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REVIEW ARTICLE
Year : 2011  |  Volume : 2  |  Issue : 2  |  Page : 81-87  

Nanosuspension: An approach to enhance solubility of drugs

Vishal R Patel, YK Agrawal
Institute of Research and Development, Gujarat Forensic Sciences University, Sector 18/A, B/H Police Bhavan, Gandhinagar, Gujarat, India

Date of Web Publication12-Jul-2011

Correspondence Address:
Y K Agrawal
Institute of Research and Development, Gujarat Forensic Sciences University, Sector 18/A, B/H Police Bhavan, Gandhinagar - 382 007, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-4040.82950

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   Abstract 

One of the major problems associated with poorly soluble drugs is very low bioavailability. The problem is even more complex for drugs like itraconazole, simvastatin, and carbamazepine which are poorly soluble in both aqueous and nonaqueous media, belonging to BCS class II as classified by biopharmaceutical classification system. Formulation as nanosuspension is an attractive and promising alternative to solve these problems. Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. Preparation of nanosuspension is simple and applicable to all drugs which are water insoluble. A nanosuspension not only solves the problems of poor solubility and bioavailability, but also alters the pharmacokinetics of drug and thus improves drug safety and efficacy. This review article describes the preparation methods, characterization, and applications of the nanosuspension.

Keywords: Bioavailability, colloidal dispersion, drug delivery, nanosuspension, solubility


How to cite this article:
Patel VR, Agrawal Y K. Nanosuspension: An approach to enhance solubility of drugs. J Adv Pharm Technol Res 2011;2:81-7

How to cite this URL:
Patel VR, Agrawal Y K. Nanosuspension: An approach to enhance solubility of drugs. J Adv Pharm Technol Res [serial online] 2011 [cited 2023 Mar 28];2:81-7. Available from: https://www.japtr.org/text.asp?2011/2/2/81/82950


   Introduction Top


A range of parameters like solubility, stability at room temperature, compatibility with solvent, excipient, and photostability play a critical role in the successful formulation of drugs. Till date, more than 40% of the new chemical entities being generated through drug discovery programs are lipophilic or poorly water-soluble compounds. [1],[2] Many formulation approaches are available to solve the problems of low solubility and low bioavailability of drugs. The conventional approaches include micronization, use of fatty solutions, use of penetration enhancer or cosolvents, surfactant dispersion method, salt formation, precipitation, etc., but still, these techniques having limited utility in solubility enhancement for poorly soluble drugs. Additional approaches are vesicular system like liposomes, dispersion of solids, emulsion and microemulsion methods, and inclusion complexes with cyclodextrins, which show beneficial effect as drug delivery system but major problems of these techniques are lack of universal applicability to all drugs. [3] Over the last decades, nanoparticle engineering has been developed and reported for pharmaceutical applications. [4] Nanotechnology can be used to solve the problems associated with various approaches described earlier. Nanotechnology is defined as the science and engineering carried out in the nanoscale that is 10−9 m. The drug microparticles/micronized drug powder is transferred to drug nanoparticles by techniques like Bottom-Up Technology and Top-Down Technology. [5] Nanosuspensions are submicron colloidal dispersions of nanosized drug particles stabilized by surfactants. [6] Nanosuspensions consist of the poorly water-soluble drug without any matrix material suspended in dispersion. [7] These can be used to enhance the solubility of drugs that are poorly soluble in water as well as lipid media. As a result of increased solubility, the rate of flooding of the active compound increases and the maximum plasma level is reached faster. This approach is useful for molecules with poor solubility, poor permeability, or both, which poses a significant challenge for the formulators. The reduced particle size renders the possibility of intravenous administration of poorly soluble drugs without any blockade of the blood capillaries. The suspensions can also be lyophilized and into a solid matrix. Apart from these advantages, it also has the advantages of liquid formulations over others. [8] In the present review, we are mainly focusing on the different methods of preparation associated merits, demerits, and its pharmaceutical application as drug delivery system.


   Advantages of Nanosuspension Top
[9]

  • Enhance the solubility and bioavailability of drugs
  • Suitable for hydrophilic drugs
  • Higher drug loading can be achieved
  • Dose reduction is possible
  • Enhance the physical and chemical stability of drugs
  • Provides a passive drug targeting

   Preparation of Nanosuspension Top


For the preparation of nanosuspensions, mostly two methods namely "Bottom up technology" and "Top down technology" are used, as shown in [Figure 1]. [10] Bottom up technology is an assembling method to form nanoparticles like precipitation, microemulsion, melt emulsification method and top down technology involves the disintegration of larger particles into nanoparticles, examples of which are high-pressure homogenization and milling methods. The principles of these methods are described in detail and their merits and demerits are shown in [Table 1]. [11],[12]
Figure 1: Approaches for preparation of nanosuspension

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Table 1: Preparative techniques for nanosuspension with merits and demerits

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Precipitation Method

Precipitation method is a general method used to prepare submicron particles of poorly soluble drugs. [13],[14],[15] In this method, drug is dissolved in solvent and then solution is mixed with solvent to which drug is insoluble in the presence of surfactant. Rapid addition of solution to such solvent (generally water) leads to rapid supersaturation of drug in the solution, and formation of ultrafine amorphous or crystalline drug. This method involves nuclei formation and crystal growth which are mainly dependent on temperature. High nucleation rate and low crystal growth rate are primary requirements for preparing a stable suspension with minimum particle size. [16]

High-Pressure Homogenization

This technique involve the following three steps: First, drug powders are dispersed in a stabilizer solution to form presuspension; after that, presuspension is homogenized by high pressure homogenizer at a low pressure sometimes for premilling; and finally homogenized at a high pressure for 10 to 25 cycles until the nanosuspensions are formed with desired size. [9]

Homogenization in Aqueous Media (Dissocubes)

Dissocubes technology was developed by Muller in 1999. The instrument can be operated at pressure varying from 100 to 1 500 bars (2 800 - 21 300 psi) and up to 2 000 bars with volume capacity of 40 ml (for laboratory scale). For preparation of nanosuspension, it is essential to prepare a presuspension of the micronized drug in a surfactant solution using high-speed stirrer. According to Bernoulli's Law, the flow volume of liquid in a closed system per cross section is constant. The reduction in diameter from 3 cm to 25 μm leads to increase in dynamic pressure and decrease of static pressure below the boiling point of water at room temperature. Due to this, water starts boiling at room temperature and forms gas bubbles, which implode when the suspension leaves the gap (called cavitation) and normal air pressure is reached. The size of the drug nanocrystals that can be achieved mainly depends on factors like temperature, number of homogenization cycles, and power density of homogenizer and homogenization pressure. Preprocessing like micronization of drug and high-cost instruments increases the overall cost of dosage form. Various drugs like Amphotericin B, Ordinon, Thiomerasol, Fenofibrate, Melarsoprol, Buparvaquone, Prednisolone, Carbamazepine And Dexamethasone were prepared as nanosuspensions using this method. [5]

Homogenization in Nonaqueous Media (Nanopure)

Nanopure is suspension homogenized in water-free medium. It is "deep-freeze" homogenization where the drug suspensions in nonaqueous medium are homogenized at 0 o C or sometimes below the freezing point. Because of very high boiling point and low vapor pressure of water, oils, and fatty acids, the drop of static pressure is not enough to begin cavitation in nanopure technology. [17] Other homogenization technologies and patents on the homogenization processes are shown in [Table 2]. [18]
Table 2: Homogenization technologies and patents on the homogenization processes

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Milling Techniques

Media milling

Liversidge et al. had a patent on nanocrystal technology. [19] In this technique, drugs are subjected to media milling for nanoparticle production. Effect of impaction between the milling media and drugs gives essential energy for disintegration of the microparticulate system into nanoparticles. In this process, the chamber of milling is charged with the milling media involving drug, stabilizer, and water or suitable buffer, which is rotated at a very high shear rate to generate suspension. Residues left behind in the finished product is a major problem of this method. [20]

Dry cogrinding

Since many years, nanosuspensions are prepared through wet grinding processes by using pearl ball mill. Nowadays, nanosuspensions can be prepared by dry milling methods. Stable nanosuspensions are prepared by using dry grinding of poorly soluble drug with soluble polymers and copolymers after dispersing in liquid medium. Itoh et al. have described the colloidal particles formation of many poorly water-soluble drugs like nifedipine, griseofulvin, and glibenclamide with sodium dodecyl sulfate and polyvinylpyrrolidone as stabilizer. [21],[22],[23]

Lipid emulsion/microemulsion template

Nanosuspensions are also obtained by just diluting the emulsion, formed by using a partially water-miscible solvent as the dispersed phase. The emulsion technique is applicable for drugs which are either partially water miscible or soluble in volatile organic solvents. Additionally, microemulsion templates can also produce nanosuspensions. Microemulsions are dispersions of two immiscible liquids like water and oil and stabilized thermodynamically by surfactant or cosurfactant. The drug is either loaded into preformed or internal phase of microemulsion and can be saturated by intimate mixing of drugs. [20] Griseofulvin nanosuspension is prepared by the microemulsion technique by using water, butyl lactate, lecithin, and the sodium salt of taurodeoxycholate. [24]

Microprecipitation - High-pressure homogenization (Nanoedge)

Nanoedge is a combination of microprecipitation and high-pressure homogenization techniques. Method includes precipitation of friable materials followed by fragmentation under high shear and/or thermal energy. [25],[26] The preparation method of nanoedge is shown in [Figure 2]. [27]
Figure 2: Method for preparation of nanoedge

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Melt emulsification method

Solid lipid nanoparticles are mainly prepared by melt emulsification method. Kipp and co workers firstly prepare nanosuspensions of ibuprofen by using melt emulsification method. It is a four-step procedure. Drug is first added to aqueous solution having stabilizer. The solution is heated at temperature higher than the melting point of the drug and then homogenized by high-speed homogenizer for the formation of emulsion. The temperature is maintained above the melting point of the drug during overall process. Finally, the emulsion is cooled to precipitate the particles. The particle size of nanosuspension mainly depends on parameters like drug concentration, concentration and type of stabilizers used, cooling temperature, and homogenization process. [28]

Nanojet technology

This technique is also called opposite stream technology, uses a chamber where a stream of suspension is divided into two or more parts. Both streams are colloid with each other at high pressure. The high shear force produced during the process results in particle size reduction. Dearns had prepared nanosuspensions of atovaquone using the microfluidization process. The major disadvantage of this technique is the high number of passes through the microfluidizer and that the product obtained contains a relatively larger fraction of microparticles. [29]

Supercritical fluid methods

Various methods like rapid expansion of supercritical solution (RESS) process, supercritical antisolvent process, and precipitation with compressed antisolvent (PCA) process are used to produce nanoparticles. In RESS technique, drug solution is expanded through a nozzle into supercritical fluid, resulting in precipitation of the drug as fine particles by loss of solvent power of the supercritical fluid. By using RESS method, Young et al. prepared cyclosporine nanoparticles having diameter of 400 to 700 nm. In the PCA method, the drug solution is atomized into the CO 2 compressed chamber. As the removal of solvent occurs, the solution gets supersaturated and finally precipitation occurs. In supercritical antisolvent process, drug solution is injected into the supercritical fluid and the solvent gets extracted as well as the drug solution becomes supersaturated. [30]


   Characterization Techniques Top


The particle size, particle size distribution, and zeta potential affect the safety, efficacy, and stability of nanodrug delivery systems as well as dissolution performance is also altered by solid state of nanoparticles. Thus, characterization of nanoparticles plays a great role in forecasting in vitro and in vivo performance of nanodrug delivery systems. In vivo pharmacokinetic performance and biological function of nanosuspension strongly depends on its particle size and distribution, particle charge (zeta potential), crystalline state, and particle morphology.

