Home  |  About JAPTR |  Editorial board  |  Search |  Ahead of print  |  Current issue  |  Archives |  Submit article  |  Instructions  |  Subscribe  |  Advertise  |  Contacts  |Login 
Users Online: 410   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size

 Table of Contents  
Year : 2012  |  Volume : 3  |  Issue : 3  |  Page : 142-146  

Influence of nanotechnology on herbal drugs: A Review

1 Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India
2 Department of Chemistry, Faculty of Science, Jamia Hamdard, New Delhi, India

Date of Web Publication14-Sep-2012

Correspondence Address:
S H Ansari
Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-4040.101006

Rights and Permissions

Herbal medicines have been widely used all over the world since ancient times and have been recognized by physicians and patients for their better therapeutic value as they have fewer adverse effects as compared with modern medicines. Phytotherapeutics need a scientific approach to deliver the components in a sustained manner to increase patient compliance and avoid repeated administration. This can be achieved by designing novel drug delivery systems (NDDS) for herbal constituents. NDDSs not only reduce the repeated administration to overcome non-compliance, but also help to increase the therapeutic value by reducing toxicity and increasing the bioavailability. One such novel approach is nanotechnology. Nano-sized drug delivery systems of herbal drugs have a potential future for enhancing the activity and overcoming problems associated with plant medicines . Hence, integration of the nanocarriers as a NDDS in the traditional medicine system is essential to conflict more chronic diseases like asthma, diabetes, cancer, and others.

Keywords: Herbal drugs, nanotechnology, novel drug delivery systems

How to cite this article:
Ansari S H, Islam F, Sameem M. Influence of nanotechnology on herbal drugs: A Review. J Adv Pharm Technol Res 2012;3:142-6

How to cite this URL:
Ansari S H, Islam F, Sameem M. Influence of nanotechnology on herbal drugs: A Review. J Adv Pharm Technol Res [serial online] 2012 [cited 2023 Mar 20];3:142-6. Available from: https://www.japtr.org/text.asp?2012/3/3/142/101006

   Introduction Top

Since ancient time, herbal remedies and natural products are being used to cure the diseases. Unlike widely used allopathic system, the herbal remedies have thousands of constituents that all work simultaneously against the diseases. [1] Phytotherapeutics need a scientific approach to deliver the components in a sustained manner to increase patient compliance and avoid repeated administration. This can be achieved by designing novel drug delivery systems (NDDSs) for herbal constituents. NDDSs not only reduce the repeated administration to overcome non-compliance, but also help to increase the therapeutic value by reducing toxicity and increasing the bioavailability, and so on. [2],[3]

Incorporation of the herbal extracts into novel formulation systems have certain added advantages, such as their bulk dosing and less absorption can be overcome which is the major problem being faced, enticing the attention of major pharmaceutical corporations.

Nanotechnology is a field of applied science and technology which aims to develop devices and dosage forms in the range of 1 to 100 nm. The applications of nanotechnology for treatment, diagnosis, monitoring, and control of biological systems have recently been referred to as nanomedicine. The nanocarriers have been made of safe materials, including synthetic biodegradable polymers, lipids, and polysaccharides.

The activity of herbal medicines depends on overall function of a variety of active components, as all the constituents provide synergistic action and thus enhance the therapeutic value. Each active constituent plays an important role and they are all related to each other. However, most of the herbal origin drugs possess insoluble character leading to lower bioavailability and increased systemic clearance requiring repeated administration or higher dose, which makes the drug as a poor candidate for therapeutic use. In phyto-formulation research, developing nano dosage forms (Polymeric Nanoparticles [Nanospheres and Nanocapsules], Liposomes, Proliposomes, Solid Lipid Nanoparticles [SLNs], Nanoemulsion, etc.) has large number of advantages for herbal drugs, including enhancement of solubility and bioavailability, protection from toxicity, enhancement of pharmacological activity, enhancement of stability, improving tissue macrophages distribution, sustained delivery, protection from physical and chemical degradation, etc. Thus, the nano-sized drug delivery systems of herbal drugs have a potential future for enhancing the activity and overcoming problems associated with plant medicines . Hence, integration of the nanocarriers as a NDDS in the traditional medicine system is essential to conflict more chronic diseases like asthma, diabetes, cancer, and others. [1] The various herbal nanoparticles delivery system has been summarized in [Table 1].
Table 1: Some herbal drug nanoparticles

Click here to view

   History and Development Top

Since ancient days, natural products, including plants, have been the basis of treatment of human diseases. The basis of concept of modern medicine development remains rooted in traditional medicine and therapies. [4],[5] In different parts of the world like ancient China, Egypt, Africa, America, and India, plants had been used for medicinal purposes long before recorded history. Chemical analysis first became available in the early 19 th century which started the extraction and modification of herbal ingredients. [4],[6] For a long time, herbal medicines were not considered for development as novel formulations owing to lack of scientific justification and processing difficulties, such as standardization, extraction, and identification of individual drug components in complex polyherbal systems. However, modern phytopharmaceuticals research solves the scientific needs for herbal medicines as in modern medicine, which gives way for developing novel formulations such as nanoparticles, microemulsions, matrix systems, solid dispersions, liposomes, SLNs, and so on. Nanomicellar system, [7] nanotubes, [8] and colloidal nanogels have been developed for curcumin to be used alone as well as in combination with other chemotherapeutic agents like paclitaxel. [1]

   Need for novel drug delivery system 'Nano carriers' for 'Herbal remedies' Top

Before reaching to the blood, many constituents of the herbal drugs will be smashed in the highly acidic pH of the stomach and other constituents might be metabolized by the liver. Resultant, the optimum quantity of the herbal drugs may not reach the blood. If the drug does not reach in the optimum amount to the infected region at "minimum effective level," then there will be no means to show the therapeutic effect of the drug. Nanocarriers applying to herbal remedies will carry optimum amount of the drug to their site of action bypassing all the barriers such as acidic pH of stomach, liver metabolism and increase the prolonged circulation of the drug into the blood due to their small size. [1],[9]

Herbal remedies were selected as feasible drug candidate for delivery through a nano delivery system because of the following properties:

  1. Effective chloroform, petrol, acetone, and methanolic extracts are available which may not be suitable for delivery as such.
  2. These are the bulk drugs so dose reduction is intended.
  3. Currently marketed formulations lack target specificity for various chronic diseases.
  4. Some other side effects are associated with currently marketed formulations.
  5. Patient non-compliance due to large doses and less effectiveness with the available formulations.

