 Hepatoprotective and hematological effects of Justicia secunda Vahl leaves on carbon tetrachloride induced toxicity in rats
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172 Antimicrobial activity of Plumbago indica and ligand screening of plumbagin against methicillin-resistant Staphylococcus aureus
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173 Inhibitory potential on key enzymes relevant to type II diabetes mellitus and antioxidant properties of the various extracts and phytochemical constituents from Rumex acetosella L
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174 Pharmacological Assessment of the Carvacrol Chemotype Essential Oil FromPlectranthus amboinicusGrowing in Cuba
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175 Ethnobotanical Description and Biological Activities of Senna alata
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176 In Silico Identification of New Targets for Diagnosis, Vaccine, and Drug Candidates against Trypanosoma cruzi
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177 Antioxidant and in vivo hepatoprotective effects of Gardenia gummifera L.f. fruit methanol extract
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178 In vitro antimitotic and cytotoxic potential of plant extracts: a comparative study of Mucuna pruriens, Asteracantha longifolia and Sphaeranthus indicus
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179 Ethnobotanical survey of the medicinal flora of Harighal, Azad Jammu & Kashmir, Pakistan
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180 Therapeutic Potential of Medicinal Plant Proteins: Present Status and Future Perspectives
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181 Antioxidant Potential of Glycyrrhiza glabra L. roots: In-Vitro Evidences
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182 Metabolism and Pharmacokinetics of Phytochemicals in the Human Body
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183 Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections
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184 RP-HPLC-UV Analysis of the Phenolic Compounds, Antimicrobial Activity Against Multi-Drug Resistant Bacteria and Antioxidant Activity of Fruit and Seed of Diospyros lotus L.ctivity of Fruit and Seed of Diospyros lotus L.
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185 Investigation of the Biological Activities of Different Extracts from Dipsacus laciniatus Aerial Parts
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186 Punica granatum L. (Pomegranate): A Potential Anti-microbial Agent
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187 Traditional and Herbal Medicines: Understanding & Exploration (Part II)
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188 Immunomodulating potential of Neolamarckia cadamba (Roxb.) Bark extract
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189 Prevention of Oxidative Stress-Induced Pancreatic Beta Cell Damage by Broussonetia kazinoki Siebold Fruit Extract via the ERK-Nox4 Pathway
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190 Assessment of the Pharmacological Properties and Phytochemical Profile of Bruguiera gymnorhiza (L.) Lam Using In Vitro Studies, In Silico Docking, and Multivariate Analysis
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191 Genista tridentata L.: A Rich Source of Flavonoids with Anti-Inflammatory Activity
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192 Chelerythrine Chloride Downregulates ß-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma
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193 Untargeted Characterization of Chestnut (Castanea sativa Mill.) Shell Polyphenol Extract: A Valued Bioresource for Prostate Cancer Cell Growth Inhibition
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194 Synthesis and Properties of CurNQ for the Theranostic Application in Ovarian Cancer Intervention
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195 Phytochemicals as Anti-Inflammatory Agents in Animal Models of Prevalent Inflammatory Diseases
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196 Phytochemicals and Enzyme Inhibitory Capacities of the Methanolic Extracts from the Italian Apple Cultivar Mela Rosa dei Monti Sibillini
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197 Lead Compounds in the Context of Extracellular Vesicle Research
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198 Effects of Hydroalcoholic Flower Extract of Marigold (Calendula officinalis) on the Biochemical and Histological Parameters in STZ-Induced Diabetic Rats
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199 Cytotoxic Potential and Phytochemical Profile of Extracts from Garcinia rubra Merr. Leaves
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200 Phytochemical Profiling of Coryphantha macromeris (Cactaceae) Growing in Greenhouse Conditions Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
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201 At-Line Monitoring of the Extraction Process of Rosmarini Folium via Wet Chemical Assays, UHPLC Analysis, and Newly Developed Near-Infrared Spectroscopic Analysis Methods
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202 Erythroxylum in Focus: An Interdisciplinary Review of an Overlooked Genus
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203 Cutting-Edge Search for Safer Opioid Pain Relief: Retrospective Review of Salvinorin A and Its Analogs
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204 Larrea tridentata Extract Mitigates Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells
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205 Phenolic Profiling and Biological Potential of Ficus curtipes Corner Leaves and Stem Bark: 5-Lipoxygenase Inhibition and Interference with NO Levels in LPS-Stimulated RAW 264.7 Macrophages
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206 Evaluating Iso-Mukaadial Acetate and Ursolic Acid Acetate as Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase Inhibitors
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207 Casticin-Induced Inhibition of Cell Growth and Survival Are Mediated through the Dual Modulation of Akt/mTOR Signaling Cascade
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208 Inhibition of Aspergillus fumigatus Biofilm and Cytotoxicity Study of Natural Compound Cis-9-Hexadecenal
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209 Deciphering the Antibacterial Mode of Action of Alpha-Mangostin on Staphylococcus epidermidis RP62A Through an Integrated Transcriptomic and Proteomic Approach
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210 Cannabis medicinal, más que una encrucijada legal para el tratamiento de la epilepsia
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211 Medicinal Plant Compounds for Combating the Multi-drug Resistant Pathogenic Bacteria: A Review
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212 The Promising Role of Plant Tannins as Bioactive Antidiabetic Agents
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213 Use of Natural Components Derived from Oil Seed Plants for Treatment of Inflammatory Skin Diseases
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214 Crystal structure and in vitro antimicrobial activity studies of Robustic acid and other Alpinumisoflavones isolated from Millettia thonningii
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215 Oral Acute and Repeated-Doses Toxicity Study of Valepotriates from Valeriana glechomifolia (Meyer) in Mice
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216 Isolation, Characterization and Assessment for Central Nervous System Effects of Novel Phytomolecule from Galphimia glauca Cav. Stems
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217 Protective Effects of Broussonetia kazinoki Siebold Fruit Extract against Palmitate-Induced Lipotoxicity in Mesangial Cells
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218 Pharmacotherapeutics and Molecular Mechanism of Phytochemicals in Alleviating Hormone-Responsive Breast Cancer
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219 Pharmacokinetics of thymoquinone in layer chickens following oral and intravenous administration
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220 Morelloflavone as a novel inhibitor of mitotic kinesin Eg5
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252 Therapeutic effect of an alkaloid-rich fraction of Abrus precatorius seed methanol extract on paracetamol-induced liver damage in rats
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292 Mucoadhesive microparticulate drug delivery system of curcumin against Helicobacter pylori infection: Design, development and optimization
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