Mean Particle Size and Particle Size Distribution

The mean particle size and particle size distribution affects saturation solubility, dissolution rate, physical stability, and in vivo performance of nanosuspensions. [9] The particle size distribution and its range named polydispersity index (PI) can be determined by laser diffraction (LD), photon correlation spectroscopy, microscope, and coulter counter. [31] PI gives the physical stability of nanosuspensions and should be as lower as possible for the long-time stability of nanosuspensions. A PI value of 0.1 to 0.25 shows a fairly narrow size distribution, and PI value more than 0.5 indicates a very broad distribution. [32] LD can detect and quantify the drug microparticles during the production process. It also gives a volume size distribution and can be used to measure particles ranging from 0.05 up to 2 000 μm. [33] The coulter counter gives the absolute number of particles per volume for the different size classes. It is more efficient and suitable than LD to quantify the contamination of nanosuspensions. [30]

Crystalline State and Particle Morphology

Polymorphic or morphological changes of nanosized particles can be checked by assessing the crystalline state and particle morphology. [30] As nanosuspension requires high-pressure homogenization, change in crystalline structure of formulation occurs which may be converted to either amorphous or other polymorphic forms. [31] Alteration in the solid state of the drug particles and the extent of the amorphous portion is determined by X-ray diffraction analysis [34] and supplemented by differential scanning calorimetry analysis. [30]

Surface Charge (Zeta Potential)

Surface charge properties of the nanosuspensions are studied through zeta potential. The value of particle surface charge indicates the stability of nanosuspensions at the macroscopic level. A minimum zeta potential of ±30 mV is required for electrostatically stabilized nanosuspensions [35],[36] and a minimum of ±20 mV for steric stabilization. [37] The zeta potential values are commonly calculated by determining the particle's electrophoretic mobility and then converting the electrophoretic mobility to the zeta potential. [38] Electroacoustic technique is also used for the determination of the zeta potential in the areas of material sciences. [39]


   Pharmaceutical Application of Nanosuspension Top


By using postproduction processing, nanosuspensions are prepared into various dosage forms. Nanosuspension increases dissolution rate and absorption of drug due to smaller particle size and larger surface area. The available marketed drugs in the form of nanosuspensions along with their routes of administration are mentioned in [Table 3]. [12]
Table 3: Available marketed drugs in the form of nanosuspension with their route of administration

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Oral Drug Delivery

Poor solubility, incomplete dissolution, and insufficient efficacy are the major problem of oral drug administration. Due to smaller particle size and much larger surface to volume ratio, oral nanosuspensions are specially used to increase the absorption rate and bioavailability of poorly soluble drugs. [40] In case of azithromycin nanosuspensions, more than 65% drug was found to be dissolved in 5 hours as compared with 20% of micronized drugs. [41] The nanosuspension have advantages like improved oral absorption, dose proportionality, and low intersubject variability. By using standard manufacturing techniques, drug nanosuspensions can be simply incorporated into various dosage forms like tablets, capsules, and fast melts. The nanosuspension of Ketoprofen was successfully incorporated into pellets for the sustained release of drug over the period of 24 hours. [42]

Parental Drug Delivery

The present approaches for parental delivery include micellar solutions, salt formation, solubilization using cosolvents, cyclodextrin complexation, and more recently vesicular systems such as liposomes and niosomes. But these methods have limitations like solubilization capacity, parental acceptability, high manufacturing cost, etc. To solve the above problems, the nanosuspension technology is used. Nanosuspensions are administered through various parental routes such as intraarticular, intraperitoneal, intravenous, etc. Additionally, nanosuspensions increase the efficacy of parenterally administered drugs. Paclitaxel nanosuspension was reported to have their superiority in reducing the median tumor burden. [43] Clofazimine nanosuspension showed an improvement in stability as well as efficacy above the liposomal clofazimine in Mycobacterium avium-infected female mice. [44] Rainbow et al. showed that intravenous nanosuspension of itraconazole enhanced efficacy of antifungal activity in rats relative to the solution formulation. [45]

Pulmonary Drug Delivery

For pulmonary delivery, nanosuspensions can be nebulized through mechanical or ultrasonic nebulizers. Due to the presence of many small particles, all aerosol droplets contain drug nanoparticles. Budesonide corticosteroid has been successfully prepared in the form of nanosuspension for pulmonary delivery. [46] Aqueous suspensions of the drug can be easily nebulized and given by pulmonary route as the particle size is very small. Different types of nebulizers are available for the administration of liquid formulations. Some of the drugs successfully tried with pulmonary route are budesonide, ketotifen, ibuprofen, indomethacin, nifedipine, itraconazole, interleukin-2, p53 gene, leuprolide, doxorubicin, etc. [47]

Ocular Drug Delivery

Nanosuspensions are used in ocular delivery of the drugs for sustained release. Liang and co-workers prepared cloricromene nanosuspension for ocular delivery using Eudragit. Experiment showed higher availability of drug in aqueous humor of rabbit eye. Thus, nanosuspension formulation offers a promising way of improving the shelf-life and bioavailability of drug after ophthalmic application. [37]

Targeted Drug Delivery

Nanosuspensions are suitable for targeting particular organs because of their surface properties. Along with this, it is easy to alter in vivo behavior by changing the stabilizer. The drug will be taken up by the mononuclear phagocytic system which allows region-specific delivery. This can be used for targeting antifungal, antimycobacterial, or antileishmanial drugs to macrophages if the pathogens persist intracellularly. [48] Kayser formulated an aphidicolin nanosuspension that improved the drug targeting to macrophages which were Leishmania infected. He stated that the drug in the form of nanosuspension had EC 50 of 0.003 μg/ml, whereas the conventional form had 0.16 μg/ml. [49] Scholer et al. described an enhanced drug targeting to brain in the treatment of toxoplasmic encephalitis using an atovaquone nanosuspension. [50]


   Conclusion Top


Nanosuspensions are distinctive and commercially feasible approach to solve the problems of hydrophobic drug such as poor solubility and poor bioavailability. For large-scale production of nanosuspensions, media milling and high-pressure homogenization technology have been successfully used. Striking characteristics, like improvement of dissolution velocity, increased saturation solubility, improved bioadhesivity, versatility in surface modification, and ease of postproduction processing, have widened the applications of nanosuspensions for various routes of administration. The applications of nanosuspensions in oral and parental routes have been very well established, although applications in pulmonary and ocular delivery have to be evaluated. However, their delivery through buccal, nasal, and topical delivery is yet to be done.

 
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    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1], [Table 2], [Table 3]