   Strategies of Nanotechnology as Novel Drug Delivery System Top

Drug delivery system fetched a NDDS, a novel approach to overcome the drawbacks of the traditional drug delivery systems.

Nano-sized delivery system was selected because of the following reasons:

  • They appear to be able to deliver high concentrations of drugs to disease sites because of their unique size and high loading capacities. [1]
  • Deliver the drug in the small particle size that enhances the entire surface area of the drugs allocating quicker dissolution in the blood.
  • The concentration seems to persist at the sites for the longer periods. [1]
  • Shows EPR (enhanced permeation and retention) effect, i.e., enhanced permeation through the barriers because of the small size and retention due to poor lymphatic drainage such in tumor. [1]
  • Exhibits passive targeting to the disease site of action without the addition of any particular ligand moiety. [1]
  • Decrease in the side effects. [1]
  • Decrease in the dose of the drug formulation. [1]

   Techniques Top

The techniques commonly used for the formulation are:

High-pressure homogenization method

In this method, the lipid is pushed with high pressure (100 to 2 000 bar) through a very high shear stress, which results in disruption of particles down to the submicrometer or nanometer range. High-pressure homogenization method is a very reliable and powerful technique for the large-scale production of nanostructured lipid carriers, lipid drug conjugate, SLNs, and parenteral emulsions. [10],[11]

Complex coacervation method

This is a spontaneous phase separation process of two liquid phases in colloidal systems, which results by the interaction of two oppositely charged polyelectrolytes upon mixing in an aqueous solution. [10]

Co-precipitation method

This method is a modification of the complex coacervation method for the preparation of nanoscale core-shell particles. This method has been reported to provide good dispersion stability to poorly water-soluble drugs. [10]

Salting-out method

This method is based on the phenomenon that the solubility of a non-electrolyte in water is decreased upon addition of an electrolyte. [10]

Nanoprecipitation method or solvent displacement method

This method is based on interfacial deposition of a polymer after displacement of a semipolar solvent miscible with water from a lipophilic solution, thereby resulting in a decrease in the interfacial tension between the two phases, which increases the surface area with a subsequent formation of small droplets of organic solvent even without any mechanical stirring. [10],[12]

Solvent emulsification-diffusion method

The method involves preparation of an o/w emulsion using oil phase containing polymer and oil in an organic solvent, which is emulsified with the aqueous phase, containing stabilizer, in high shear mixer, followed by addition of water to induce the diffusion of organic solvent, thus resulting in formation of nanoparticles. [10]

Supercritical fluid methods

This method can be used to prepare submicrometer-sized and nano-sized formulations. A supercritical fluid (SCFs) can either be a liquid or gas and used above its thermodynamic critical point of temperature and pressure. The most commonly used SCFs are carbon dioxide and water. [10],[13]

Self-assembly methods

Self-assembly is the physical process wherein pre-existing disordered components, atoms, or molecules organize themselves into regulated nanoscale structures by physical or chemical reactions without any contribution from any external source. [10]

   Types of Nanopharmaceuticals Top

  • Polymeric nanoparticles
  • Solid lipid nanoparticles
  • Magnetic nanoparticles
  • Metal and inorganic nanoparticles
  • Quantum dots
  • Polymeric micelles
  • Phospholipids micelles
  • Colloidal nano-liposomes
  • Dendrimers

   Recent Development Top

The nanoparticles have come forward as the capable approach in drug delivery systems for the well-organized delivery of drugs utilized in the treatment of various diseases such as cancer by crossing the reticuloendothelial system, enhanced permeability and retention effect, and tumor-specific targeting.

Recently, pharmaceutical scientists have shifted their focus to designing a drug delivery system for herbal medicines using a scientific approach. Cuscuta chinensis is a commonly used traditional Chinese medicine to nourish the liver and kidney. Due to the poor water solubility of its major constituents such as flavonoids and lignans, its absorption upon oral administration could be limited. So, the nanoparticles for the same were developed. [1],[14] A recent experimental study of polylactic acid nanoparticles of lipophilic anti-cancer herb drug (Cucurbitacins and Curcuminoids) using a precipitation method have been developed. [1],[15] Work has also been carried out in the development and characterization of SLNs for the traditional Chinese medicine for their targeted delivery and increased bioavailability and efficacy. [1],[16] In the recent years, nanostructured carrier system like polymeric nanoparticles, liposomes, SLNs, polymeric micelles, nanoemulsions, etc., have been investigated for their potential to deliver anticancer drugs by oral route. [1],[17],[18] Moreover, the oral route offers great potential for delivery of cytotoxic agents and therefore the attention has focused on the development of oral chemotherapy in oncology. [1],[19],[20]

   Toxicity Issues Top

Although nanopharmaceuticals may promise endless opportunities in the field of drug delivery for the diagnosis and treatment of various diseases, their safety should not be ignored. [10]

The change in the physicochemical and structural properties of engineered nano-sized materials with a decrease in size could be responsible for a number of material interactions that could lead to toxicological effects. At present, scientists must accept that it is still very early in the toxicological evaluation for nanomaterials and nanomedicines, and there are only few data on the safety and toxicity.

   Future Prospective Top

All over the world, the research has been going on herbal remedies and natural products. The development of herbal remedies in the drug delivery system in a number of institutes is being carried out at basic and clinical trial levels. The only requirement is to develop the better systems for the proper delivery of such drugs at the sites and in the whole body in the doses which will not compromise with the existing treatment. Something that would not only give relieve from side effects like toxicity and hypersensitive reactions but also will increase the patient's strength from inside is very much desirable. In the future, the concept of herbal nanoparticles for cancer drug delivery may also fascinate some potential research groups and potentially create attention-grabbing results.

