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GUEST EDITORIAL
Year : 2012  |  Volume : 3  |  Issue : 4  |  Page : 200-201  

Natural products derived from plants as a source of drugs

Ciddi Veeresham
Department of Pharmacy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India

Date of Web Publication14-Dec-2012

Correspondence Address:
Ciddi Veeresham
Department of Pharmacy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-4040.104709

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How to cite this article:
Veeresham C. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res 2012;3:200-1

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Veeresham C. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res [serial online] 2012 [cited 2022 Aug 14];3:200-1. Available from: https://www.japtr.org/text.asp?2012/3/4/200/104709

Nature, the master of craftsman of molecules created almost an inexhaustible array of molecular entities. It stands as an infinite resource for drug development, novel chemotypes and pharmacophores, and scaffolds for amplification into efficacious drugs for a multitude of disease indications and other valuable bioactive agents. Since time immemorial, natural products have been the backbone of traditional system of healing throughout the globe, and have also been an integral part of history and culture. Although the use of bioactive natural products as herbal drug preparations dates back hundreds, even thousands, of years ago, their application as isolated and characterized compounds to modern drug discovery and development started only in the 19 th century. It has been well documented that natural products played critical roles in modern drug development, especially for antibacterial and antitumor agents. Even though popularity of the synthetic products increased due to its production cost, time effectiveness, easy quality control, stringent regulation and quick effects, but their safety and efficacy was always remained questionable, resulting in the dependence on the natural products by more than 80% of the total population in the developing world, because of its time tested safety and efficacy. A huge number of natural product-derived compounds in various stages of clinical development highlighted the existing viability and significance of the use of natural products as sources of new drug candidates.

Until recently, plants were an important source of novel pharmacologically active compounds with many blockbuster drugs being derived directly or indirectly from plants. Despite the current preoccupation with synthetic chemistry as a vehicle to discover and manufacture drugs, the contribution of plants to disease treatment and prevention is still enormous. Even at the dawn of 21 st century, 11% of the 252 drugs considered as basic and essential by the WHO were exclusively of flowering plant origin.

Obviously natural products will continue to be extremely important as sources of medicinal agents. In addition to the natural products which have found direct medicinal application as drug entities, many others can serve as chemical models or templates for the design, synthesis, and semi synthesis of novel substances for treating humankind's diseases. Although there are some new approaches to drug discovery, such as combinatorial chemistry and computer-based molecular modeling design, and many drugs are made by synthetic chemistry, none of them can replaced the important role of natural products in drug discovery and development as most of the core structures or scaffolds for synthetic chemicals are based upon natural products.

According to Newman and Cragg 2012, the utility of natural products as sources of novel structures is still alive and well. Up to 50% the approved drugs during the last 30 years are from either directly or indirectly from natural products and in the area of cancer, over the time frame from around the 1940s to date, of the 175 small molecules 85 actually being either natural products or directly derived there from.

The use of plants as medicines has a long history in the treatment of various diseases. The plant-derived compounds have a long history of clinical use, better patient tolerance and acceptance. To date, 35,000-70,000 plant species have been screened for their medicinal use. Plants especially those with ethnopharmacological uses have been the primary sources of medicine for early drug discovery. Fabricant and Farnsworth, (2001) reported that, 80% of 122 plant derived drugs were related to their original ethnopharmacological purposes. Current drug discovery from plants mainly relied on bioactivity-guided fractionation and led to isolation of many important anticancer drugs such as paclitaxel, camptothecin etc.

The first commercial pure natural product introduced for therapeutic use is morphine marketed by Merck in 1826, and the first semi-synthetic pure drug aspirin, based on a natural product salicin isolated from Salix alba, was introduced by Bayer in 1899. This led to the isolation of early drugs such as cocaine, codeine, digitoxin, quinine and pilocarpine, of which some are still in use and several other recent plant derived compounds, which have undergone development and have been marketed as drugs which include Paclitaxel from Taxus brevifolia for lung, ovarian and breast cancer, Artemisinin from traditional Chinese plant Artemisia annua to combat multidrug resistant malaria, Silymarin extracted from the seeds of Silybum marianum for the treatment of liver diseases.

There is growing evidence that the old molecules are finding new applications through better understanding of molecular biology and clinical observations. For instance, the alkaloid, forskolin from Coleus forskohlii and phytochemicals from Stephania glabra, are now being rediscovered as adenylate cyclase and nitric oxide activators, which may help in preventing conditions including obesity and atherosclerosis.

During the last decade few plant derived drugs have been launched include Arteether, endoperoxide sesquiterpene lactone and semisynthetic natural product derived from Artemisinin used in malarial treatment, Nitisinone derived from natural product Leptospermone (Callistemon citrinus) is used in treatment of antityrosinaemia, galantamine is a natural alkaloid (obtained from Galanthus nivalis) for Alzhemer's, apomorphine is a semisynthetic compound derived from morphine (Papaver somniferum) used in Parkinson's disease, Tiotropium a derivative of atropine from Atropa belladonna in chronic obstructive pulmonary disease, Dronabinol and Cannabidiol obtained from cannabis plant (Cannabis sativa) and Capsaicin active compound from Capsicum annuum are used as pain relievers.

Natural products discovered so far have played a vital role in improving the human health and have been the drugs of choice despite facing a tough competition from compounds derived from computational and combinatorial chemistry, due to their safety and efficacy. The most striking feature of natural products in connection to their long lasting importance in drug discovery is their structural diversity that is still largely untapped.