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3 Highly water-soluble dapsone nanocrystals: Towards innovative preparations for an undermined drug
Nataly Paredes da Rocha, Aline de Souza, Megumi Nishitani Yukuyama, Thayna Lopes Barreto, Luiza de O. Macedo, Raimar Löbenberg, Gabriel Lima Barros de Araújo, Kelly Ishida, Nádia Araci Bou-Chacra
International Journal of Pharmaceutics. 2023; 630: 122428
[Pubmed] | [DOI]
4 Radiolabeling of statistically optimized nanosized atorvastatin suspension for liver targeting and extensive imaging of hepatocellular carcinoma
Carol Yousry, Nourihan S. Farrag, Abeer M. Amin
Journal of Drug Delivery Science and Technology. 2023; : 104171
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5 Formulation and evaluation of antidepressants loaded with biopolymer for brain specificity
Ravi Goyal, Deepika Raina, Vishakha Jaiswal
Materials Today: Proceedings. 2023;
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6 Functionalized Silicon Particles for Enhanced Half- and Full-Cell Cycling of Si-Based Li-Ion Batteries
Khryslyn G. Araño, Beth L. Armstrong, Ethan Boeding, Guang Yang, Harry M. Meyer, Evelyna Wang, Rachel Korkosz, Katie L. Browning, Thomas Malkowski, Baris Key, Gabriel M. Veith
ACS Applied Materials & Interfaces. 2023;
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7 Improved anti-Candida activity of hydrogel containing tea tree oil-loaded solid lipid nanoparticles for the treatment of oropharyngeal candidiasis
Hanny Reis Mockdeci, Laura Andrade Junqueira, Lucas Mattos Duarte, Carolina Paula de Souza Moreira, Marcone Augusto Leal de Oliveira, Marcos Antônio Fernandes Brandão, Guilherme Diniz Tavares, Nádia Rezende Barbosa Raposo
RPS Pharmacy and Pharmacology Reports. 2023; 2(1)
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8 Aggregation of Magnetic Nanoparticles in Biological Solvents Evaluated by HTS-SQUID Magnetic Immunoassay System
K. Yamashita, K. Kishimoto, H. Kuroda, J. Wang, K. Sakai, M. M. Saari, T. Kiwa
IEEE Transactions on Applied Superconductivity. 2023; 33(5): 1
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9 Preparation of pickering emulsion of cinnamon essential oil using soybean protein isolate-chitosan particles as stabilizers
Zijun WU, Jie YAN, Zhijian ZHOU, Qiulin XU, Qiaoguang LI, Guangqing LI, Xigui LI, Xitong FANG, QiuLing ZHONG
Food Science and Technology. 2023; 43
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10 DEVELOPMENT AND OPTIMIZATION OF INDOMETHACIN NANOSUSPENSIONS USING DESIGN OF EXPERIMENT APPROACHES
Gizem Rüya TOPAL, Cansel KÖSE ÖZKAN, Yalçin ÖZKAN
Ankara Universitesi Eczacilik Fakultesi Dergisi. 2023;
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11 Stimuli-Responsive Boron-Based Materials in Drug Delivery
Bhaskar C. Das, Parthiban Chokkalingam, Pavithra Masilamani, Srushti Shukla, Sasmita Das
International Journal of Molecular Sciences. 2023; 24(3): 2757
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12 Maleic Acid as a Co-Former for Pharmaceutically Active GABA Derivatives: Mechanochemistry or Solvent Crystallization?
Daniel Komisarek, Ebru Taskiran, Vera Vasylyeva
Materials. 2023; 16(6): 2242
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13 Unveiling the Pharmacological and Nanotechnological Facets of Daidzein: Present State-of-the-Art and Future Perspectives
Sukhbir Singh, Sonam Grewal, Neelam Sharma, Tapan Behl, Sumeet Gupta, Md. Khalid Anwer, Celia Vargas-De-La-Cruz, Syam Mohan, Simona Gabriela Bungau, Adrian Bumbu
Molecules. 2023; 28(4): 1765
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14 Updates on Biodegradable Formulations for Ocular Drug Delivery
Ta-Hsin Tsung, Yi-Hao Chen, Da-Wen Lu
Pharmaceutics. 2023; 15(3): 734
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15 Study of Formulation and Process Variables for Optimization of Piroxicam Nanosuspension Using 32 Factorial Design to Improve Solubility and In Vitro Bioavailability
Yahya Alhamhoom, Sandip M. Honmane, Umme Hani, Riyaz Ali M. Osmani, Geetha Kandasamy, Rajalakshimi Vasudevan, Sharanya Paramshetti, Ravindra R. Dudhal, Namrata K. Kengar, Manoj S. Charde
Polymers. 2023; 15(3): 483
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16 Synthesis, Characterization, and Biodistribution of GdF3:[email protected] Nanocomposites
Oleg E. Polozhentsev, Ilia A. Pankin, Darya V. Khodakova, Pavel V. Medvedev, Anna S. Goncharova, Aleksey Yu. Maksimov, Oleg I. Kit, Alexander V. Soldatov
Materials. 2022; 15(2): 569
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17 Influence of the Poly(ethylene Glycol) Methyl Ether Methacrylates on the Selected Physicochemical Properties of Thermally Sensitive Polymeric Particles for Controlled Drug Delivery
Agnieszka Gola, Maria Kozlowska, Witold Musial
Polymers. 2022; 14(21): 4729
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18 Evaluation of In Vitro Cytotoxic, Genotoxic, Apoptotic, and Cell Cycle Arrest Potential of Iron–Nickel Alloy Nanoparticles
Özgür Vatan
Toxics. 2022; 10(9): 492
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19 Nanosuspension: A New Horizon in the Drug Delivery System
Laxmikant Zawar, Gaurav Patil, Nitin Shirsath, Piyush Bafna
International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN). 2022; 15(5): 6169
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20 Characterization and Toxicity of Hypoxoside Capped Silver Nanoparticles
Umar M. Badeggi, Sylvester I. Omoruyi, Enas Ismail, Charlene Africa, Subelia Botha, Ahmed A. Hussein
Plants. 2022; 11(8): 1037
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21 Development of Nanosuspension Formulations Compatible with Inkjet Printing for the Convenient and Precise Dispensing of Poorly Soluble Drugs
Dennis H. Leung
Pharmaceutics. 2022; 14(2): 449
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22 Preparation, Characterization, and Evaluation of Breviscapine Nanosuspension and Its Freeze-Dried Powder
Ting Zhang, Xixi Li, Juewen Xu, Jingbao Shao, Meihong Ding, Senlin Shi
Pharmaceutics. 2022; 14(5): 923
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23 Therapeutic Potential of Naringenin Nanosuspension: In Vitro and In Vivo Anti-Osteoporotic Studies
Sonia Gera, Sunitha Sampathi, Sravya Maddukuri, Sujatha Dodoala, Vijayabhaskarreddy Junnuthula, Sathish Dyawanapelly
Pharmaceutics. 2022; 14(7): 1449
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24 Nanocrystal Preparation of Poorly Water-Soluble Drugs with Low Metal Contamination Using Optimized Bead-Milling Technology
Hironori Tanaka, Yuya Ochii, Yasushi Moroto, Daisuke Hirata, Tetsuharu Ibaraki, Ken-ichi Ogawara
Pharmaceutics. 2022; 14(12): 2633
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25 Deferasirox Nanosuspension Loaded Dissolving Microneedles for Intradermal Delivery
Hafsa Shahid Faizi, Lalitkumar K. Vora, Muhammad Iqbal Nasiri, Yu Wu, Deepakkumar Mishra, Qonita Kurnia Anjani, Alejandro J. Paredes, Raghu Raj Singh Thakur, Muhammad Usman Minhas, Ryan F. Donnelly
Pharmaceutics. 2022; 14(12): 2817
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26 Preparation of Naringenin Nanosuspension and Its Antitussive and Expectorant Effects
Zhengqi Dong, Rui Wang, Mingyue Wang, Zheng Meng, Xiaotong Wang, Meihua Han, Yifei Guo, Xiangtao Wang
Molecules. 2022; 27(3): 741
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27 ZnO Nanoparticles of Rubia cordifolia Extract Formulation Developed and Optimized with QbD Application, Considering Ex Vivo Skin Permeation, Antimicrobial and Antioxidant Properties
Jasmeet Kaur, Md. Khalid Anwer, Ali Sartaj, Bibhu Prasad Panda, Abuzer Ali, Ameeduzzafar Zafar, Vinay Kumar, Sadaf Jamal Gilani, Chandra Kala, Mohamad Taleuzzaman
Molecules. 2022; 27(4): 1450
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28 Docetaxel Loaded in Copaiba Oil-Nanostructured Lipid Carriers as a Promising DDS for Breast Cancer Treatment
Fabiola Vieira de Carvalho, Ligia Nunes de Morais Ribeiro, Ludmilla David de Moura, Gustavo Henrique Rodrigues da Silva, Hery Mitsutake, Talita Cesarim Mendonça, Gabriela Geronimo, Marcia Cristina Breitkreitz, Eneida de Paula
Molecules. 2022; 27(24): 8838
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29 Continuous Manufacturing and Molecular Modeling of Pharmaceutical Amorphous Solid Dispersions
Amritha G Nambiar, Maan Singh, Abhishek R Mali, Dolores R Serrano, Rajnish Kumar, Anne Marie Healy, Ashish Kumar Agrawal, Dinesh Kumar
AAPS PharmSciTech. 2022; 23(7)
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30 Optimization of Milling Parameters for Low Metal Contamination in Bead Milling Technology
Hironori Tanaka, Yuya Ochii, Yasushi Moroto, Daisuke Hirata, Tetsuharu Ibaraki, Ken-ichi Ogawara
BPB Reports. 2022; 5(3): 45
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31 FORMULATION DEVELOPMENT AND CHARACTERIZATION OF LYOPHILIZED FEBUXOSTAT NANOSUSPENSION
ANKITA HADKE, ANIL PETHE, SUNITA VAIDYA, SUNIL DEWANI
International Journal of Applied Pharmaceutics. 2022; : 91
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32 Interspecies Comparison and Radiation Effect on Pharmacokinetics of BIO 300, a Nanosuspension of Genistein, after Different Routes of Administration in Mice and Non-Human Primates
Ahmed M. Salem, Isabel L. Jackson, Allison Gibbs, Yannick Poirier, Diana Newman, Andrew Zodda, Zeljko Vujaskovic, Michael D. Kaytor, Artur A. Serebrenik, Jogarao Gobburu, Mathangi Gopalakrishnan
Radiation Research. 2022; 197(5)
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33 Potential of Nanotechnology-based Formulations in Combating Pulmonary Infectious Diseases: A Current Scenario
Manisha Patel, Rupa Mazumder, Rakhi Mishra, Kamal Kant Kaushik
Current Pharmaceutical Design. 2022; 28(42): 3413
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34 The Therapeutic Potential of Algal Nanoparticles: A Brief Review
Pallavi Singh Chauhan, Dhananjay Yadav, Jun O. Jin
Combinatorial Chemistry & High Throughput Screening. 2022; 25(14): 2443
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35 Formulation and Evaluation of Isradipine Nanosuspension and Exploring its Role as a Potential Anticancer Drug by Computational Approach
Prasanta Kumar Mohapatra, Rajnish Srivastava, Krishna Kumar Varshney, S. Haresh Babu
Anti-Cancer Agents in Medicinal Chemistry. 2022; 22(10): 1984
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36 Advances and Challenges in Intranasal Delivery of Antipsychotic Agents Targeting the Central Nervous System
Manisha Pandey, Neha Jain, Jovita Kanoujia, Zahid Hussain, Bapi Gorain
Frontiers in Pharmacology. 2022; 13
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37 Anti-EpCAM Functionalized I-131 Radiolabeled Biomimetic Nanocarrier Sodium/Iodide-Symporter-Mediated Breast-Cancer Treatment