Hence, using "herbal remedy" in the nanocarriers will increase its potential for the treatment of various chronic diseases and health benefits. Many successful examples with experienced evidences are present among us in the direction of nano research. Herbal remedies are also prosperous resources of advantageous compounds holding antioxidants and constituents that can be made use in purposeful foods. [28] This type of collaborative research among the traditional "Herbal remedies" and newer approaches of modern drug delivery system, i.e., "Nanotechnology" has established the attractive therapies to the pharmaceutical in near future that will enhance health of people. It is anticipated that the effectual and valuable relevance of the natural products and herbal remedies being applied with the nanocarrier will enhance the significance of existing drug delivery systems. [1]

   References Top

1.Yadav D, Suri S, Choudhary AA, Sikender M, Hemant, Beg NM, et al. Novel approach: Herbal remedies and natural products in pharmaceutical science as nano drug delivery systems. Int J Pharm Tech 2011;3:3092-116.  Back to cited text no. 1
2.Singh RP, Singh SG, Naik H, Jain D, Bisla S. Herbal excipients in novel drug delivery system. Int J Comprehensive Pharm 2011;2:1-7.  Back to cited text no. 2
3.Sungthongjeen S, Pitaksuteepong T, Somsiri A, Sriamornsak P. Studies on Pectins as Potential Hydrogel Matrices for Controlled-Release Drug Delivery. Drug Develop Ind Pharm 1999;25:1271-6.   Back to cited text no. 3
4.Sharma AT, Mitkare SS, Moon RS. Multicomponent herbal therapy: A review. Int J Pharm Sci Rev Res 2011;6:185-7.  Back to cited text no. 4
5.Patwardhan B, Vaidya AD, Chorghade M. Ayurveda and natural products drug discovery. Curr Sci 2004;86:789.  Back to cited text no. 5
6.Currier SJ, Johnston PD, Gorelick KJ. Complementary and Alternative Medicine-Herbal Medicines. Sci Med 2000;7:40-3.  Back to cited text no. 6
7.Bisht S, Feldmann G, Soni S, Ravi R, Karikar C, Maitra A, et al. Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): A novel strategy for human cancer therapy. J Nanobio 2007;5:1-18.  Back to cited text no. 7
8.Zheng L, Song JF. Curcumin multi-wall carbon nanotubes modified glassy carbon electrode and its electrocatalytic activity towards oxidation of hydrazine. Sens Actuators B Chem 2009;135:650-5.  Back to cited text no. 8
9.Bairwa NK. Sethiya NK, Mishra SH. Protective effect of stem bark of Ceiba pentandra Linn. against Paracetamol-induced hepatotoxicity in Rats. Pharmacognosy Res 2010;2:26-30.   Back to cited text no. 9
10.Sahni JK, Baboota S, Ali J. Promising Role of Nanopharmaceuticals in Drug Delivery. Pharma Times 2011;43:16-8.  Back to cited text no. 10
11.Mueller RH, Maeder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. Eur J Pharm Biopharm 2000;50:161-77.  Back to cited text no. 11
12.Fessi H, Puisieux F, Devissaguet JP, Ammoury N, Benita S. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm 1989;55:R1-4.  Back to cited text no. 12
13.Jung J, Perrut M. Particle design using supercritical fluids: Literature and patent survey. J Supercrit Fluids 2001;20:179-219.  Back to cited text no. 13
14.Yen FL, Wu TH, Lin GT, Cham TM, Lin CC. Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats. Food Chem Toxicol 2008;46:1771-7.  Back to cited text no. 14
15.Zhang JF, Hou SX, Liu HL. Comparison of preparing two polylactide nanoparticles loaded lipophilic anti-cancer herb drug by nanoprecipitation method. Zhongguo Zhong Yao Za Zhi 2007;32:303-6.  Back to cited text no. 15
16.Li Y, Dong L, Jia A, Chang X, Xue H. Preparation and characterization of solid lipid nanoparticles loaded traditional chinese medicine. Int J Biol Macromol 2006;38:296-9.  Back to cited text no. 16
17.Robinson JR. Introduction: semi-solid formulations for oral drug delivery. Bull Tech Gattefosse 1996;89:11-3.  Back to cited text no. 17
18.Aungst BJ. Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism. J Pharm Sci 1993;82:979-87.  Back to cited text no. 18
19.DeMario MD, Ratain MJ. Oral chemotherapy: rationale and future directions. J Clin Oncol 1998;16:2557-67.  Back to cited text no. 19
20.Pouton CW. Formulation of self-emulsifying drug delivery systems. Adv Drug Del Rev 1997;25:47-58.   Back to cited text no. 20
21.Mukerjee A, Vishwanathan JK. Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res 2009;29:3867-75.  Back to cited text no. 21
22.Hou J, Zhou SW. Formulation and preparation of glycyrrhizic acid solid lipid nanoparticles. ACTA 2008;30:1043-5.   Back to cited text no. 22
23.Yen FL, Wu TH, Tzeng CW, Lin LT, Lin CC. Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities. J Agric Food Chem 2010;58:7376-82.  Back to cited text no. 23
24.Li D, Zhong X, Zeng Z, Jiang J, Li L, Zhao M, et al. Application of targeted drug delivery system in Chinese medicine. J Control Rel 2009;138:103-12.  Back to cited text no. 24
25.Chen Y, Lin X, Park H, Greever R. Study of artemisinin nanocapsules as anticancer drug delivery systems Nanomedicine: Nanotechnology. Biol Med 2009;5:316-22.  Back to cited text no. 25
26.Min KH, Park K, Kim YS, Bae SM, Lee S, Jo HG, et al. Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy. J Control Release 2008;127:208-18.  Back to cited text no. 26
27.Lin AH, Li HY, Liu YM. Preparation and release characteristics of berberine chitosan nanoparticles in vitro. China Pharm 2007;18:755- 7.  Back to cited text no. 27
28.Sethiya NK. Trivedi A, Patel MB, Mishra SH. Comparative pharmacognostical investigation on four ethanobotanicals traditionally used as Shankhpushpi in India. J Adv Pharm Tech Res 2010;1:388-95.  Back to cited text no. 28