Revitalization of the natural products is bringing newer challenges with respect to quality control and standardization along with cost effectiveness. The renewed interest in the development of natural products requires the confluence of the modern techniques and harmonization of regulations related to their research and development between various fields of science.

 
   Authors Top

Prof. (Dr.) Ciddi Veeresham



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62 Antioxidant, Anti-Inflammatory and Cytotoxic Properties of Centaurea africana Lamk var. [Bonnet] M
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63 Phytochemistry, Traditional Uses and Pharmacological Properties of Enhydra fluctuans Lour: a Comprehensive Review
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64 Current Knowledge Regarding Pharmacological Profile and Chemical Constituents of Gynura procumbens
Ehfazul Haque, Mir Shahriar Kamal, Md. Rafat Tahsin, Raju Ahmed, Jakir Ahmed Choudhury, Abu Asad Choudhury, Shaila Kabir, Md. Shah Amran, Md. Sahab Uddin
Current Topics in Medicinal Chemistry. 2021; 21
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65 Green synthesis of silver nanoparticles using Tropaeolum majus: Phytochemical screening and antibacterial studies
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66 Thymoquinone and its derivatives against breast cancer with HER2 positive: in silico studies of ADMET, docking and QSPR
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67 Alkaloidal Extract From Carica papaya Seeds Ameliorates CCl 4-Induced Hepatocellular Carcinoma in Rats
Isaac Kyei-Barffour,Roselind Kyei Baah Kwarkoh,Desmond Omane Acheampong,Augustine Suurinobah Brah,Samuel Akwetey Addo,Benjamin Benjamin Aboagye,Alex Boye
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68 Toxicological evaluations of betulinic acid and ursolic acid; common constituents of Houttuynia cordata used as an anthelmintic by the Naga tribes in North-east India
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69 The neuroprotective attribution of Ocimum basilicum: a review on the prevention and management of neurodegenerative disorders
Mohamed Ali Seyed,Siddiqua Ayesha,Norazrina Azmi,Fahad Mohamed Al-Rabae,Adel Ibrahim Al-Alawy,Othman Rashed Al-Zahrani,Yousef Hawsawi
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70 Sub-Acute Oral Toxicity Study of Ethanol Extract of Oroxylum Indicum Leafin C57BL/6 Mice
Mohd Farhan Hanif Reduan,Mohammad Rasul Arif Mastika,Fathin Faahimaah Abdul Hamid,Noramalina Noralidin,Nur Athirah Abd Manaf,Rumaizi Shaari,Intan Noor Aina Kamaruzaman,Muhammad Luqman Nordin
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71 COVID-19: Challenges, Preventive Measures and Remediation
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Oriental Journal Of Chemistry. 2021; 37(2): 285
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72 Isolation, Characterization of Active Constituent and Evaluation of Hepatoprotective Activity of Inula Racemosa Hook. F. Roots
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73 An in vitro study of an Artocarpus heterophyllus substance as a hepatitis C antiviral and its combination with current anti-HCV drugs
Adita Ayu Permanasari,Chie Aoki-Utsubo,Tutik Sri Wahyuni,Lidya Tumewu,Myrna Adianti,Aty Widyawaruyanti,Hak Hotta,Achmad Fuad Hafid
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74 Evaluation of the Hypoglycemic Potential of Leaves Extract of Spondias pinnata (L.f.) Kurz. from Nepal
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The Scientific World Journal. 2021; 2021: 1
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75 Traditional Medicinal Vegetables in Northern Uganda: An Ethnobotanical Survey
Rebecca Nakaziba,Maxson Kenneth Anyolitho,Sharon Bright Amanya,Crispin Duncan Sesaazi,Frederick Byarugaba,Jasper Ogwal-Okeng,Paul E. Alele,Severino Matias de Alencar
International Journal of Food Science. 2021; 2021: 1
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76 Antifungal and Antibacterial Activities of Apple Vinegar of Different Cultivars
Driss Ousaaid,Hassan Laaroussi,Meryem Bakour,Hayat Ennaji,Badiaa Lyoussi,Ilham El Arabi,Giuseppe Comi
International Journal of Microbiology. 2021; 2021: 1
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77 Evaluation of the Antidiarrheal and Antioxidant Effects of Some Chewing Sticks Commonly Used for Oral Hygiene in Ghana
Edward Ken Essuman,Adjoa Agyemang Boakye,Clement Okraku Tettey,Gaston Hunkpe,Nii Korley Kortei,Henrietta Kwansa-Bentum,Sayanika Davi Waikhom,Enoch Aninagyei,Harish Chandra
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78 Therapeutic potential and pharmacological activities of ß-eudesmol
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79 A Review on Pharmacological, Anti-oxidant Activities and Phytochemical Constituents of a Novel Lichen Parmotrema Species
Saparja Saha,Amrita Pal,Santanu Paul
Journal of Biologically Active Products from Nature. 2021; 11(3): 190
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80 Pharmacological profile of Shiva Gutika: an uncharted and versatilepolyherbal drug
V. H. Pushpa, M. K. Jayanthi, Shashank M. Patil, Ramith Ramu
All Life. 2021; 14(1): 215
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81 Hesperidin-An Emerging Bioactive Compound against Metabolic Diseases and Its Potential Biosynthesis Pathway in Microorganism.
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82 Aerosol-based Pulmonary Delivery of Therapeutic Molecules from Food Sources: Delivery Mechanism, Research Trends, and the Way Forward
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83 New 3-O-substituted xanthone derivatives as promising acetylcholinesterase inhibitors
Zi Han Loh,Huey Chong Kwong,Kok Wai Lam,Soek Sin Teh,Gwendoline Cheng Lian Ee,Ching Kheng Quah,Anthony Siong Hock Ho,Siau Hui Mah
Journal of Enzyme Inhibition and Medicinal Chemistry. 2021; 36(1): 627
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84 Herbal antioxidants in dialysis patients: a review of potential mechanisms and medical implications
Masoumeh Asgharpour,Amirhesam Alirezaei
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85 Recent development in biological activities and safety concerns of perillaldehyde from perilla plants: A review