Suphalak Khamruang Marshall, Yada Panrak, Naritsara Makchuchit, Passara Jaroenpakdee, Boonyisa Saelim, Maneerat Taweesap, Verachai Pachana
Bioengineering. 2022; 9(7): 294
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38 Implication of Nanoparticles to Combat Chronic Liver andKidney Diseases: Progress and Perspectives
Mariam Hashim, Huma Mujahid, Samina Hassan, Shanila Bukhari, Iram Anjum, Christophe Hano, Bilal Haider Abbasi, Sumaira Anjum
Biomolecules. 2022; 12(10): 1337
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39 Synthesis of Artemether-Loaded Albumin Nanoparticles and Measurement of Their Anti-Cancer Effects
Zeynab Pirali-Hamedani, Ardeshir Abbasi, Zuhair Mohammad Hassan
Biomedicines. 2022; 10(11): 2713
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40 Effect of Acyl Chain Length on Hydrophobized Cashew Gum Self-Assembling Nanoparticles: Colloidal Properties and Amphotericin B Delivery
Ana R. Richter, José G. Veras-Neto, Jeanlex S. Sousa, Josilayne F. S. Mendes, Raquel O. S. Fontenelle, Stéphanie A. N. M. Silva, José D. B. Marinho-Filho, Ana J. Araújo, Judith P. A. Feitosa, Haroldo C. B. Paula, Francisco M. Goycoolea, Regina C. M. de Paula
Colloids and Interfaces. 2022; 6(4): 65
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41 Biosynthesis of silver nanoparticles from Syzygium cumini leaves and their potential effects on odontogenic pathogens and biofilms
Wagner Luis de Carvalho Bernardo, Marcelo Fabiano Gomes Boriollo, Caroline Coradi Tonon, Jeferson Júnior da Silva, Mateus Cardoso Oliveira, Fernando Cruz de Moraes, Denise Madalena Palomari Spolidorio
Frontiers in Microbiology. 2022; 13
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42 Squalene-Rich Amaranth Oil Pickering Emulsions Stabilized by Native a-Lactalbumin Nanoparticles
Andrea P. Cuevas-Gómez, Berenice González-Magallanes, Izlia J. Arroyo-Maya, Gustavo F. Gutiérrez-López, Maribel Cornejo-Mazón, Humberto Hernández-Sánchez
Foods. 2022; 11(14): 1998
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43 Silybin-based herbal nanocarriers: an advancement in anticancer therapy
Meghanath B. Shete, Ashwini S. Deshpande, Pravin Shende
Materials Technology. 2022; : 1
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44 Micro-nano-bubble technology and its applications in food industry: A critical review
Zhi-Hong Zhang, Shaomeng Wang, Lina Cheng, Haile Ma, Xianli Gao, Charles S. Brennan, Jing-Kun Yan
Food Reviews International. 2022; : 1
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45 Research on selective uptake of photosensitizer [email protected] by different cancer cells
Jiaxiu Liu, Jingying Chen, Xitong Lin, Shuchao Zhang
Materials Research Express. 2022; 9(6): 065402
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46 Clinical translation of long-acting drug delivery formulations
Wei Li, Jie Tang, Dennis Lee, Thomas R. Tice, Steven P. Schwendeman, Mark R. Prausnitz
Nature Reviews Materials. 2022; 7(5): 406
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47 Amikacin potentiator activity of zinc complexed to a pyrithione derivative with enhanced solubility
Jesus Magallon, Peter Vu, Craig Reeves, Stella Kwan, Kimberly Phan, Crista L. Oakley-Havens, Kenneth Rocha, Veronica Jimenez, María Soledad Ramirez, Marcelo E. Tolmasky
Scientific Reports. 2022; 12(1)
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48 Adding a new Dimension to the Amorphous Solid Dispersion Phase Diagram: Studying Dissolution Kinetics of Crystalline Drugs in a Polymer Matrix using temperature dependent XRPD and DSC
Vanessa K. Seiler, Frank Theil, Norbert Nagel, Holger van Lishaut
Journal of Pharmaceutical Sciences. 2022;
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49 Self-Assembled Nanostructures from Amphiphilic Sucrose-Soyates for Solubilizing Hydrophobic Guest Molecules
Karan Bansal, Dean Webster, Mohiuddin Quadir
Langmuir. 2022;
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50 Genotoxic effects of silver nanoparticles on a tropical marine amphipod via feeding exposure
Marina Tenório Botelho, Maria José de Arruda Rocha Campos Passos, Tailisi Hoppe Trevizani, Rubens Cesar Lopes Figueira, Gisela de Aragão Umbuzeiro, Vicente Gomes
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2022; : 503527
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51 Eco-friendly Biosynthesis of Silver Nanoparticles using Aloysia citrodora leaf extract and Evaluations of their Bioactivities
Mohadeseh Hassanisaadi, Amir Hashem Shahidi Bonjar, Abbas Rahdar, Rajender S. Varma, Narges Ajalli, Sadanand Pandey
Materials Today Communications. 2022; : 104183
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52 Development and characterization of nanodispersion-based sildenafil pressurized metered-dose inhaler using combined small-angle X-ray scattering, dynamic light scattering, and impactors
Charisopon Chunhachaichana, Somchai Sawatdee, Supagorn Rugmai, Teerapol Srichana
Journal of Drug Delivery Science and Technology. 2022; 76: 103749
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53 Production of herbal nanocolloids from Rubia tinctorum L. roots by rapid expansion from supercritical solution into suspension system
Milad Yekefallah, Farhad Raofie
Industrial Crops and Products. 2022; 176: 114286
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54 Association of cellulose micro/nanofibrils and silicates for cardboard coating: Technological aspects for packaging
Adriano Reis Prazeres Mascarenhas, Mário Vanoli Scatolino, Matheus Cordazzo Dias, Maria Alice Martins, Rafael Rodolfo de Melo, Maressa Carvalho Mendonça, Gustavo Henrique Denzin Tonoli
Industrial Crops and Products. 2022; 188: 115667
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55 “TPGS Surface Modified Bilosomes As Boosting Cytotoxic Oral Delivery systems of Curcumin Against Doxorubicin Resistant MCF-7 Breast Cancer Cells”
Hanaa Hegazy, Maha M Amin, Walid Fayad, Mohamed Y. Zakaria
International Journal of Pharmaceutics. 2022; : 121717
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56 In vitro bioaccessibility evaluation of pheophytins in gelatin/polysaccharides carrier
Zihan Jin, Israel Emiezi Agarry, Yunchang Li, Desheng Ding, Tian Cai, Kewei Chen
Food Chemistry. 2022; : 135252
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57 Another perspective to explain green tea cream: utilizing engineered catechin-caffeine complex
Gang Zhang, Yanyan Cao, Sifan Mei, Yating Guo, Shuying Gong, Qiang Chu, Ping Chen
Food Research International. 2022; : 111542
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58 Nanosuspension-loaded dissolving bilayer microneedles for hydrophobic drug delivery to the posterior segment of the eye
Yu Wu, Lalitkumar K. Vora, Deepakkumar Mishra, Muhammad Faris Adrianto, Shilpkala Gade, Alejandro J. Paredes, Ryan F. Donnelly, Thakur Raghu Raj Singh
Biomaterials Advances. 2022; : 212767
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59 Synergistic anti-inflammatory effects of graphene oxide quantum dots and trans-10-hydroxy-2-decenoic acid on LPS-stimulated RAW 264.7 macrophage cells
Minjie Huang, Minhui Xiao, Jie Dong, Yee Huang, Haiyan Sun, Deqian Wang
Biomaterials Advances. 2022; : 212774
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60 Comparison of catalytic activity and antimicrobial properties of palladium nanoparticles obtained by Aloe barbadensis and Glycine max extracts, and chemical synthesis
Francisco Javier Morales Santos, Hilda Amelia Piñón Castillo, Armando QuinteroRamos, Gerardo Zaragoza Galán, Robert Duran, Erasmo Orrantia Borunda
Applied Nanoscience. 2022;
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61 Gellan gum–based in situ gelling ophthalmic nanosuspension of Posaconazole
Purva Khare, Manasi M. Chogale, Pratik Kakade, Vandana B. Patravale
Drug Delivery and Translational Research. 2022;
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62 An expanding horizon of complex injectable products: development and regulatory considerations
Kanan Panchal, Sumeet Katke, Sanat Kumar Dash, Ankit Gaur, Aishwarya Shinde, Nithun Saha, Neelesh Kumar Mehra, Akash Chaurasiya
Drug Delivery and Translational Research. 2022;
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63 Nanoencapsulated a-terpineol attenuates neuropathic pain induced by chemotherapy through calcium channel modulation
Daniele N. Gouveia, Adriana G. Guimarães, Marlange A. Oliveira, Thallita K. Rabelo, Lícia T. S. Pina, Wagner B. R. Santos, Iggo K. S. Almeida, Tatianny A. Andrade, Mairim Russo Serafini, Bruno S. Lima, Adriano A. S. Araújo, José Evaldo R. Menezes-Filho, Artur Santos-Miranda, Luciana Scotti, Marcus Tullius Scotti, Henrique Douglas Melo Coutinho, Jullyana S. S. Quintans, Raffaele Capasso, Lucindo J. Quintans-Júnior
Polymer Bulletin. 2022;
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64 Marine collagen polymeric sponge impregnated with phyto-silver nanoparticles for burn therapy
Gayathri Sundar, Josna Joseph, Prabhakumari Chellamma, Annie John, Annie Abraham
Polymer Bulletin. 2022;
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65 Revisiting Zeta Potential, the Key Feature of Interfacial Phenomena, with Applications and Recent Advancements
Shashikant Kamble, Santosh Agrawal, Sandeep Cherumukkil, Vipul Sharma, Raksh Vir Jasra, Pradip Munshi
ChemistrySelect. 2022; 7(1)
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66 Physicochemical–Electrochemical Characterization of the Nanocomposite Chitosan-Coated Magnetite Nanoparticles
A. Y. Flores-Ramírez, S. Aguilera-Aguirre, M. A. Chacón-López, L. A. Ortiz-Frade, R. Antaño-López, A. Álvarez-López, A. Rodríguez-López, U. M. López-García
Journal of Cluster Science. 2022;
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67 Size-dependent effects of nanoplastics on structure and function of superoxide dismutase
Yaoyue Wang, Huijian Shi, Tao Li, Lei Yu, Yuntao Qi, Guang Tian, Falin He, Xiangxiang Li, Ning Sun, Rutao Liu
Chemosphere. 2022; 309: 136768
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68 Effect of concentration of silica encapsulated ds-DNA colloidal microparticles on their transport through saturated porous media
Swagatam Chakraborty, Jan Willem Foppen, Jack F. Schijven
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2022; : 129625
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69 Drug delivery challenges and formulation aspects of proteolysis targeting chimera (PROTACs)
Aishwarya L. Saraswat, Richa Vartak, Rehab Hegazy, Akanksha Patel, Ketan Patel
Drug Discovery Today. 2022; : 103387