  [Table 1]

This article has been cited by
1 Electrospun nanofibres in drug delivery: advances in controlled release strategies
Mrunalini K. Gaydhane, Chandra Shekhar Sharma, Saptarshi Majumdar
RSC Advances. 2023; 13(11): 7312
[Pubmed] | [DOI]
2 Garlic Extract-Mediated Synthesis of ZnS Nanoparticles: Structural, Optical, Antibacterial, and Hemolysis Studies
Adnan Alnehia, Abdel-Basit Al-Odayni, A. H. Al-Hammadi, Safiah A. Alramadhan, Hisham Alnahari, Waseem Sharaf Saeed, Annas Al-Sharabi, Abdelwahab Omri
Journal of Nanomaterials. 2023; 2023: 1
[Pubmed] | [DOI]
3 Nanoencapsulation of Vaccinium ashei Leaf Extract in Eudragit® RS100-Based Nanoparticles Increases Its In Vitro Antioxidant and In Vivo Antidepressant-like Actions
Verciane Schneider Cezarotto, Eduarda Piovesan Franceschi, Ana Cristina Stein, Tatiana Emanuelli, Luana Haselein Maurer, Marcel Henrique Marcondes Sari, Luana Mota Ferreira, Letícia Cruz
Pharmaceuticals. 2023; 16(1): 84
[Pubmed] | [DOI]
4 Comparative Cytotoxic Evaluation of Zygophyllum album Root and Aerial Parts of Different Extracts and Their Biosynthesized Silver Nanoparticles on Lung A549 and Prostate PC-3 Cancer Cell Lines
Reda F. A. Abdelhameed, Mohamed S. Nafie, Dina M. Hal, Ali M. Nasr, Shady A. Swidan, Maged S. Abdel-Kader, Amany K. Ibrahim, Safwat A. Ahmed, Jihan M. Badr, Enas E. Eltamany
Pharmaceuticals. 2022; 15(11): 1334
[Pubmed] | [DOI]
5 Phytochemical Analysis Both of Water and Ethanol Extract from Some Herbs Combinations, Nanoemulsion Formulation, and Antioxidant Effects
Sri Atun, Kartika R Pertiwi, Mahclisatul Qolbiah, Salsabila Safa
Open Access Macedonian Journal of Medical Sciences. 2022; 10(A): 95
[Pubmed] | [DOI]
6 ?Acute toxicity test nanoherbal mahkota dewa fruit (Phaleria macrocarpa)
Leo Jumadi Simanjuntak, Cheryl Grace Pratiwi Rumahorbo
Pharmacia. 2022; 69(4): 1063
[Pubmed] | [DOI]
7 Dynamics of herbal medicine processing and production in Benue State Nigeria
P. Adigwe Obi, F. Builders Philip, Alfa John, Oladosu Peter
African Journal of Pharmacy and Pharmacology. 2022; 16(7): 110
[Pubmed] | [DOI]
8 Eco-Friendly Synthesis of Multishaped Crystalline Silver Nanoparticles Using Hill Garlic Extract and Their Potential Application as an Antifungal Agent
V. Uma Maheshwari Nallal, M. Razia, Ozlem Ates Duru, G. Ramalingam, Sasikala Chinnappan, Murugesan Chandrasekaran, R. M. Gengan, Woo Jin Chung, Soon Woong Chang, Balasubramani Ravindran, Karthikeyan Sathasivam
Journal of Nanomaterials. 2022; 2022: 1
[Pubmed] | [DOI]
9 Cytotoxic effects of chitosan nanoparticles containing Zataria multiflora essential oil against human breast and melanoma cells
Hiva Alipanah, Fatemeh Yarian, Fatemeh Rasti, Mojdeh Safari, Shekoufeh Hatami, Mahmoud Osanloo
Beni-Suef University Journal of Basic and Applied Sciences. 2022; 11(1)
[Pubmed] | [DOI]
10 Green synthesis of nanoparticles for varied applications: Green renewable resources and energy-efficient synthetic routes
Mohamed Madani, Shimaa Hosny, Dalal Mohamed Alshangiti, Norhan Nady, Sheikha A. Alkhursani, Huda Alkhaldi, Samera Ali Al-Gahtany, Mohamed Mohamady Ghobashy, Ghalia A. Gaber
Nanotechnology Reviews. 2022; 11(1): 731
[Pubmed] | [DOI]
11 Green synthesis of ZnS nanoparticles using allium sativum l. extract and study of their structural, optical and electrical properties
U. S. Senapati, R. Athparia
Chalcogenide Letters. 2022; 19(3): 203
[Pubmed] | [DOI]
12 Nano Metal Based Herbal Theranostics for Cancer Management: Coalescing Nature’s Boon with Nanotechnological Advancement
Yogesh Pandey, Sonu Ambwani
Current Pharmaceutical Biotechnology. 2022; 23(1): 30
[Pubmed] | [DOI]
13 Nanomaterials for the Delivery of Herbal Bioactive Compounds
Shadma Wahab, Md. Parwez Ahmad, Arshad Hussain, Shaik Fayazuddin Abdul Qadir
Current Nanoscience. 2022; 18(4): 425
[Pubmed] | [DOI]
14 Nanotechnology-based Herbal Formulations: A Survey of Recent Patents, Advancements, and Transformative Headways
Anureet Kaur, Lakhvir Kaur, Gurjeet Singh, R.K. Dhawan, Ayushi Mahajan
Recent Patents on Nanotechnology. 2022; 16(4): 295
[Pubmed] | [DOI]
15 Effect of Banana (Musa sp.) Peels Extract in Nanoemulsion Dosage Forms for the Improvement of Memory: In Vitro & In Vivo Studies
Nur Achsan Al-Hakim, Irda Fidrianny, Kusnandar Anggadiredja, Rachmat Mauludin
Pharmaceutical Nanotechnology. 2022; 10(4): 299
[Pubmed] | [DOI]
16 Novel Herbal Nanocarriers for Treatment of Dermatological Disorders
Dipthi Shree, Chinam Niranjan Patra, Biswa Mohan Sahoo
Pharmaceutical Nanotechnology. 2022; 10(4): 246