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86 Nutraceuticals: unlocking newer paradigms in the mitigation of inflammatory lung diseases
Yinghan Chan,Venkata Sita Rama Raju Allam,Keshav Raj Paudel,Sachin K. Singh,Monica Gulati,Muralikrishnan Dhanasekaran,Piyush Kumar Gupta,Niraj Kumar Jha,Hari Prasad Devkota,Gaurav Gupta,Philip M Hansbro,Brian Gregory George Oliver,Dinesh Kumar Chellappan,Kamal Dua
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87 Molecular pharming to support human life on the moon, mars, and beyond
Matthew J. McNulty,Yongao (Mary) Xiong,Kevin Yates,Kalimuthu Karuppanan,Jacob M. Hilzinger,Aaron J. Berliner,Jesse Delzio,Adam P. Arkin,Nancy E. Lane,Somen Nandi,Karen A. McDonald
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88 Resveratrol impairs acquisition, reinstatement and precipitates extinction of alcohol-induced place preference in mice
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89 In-silico screening and identification of phytochemicals from Centella asiatica as potential inhibitors of sodium-glucose co-transporter 2 for treating diabetes
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90 Antiglycation and enzyme inhibitory potential of salicylalazine isolated from Micromeria biflora (Buch.-Ham.ex D.Don) Benth
Abdur Rauf,Saud Bawazeer,Umer Rashid,Mohamed A. El-Esawi,Muhammad Humayun Khan,Syed Uzair Ali Shah,Mohammad S. Mubarak,Kannan RR Rengasamy
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91 Acute and sub-acute oral toxicity Lagerstroemia speciosa in Sprague-Dawley rats
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Saudi Journal of Biological Sciences. 2021;
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92 Electrospun nanocarriers for delivering natural products for cancer therapy
Reza Mohammadinejad,Vijay Sagar Madamsetty,Anuj Kumar,Mohammad Varzandeh,Ali Dehshahri,Ali Zarrabi,Fariba Sharififar,Mehdi Mohammadi,Amir Fahimipour,Seeram Ramakrishna
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93 Glycine betaine-based ionic liquids and their influence on bacteria, fungi, insects and plants
Damian Krystian Kaczmarek,Daniela Gwiazdowska,Krzysztof Jus,Tomasz Klejdysz,Marta Wojcieszak,Katarzyna Materna,Juliusz Pernak
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94 A Study on the Effect of Valeric Acid in Alzheimer's Induced Rats by the Estimation of Aß 1-42 Biomarker
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95 Linalool attenuates acquisition and reinstatement and accelerates the extinction of nicotine-induced conditioned place preference in male mice
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96 Antiplasmodial diterpenoid alkaloid from Aconitum heterophyllum Wall. ex Royle: Isolation, characterization, and UHPLC-DAD based quantification
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97 Evaluation of the antiulcerogenic activity of hydromethanol extracts of Solanum incanum L. (Solanaceae) leaves and roots in mice; single and repeated dose study
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98 Molecular docking and network pharmacology-based approaches to explore the potential of terpenoids for Mycobacterium tuberculosis
K. Kalaimathi,G. Thiyagarajan,S. Vijayakumar,K. Bhavani,K. Karthikeyan,J. Maria Jancyrani,K. Doss,J. Sureshkumar,S. Prabhu
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99 Red laser-mediated alterations in seed germination, growth, pigments and withanolide content of Ashwagandha [Withania somnifera (L.) Dunal]
Sachin Ashok Thorat,Poornima Poojari,Arya Kaniyassery,Kodsara Ramachandra Kiran,Kapaettu Satyamoorthy,Krishna Kishore Mahato,Annamalai Muthusamy
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100 Combination of docosahexaenoic acid and Ginko biloba extract improves cognitive function and hippocampal tissue damages in a mouse model of Alzheimer’s disease
Nabila E. Abdelmeguid,Mahmoud I.M. Khalil,Rasha Elhabet,Ahmed S. Sultan,Sherine Abdel Salam
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101 Alkaloidal extract from Carica papaya seeds ameliorates CCl4-induced hepatocellular carcinoma in rats
Isaac Kyei-Barffour,Roselind Kyei Baah Kwarkoh,Desmond Omane Acheampong,Augustine Suurinobah Brah,Samuel Addo Akwetey,Benjamin Aboagye
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102 An insight into Verbascum bombyciferum extracts: Different extraction methodologies, biological abilities and chemical profiles
Simone Angeloni,Gokhan Zengin,Kouadio Ibrahim Sinan,Gunes Ak,Filippo Maggi,Giovanni Caprioli,Alevcan Kaplan,Muammer Bahsi,Ugur Çakilcioglu,Abdelhakim Bouyahya,Sharmeen Jugreet,Mohamad Fawzi Mahomoodally
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103 Camptothecinæs Journey from Discovery to WHO Essential Medicine: Fifty Years of Promise
Noura Khaiwa,Noor R. Maarouf,Mhd H. Darwish,Dima W.M. Alhamad,Anusha Sebastian,Mohamad Hamad,Hany A. Omar,Gorka Orive,Taleb H. Al-Tel
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104 Optimization of ultrasound-assisted, microwave-assisted and Soxhlet extraction of bioactive compounds from Lagenaria siceraria: A comparative analysis
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105 Challenges and recent trends with the development of hydrogel fiber for biomedical applications
Reema Ansar,Sidra Saqib,Ahmad Mukhtar,Muhammad Bilal Khan Niazi,Muhammad Shahid,Zaib Jahan,Salik Javed Kakar,Bushra Uzair,Muhammad Mubashir,Sami Ullah,Kuan Shiong Khoo,Hooi Ren Lim,Pau Loke Show
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106 Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging
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107 Therapeutic effects of medicinal plants on isoproterenol-induced heart failure in rats
Faeze Keihanian,Mohsen Moohebati,Amin Saeidinia,Seyed Ahmad Mohajeri,Saeid Madaeni
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108 Ex vivo and in vivo chemoprotective activity and potential mechanism of Martynoside against 5-fluorouracil-induced bone marrow cytotoxicity
Mengying Hong, Dongdong Chen, Zhuping Hong, Kejun Tang, Yuanyuan Yao, Liubo Chen, Tingting Ye, Jing Qian, Yushen Du, Ren Sun