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70 Application of protein fractions from selenized sprouted chickpeas as emulsifying agents and evaluation of their antioxidant properties
Mónica I. Hernández-Grijalva, Sayra N. Serrano-Sandoval, Janet A. Gutiérrez-Uribe, Sergio O. Serna-Saldivar, Jorge Milán-Carrillo, Marilena Antunes-Ricardo, Javier Villela-Castrejón, Daniela Guardado-Félix
Food and Bioproducts Processing. 2022;
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71 Confinement of FRP concrete columns: Review of design guidelines and comparison with experimental results
A. Salesa, L.M. Esteban, C. Barris
Materiales de Construcción. 2022; 72(345): e274
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72 Nanosuspension as an emerging Nanotechnology and Techniques for its Development
Runa Chakravorty
Research Journal of Pharmacy and Technology. 2022; : 489
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73 LIPID AS AN EXCIPIENT FOR DESIGN AND DEVELOPMENT OF FORMULATIONS
Apoorva V. More, Bharat V. Dhokchawle, Savita J. Tauro, Savita V. Kulkarni
Indian Drugs. 2022; 59(07): 7
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74 Hepatoprotective Effects of Chitosan and Chitosan Nanoparticles Against Biochemical, Genetic, and Histological Disorders Induced by the Toxicity of Emamectin Benzoate
Sherifa Fathalla Dawoud, Tarek Mostafa Al-Akra, Amina Mohamed Zedan
Reports of Biochemistry and Molecular Biology. 2021; 10(3): 506
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75 Effects of polysaccharide charge density on the structure and stability of carboxymethylcellulose-casein nanocomplexes at pH 4.5 prepared with and without a pH-cycle
Nan Li,Qixin Zhong
Food Hydrocolloids. 2021; : 106718
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76 Application of starch nanoparticles as a stabilizer for Pickering emulsions: effect of environmental factors and approach for enhancing its storage stability
Eun Byul Ko,Jong-Yea Kim
Food Hydrocolloids. 2021; : 106984
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77 Redispersible Nanosuspensions as a Plausible Oral Delivery System for Curcumin
Nancy M. Elbaz,Lee M. Tatham,Andrew Owen,Steve Rannard,Tom O. McDonald
Food Hydrocolloids. 2021; : 107005
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78 Effect of surfactants and pH values on stability of ?-Al2O3 nanofluids
Junyu Ji,Xiangyang Yao,Jun Gao,Wei Lu,Weihua Wang,Delin Chu
Chemical Physics Letters. 2021; 781: 138996
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79 Foams as unique drug delivery systems
Dagmara Hoc,Dorota Haznar-Garbacz
European Journal of Pharmaceutics and Biopharmaceutics. 2021; 167: 73
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80 Coupling coagulation-flocculation to volcanic tuff-magnetite nanoparticles adsorption for olive mill wastewater treatment
Muna Abu-Dalo, Jehad Abdelnabi, Nathir A.F. Al-Rawashdeh, Borhan Albiss, Abeer Al Bawab
Environmental Nanotechnology, Monitoring & Management. 2021; : 100626
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81 Pharmaceutical manipulation of citrus flavonoids towards improvement of its bioavailability and stability. A mini review and a meta-analysis study
Sahar Elmeligy, Rania M. Hathout, Shaden A.M. Khalifa, Hesham R. El-Seedi, Mohamed A. Farag
Food Bioscience. 2021; 44: 101428
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82 The influence of ergosterol on the action of the hop oil and its major terpenes on model fungi membranes. Towards understanding the mechanism of action of phytocompounds for food and plant protection
Karolina Polec,Karolina Olechowska,Amanda Klejdysz,Michal Dymek,Rafal Rachwalik,Elzbieta Sikora,Katarzyna Hac-Wydro
Chemistry and Physics of Lipids. 2021; : 105092
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83 Characterisation of selenium and tellurium nanoparticles produced by Aureobasidium pullulans using a multi-method approach.
Kenneth C Nwoko,Xinjin Liang,Magali AMJ Perez,Eva Krupp,Geoffrey Michael Gadd,Jörg Feldmann
Journal of Chromatography A. 2021; : 462022
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84 Physicochemical characterization of a DMPC-based nanoemulsion for dry eye and compatibility test with soft contact lenses in vitro
Paulina Chávez-Hurtado,Luciano Pesqueda-Pinedo,Hector A. Ceballos-Delgadillo,Addy Liñán-Segura,Humberto Figueroa-Ponce,Juan D. Quintana-Hau
Contact Lens and Anterior Eye. 2021;
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85 Antimicrobial effects of silver nanoparticles and extracts of Syzygium cumini flowers and seeds: periodontal, cariogenic and opportunistic pathogens
Wagner Luís de Carvalho Bernardo,Marcelo Fabiano Gomes Boriollo,Caroline Coradi Tonon,Jeferson Júnior da Silva,Fernando Moraes Cruz,Adriano Luis Martins,José Francisco Höfling,Denise Madalena Palomari Spolidorio
Archives of Oral Biology. 2021; : 105101
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86 Effect of pH on the formation of U(VI) colloidal particles in a natural groundwater
Yanlin Shi,Wanqiang Zhou,Jingyi Wang,Dongfan Xian,Zhaoyi Tan,Liang Du,Xiaolong Li,Duoqiang Pan,Zongyuan Chen,Wangsuo Wu,Chunli Liu
Journal of Radioanalytical and Nuclear Chemistry. 2021;
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87 Poly-L -lysine-coated a-lactalbumin nanoparticles: preparation, effect of pH, and stability under in vitro simulated gastrointestinal conditions
Esmeralda Jiménez-Cruz, Andrea P. Cuevas-Gómez, Larry Unsworth, Maribel Cornejo-Mazón, Izlia J. Arroyo-Maya, Humberto Hernandez-Sanchez
Journal of Chemical Technology & Biotechnology. 2021;
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88 Two Temperatures Biogenic Synthesis of Silver Nanoparticles from Grewia lasiocarpa E. Mey. ex Harv. Leaf and Stem Bark Extracts: Characterization and Applications
Nneka Augustina Akwu,Yougasphree Naidoo,Moganavelli Singh,Nirasha Nundkumar,Aliscia Daniels,Johnson Lin
BioNanoScience. 2021;
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89 Solubility and Dissolution Study of Prochlorperazine Maleate Nanoparticle Prepared by Design of Experiment
Mihir Raval,Hina L. Bagada
BioNanoScience. 2021;
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90 Nano-based pesticides: challenges for pest and disease management
Lobna Hajji-Hedfi, Hemraj Chhipa
Euro-Mediterranean Journal for Environmental Integration. 2021; 6(3)
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91 Comparative analysis of physical and functional properties of cellulose nanofibers isolated from alkaline pre-treated wheat straw in optimized hydrochloric acid and enzymatic processes
Regan Ceaser,Annie F.A. Chimphango
International Journal of Biological Macromolecules. 2021; 171: 331
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92 Utilization of tea resources with the production of superparamagnetic biogenic iron oxide nanoparticles and an assessment of their antioxidant activities
Rajiv Periakaruppan,Xuan Chen,Kuberan Thangaraj,Anburaj Jeyaraj,Hoang Ha Nguyen,Ying Yu,Shunkai Hu,Li Lu,Xinghui Li
Journal of Cleaner Production. 2021; 278: 123962
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93 AGRO-WASTE mediated biopolymer for production of biogenic nano iron oxide with superparamagnetic power and antioxidant strength
Rajiv Periakaruppan,Jianjie Li,Huiling Mei,Ying Yu,Shunkai Hu,Xuan Chen,Xinghui Li,Guiyi Guo
Journal of Cleaner Production. 2021; : 127512
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94 Refinement of the selection of physicochemical properties for grouping and read-across of nanoforms
Frédéric Loosli, Kirsten Rasmussen, Hubert Rauscher, Richard K. Cross, Nathan Bossa, Willie Peijnenburg, Josje Arts, Marianne Matzke, Claus Svendsen, David Spurgeon, Per Axel Clausen, Emmanuel Ruggiero, Wendel Wohlleben, Frank von der Kammer
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95 Preparation and physicochemical stability of hemp seed oil liposomes
Yanguo Shi,Wen Wang,Xiuqing Zhu,Bing Wang,Yue Hao,Liqi Wang,Dianyu Yu,Walid Elfalleh
Industrial Crops and Products. 2021; 162: 113283
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96 Light-responsive polymeric nanoparticles based on a novel nitropiperonal based polyester as drug delivery systems for photosensitizers in PDT
Timo Schoppa,Dimitri Jung,Tarik Rust,Dennis Mulac,Dirk Kuckling,Klaus Langer
International Journal of Pharmaceutics. 2021; 597: 120326
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97 Comparative in vitro evaluation of glimepiride containing nanosuspension drug delivery system developed by different techniques
Sujit Bose,Pooja Sharma,Vijay Mishra,Swati Patial,Gaurav K. Saraogi,Murtaza M. Tambuwala,Kamal Dua
Journal of Molecular Structure. 2021; : 129927
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98 Effect of nanoencapsulation of blueberry (Vaccinium myrtillus): A green source of flavonoids with antioxidant and photoprotective properties
Julia Gomes Franco,Letícia Caramori Cefali,Janaína Artem Ataide,Antonello Santini,Eliana B. Souto,Priscila Gava Mazzola
Sustainable Chemistry and Pharmacy. 2021; 23: 100515
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99 Investigation on Surface interaction between Graphene Nanobuds and Cerium(III) via Fluorescence excimer, Theoretical, Real water sample, and Bioimaging studies
V.R. Pavithra,T. Daniel Thangadurai,G. Manonmani,K. Senthilkumar,D. Nataraj,J. Jiya,K. Nandakumar,S. Thomas
Materials Chemistry and Physics. 2021; : 124453
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100 Characterization of gold nanoparticles synthesized from Solanum torvum (Turkey Berry) fruit extract and its application in catalytic degradation of methylene blue and antibacterial properties
Ami Ansul Shah,D. Jayalakshmi,Belina Xavier
Materials Today: Proceedings. 2021;
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101 A biocompatible and injectable hydrogel to boost the efficacy of stem cells in neurodegenerative diseases treatment
Helena Ferreira, Diana Amorim, Ana Cláudia Lima, Rogério P. Pirraco, Ana Rita Costa-Pinto, Rui Almeida, Armando Almeida, Rui L. Reis, Filipa Pinto-Ribeiro, Nuno M. Neves
Life Sciences. 2021; 287: 120108
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102 Liposomes containing 3-arylamino-nor-ß-lapachone derivative: development, characterization, and in vitro evaluation of the cytotoxic activity
Luciana V. Rebouças,Fátima C.E. Oliveira,Daniel P. Pinheiro,Maria Francilene S. Silva,Vanessa Pinheiro G. Ferreira,Roberto Nicolete,Augusto C.A. Oliveira,Renata G. Almeida,Eufrânio N. da Silva Júnior,Marcia S. Rizzo,Marcília P. Costa,Guilherme Zocolo,Fábio O.S. Ribeiro,Durcilene A. da Silva,Claudia Pessoa
Journal of Drug Delivery Science and Technology. 2021; : 102348