[Pubmed] | [DOI]
17 Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges
Vivek P. Chavda, Aayushi B. Patel, Kavya J. Mistry, Suresh F. Suthar, Zhuo-Xun Wu, Zhe-Sheng Chen, Kaijian Hou
Frontiers in Oncology. 2022; 12
[Pubmed] | [DOI]
18 The Advancement of Herbal-Based Nanomedicine for Hair
Komal Padule, Sonali Shinde, Sohan Chitlange, Prabhanjan Giram, Dheeraj Nagore
Cosmetics. 2022; 9(6): 118
[Pubmed] | [DOI]
19 Nano Phytoceuticals: A Step Forward in Tracking Down Paths for Therapy Against Pancreatic Ductal Adenocarcinoma
Shruti Gupta, Kiran Kumar Tejavath
Journal of Cluster Science. 2022;
[Pubmed] | [DOI]
20 Perspectives on nano-nutraceuticals to manage pre and post COVID-19 infections
Ankit Kumar Dubey, Suman Kumar Chaudhry, Harikesh Bahadur Singh, Vijai Kumar Gupta, Ajeet Kaushik
Biotechnology Reports. 2022; : e00712
[Pubmed] | [DOI]
21 Advanced drug delivery systems containing herbal components for wound healing
Bapi Gorain, Manisha Pandey, Ng Hui Leng, Cho Wei Yan, Kuek Wee Nie, Simran Jeet Kaur, Vincent Marshall, Sreenivas Patro Sisinthy, Jithendra Panneerselvam, Nagashekhara Molugulu, Prashant Kesharwani, Hira Choudhury
International Journal of Pharmaceutics. 2022; 617: 121617
[Pubmed] | [DOI]
22 Citrus limetta Risso peel mediated green synthesis of gold nanoparticles and its antioxidant and catalytic activity
M. Sivakavinesan, M. Vanaja, Rashid Lateef, Hisham A. Alhadlaq, Raja Mohan, G. Annadurai, Maqusood Ahamed
Journal of King Saud University - Science. 2022; : 102235
[Pubmed] | [DOI]
23 Re-establishing the comprehension of phytomedicine and nanomedicine in inflammation-mediated cancer signaling
Niraj Kumar Jha, Saniya Arfin, Saurabh Kumar Jha, Rohan Kar, Abhijit Dey, Rohit Gundamaraju, Ghulam Md. Ashraf, Piyush Kumar Gupta, Sugapriya Dhanasekaran, Mosleh Mohammad Abomughaid, Sabya Sachi Das, Sachin Kumar Singh, Kamal Dua, Shubhadeep Roychoudhury, Dhruv Kumar, Janne Ruokolainen, Shreesh Ojha, Kavindra Kumar Kesari
Seminars in Cancer Biology. 2022;
[Pubmed] | [DOI]
24 Preparation and characterisation of liposomes of Bergenia ciliata extract and evaluation of their hepatoprotective activity
Uzma Latief, Manjot Kaur, Sajad Hussain Dar, Shubham Thakur, Tasir Sharief Per, Gurleen Kaur Tung, Subheet Kumar Jain
Journal of Pharmaceutical Sciences. 2022;
[Pubmed] | [DOI]
25 Nanoformulation of Curcuma longa Root Extract and Evaluation of Its Dissolution Potential
Amjad Hussain, Faisal Attique, Syed Ali Raza Naqvi, Akbar Ali, Muhammad Ibrahim, Hidayat Hussain, Fatiqa Zafar, Rana Saqib Iqbal, Muhammad Adnan Ayub, Mohammed A. Assiri, Muhammad Imran, Shaheed Ullah
ACS Omega. 2022;
[Pubmed] | [DOI]
26 Nanosuspension of flavonoid-rich fraction from Psidium guajava Linn for improved type 2-diabetes potential
Praveen Kumar Gaur
Journal of Drug Delivery Science and Technology. 2021; : 102358
[Pubmed] | [DOI]
27 Herbal nanomedicines: Recent advancements, challenges, opportunities and regulatory overview
Parusu Kavya Teja, Jinal Mithiya, Abhijeet S. Kate, Khemraj Bairwa, Siddheshwar K Chauthe
Phytomedicine. 2021; : 153890
[Pubmed] | [DOI]
28 Antimicrobial Potential and Phytochemical Profiling of Ethnomedicinal Plant Trillium govanianum Wall. ex D. Don in Western Himalaya
Rachna Verma,Ashwani Tapwal,Dinesh Kumar,Sunil Puri
Journal of Herbal Medicine. 2021; : 100491
[Pubmed] | [DOI]
29 A novel drug delivery system using acyclovir nanofiber patch for topical treatment of recurrent herpes labialis: A randomized clinical trial
Zahra Golestannejad, Faezeh Khozeimeh, Mohammad Mehrasa, Shahla Mirzaeei, Dorna Sarfaraz
Clinical and Experimental Dental Research. 2021;
[Pubmed] | [DOI]
30 Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties
Rizwan Ahmad,Muhammad Riaz,Aslam Khan,Ahmed Aljamea,Mohammad Algheryafi,Deya Sewaket,Aljawharah Alqathama
Phytotherapy Research. 2021;
[Pubmed] | [DOI]
31 Pungent anti-infective nanocolloids manipulate growth, biofilm formation, and CTX-M-15 gene expression in pathogens causing vibriosis
Ranjani S,Pradeep Parthasarathy,Rameshkumar P,VimalKumar U,Hemalatha S
Aquaculture International. 2021;
[Pubmed] | [DOI]
32 Downregulation of MMP1 expression mediates the anti-aging activity of Citrus sinensis peel extract nanoformulation in UV induced photoaging in mice
Reham I. Amer,Shahira M. Ezzat,Nora M. Aborehab,Mai F. Ragab,Dalia Mohamed,Amira Hashad,Dalia Attia,Maha M. Salama,Mahitab H. El Bishbishy
Biomedicine & Pharmacotherapy. 2021; 138: 111537
[Pubmed] | [DOI]