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109 Chitosan-tripolyphosphate nanoparticles designed to encapsulate polyphenolic compounds for biomedical and pharmaceutical applications - A review
Mariana Carolina Di Santo,Cecilia Luciana D’ Antoni,Ana Paula Domínguez Rubio,Agustina Alaimo,Oscar Edgardo Pérez
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110 Computational screening of natural compounds from Salvia plebeia R. Br. for inhibition of SARS-CoV-2 main protease
Afraa Aqeel Zackria, Ramya Pattabiraman, T. P. Krishna Murthy, S. Birendra Kumar, Blessy Baby Mathew, Vinai George Biju
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111 Non-toxic nature of chebulinic acid on biochemical, hematological and histopathological analysis in normal Sprague Dawley rats
Khurram Aamir,Vaisnevee Sugumar,Hidayat Ullah Khan,Chung Yeng Looi,Rajesh Juneja,Muhammad Waqas,Aditya Arya
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112 Anti-Leishmania Effects of Volatile Oils and Their Isolates
Patrícia Fampa,Melissa Florencio,Raissa Couto Santana,Dayana Rosa,Deivid Costa Soares,Herbert Leonel de Matos Guedes,Anabela Cordeiro da Silva,Douglas Siqueira A. Chaves,Lucia H. Pinto-da-Silva
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113 Coumarins as Potential Antiprotozoal Agents: Biological Activities and Mechanism of Action
Elkin Jose Torres Sierra,Cleydson Finotti Cordeiro,Livia de Figueiredo Diniz,Ivo Santana Caldas,Jamie Anthony Hawkes,Diogo Teixeira Carvalho
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114 Natural Bioactive Compounds as Potential Browning Agents in White Adipose Tissue
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115 In Vitro Anthelmintic Efficacy of Sesbania sesban var. bicolor, Cyperus compressus and Asparagus racemosus Against Gastrothylax crumenifer (Trematoda)
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116 Eight key rules for successful data-dependent acquisition in mass spectrometry-based metabolomics
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117 Prospects and Challenges of Developing Plant-Derived Snake Antivenin Natural Products: A Focus on West Africa
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118 Phytochemicals and biological activities of species from the genus Maytenus
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119 Anti-Cancer and Anti-Inflammatory Activities of Bromo- and Cyano-Substituted Azulene Derivatives
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120 Generation of A Stable GFP-reporter Zika Virus System for High-throughput Screening of Zika Virus Inhibitors
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121 Urolithin A Induces Brown-like Phenotype in 3T3-L1 White Adipocytes via ß3-adrenergic Receptor-p38 MAPK Signaling Pathway
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122 Production of plant natural products through engineered Yarrowia lipolytica
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123 Calotropis - A multi-potential plant to humankind: Special focus on its wound healing efficacy
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Biocatalysis and Agricultural Biotechnology. 2020; 28: 101725
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124 Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways
Ayesha Sarfraz,Azhar Rasul,Iqra Sarfraz,Muhammad Ajmal Shah,Ghulam Hussain,Nusrat Shafiq,Muqaddas Masood,Sevki Adem,Satyajit D. Sarker,Xiaomeng Li
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125 Resveratrol encapsulation in high molecular weight chitosan-based nanogels for applications in ocular treatments: Impact on human ARPE-19 culture cells
Florencia Solana Buosi,Agustina Alaimo,Mariana Carolina Di Santo,Fernanda Elías,Guadalupe García Liñares,Sofía Lorena Acebedo,Mayra Alejandra Castañeda Cataña,Carla Cecilia Spagnuolo,Leonardo Lizarraga,Karina Dafne Martínez,Oscar Edgardo Pérez
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126 Nanocapsules Containing Saussurea lappa Essential Oil: Formulation, Characterization, Antidiabetic, Anti-Cholinesterase and Anti-Inflammatory Potentials
Narimane Lammari,Tanguy Demautis,Ouahida Louaer,Abdeslam Hassen Meniai,Herve Casabianca,Chawki Bensouici,Gilles Devouassoux,Hatem Fessi,Abderrazzak Bentaher,Abdelhamid Elaissari
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127 Constituents of essential oil of Origanum minutiflorum and its in vitro antioxidant, scolicidal and anticancer activities
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128 Bioassay-guided isolation of antiplasmodial and antimicrobial constituents from the roots of Terminalia albida
Mamadou Aliou Baldé,Emmy Tuenter,An Matheeussen,Mohamed Sahar Traoré,Paul Cos,Louis Maes,Aïssata Camara,Mamadou Saliou Telly Diallo,Elhadj Saïdou Baldé,Aliou Mamadou Balde,Luc Pieters,Kenn Foubert
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129 Therapeutic potential of sulfur-containing natural products in inflammatory diseases
Xu Cao,Lei Cao,Wencan Zhang,Rongzhu Lu,Jin-Song Bian,Xiaowei Nie
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130 Anti-diabetic potential of plant alkaloids: Revisiting current findings and future perspectives
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131 Sugiol, a diterpenoid: Therapeutic actions and molecular pathways involved
Vivek K. Bajpai,Sonam Sonwal,Seung-Kyu Hwang,Shruti Shukla,Imran Khan,Debasish Kumar Dey,Lei Chen,Jesus Simal-Gandara,Jianbo Xiao,Yun Suk Huh,Young-Kyu Han
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132 Davilla elliptica (Dilleniaceae) a. St.-Hil. Ethnomedicinal, phytochemical, and pharmacological aspects: A review
Jaciara Neves Sousa,Valéria Mafra,Victor Hugo Dantas Guimarães,Alanna Fernandes Paraiso,Deborah de Farias Lelis,Sérgio Henrique Sousa Santos
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133 Antioxidant properties of the Lebanese plantIrisxgermanicaL. crude extracts and antagonism of chlorpromazine toxicity onSaccharomyces cerevisiae
Katia Sayyed,Ibrahim Hdayed,Mohamad Tabcheh,Ziad Abdel-Razzak,Hoda El-Bitar
Drug and Chemical Toxicology. 2020; : 1
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134 Dark Classics in Chemical Neuroscience: An Evidence-Based Systematic Review of Belladonna
Vimal K Maurya,Swatantra Kumar,Russell Kabir,Gaurav Shrivastava,Karuna Shanker,Debadatta Nayak,Anil Khurana,Raj K Manchanda,Srinivasulu Gadugu,Sujita K Kar,Anoop K. Verma,Shailendra K Saxena