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103 Nanosuspension of flavonoid-rich fraction from Psidium guajava Linn for improved type 2-diabetes potential
Praveen Kumar Gaur
Journal of Drug Delivery Science and Technology. 2021; : 102358
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104 Exploring green and industrially scalable MICROFLUIDIZER™ technology for DEVELOPMENT of barium sulphate nanosuspension for ENHANCED contrasting
Susmit Mhatre,Shivraj Naik,Vandana Patravale
Journal of Drug Delivery Science and Technology. 2021; : 102567
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105 Adaptive Focused Acoustics™ for Nanosuspensions to Enable Pharmacology Assessment of Poorly Soluble Molecules in Lead Optimization
Kathy Stavropoulos,Jim Bernhard,Kwame Nti-Addae,Elisabeth Doyle,Wojciech Dworakowski,Andrey Peresypkin,Setu Roday
Journal of Pharmaceutical Sciences. 2021;
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106 Curcumin nanoparticles supported gelatin-collagen scaffold: Preparation, characterization, and in vitro study
Serdar Batikan Kavukcu,Sinem Çakir,Aslihan Karaer,Hayati Türkmen,Senthil Rethinam
Toxicology Reports. 2021;
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107 Co-delivery of doxorubicin and conferone by novel pH-responsive ß-cyclodextrin grafted micelles triggers apoptosis of metastatic human breast cancer cells
Akram Rahmani, Fariborz Rahimi, Mehrdad Iranshahi, Houman Kahroba, Amir Zarebkohan, Mehdi Talebi, Roya Salehi, Hassan Zavvar Mousavi
Scientific Reports. 2021; 11(1)
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108 Protective Effect of Natural Products against Huntington’s Disease: An Overview of Scientific Evidence and Understanding Their Mechanism of Action
Pei Teng Lum,Mahendran Sekar,Siew Hua Gan,Srinivasa Reddy Bonam,Mohd. Farooq Shaikh
ACS Chemical Neuroscience. 2021;
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109 Development of Cyclosporine A nanosuspension: Cytotoxicity and permeability on Caco-2 cell lines
Sila Gülbag Pinar, Esra Pezik, Basaran Mutlu Agardan, Nevin Çelebi
Pharmaceutical Development and Technology. 2021; : 1
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110 An in-depth analysis of novel combinatorial drug therapy via nanocarriers against HIV/AIDS infection and their clinical perspectives: A systematic review
Abdul Muheem,Sanjula Baboota,Javed Ali
Expert Opinion on Drug Delivery. 2021;
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111 Application of ultrasonics for nanosizing drugs and drug formulations
Ioannis Partheniadis,Rumit R. Shah,Ioannis Nikolakakis
Journal of Dispersion Science and Technology. 2021; : 1
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112 The antioxidant and anti-apoptotic potential of Pleurotus eryngii extract and its chitosan-loaded nanoparticles against doxorubicin-induced testicular toxicity in male rats
Elif Erdem Guzel,Nalan Kaya Tektemur,Ahmet Tektemur,Hilal Acay,Ayfer Yildirim
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113 Application of Nanoparticles in Drug Delivery for the Treatment of Osteosarcoma: Focusing on the Liposomes
Wenqing Liang, Yongqiang Dong, Ruyi Shao, Songou Zhang, Xudong Wu, Xiaogang Huang, Bin Sun, Bin Zeng, Jiayi Zhao
Journal of Drug Targeting. 2021; : 1
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114 Development of a BCS Class II Drug Microemulsion for Oral Delivery: Design, Optimization, and Evaluation
Marwa Tlijani,Mohamed Ali Lassoued,Badr Bahloul,Souad Sfar,Hassan Karimi-Maleh
Journal of Nanomaterials. 2021; 2021: 1
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115 Synergistic antioxidant capacities of vanillin and chitosan nanoparticles against reactive oxygen species, hepatotoxicity, and genotoxicity induced by aging in male Wistar rats
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Human & Experimental Toxicology. 2021; 40(1): 183
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116 Nanotechnology based solutions for anti-leishmanial impediments: a detailed insight
Humzah Jamshaid,Fakhar ud Din,Gul Majid Khan
Journal of Nanobiotechnology. 2021; 19(1)
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117 Development of Novel Bead Milling Technology with Less Metal Contamination by pH Optimization of the Suspension Medium
Hironori Tanaka,Yuya Ochii,Yasushi Moroto,Tetsuharu Ibaraki,Ken-ichi Ogawara
Chemical and Pharmaceutical Bulletin. 2021; 69(1): 81
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118 Formulation, Characterization and Cytotoxicity Effects of Novel Thymoquinone-PLGA-PF68 Nanoparticles
Nurul Shahfiza Noor,Noor Haida Mohd Kaus,Myron R. Szewczuk,Shahrul Bariyah Sahul Hamid
International Journal of Molecular Sciences. 2021; 22(17): 9420
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119 Targeted Nanoparticle Photodynamic Diagnosis and Therapy of Colorectal Cancer
Nokuphila Winifred Nompumelelo Simelane,Cherie Ann Kruger,Heidi Abrahamse
International Journal of Molecular Sciences. 2021; 22(18): 9779
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120 BaGdF5 Nanophosphors Doped with Different Concentrations of Eu3+ for Application in X-ray Photodynamic Therapy
Zaira Gadzhimagomedova, Vladimir Polyakov, Ilia Pankin, Vera Butova, Daria Kirsanova, Mikhail Soldatov, Darya Khodakova, Anna Goncharova, Elizaveta Mukhanova, Anna Belanova, Aleksey Maksimov, Alexander Soldatov
International Journal of Molecular Sciences. 2021; 22(23): 13040
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121 The Emerging Role of Nanosuspensions for Drug Delivery and Stability
Hitesh Kumar Dewangan
Current Nanomedicine. 2021; 11(4): 213
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122 Colloidal Particles for Pickering Emulsion Stabilization Prepared via Antisolvent Precipitation of Lignin-Rich Cocoa Shell Extract
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Foods. 2021; 10(2): 371
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123 Application of Fundamental Techniques for Physicochemical Characterizations to Understand Post-Formulation Performance of Pharmaceutical Nanocrystalline Materials
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Crystals. 2021; 11(3): 310
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124 An Experimental Study of the Influence of the Preflush Salinity on Enhanced Oil Recovery Using Silica-Based Nanofluids
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Energies. 2021; 14(21): 6922
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125 TRIIYODOANILIN’IN SENTEZLENMESI, NANOSÜSPANSIYONLARININ HAZIRLANMASI, IN VITRO KARAKTERIZASYONU VE RADYOKONTRAST ÖZELLIKLERININ INCELENMESI
Mehmet KOCA,Emrah ÖZAKAR,Rukiye SEVINÇ ÖZAKAR
Ankara Universitesi Eczacilik Fakultesi Dergisi. 2021; : 9
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126 Chitosan, Polyethylene Glycol and Polyvinyl Alcohol Modified MgFe2O4 Ferrite Magnetic Nanoparticles in Doxorubicin Delivery: A Comparative Study In Vitro
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Molecules. 2021; 26(13): 3893
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127 Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides
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Molecules. 2021; 27(1): 51
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128 Synthesis of Poly(Malic Acid) Derivatives End-Functionalized with Peptides and Preparation of Biocompatible Nanoparticles to Target Hepatoma Cells
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Nanomaterials. 2021; 11(4): 958
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129 Mesoporous Silica Particles as Drug Delivery Systems—The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes
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130 Rifampicin–Liposomes for Mycobacterium abscessus Infection Treatment: Intracellular Uptake and Antibacterial Activity Evaluation
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131 An Iron Shield to Protect Epigallocatehin-3-Gallate from Degradation: Multifunctional Self-Assembled Iron Oxide Nanocarrier Enhances Protein Kinase CK2 Intracellular Targeting and Inhibition
Luca Fasolato,Massimiliano Magro,Giorgio Cozza,Ferruccio Sbarra,Simone Molinari,Enrico Novelli,Fabio Vianello,Andrea Venerando
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132 Histidine-Tagged Folate-Targeted Gold Nanoparticles for Enhanced Transgene Expression in Breast Cancer Cells In Vitro
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133 Chitosan-Based Nanoparticles of Targeted Drug Delivery System in Breast Cancer Treatment
Yedi Herdiana,Nasrul Wathoni,Shaharum Shamsuddin,I Made Joni,Muchtaridi Muchtaridi
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134 Nanotechnological Manipulation of Nutraceuticals and Phytochemicals for Healthy Purposes: Established Advantages vs. Still Undefined Risks
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Polymers. 2021; 13(14): 2262
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135 Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells
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Molecules. 2020; 25(19): 4469
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136 Anti-Metastatic Effects of Plant Sap-Derived Extracellular Vesicles in a 3D Microfluidic Cancer Metastasis Model
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Journal of Functional Biomaterials. 2020; 11(3): 49
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137 Effect of UV and Gamma Irradiation Sterilization Processes in the Properties of Different Polymeric Nanoparticles for Biomedical Applications
Y. S. Tapia-Guerrero,M. L. Del Prado-Audelo,F. V. Borbolla-Jiménez,D. M. Giraldo Gomez,I. García-Aguirre,C. A. Colín-Castro,J. A. Morales-González,G. Leyva-Gómez,J. J. Magaña
Materials. 2020; 13(5): 1090
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138 Improving Glycerol Photoreforming Hydrogen Production Over Ag2O-TiO2 Catalysts by Enhanced Colloidal Dispersion Stability
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Frontiers in Chemistry. 2020; 8
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139 Dermal Delivery of Meloxicam Nanosuspensions based Gel: Optimization with Box Behnken Design Experiment Approach: Ex Vivo and In Vivo Study
Inayat B. Pathan, Mahesh Sakhare, Wahid Ambekar, Chitral M. Setty
Nanoscience & Nanotechnology-Asia. 2020; 10(6): 766
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140 Development and Characterization of Oral Nanosuspension Using Esomeprazole Magnesium Trihydrate
Surya Goel, Vijay Agarwal, Monika Sachdeva
Nanoscience & Nanotechnology-Asia. 2020; 10(6): 909
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141