33 A comprehensive review on efficient approaches for combating coronaviruses
Mahdi Pouresmaieli, Elena Ekrami, Ali Akbari, Negin Noorbakhsh, Negin Borzooee Moghadam, Matin Mamoudifard
Biomedicine & Pharmacotherapy. 2021; 144: 112353
[Pubmed] | [DOI]
34 Development, Characterization and Evaluation of Nanoemulgel Used for the Treatment of Skin Disorders
Sasmita Padhy, Biswa M. Sahoo, Bera V.V.R. Kumar, Chinam N. Patra
Current Nanomaterials. 2021; 6(1): 43
[Pubmed] | [DOI]
35 Natural and Nanotechnology Based Treatment: An Alternative Approach to Psoriasis
Nishu Yadav,Rohan Aggarwal,Monika Targhotra,Prabhat K. Sahoo,Meenakshi K. Chauhan
Current Nanomedicine. 2021; 11(1): 21
[Pubmed] | [DOI]
36 Nanosponges Encapsulated Phytochemicals for Targeting Cancer: A Review
Shailaja Dombe, Pramodkumar Shirote
Current Drug Targets. 2021; 22(4): 443
[Pubmed] | [DOI]
37 Could Nanotechnology Help to End the Fight Against COVID-19? Review of Current Findings, Challenges and Future Perspectives
Ashagrachew Tewabe Yayehrad,Ebrahim Abdela Siraj,Gebremariam Birhanu Wondie,Atlaw Abate Alemie,Manaye Tamrie Derseh,Abyou Seyfu Ambaye
International Journal of Nanomedicine. 2021; Volume 16: 5713
[Pubmed] | [DOI]
38 Nanoencapsulation of Chromolaena odorata Extract Using Pluronic F127 as an Effectively Herbal Delivery System for Wound Healing
Ngoc-Dung Huynh Luu,Le Hang Dang,Hoang Minh Bui,Trang Thuy Thi Nguyen,Bich Tram Nguyen,Le Son Hoang,Ngoc Quyen Tran,Linh Nguyen
Journal of Nanomaterials. 2021; 2021: 1
[Pubmed] | [DOI]
39 Evaluation of anti-scorpion (Hottentota tamulus) venom potential of native plants extracts using mice model
Samima Asad Butt,Hafiz Muhammad Tahir,Shaukat Ali,Muniba Tariq,Ali Hassan,Muhammad Summer,Chand Raza,Shafaat Yar Khan
Toxin Reviews. 2021; : 1
[Pubmed] | [DOI]
40 Recent advances in herbal combination nanomedicine for cancer: Delivery technology and therapeutic outcomes
Doaa M. Anwar,Mousa El-Sayed,Asmaa Reda,Jia-You Fang,Sherine N. Khattab,Ahmed O. Elzoghby
Expert Opinion on Drug Delivery. 2021;
[Pubmed] | [DOI]
41 Annona muricata silver nanoparticles exhibit strong anticancer activities against cervical and prostate adenocarcinomas through regulation of CASP9 and the CXCL1/CXCR2 genes axis
Yahaya Gavamukulya,Esther N. Maina,Hany A. El-Shemy,Amos M. Meroka,Geoffrey K. Kangogo,Gabriel Magoma,Fred Wamunyokoli
Tumor Biology. 2021; 43(1): 37
[Pubmed] | [DOI]
42 Smart therapeutic-polymer-loaded silica nanomaterials. Nanomedicine
Ignác Capek
Polymer-Plastics Technology and Materials. 2020; : 1
[Pubmed] | [DOI]
43 Nanoformulations of Coumarins and the Hybrid Molecules of Coumarins with Potential Anticancer Effects
Mukerrem Betul Yerer,Serkan Dayan,M. Ihsan Han,Ajay Sharma,Hardeep S. Tuli,Katrin Sak
Anti-Cancer Agents in Medicinal Chemistry. 2020; 20(15): 1797
[Pubmed] | [DOI]
44 Chemically Nano-Engineered Theranostics for Phytoconstituents as Healthcare Application
Sadaf Jamal Gilani,Sarwar Beg,Chandra Kala,Mohammed Shivli Nomani,Debarshi Kar Mahapatra,Syed Sarim Imam,Mohamad Taleuzzaman
Current Biochemical Engineering. 2020; 6(1): 53
[Pubmed] | [DOI]
45 Nanoparticles as Budding Trends in Colon Drug Delivery for the Management of Ulcerative Colitis
Amandeep Singh,Kirandeep Kaur,Uttam Kumar Mandal,Raj Kumar Narang
Current Nanomedicine. 2020; 10(3): 225
[Pubmed] | [DOI]
46 A nanoemulsion-based nanogel of Citrus limon essential oil with leishmanicidal activity against Leishmania tropica and Leishmania major
Elham Zarenezhad,Mahmoud Agholi,Ali Ghanbariasad,Ali Ranjbar,Mahmoud Osanloo
Journal of Parasitic Diseases. 2020;
[Pubmed] | [DOI]
47 Catalytic and eco-toxicity investigations of bio-fabricated monometallic nanoparticles along with their anti-bacterial, anti-inflammatory, anti-diabetic, anti-oxidative and anti-cancer potentials
Aditya Velidandi,Ninian Prem Prashanth Pabbathi,Swati Dahariya,Rama Raju Baadhe
Colloid and Interface Science Communications. 2020; 38: 100302
[Pubmed] | [DOI]
48 Controlled and Manageable Release of Antimalarial Artemisone by Encapsulation in Biodegradable Carriers
Amir Reza Bagheri,Jacob Golenser,Andreas Greiner
European Polymer Journal. 2020; : 109625
[Pubmed] | [DOI]
49 Liposomal drug delivery of Aphanamixis polystachya leaf extracts and its neurobehavioral activity in mice model
Mohammad H. Shariare,Mahbubur Rahman,Shamshad R. Lubna,Reeti S. Roy,Joynal Abedin,Akbar L. Marzan,Mohammad A. Altamimi,Syed Rizwan Ahamad,Ajaz Ahmad,Fars K. Alanazi,Mohsin Kazi
Scientific Reports. 2020; 10(1)
[Pubmed] | [DOI]