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135 cis-9-Hexadecenal, a Natural Compound Targeting Cell Wall Organization, Critical Growth Factor, and Virulence of Aspergillus fumigatus
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136 A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids
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137 Biochanin A: A novel bioactive multifunctional compound from nature
Ayesha Sarfraz,Maria Javeed,Muhammad Ajmal Shah,Ghulam Hussain,Nusrat Shafiq,Iqra Sarfraz,Ammara Riaz,Ayesha Sadiqa,Rabia Zara,Saba Zafar,Lubna Kanwal,Satyajit D. Sarker,Azhar Rasul
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138 Antimicrobial activity of Plumbago indica and ligand screening of plumbagin against methicillin-resistant Staphylococcus aureus
D. M. I. H. Dissanayake,D. D. B. D. Perera,L. R. Keerthirathna,Saumya Heendeniya,Raymond J. Anderson,David E. Williams,L. Dinithi C. Peiris
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139 Antiproliferative activity of new pentacyclic triterpene and a saponin from Gladiolus segetum Ker-Gawl corms supported by molecular docking study
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140 Hepatoprotective and hematological effects of Justicia secunda Vahl leaves on carbon tetrachloride induced toxicity in rats
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141 Inhibitory potential on key enzymes relevant to type II diabetes mellitus and antioxidant properties of the various extracts and phytochemical constituents from Rumex acetosella L
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142 Ethnobotanical Description and Biological Activities of Senna alata
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Evidence-Based Complementary and Alternative Medicine. 2020; 2020: 1
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143 In Silico Identification of New Targets for Diagnosis, Vaccine, and Drug Candidates against Trypanosoma cruzi
Rafael Obata Trevisan,Malú Mateus Santos,Chamberttan Souza Desidério,Leandro Gomes Alves,Thiago de Jesus Sousa,Letícia de Castro Oliveira,Arun Kumar Jaiswal,Sandeep Tiwari,Weslley Guimarães Bovi,Mariana de Oliveira-Silva,Juliana Cristina Costa-Madeira,Lúcio Roberto Cançado Castellano,Marcos Vinicius Silva,Vasco Azevedo,Virmondes Rodrigues Junior,Carlo José Freire Oliveira,Siomar de Castro Soares,Paolo Cameli
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144 Pharmacological Assessment of the Carvacrol Chemotype Essential Oil FromPlectranthus amboinicusGrowing in Cuba
Lianet Monzote, Alexander M. Scherbakov, Ramón Scull, Yamilet I. Gutiérrez, Prabodh Satyal, Paul Cos, Andrey E. Shchekotikhin, Lars Gille, William N. Setzer
Natural Product Communications. 2020; 15(10): 1934578X20
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145 Antioxidant and in vivo hepatoprotective effects of Gardenia gummifera L.f. fruit methanol extract
N. M. Vinaykumar,Riaz Mahmood,V. Krishna,B. Ravishankara,Sudhesh L. Shastri
Clinical Phytoscience. 2020; 6(1)
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146 In vitro antimitotic and cytotoxic potential of plant extracts: a comparative study of Mucuna pruriens, Asteracantha longifolia and Sphaeranthus indicus
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Future Journal of Pharmaceutical Sciences. 2020; 6(1)
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147 Ethnobotanical survey of the medicinal flora of Harighal, Azad Jammu & Kashmir, Pakistan
Muhammad Shoaib Amjad,Ujala Zahoor,Rainer W. Bussmann,Muhammad Altaf,Syed Mubashar Hussain Gardazi,Arshad Mehmood Abbasi
Journal of Ethnobiology and Ethnomedicine. 2020; 16(1)
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148 RP-HPLC-UV Analysis of the Phenolic Compounds, Antimicrobial Activity Against Multi-Drug Resistant Bacteria and Antioxidant Activity of Fruit and Seed of Diospyros lotus L.ctivity of Fruit and Seed of Diospyros lotus L.
Zeynep AKAR,Aylin KARAKURT,Funda OKUMUS,Sedanur CINEMRE,Azer ÖZAD DÜZGÜN,Bülent AKAR,Zehra CAN
International Journal of Secondary Metabolite. 2020; : 237
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149 Therapeutic Potential of Medicinal Plant Proteins: Present Status and Future Perspectives
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Current Protein & Peptide Science. 2020; 21(5): 443
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150 Antioxidant Potential of Glycyrrhiza glabra L. roots: In-Vitro Evidences
Varinder Singh,Amit Kumar
Journal of Pharmaceutical Technology, Research and Management. 2020; 8(1): 9
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151 Metabolism and Pharmacokinetics of Phytochemicals in the Human Body
Pooja Rathaur,Kaid Johar SR
Current Drug Metabolism. 2020; 20(14): 1085
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152 Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections
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153 Investigation of the Biological Activities of Different Extracts from Dipsacus laciniatus Aerial Parts
Turgut Taskin,Yeliz Akkiliç,Berna Özbek Çelik,Ismail Senkardes,Özlem B. Özakpinar
The Natural Products Journal. 2020; 10(1): 15
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154 Punica granatum L. (Pomegranate): A Potential Anti-microbial Agent
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Anti-Infective Agents. 2020; 18(1): 2
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155 Traditional and Herbal Medicines: Understanding & Exploration (Part II)
Ashish Baldi,Puneet Kumar Bansal
Current Traditional Medicine. 2020; 6(4): 258
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156 Immunomodulating potential of Neolamarckia cadamba (Roxb.) Bark extract
Vishal Khandelwal,Pradeep Kumar Choudhary
Journal of Pure and Applied Microbiology. 2020; 14(1): 641
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157 Prevention of Oxidative Stress-Induced Pancreatic Beta Cell Damage by Broussonetia kazinoki Siebold Fruit Extract via the ERK-Nox4 Pathway
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Antioxidants. 2020; 9(5): 406