Recent Advances in Oral Nano-Antibiotics for Bacterial Infection Therapy
Ze-Liang Wu,Jun Zhao,Rong Xu
International Journal of Nanomedicine. 2020; Volume 15: 9587
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142 Preparation of Terpenoid-Invasomes with Selective Activity against S. aureus and Characterization by Cryo Transmission Electron Microscopy
Bernhard P. Kaltschmidt,Inga Ennen,Johannes F. W. Greiner,Robin Dietsch,Anant Patel,Barbara Kaltschmidt,Christian Kaltschmidt,Andreas Hütten
Biomedicines. 2020; 8(5): 105
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143 Dextran-Thyme Magnesium-Doped Hydroxyapatite Composite Antimicrobial Coatings
Simona Liliana Iconaru,Mihai Valentin Predoi,Mikael Motelica-Heino,Daniela Predoi,Nicolas Buton,Christelle Megier,George E. Stan
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144 Emerging role of nanosuspensions in drug delivery systems
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145 Study of homogenization on media milling time in preparation of irbesartan nanosuspension and optimization using design of experiments (DoE)
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Future Journal of Pharmaceutical Sciences. 2020; 6(1)
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146 Kaempferia parviflora Nanosuspension Formulation for Scalability and Improvement of Dissolution Profiles and Intestinal Absorption
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AAPS PharmSciTech. 2020; 21(2)
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147 Meloxicam Carrier Systems Having Enhanced Release and Aqueous Wettability Prepared Using Micro-suspensions in Different Liquid Media
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AAPS PharmSciTech. 2020; 21(5)
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148 Development of Polymer and Surfactant Based Naringenin Nanosuspension for Improvement of Stability, Antioxidant, and Antitumour Activity
Shadab Md,Nabil A. Alhakamy,Sohail Akhter,Zuhier A. Y. Awan,Hibah M. Aldawsari,Waleed S. Alharbi,Anzarul Haque,Hira Choudhury,Ponnurengam Malliappan Sivakumar
Journal of Chemistry. 2020; 2020: 1
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149 Effects of preheat treatments on the composition, rheological properties, and physical stability of soybean oil bodies
Liwei Fu,Zhiyong He,Maomao Zeng,Fang Qin,Jie Chen
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150 Formulation development and characterization of Lumefantrine nanosuspension for enhanced antimalarial activity
Ripalkumar Shah,Tejal Soni,Unnati Shah,B. N. Suhagia,M. N. Patel,Tejas Patel,Gamal A. Gabr,Bapi Gorain,Prashant Kesharwani
Journal of Biomaterials Science, Polymer Edition. 2020; : 1
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151 Combustion Characteristics of Suspended Hydrocarbon Fuel Droplets with Various Nanoenergetic Additives
John W. Bennewitz,Alireza Badakhshan,Douglas G. Talley
Combustion Science and Technology. 2020; : 1
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152 Biological synthesis and characterization of silver nanoparticles synthesized from Pometia pinnata and Diospyros discolor Fruits
W Handayani,I Nolia,R M Sundari,C Imawan
IOP Conference Series: Earth and Environmental Science. 2020; 457: 012042
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153 Dispersion state phase diagram of citrate-coated metallic nanoparticles in saline solutions
Sebastian Franco-Ulloa,Giuseppina Tatulli,Sigbjørn Løland Bore,Mauro Moglianetti,Pier Paolo Pompa,Michele Cascella,Marco De Vivo
Nature Communications. 2020; 11(1)
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154 Synthesis of PDA-Mediated Magnetic Bimetallic Nanozyme and Its Application in Immunochromatographic Assay
Xiaocui Lai,Ganggang Zhang,Lifeng Zeng,Xiaoyue Xiao,Juan Peng,Ping Guo,Wei Zhang,Weihua Lai
ACS Applied Materials & Interfaces. 2020;
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155 A novel study on curcumin metal complexes: solubility improvement, bioactivity, and trial burn wound treatment in rats
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New Journal of Chemistry. 2020; 44(30): 13036
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156 Comparative proteomic analysis of serum from nonhuman primates administered BIO 300: a promising radiation countermeasure
Michael Girgis,Yaoxiang Li,Junfeng Ma,Miloslav Sanda,Stephen Y. Wise,Oluseyi O. Fatanmi,Michael D. Kaytor,Amrita K. Cheema,Vijay K. Singh
Scientific Reports. 2020; 10(1)
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157 Formulation Stability of Amphiphilic Poly(?-Glutamic Acid) Nanoparticle and Evaluation of Cardiotoxicity of NPs With Human iPSC-Derived 3D-Cardiomyocyte Tissues
Mayumi Ikeda,Takami Akagi,Masao Nagao,Mitsuru Akashi
Journal of Pharmaceutical Sciences. 2020;
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158 Combining Two Antitubercular Drugs, Clofazimine and 4-Aminosalicylic Acid, in Order to Improve Clofazimine Aqueous Solubility and 4-Aminosalicylic Acid Thermal Stability
Laurie Bodart,Amélie Derlet,Xavier Buol,Tom Leyssens,Nikolay Tumanov,Johan Wouters
Journal of Pharmaceutical Sciences. 2020;
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159 Probing in vitro Release Kinetics of Long-Acting Injectable Nanosuspensions via Flow-NMR Spectroscopy
Nathan D. Rudd,Roy Helmy,Peter G. Dormer,R. Thomas Williamson,W Peter Wuelfing,Paul L. Walsh,Mikhail Reibarkh,William P. Forrest
Molecular Pharmaceutics. 2020;
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160 Molecular Distribution of Indomethacin: Impact on the Precipitation of Glassy Curcumin pH-Responsive Nanoparticles with Enhanced Solubility
Kajal Sharma,Bidisa Das,Prem Felix Siril
Crystal Growth & Design. 2020;
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161 Polymer-Coated Hydroxyapatite Nanocarrier for Double-Stranded RNA Delivery
Zeinah Elhaj Baddar,Dhandapani Gurusamy,Jérôme Laisney,Priyanka Tripathi,Subba R. Palli,Jason M. Unrine
Journal of Agricultural and Food Chemistry. 2020;
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162 Screening of stabilizing agents to optimize flurbiprofen nanosuspensions using experimental design
Ayse Nur Oktay,Sibel Ilbasmis-Tamer,Alptug Karakucuk,Nevin Celebi
Journal of Drug Delivery Science and Technology. 2020; : 101690
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163 Clotrimazole nanosuspensions-loaded hyaluronic acid-catechol/polyvinyl alcohol mucoadhesive films for oral candidiasis treatment
Chaiyakarn Pornpitchanarong,Theerasak Rojanarata,Praneet Opanasopit,Tanasait Ngawhirunpat,Prasopchai Patrojanasophon
Journal of Drug Delivery Science and Technology. 2020; 60: 101927
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164 Fast disintegrating tablet of Doxazosin Mesylate nanosuspension: Preparation and characterization
Al Zahraa G. Al Ashmawy,Noura G. Eissa,Hanan M. El Nahas,Gehan F. Balata
Journal of Drug Delivery Science and Technology. 2020; : 102210
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165 Development of lipid nanoparticles containing the xanthone LEM2 for topical treatment of melanoma
Rafaela Malta,Joana B. Loureiro,Paulo Costa,Emília Sousa,Madalena Pinto,Lucília Saraiva,M. Helena Amaral
Journal of Drug Delivery Science and Technology. 2020; : 102226
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166 Ultra-sensitive detection of commercial vitamin B9 and B12 by graphene nanobuds through inner filter effect
Pavithra V. Ravi,T. Daniel Thangadurai,D. Nataraj
Journal of Photochemistry and Photobiology A: Chemistry. 2020; 400: 112691
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167 Nanotechnology as a Tool to Overcome the Bariatric Surgery Malabsorption
Osaid Almeanazel,Fars Alanazi,Ibrahim Alsarra,Doaa Alshora,Faiyaz Shakeel,Ahmad Almnaizel,Mohammed Alahmed,Ehab Fouad
Saudi Pharmaceutical Journal. 2020;
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168 Formulation of a responsive in vitro digestion wall material, sensory and market analyses for chia seed oil capsules
Juan Sebastián Amaya Cano,Santiago Segura Pacheco,Felipe Salcedo Galán,Isabella Arenas Bustos,Camila Rincón Durán,María Hernández Carrión
Journal of Food Engineering. 2020; : 110460
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169 Biomimetic graphene oxide-cationic multi-shaped gold nanoparticle-hemin hybrid nanozyme: Tuning enhanced catalytic activity for the rapid colorimetric apta-biosensing of amphetamine-type stimulants
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Talanta. 2020; 216: 120990
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170 Self-dispersible nanocrystals of azoxystrobin and cyproconazole with increased efficacy against soilborne fungal pathogens isolated from peanut crops
Boris X. Camiletti,Nahuel M. Camacho,Alejandro J. Paredes,Daniel A. Allemandi,Santiago D. Palma,Nelson R. Grosso
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171 A novel method for in situ encapsulation of curcumin in magnetite-silica core-shell nanocomposites: A multifunctional platform for drug delivery and magnetic hyperthermia therapy
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Journal of Molecular Liquids. 2020; : 114731
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172 Nasal delivery of nanosuspension-based mucoadhesive formulation with improved bioavailability of loratadine: Preparation, characterization, and in vivo evaluation
Areen Alshweiat,IIdikó Csóka,Ferenc Tömösi,Tamás Janáky,Anita Kovács,Róbert Gáspár,Anita Sztojkov-Ivanov,Eszter Ducza,Árpád Márki,Piroska Szabó-Révész,Rita Ambrus
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173 Bile acid transporter-mediated oral drug delivery
Feiyang Deng,You Han Bae
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174 Folate receptor alpha targeted delivery of artemether to breast cancer cells with folate-decorated human serum albumin nanoparticles
Asiye Akbarian,Masoumeh Ebtekar,Nafiseh Pakravan,Zuhair Mohammad Hassan
International Journal of Biological Macromolecules. 2020;
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175 Intracellular protein kinase CK2 inhibition by ferulic acid-based trimodal nanodevice
Sofia Zanin,Simone Molinari,Giorgio Cozza,Massimiliano Magro,Giorgio Fedele,Fabio Vianello,Andrea Venerando
International Journal of Biological Macromolecules. 2020;
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176 Strategy to inhibit effective differentiation of RANKL-induced osteoclasts using vitamin D-conjugated gold nanoparticles
Haram Nah,Donghyun Lee,Jae Seo Lee,Sang Jin Lee,Dong Nyoung Heo,Yeon-Hee Lee,Jae Beum Bang,Yu-Shik Hwang,Ho-Jin Moon,Il Keun Kwon
Applied Surface Science. 2020; 527: 146765
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177 Electrocatalytic nanostructured ferric tannate as platform for enzyme conjugation: Electrochemical determination of phenolic compounds
Massimiliano Magro,Davide Baratella,Veronica Colò,Francesca Vallese,Carlo Nicoletto,Silvia Santagata,Paolo Sambo,Simone Molinari,Gabriella Salviulo,Andrea Venerando,Caroline R. Basso,Valber A. Pedrosa,Fabio Vianello
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178 Enhancement of Curcumin Solubility Using a Novel Solubilizing Polymer Soluplus®
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Journal of Pharmaceutical Innovation. 2020;
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179 Modulating chitosan-PLGA nanoparticle properties to design a co-delivery platform for glioblastoma therapy intended for nose-to-brain route
Natália N. Ferreira,Sara Granja,Fernanda I. Boni,Fabíola G. Prezotti,Leonardo M. B. Ferreira,Beatriz S. F. Cury,Rui M. Reis,Fátima Baltazar,Maria Palmira D. Gremião
Drug Delivery and Translational Research. 2020;
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180 An evaluation of Acacia mearnsii tannin as an aluminum corrosion inhibitor in acid, alkaline, and neutral media
Silvia R. S. Rodrigues,Viviane Dalmoro,João H. Z. Santos
Materials and Corrosion. 2020;
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181 Enhanced Anti-Bacterial Activity of Non-Antibacterial Drug Candesartan Cilexetil by Delivery through Polymeric Micelles
Faheem Kareem,Rubina Abdul-Karim,Rukesh Maharjan,Muhammad Raza Shah,Shabana U. Simjee,Khalid M. Khan,Muhammad Imran Malik
ChemistrySelect. 2020; 5(12): 3605
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182 Electrochemical DNA detection of hepatitis E virus genotype 3 using PbS quantum dot labelling
Duy Ba Ngo,Thanyarat Chaibun,Lee Su Yin,Benchaporn Lertanantawong,Werasak Surareungchai
Analytical and Bioanalytical Chemistry. 2020;
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183 Biotechnological applications of nanostructured hybrids of polyamine carbon quantum dots and iron oxide nanoparticles
A. Venerando,M. Magro,D. Baratella,J. Ugolotti,S. Zanin,O. Malina,R. Zboril,H. Lin,F. Vianello
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184 Babassu mesocarp (Orbignya phalerata Mart) nanoparticle-based biosensors for indirect sulfite detection in industrial juices
Ana Siqueira Siqueira do Nascimento Marreiro Teixeira,Paulo Ronaldo Sousa Teixeira,Emanuel Airton de Oliveira Farias,Brandon Ferraz e Sousa,Kátia Bonfim de Leite Moura Sérvulo,Durcilene Alves da Silva,Carla Eiras
Journal of Solid State Electrochemistry. 2020;
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185 Methods to improve the solubility of therapeutical natural products: a review
Harsha Jain,Naveen Chella
Environmental Chemistry Letters. 2020;
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186 Serratiopeptidase: Insights into the therapeutic applications
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187 Effects of the chemical and physical reaction conditions on the formation of nanocomposites made of starch and stearic acid
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Carbohydrate Polymers. 2020; : 116066
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188 Sonocrystallization: Monitoring and controlling crystallization using ultrasound
Rupanjali Prasad,Sameer V. Dalvi
Chemical Engineering Science. 2020; : 115911
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189 Nano-immobilized flumequine with preserved antibacterial efficacy
Martina Bortoletti,Simone Molinari,Luca Fasolato,Juri Ugolotti,Roberta Tolosi,Andrea Venerando,Giuseppe Radaelli,Daniela Bertotto,Marco De Liguoro,Gabriella Salviulo,Radek Zboril,Fabio Vianello,Massimiliano Magro
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190 Multitherapy magnetic theranostic: Synthesis, characterization and in vitro evaluation of their performance
María Gabriela Montiel Schneider,María Florencia Favatela,Guillermo Arturo Muñoz Medina,Marcela Fernandez van Raap,Verónica Leticia Lassalle
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191 Self-cleaning and air purification performance of Portland cement paste with low dosages of nanodispersed TiO2 coatings
Zixiao Wang,Florent Gauvin,Pan Feng,H.J.H. Brouwers,Qingliang Yu
Construction and Building Materials. 2020; 263: 120558
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192 Role of micellar interface in the synthesis of chitosan nanoparticles formulated by reverse micellar method
M. Soledad Orellano,Gabriel S. Longo,Carina Porporatto,N. Mariano Correa,R. Darío Falcone
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020; : 124876
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193 Toxicity evaluation of nanocrystalline silver-impregnated coated dressing on the life cycle of worm Caenorhabditis elegans