50 PLGA nanoparticles loaded with Gallic acid- a constituent of Leea indica against Acanthamoeba triangularis
Tooba Mahboob,Muhammad Nawaz,Maria de Lourdes Pereira,Tan Tian-Chye,Chandramathi Samudi,Shamala Devi Sekaran,Christophe Wiart,Veeranoot Nissapatorn
Scientific Reports. 2020; 10(1)
[Pubmed] | [DOI]
51 Process optimization for green synthesis of gold nanoparticles mediated by extract of Hygrophila spinosa T. Anders and their biological applications
Swaha Satpathy,Arjun Patra,Bharti Ahirwar,Muhammad Delwar Hussain
Physica E: Low-dimensional Systems and Nanostructures. 2019; : 113830
[Pubmed] | [DOI]
52 An overview of the neuroprotective potential of rosmarinic acid and its association with nanotechnology-based delivery systems: A novel approach to treating neurodegenerative disorders
Flávia Nathiely Silveira Fachel,Roselena Silvestri Schuh,Kleyton Santos Veras,Valquíria Linck Bassani,Letícia Scherer Koester,Amelia Teresinha Henriques,Elizandra Braganhol,Helder Ferreira Teixeira
Neurochemistry International. 2019; 122: 47
[Pubmed] | [DOI]
53 Euphorbia milii extract-mediated zinc oxide nanoparticles and their antinociceptive, muscle relaxant, and sedative activities for pain management in pediatric children
Tong Shen,Qun Wang,Chengjun Liu,Fengfei Yu,Da Yu,Chengling Li
Applied Nanoscience. 2019;
[Pubmed] | [DOI]
54 Application of the combinatorial approaches of medicinal  and aromatic plants with nanotechnology and its impacts on healthcare
Priyanka Kumari,Suaib Luqman,Abha Meena
DARU Journal of Pharmaceutical Sciences. 2019;
[Pubmed] | [DOI]
55 Effects of graded levels of Azadirachta indica seed oil on growth performance and biochemical profiles of broiler chickens
Vanessa Mafouo Sonhafouo,Jean Raphaël Kana,Kissel Nguepi Dongmo
Veterinary Medicine and Science. 2019;
[Pubmed] | [DOI]
56 Poly (e-caprolactone) Microsphere Decorated with Nano-ZnO Based Phytoformulation: A Promising Antimicrobial Agent
S. Snigdha,M. Rahul,Nandakumar Kalarikkal,Sabu Thomas,E. K. Radhakrishnan
Journal of Inorganic and Organometallic Polymers and Materials. 2019;
[Pubmed] | [DOI]
57 Green Synthesis and Characterization of Highly Stable Silver Nanoparticles from Ethanolic Extracts of Fruits of Annona muricata
Yahaya Gavamukulya,Esther N. Maina,Amos M. Meroka,Edwin S. Madivoli,Hany A. El-Shemy,Fred Wamunyokoli,Gabriel Magoma
Journal of Inorganic and Organometallic Polymers and Materials. 2019;
[Pubmed] | [DOI]
58 Analysis of inequality in nanomedicine using clinical trials and disease burden
Thomas Woodson,Victor Rodriguez
Nanomedicine. 2019; 14(13): 1745
[Pubmed] | [DOI]
59 Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug
Mubin Mustafa Kiyani,Muhammad Farhan Sohail,Gul Shahnaz,Hamza Rehman,Muhammad Furqan Akhtar,Irum Nawaz,Tariq Mahmood,Mobina Manzoor,Syed Ali Imran Bokhari
Medicina. 2019; 55(1): 10
[Pubmed] | [DOI]
60 Study of Combination of Nanoherbal Andaliman (Zanthoxylum acanthopodium) and Extra Virgin Olive Oil (EVOO) Effects in the Expression of Malondialdehyde (MDA), Heat Shock Protein-70 (HSP70) and Placental Histology of Preeclamptic Rats
Putri Cahaya Situmorang,Syafruddin Ilyas,Salomo Hutahaean
Pharmaceutical Sciences. 2019; 25(3): 205
[Pubmed] | [DOI]
61 Metal Nanodelivery Systems for Improved Efficacy of Herbal Drugs
Sonu Ambwani,Roopali Tandon,Tanuj Kumar Ambwani
Biosciences, Biotechnology Research Asia. 2019; 16(2): 251
[Pubmed] | [DOI]
62 Multivariate Statistical Optimization of Tablet Formulations Incorporating High Doses of a Dry Herbal Extract
Euichaul Oh,Uijung Kim,Beom-Jin Lee,Cheol Moon
Pharmaceutics. 2019; 11(2): 79
[Pubmed] | [DOI]
63 An Overview of Nanotechnology in Food Science: Preparative Methods, Practical Applications, and Safety
Hyunjong Yu,Jun-Young Park,Chang Woo Kwon,Sung-Chul Hong,Kyung-Min Park,Pahn-Shick Chang
Journal of Chemistry. 2018; 2018: 1
[Pubmed] | [DOI]
64 Gold and Silver Nanoparticles Biomimetically Synthesized Using Date Palm Pollen Extract-Induce Apoptosis and Regulate p53 and Bcl-2 Expression in Human Breast Adenocarcinoma Cells
Hussaina Banu,N. Renuka,S.M. Faheem,Raees Ismail,Vinita Singh,Zahra Saadatmand,Saad Sultan Khan,Kavya Narayanan,Alma Raheem,Kumpati Premkumar,Geetha Vasanthakumar
Biological Trace Element Research. 2018;
[Pubmed] | [DOI]
65 Pregnancy and herbal medicines: An unnecessary risk for womenæs health-A narrative review
Luciana O. Bruno,Ricardo Santos Simoes,Manuel de Jesus Simoes,Manoel João Batista Castello Girão,Oliver Grundmann
Phytotherapy Research. 2018;
[Pubmed] | [DOI]