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158 Assessment of the Pharmacological Properties and Phytochemical Profile of Bruguiera gymnorhiza (L.) Lam Using In Vitro Studies, In Silico Docking, and Multivariate Analysis
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159 Genista tridentata L.: A Rich Source of Flavonoids with Anti-Inflammatory Activity
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160 Chelerythrine Chloride Downregulates ß-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma
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Molecules. 2020; 25(1): 224
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161 Untargeted Characterization of Chestnut (Castanea sativa Mill.) Shell Polyphenol Extract: A Valued Bioresource for Prostate Cancer Cell Growth Inhibition
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162 Synthesis and Properties of CurNQ for the Theranostic Application in Ovarian Cancer Intervention
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163 Phytochemicals as Anti-Inflammatory Agents in Animal Models of Prevalent Inflammatory Diseases
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164 Lead Compounds in the Context of Extracellular Vesicle Research
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165 Phytochemicals and Enzyme Inhibitory Capacities of the Methanolic Extracts from the Italian Apple Cultivar Mela Rosa dei Monti Sibillini
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166 Therapeutic uses of post-partum tissue-derived mesenchymal stromal cell secretome
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167 Factorial design-guided optimization of extraction of therapeutically active furanocoumarin khellin from Ammi majus L. fruits
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168 Cytotoxic Potential and Phytochemical Profile of Extracts from Garcinia rubra Merr. Leaves
Carlo Avila Limbo,Sonia Donaldo Jacinto
International Journal of Cancer Research. 2019; 15(2): 38
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169 Effects of Hydroalcoholic Flower Extract of Marigold (Calendula officinalis) on the Biochemical and Histological Parameters in STZ-Induced Diabetic Rats
Esmaeel Ebrahimi,Alireza Kheirollah,Esrafil Mansouri,Hossein Babaahmadi-Razaei,Ghorban Mohammadzadeh
Jundishapur Journal of Natural Pharmaceutical Products. 2019; In Press(In Press)
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170 Phytochemical Profiling of Coryphantha macromeris (Cactaceae) Growing in Greenhouse Conditions Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
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171 At-Line Monitoring of the Extraction Process of Rosmarini Folium via Wet Chemical Assays, UHPLC Analysis, and Newly Developed Near-Infrared Spectroscopic Analysis Methods
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172 Erythroxylum in Focus: An Interdisciplinary Review of an Overlooked Genus
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173 Deciphering the Antibacterial Mode of Action of Alpha-Mangostin on Staphylococcus epidermidis RP62A Through an Integrated Transcriptomic and Proteomic Approach
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Frontiers in Microbiology. 2019; 10
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174 Larrea tridentata Extract Mitigates Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells
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175 Cutting-Edge Search for Safer Opioid Pain Relief: Retrospective Review of Salvinorin A and Its Analogs
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176 Phenolic Profiling and Biological Potential of Ficus curtipes Corner Leaves and Stem Bark: 5-Lipoxygenase Inhibition and Interference with NO Levels in LPS-Stimulated RAW 264.7 Macrophages
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177 Evaluating Iso-Mukaadial Acetate and Ursolic Acid Acetate as Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase Inhibitors
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178 Casticin-Induced Inhibition of Cell Growth and Survival Are Mediated through the Dual Modulation of Akt/mTOR Signaling Cascade
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179 Inhibition of Aspergillus fumigatus Biofilm and Cytotoxicity Study of Natural Compound Cis-9-Hexadecenal
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180 Cannabis medicinal, más que una encrucijada legal para el tratamiento de la epilepsia
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181 Medicinal Plant Compounds for Combating the Multi-drug Resistant Pathogenic Bacteria: A Review
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182 Oral Acute and Repeated-Doses Toxicity Study of Valepotriates from Valeriana glechomifolia (Meyer) in Mice
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183 The Promising Role of Plant Tannins as Bioactive Antidiabetic Agents
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184 Use of Natural Components Derived from Oil Seed Plants for Treatment of Inflammatory Skin Diseases
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185 Crystal structure and in vitro antimicrobial activity studies of Robustic acid and other Alpinumisoflavones isolated from Millettia thonningii
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186 Isolation, Characterization and Assessment for Central Nervous System Effects of Novel Phytomolecule from Galphimia glauca Cav. Stems
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187 Protective Effects of Broussonetia kazinoki Siebold Fruit Extract against Palmitate-Induced Lipotoxicity in Mesangial Cells
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188 Pharmacotherapeutics and Molecular Mechanism of Phytochemicals in Alleviating Hormone-Responsive Breast Cancer
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189 Pharmacokinetics of thymoquinone in layer chickens following oral and intravenous administration
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190 Morelloflavone as a novel inhibitor of mitotic kinesin Eg5
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191 Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?
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192 In silico identification of mimicking molecule(s) triggering von Willebrand factor in human: a molecular drug target for regulating coagulation pathway