66 Cassia grandis Lf nanodispersion is a hypoglycemic product with a potent a-glucosidase and pancreatic lipase inhibitor effect
Ariadna Lafourcade Prada,Hady Keita,Tatiane Pereira de Souza,Emerson Silva Lima,Leonard Domingo Rosales Acho,Márcia de Jesus Amazonas da Silva,José Carlos Tavares Carvalho,Jesus Rafael Rodriguez Amado
Saudi Pharmaceutical Journal. 2018;
[Pubmed] | [DOI]
67 Synthesis and evaluation of the antiproliferative efficacy of BRM270 phytocomposite nanoparticles against human hepatoma cancer cell lines
Meeta Gera,Nameun Kim,Mrinmoy Ghosh,Neelesh Sharma,Do Luong Huynh,Nisansala Chandimali,Hyebin Koh,Jiao Jiao Zhang,Tae Yoon Kang,Yang Ho Park,Taeho Kwon,Dong Kee Jeong
Materials Science and Engineering: C. 2018;
[Pubmed] | [DOI]
68 Ethnopharmacological investigation of the aerial part of Phragmites karka (Poaceae)
Ramiz Ahmed Sultan,Mohammad Shah Hafez Kabir,Mir Muhammad Nasir Uddin,Mohi Uddin,Zobaer Al Mahmud,Sheikh Zahir Raihan,Nazmul Qais
Journal of Basic and Clinical Physiology and Pharmacology. 2017; 28(3)
[Pubmed] | [DOI]
69 Phospholipid Complex Technique for Superior Bioavailability of Phytoconstituents
Kattamanchi Gnananath,Kalakonda Sri Nataraj,Battu Ganga Rao
Advanced Pharmaceutical Bulletin. 2017; 7(1): 35
[Pubmed] | [DOI]
70 Application of Nanotechnology in Phytochemical Research
Satyajit D Sarker,Lutfun Nahar
Pharmaceutical Sciences. 2017; 23(3): 170
[Pubmed] | [DOI]
71 A multi-target therapeutic potential of Prunus domestica gum stabilized nanoparticles exhibited prospective anticancer, antibacterial, urease-inhibition, anti-inflammatory and analgesic properties.
Nazar Ul Islam,Raza Amin,Muhammad Shahid,Muhammad Amin,Sumera Zaib,Jamshed Iqbal
BMC Complementary and Alternative Medicine. 2017; 17(1)
[Pubmed] | [DOI]
72 Fabrication and characterization of PCL/gelatin/curcumin nanofibers and their antibacterial properties
Mona Fallah,S Hajir Bahrami,Marziyeh Ranjbar-Mohammadi
Journal of Industrial Textiles. 2016; 46(2): 562
[Pubmed] | [DOI]
73 Biosynthesis and Biomedical Applications of Gold Nanoparticles Using Eclipta prostrata Leaf Extract
Govindasamy Rajakumar,Thandapani Gomathi,Abdul Abdul Rahuman,Muthu Thiruvengadam,Govindarasu Mydhili,Seung-Hyun Kim,Tak-Jun Lee,II-Min Chung
Applied Sciences. 2016; 6(8): 222
[Pubmed] | [DOI]
74 Gummy gold and silver nanoparticles of apricot (Prunus armeniaca) confer high stability and biological activity
Nazar Ul Islam,Raza Amin,Muhammad Shahid,Muhammad Amin
Arabian Journal of Chemistry. 2016;
[Pubmed] | [DOI]
75 Advanced targeted nanomedicine
Mohan C.M. Arachchige,Yana K. Reshetnyak,Oleg A. Andreev
Journal of Biotechnology. 2015;
[Pubmed] | [DOI]
76 Pistacia integerrima gall extract mediated green synthesis of gold nanoparticles and their biological activities
Nazar Ul Islam,Kamran Jalil,Muhammad Shahid,Naveed Muhammad,Abdur Rauf
Arabian Journal of Chemistry. 2015;
[Pubmed] | [DOI]
77 Green synthesis and biological activities of gold nanoparticles functionalized with Salix alba
Nazar Ul Islam,Kamran Jalil,Muhammad Shahid,Abdur Rauf,Naveed Muhammad,Ajmal Khan,Muhammad Raza Shah,Muhammad Atif Khan
Arabian Journal of Chemistry. 2015;
[Pubmed] | [DOI]
78 Antinociceptive, muscle relaxant and sedative activities of gold nanoparticles generated by methanolic extract of Euphorbia milii
Nazar Ul Islam,Ibrahim Khan,Abdur Rauf,Naveed Muhammad,Muhammad Shahid,Mohammad Raza Shah
BMC Complementary and Alternative Medicine. 2015; 15(1)
[Pubmed] | [DOI]
79 Multiple Beneficial Applications and Modes of Action of Herbs in Poultry Health and Production-A Review
Kuldeep Dhama,Shyma K. Latheef,Saminathan Mani,Hari Abdul Samad,K. Karthik,Ruchi Tiwari,Rifat Ullah Khan,Mahmoud Alagawany,Mayada R. Farag,Gazi Mahabubul Alam,Vito Laudadio,Vincenzo Tufarelli
International Journal of Pharmacology. 2015; 11(3): 152
[Pubmed] | [DOI]
80 Advanced drug delivery nanosystems (aDDnSs): a mini-review
Costas Demetzos,Natassa Pippa
Drug Delivery. 2014; 21(4): 250
[Pubmed] | [DOI]
81 Nanoparticles laden in situ gelling system for ocular drug targeting
Kumar, D., Jain, N., Gulati, N., Nagaich, U.
Journal of Advanced Pharmaceutical Technology and Research. 2013;


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
    History and Deve...
    Strategies of Na...
    Types of Nanopha...
   Recent Development
   Toxicity Issues
   Future Prospective
    Need for novel d...
    Article Tables

 Article Access Statistics
    PDF Downloaded2115    
    Comments [Add]    
    Cited by others 81    

Recommend this journal