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193 Accessing to the Nicotiana tabacum leaf antimicrobial activity: In-silico and in-vitro investigations
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194 Progress in the discovery of naturally occurring anti-diabetic drugs and in the identification of their molecular targets
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195 Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system
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European Journal of Medicinal Chemistry. 2019;
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196 Essential oil yield estimation by Gas chromatography–mass spectrometry (GC–MS) after Methyl jasmonate (MeJA) elicitation in in vitro cultivated tissues of Coriandrum sativum L.
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197 Status and future scope of plant-based green hydrogels in biomedical engineering
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198 Antifungal Activity of Essential Oils Against Candida Species Isolated from Clinical Samples
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199 The genus Laggera (Asteraceae) – Ethnobotanical and Ethnopharmacological Information, Chemical Composition as well as Biological Activities of Its Essential Oils and Extracts: A Review
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Chemistry & Biodiversity. 2019;
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200 Effect of Synadenium grantii and its isolated compound on dysmenorrhea behavior model in mice
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Inflammopharmacology. 2018;
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201 Comprehensive review of antimicrobial activities of plant flavonoids
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202 Phytochemical screening, free radical scavenging and antimicrobial potential of Chromolaena odorata leaf extracts against pathogenic bacterium in wound infections– a multispectrum perspective
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203 Evaluation of Boerhavia erecta L. for potential antidiabetic and antihyperlipidemic activities in streptozotocin-induced diabetic Wistar rats
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204 HPLC-DAD profiles and pharmacological insights of Onobrychis argyrea subsp isaurica extracts
Gokalp Ozmen Guler,Gokhan Zengin,Firat Karadag,Adriano Mollica,Carene Marie Nancy Picot,Mohamad Fawzi Mahomoodally
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205 Optimization of extraction parameters of antioxidant activity of extracts from New Zealand and Chinese Asparagus officinalis L root cultivars
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206 Lotus aegaeus (Gris.) Boiss and Iberis sempervirens L.: Chemical fingerprints, antioxidant potential, and inhibition activities and docking on key enzymes linked to global health problems
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207 The Medicinal Uses, Toxicities and Anti-inflammatory Activity of Polyalthia Species (Annonaceae)
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208 Alkaloid rich fraction of Datura alba Rumph. ex Nees leaves possesses antitumor and antimitotic activity
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209 Bioactive Compounds Extracted from Mangrove Plants (Avicennia marina and Rhizophora mucronata): an Overview
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210 Recommended Medicinal Plants as Source of Natural Products: A Review
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211 Toxic effect of Moringa peregrina seeds on histological and biochemical analyses of adult male Albino rats
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212 Toxicity and Antigenotoxic Effect of Hispolon Derivatives: Role of Structure in Modulating Cellular Redox State and Thioredoxin Reductase
Pogakula Chethna,Shruti S. Iyer,Vishwa V. Gandhi,Amit Kunwar,Beena G. Singh,Atanu Barik,Neduri V. Balaji,Modukuri V. Ramani,Gottumukkala V. Subbaraju,K. Indira Priyadarsini
ACS Omega. 2018; 3(6): 5958
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213 Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities
Ammara Riaz,Azhar Rasul,Ghulam Hussain,Muhammad Kashif Zahoor,Farhat Jabeen,Zinayyera Subhani,Tahira Younis,Muhammad Ali,Iqra Sarfraz,Zeliha Selamoglu
Advances in Pharmacological Sciences. 2018; 2018: 1
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214 Isolation of anticancer constituents from Cucumis prophetarum var. prophetarum through bioassay-guided fractionation
Abdulrhman Alsayari,Lucas Kopel,Mahmoud Salama Ahmed,Hesham S. M. Soliman,Sivakumar Annadurai,Fathi T. Halaweish
BMC Complementary and Alternative Medicine. 2018; 18(1)
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215 Antioxidant activity, antibacterial potential and characterization of active fraction of Dioscorea pentaphylla L. tuber extract collected from Similipal Biosphere Reserve, Odisha, India
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Brazilian Journal of Pharmaceutical Sciences. 2018; 53(4)
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216 Effects of Mulberry Fruit (Morus alba L.) Consumption on Health Outcomes: A Mini-Review
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217 Evaluation of Manganese Chloride’s Effect on Biosynthetic Properties of In Vitro Cultures of Eschscholzia californica Cham.
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Molecules. 2018; 23(4): 971
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218 Molecular Targets Modulated by Fangchinoline in Tumor Cells and Preclinical Models
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219 Transcriptional Profiles of Secondary Metabolite Biosynthesis Genes and Cytochromes in the Leaves of Four Papaver Species
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220 Natural Products Extraction of the Future—Sustainable Manufacturing Solutions for Societal Needs
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221 Cytotoxicity of n-Butanol Extracts of Streptomyces Against Human Breast Cancer Cells
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222 Therapeutic effect of an alkaloid-rich fraction of Abrus precatorius seed methanol extract on paracetamol-induced liver damage in rats
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223 Bioactive Steroids and Saponins of the Genus Trillium
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224 Optimizing the Maximum Recovery of Dihydromyricetin from Chinese Vine Tea, Ampelopsis grossedentata, Using Response Surface Methodology
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225 An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae
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226 Magnolol inhibits venous remodeling in mice
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227 Biological activities of plant extracts from Ficus elastica and Selaginella vogelli : An antimalarial, antitrypanosomal and cytotoxity evaluation
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228 Bioavailability-enhanced Resveramax™ modulates quorum sensing and inhibits biofilm formation in Pseudomonas aeruginosa PAO1
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229 A polyphenolic extract from green tea leaves activates fat browning in high fat diet-induced obese mice
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230 Broadening our perspectives on complementary and alternative medicine for menopause: A narrative review
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231 In vitro antimicrobial activity of the methanol extract and compounds from the wood of Ficus elastica Roxb. ex Hornem. aerial roots
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232 Molecular binding mechanism of 5-hydroxy-1-methylpiperidin-2-one with human serum albumin
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233 Traditional Chinese herbal medicine and its effects on the quality of life of lung cancer patients: a meta-analysis
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234 The role of spices in nutrition and health: a review of three popular spices used in Southern Nigeria
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236 Antibacterial activity of medicinal plants from The Physicians of Myddvai, a 14th century Welsh medical manuscript
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237 Topical aqueous extract of Ephedra alata can improve wound healing in an animal model
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238 Exploiting natural variation for accelerating discoveries in plant specialized metabolism
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239 Euclea undulata Thunb.: Review of its botany, ethnomedicinal uses, phytochemistry and biological activities
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240 A Novel DSC Approach for Evaluating Protectant Drugs Efficacy against Dementia
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242 Antidiabetic plant-derived nutraceuticals: a critical review
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243 Metal-Free trans -Aziridination of Zerumbone: Synthesis and Biological Evaluation of Aziridine Derivatives of Zerumbone
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244 High-throughput sequencing and de novo transcriptome assembly of Swertia japonica to identify genes involved in the biosynthesis of therapeutic metabolites
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245 Safety assessment of aqueous acetone extract of Clerodendrum infortunatum L. in Wistar rats
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246 In vitro inhibitory effects on a-glucosidase and a-amylase level and antioxidant potential of seeds of Phoenix dactylifera L.
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247 Synthesis and Characterization of Sygyzium cumini Nanoparticles for Its Protective Potential in High Glucose-Induced Cardiac Stress: a Green Approach
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248 An overview of herb and dietary supplement efficacy, safety and government regulations in the United States with suggested improvements. Part 1 of 5 series
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249 New potential phytotherapeutics obtained from white mulberry (Morus alba L.) leaves
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250 Alzheimeræs disease: An overview of amyloid beta dependent pathogenesis and its therapeutic implications along with in silico approaches emphasizing the role of natural products
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251 The GenusHeracleum: A Comprehensive Review on Its Phytochemistry, Pharmacology, and Ethnobotanical Values as a Useful Herb
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252 Extraction of bioactive plant materials by simultaneous enzyme treatment and lactic acid fermentation – a mini-review
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253 A reexamination of poneratoxin from the venom of the bullet ant Paraponera clavata
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254 Fraxinus xanthoxyloides leaves reduced the level of inflammatory mediators during in vitro and in vivo studies
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255 Preliminary assessment of free radical scavenging, thrombolytic and membrane stabilizing capabilities of organic fractions of Callistemon citrinus (Curtis.) skeels leaves
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256 Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action
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259 Study of microbial proliferation and the in vitro antibacterial traits of commonly available flowers in Dhaka Metropolis
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260 The Anticandidal and Toxicity Properties ofLampranthus francisci
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261 Efficacy and safety ofStephania glabra: an alkaloid-rich traditional medicinal plant
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262 Mucoadhesive microparticulate drug delivery system of curcumin against Helicobacter pylori infection: Design, development and optimization
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263 Microbiological profiling and the demonstration of in vitro anti-bacterial traits of the major oral herbal medicines used in Dhaka Metropolis
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