A. Ayech,M.E. Josende,J. Ventura-Lima,C. Ruas,M.A. Gelesky,A. Ale,J. Cazenave,J.M. Galdopórpora,M.F. Desimone,M. Duarte,P. Halicki,D. Ramos,L.M. Carvalho,G.C. Leal,J.M. Monserrat
Ecotoxicology and Environmental Safety. 2020; 197: 110570
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194 Preparation and in vitro / in vivo evaluation of flurbiprofen nanosuspension-based gel for dermal application
Ayse Nur Oktay,Sibel Ilbasmis-Tamer,Sevtap Han,Orhan Uludag,Nevin Celebi
European Journal of Pharmaceutical Sciences. 2020; 155: 105548
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195 Effect of Lyophilization on the Physicochemical and Rheological Properties of Food Grade Liposomes that Encapsulate Rutin
Johana Lopez-Polo,Andrea Silva-Weiss,Begoña Giménez,Plinio Cantero-López,Ricardo Vega,Fernando A. Osorio
Food Research International. 2019; : 108967
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196 Formation and characterization of self-assembled bovine serum albumin nanoparticles as chrysin delivery systems
Joana B. Ferrado,Adrián A. Perez,Flavia F. Visentini,Germán A. Islan,Guillermo R. Castro,Liliana G. Santiago
Colloids and Surfaces B: Biointerfaces. 2019; 173: 43
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197 Biologically safe colloidal suspensions of naked iron oxide nanoparticles for in situ antibiotic suppression
Massimiliano Magro,Davide Baratella,Simone Molinari,Andrea Venerando,Gabriella Salviulo,Giulia Chemello,Ike Olivotto,Giorgio Zoppellaro,Juri Ugolotti,Claudia Aparicio,Jiri Tucek,Anna P. Fifi,Giuseppe Radaelli,Radek Zboril,Fabio Vianello
Colloids and Surfaces B: Biointerfaces. 2019; 181: 102
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198 Agglomeration of iron oxide nanoparticles: pH effect is stronger than amino acid acidity
Anna Godymchuk,Iuliia Papina,Elizaveta Karepina,Denis Kuznetsov,Ivan Lapin,Valery Svetlichnyi
Journal of Nanoparticle Research. 2019; 21(10)
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199 Nanocrystals: A perspective on translational research and clinical studies
Maria Jarvis,Vinu Krishnan,Samir Mitragotri
Bioengineering & Translational Medicine. 2019; 4(1): 5
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200 State of the Art of Pharmaceutical Solid Forms: from Crystal Property Issues to Nanocrystals Formulation
Brice Martin Couillaud,Philippe Espeau,Nathalie Mignet,Yohann Corvis
ChemMedChem. 2019; 14(1): 8
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201 Protective effect of surface-modified berberine nanoparticles against LPS-induced neurodegenerative changes: a preclinical study
Salma A. Soudi,Mohamed I. Nounou,Salah A. Sheweita,Doaa A. Ghareeb,Layla K. Younis,Labiba K. El-Khordagui
Drug Delivery and Translational Research. 2019;
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202 Annona muricata assisted biogenic synthesis of silver nanoparticles regulates cell cycle arrest in NSCLC cell lines
Shanmugapriya Meenakshisundaram,Varunkumar Krishnamoorthy,Yogeswaran Jagadeesan,Ravikumar Vilwanathan,Anandaraj Balaiah
Bioorganic Chemistry. 2019; : 103451
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203 Development of methotrexate loaded fucoidan/chitosan nanoparticles with anti-inflammatory potential and enhanced skin permeation
Ana Isabel Barbosa,Sofia A. Costa Lima,Salette Reis
International Journal of Biological Macromolecules. 2019; 124: 1115
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204 Emulsions prepared by ultrahigh methoxylated pectin through the phase inversion method
Xiao Hua,Ping Ding,Mingming Wang,Kunrui Chi,Ruijin Yang,Yanping Cao
International Journal of Biological Macromolecules. 2019; 128: 167
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205 Encapsulation and sustained release properties of watermelon flavor and its characteristic aroma compounds from ?-cyclodextrin inclusion complexes
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206 The Characterization and Stability of the Soy Protein Isolate / 1-Octacosanol Nanocomplex
Dongze Li,Xiaojing Li,Gangcheng Wu,Peiyan Li,Hui Zhang,Xiguang Qi,Li Wang,Haifeng Qian
Food Chemistry. 2019;
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207 Enhancement of thermal conductivity of titanium dioxide nanoparticle suspensions by femtosecond laser irradiation
Jeonghong Ha,Hyeonjin Jeon,Tae-Youl Choi,Dongsik Kim
International Journal of Heat and Mass Transfer. 2019; 133: 662
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208 Treatment for chemical burning using liquid crystalline nanoparticles as an ophthalmic delivery system for pirfenidone
Rummenigge Oliveira Silva,Bruna Lopes da Costa,Flavia Rodrigues da Silva,Carolina Nunes da Silva,Mayara Brandão de Paiva,Lays Fernanda Nunes Dourado,Ângelo Malachias,Adriano Antunes de Souza Araújo,Paula Santos Nunes,Armando Silva-Cunha
International Journal of Pharmaceutics. 2019; 568: 118466
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209 Molecular simulation driven experiment for formulation of fixed dose combination of Darunavir and ritonavir as anti-HIV nanosuspension
Chetan Hasmukh Mehta,Reema Narayan,Gururaj Aithal,Sudharsan Pandiyan,Pritesh Bhat,Swapnil Dengale,Abhishek Shah,Usha Yogendra Nayak,Sanjay Garg
Journal of Molecular Liquids. 2019; : 111469
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210 Synergistic assembly of peptide amphiphiles with varying polarities for encapsulation of Camptothecin
Steffie Mano,Yen Wah Tong
Materialia. 2019; : 100516
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211 Engineered polymeric iron oxide nanoparticles as potential drug carrier for targeted delivery of docetaxel to breast cancer cells
Jnanranjan Panda,Bhabani Sankar Satapathy,Sumit Majumder,Ratan Sarkar,Biswajit Mukherjee,Bharati Tudu
Journal of Magnetism and Magnetic Materials. 2019; 485: 165
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212 Development of a topical applied functional food formulation: Adlay bran oil nanoemulgel
Wen-Chang Chang,Yin-Ting Hu,Qingrong Huang,Shu-Chen Hsieh,Yuwen Ting
LWT. 2019; : 108619
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213 Production of dasatinib encapsulated spray-dried poly (lactic-co-glycolic acid) particles
Rajat Chauhan,Rayeanne Balgemann,Christopher Greb,Betty M. Nunn,Shunichiro Ueda,Hidetaka Noma,Kevin McDonald,Henry J. Kaplan,Shigeo Tamiya,Martin G. OæToole
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214 Moringa oleifera leaf extract–loaded phytophospholipid complex for potential application as wound dressing
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215 Advances in the Study of Cerium Oxide Nanoparticle: New Insights into Anti-amyloidogenic Activity
Katarina Siposova,Veronika Huntosova,Yulia Shlapa,Lenka Lenkavska,Mariana Macajova,Anatolii Grigorievich Belous,Andrey Musatov
ACS Applied Bio Materials. 2019;
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216 Covalent Poly(Lactic Acid) Nanoparticles for the Sustained Delivery of Naloxone
Andrew J. Kassick,Heather N. Allen,Saigopalakrishna Saileelaprasad Yerneni,Fathima Pary,Marina Kovaliov,Cooper Cheng,Marco Pravetoni,Nestor D. Tomycz,Donald M. Whiting,Toby L. Nelson,Michael Geoffery Feasel,Phil Gordon Campbell,Benedict Kolber,Saadyah E. Averick
ACS Applied Bio Materials. 2019;
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217 Interaction of Phosphate with Lithium Cobalt Oxide Nanoparticles: A Combined Spectroscopic and Calorimetric Study
Elizabeth D. Laudadio,Poorandokht Ilani-Kashkouli,Curtis M. Green,Nadine J. Kabengi,Robert J. Hamers
Langmuir. 2019;
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218 Nano-TiO2 stability in medium and size as important factors of toxicity in macrophage-like cells
T. Brzicova,J. Sikorova,A. Milcova,K. Vrbova,J. Klema,P. Pikal,Z. Lubovska,V. Philimonenko,F. Franco,J. Topinka,P. Rossner
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219 Preparation of smectic itraconazole nanoparticles with tunable periodic order using microfluidics-based anti-solvent precipitation
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220 Mechanical and Thermal Behavior of Canola Protein Isolate Films As Improved by Cellulose Nanocrystals
Alex Osorio-Ruiz,Roberto J. Avena-Bustillos,Bor-Sen Chiou,Francisco Rodríguez-González,Alma-Leticia Martinez-Ayala
ACS Omega. 2019;
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221 Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome
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222 Synthesis of natural nanopesticides with the origin of Eucalyptus globulus extract for pest control
Zohreh Khoshraftar,Ali Akbar Safekordi,Ali Shamel,Mohammad Zaefizadeh
Green Chemistry Letters and Reviews. 2019; 12(3): 286
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223 Multiple linear regression applied to predicting droplet size of complex perfluorocarbon nanoemulsions for biomedical applications
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Pharmaceutical Development and Technology. 2019; : 1
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224 Development of nanodispersion-based sildenafil metered-dose inhalers stabilized by poloxamer 188: a potential candidate for the treatment of pulmonary arterial hypertension
Charisopon Chunhachaichana,Rutthapol Sritharadol,Somchai Sawatdee,Paul Wan Sia Heng,Teerapol Srichana
Pharmaceutical Development and Technology. 2019; : 1
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225 Synergy of the flow behaviour and disperse phase of cellulose nanoparticles in enhancing oil recovery at reservoir condition
Augustine Agi,Radzuan Junin,Agus Arsad,Azza Abbas,Afeez Gbadamosi,Nur Bashirah Azli,Jeffrey Oseh,Kalisadhan Mukherjee
PLOS ONE. 2019; 14(9): e0220778
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226 Nano-antimicrobials: A New Paradigm for Combating Mycobacterial Resistance
Prasad Minakshi,Mayukh Ghosh,Basanti Brar,Rajesh Kumar,Upendra P. Lambe,Koushlesh Ranjan,Jinu Manoj,Gaya Prasad
Current Pharmaceutical Design. 2019; 25(13): 1554
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227 Development of Universal Formulation with Superior Re-dispersion Using Nanocrystal Approach with Simultaneous Identification of API Physicochemical Properties
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Chemical and Pharmaceutical Bulletin. 2019; 67(10): 1050
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228 Fabrication and Evaluation of Lambda-Cyhalothrin Nanosuspension by One-Step Melt Emulsification Technique
Chunxin Wang,Bo Cui,Liang Guo,Anqi Wang,Xiang Zhao,Yan Wang,Changjiao Sun,Zhanghua Zeng,Heng Zhi,Hongyan Chen,Guoqiang Liu,Haixin Cui
Nanomaterials. 2019; 9(2): 145
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229 Biosynthesis of Silver Nanoparticles Mediated by Extracellular Pigment from Talaromyces purpurogenus and Their Biomedical Applications
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Nanomaterials. 2019; 9(7): 1042
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230 Development of Novel EE/Alginate Polyelectrolyte Complex Nanoparticles for Lysozyme Delivery: Physicochemical Properties and In Vitro Safety
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Pharmaceutics. 2019; 11(3): 103
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231 Development and Characterization of Liposomal Formulations Containing Phytosterols Extracted from Canola Oil Deodorizer Distillate along with Tocopherols as Food Additives
Asmita Poudel,George Gachumi,Kishor M. Wasan,Zafer Dallal Bashi,Anas El-Aneed,Ildiko Badea
Pharmaceutics. 2019; 11(4): 185
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232 Advanced Formulation Approaches for Ocular Drug Delivery: State-Of-The-Art and Recent Patents
Eliana B. Souto,João Dias-Ferreira,Ana López-Machado,Miren Ettcheto,Amanda Cano,Antonio Camins Espuny,Marta Espina,Maria Luisa Garcia,Elena Sánchez-López
Pharmaceutics. 2019; 11(9): 460
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233 Tunable Composition of Dynamic Non-Viral Vectors over the DNA Polyplex Formation and Nucleic Acid Transfection
Lilia Clima,Bogdan Florin Craciun,Gabriela Gavril,Mariana Pinteala
Polymers. 2019; 11(8): 1313
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234 Gold-coated plant virus as computed tomography imaging contrast agent
Alaa A A Aljabali,Mazhar S Al Zoubi,Khalid M Al-Batanyeh,Ali Al-Radaideh,Mohammad A Obeid,Abeer Al Sharabi,Walhan Alshaer,Bayan AbuFares,Tasnim Al-Zanati,Murtaza M Tambuwala,Naveed Akbar,David J Evans
Beilstein Journal of Nanotechnology. 2019; 10: 1983
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235 Injectable Chitosan Scaffolds with Calcium ß-Glycerophosphate as the Only Neutralizing Agent
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236 Effect of Physiochemical Factors and Peanut Varieties on the Charge Stability of Oil Bodies Extracted by Aqueous Method
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237 DEVELOPMENT, VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF TENOFOVIR DISPROXIL FUMARATE, EMTRICITABINE AND RILPIVIRINE HYDROCHLORIDE IN BULK, FORMULATION AND USED IN NANOSUSPENSION
K Vijaya Sri, M. Madhuri, V. Anusha, V.R.K. Siresha
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238 Synergistic Antioxidant Capacity of Chitosan Nanoparticles and Lycopene Against Aging Hepatotoxicity Induced by D-galactose in Male Rats
Rasha A. Al-Eisa
International Journal of Pharmacology. 2018; 14(6): 811
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239 Topical delivery of ebselen encapsulated in biopolymeric nanocapsules: drug repurposing enhanced antifungal activity
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Nanomedicine. 2018; 13(10): 1139
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240 Liposome: composition, characterisation, preparation, and recent innovation in clinical applications
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241 A quality-by-design study to develop Nifedipine nanosuspension: examining the relative impact of formulation variables, wet media milling process parameters and excipient variability on drug product quality attributes
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Drug Development and Industrial Pharmacy. 2018; : 1
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242 Deep insight into PEGylation of bioadhesive chitosan nanoparticles: Sensitivity study for the key parameters through artificial neural network model
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ACS Applied Materials & Interfaces. 2018;
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243 FSE–Ag complex NS: preparation and evaluation of antibacterial activity
Rahul S. Kalhapure,Pradeep Bolla,Delfina C. Dominguez,Amit Dahal,Sai H.S. Boddu,Jwala Renukuntla
IET Nanobiotechnology. 2018;
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244 Impact of Phosphate Adsorption on Complex Cobalt Oxide Nanoparticle Dispersibility in Aqueous Media
Elizabeth D. Laudadio,Joseph W. Bennett,Curtis M. Green,Sara E. Mason,Robert J. Hamers
Environmental Science & Technology. 2018;
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245 Effects of ZnO nanoparticles in the Caspian roach ( Rutilus rutilus caspicus )
K. Khosravi-Katuli,G. Lofrano,H. Pak Nezhad,A. Giorgio,M. Guida,F. Aliberti,A. Siciliano,M. Carotenuto,E. Galdiero,E. Rahimi,G. Libralato
Science of The Total Environment. 2018; 626: 30
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246 Development of Fluorometholone-loaded PLGA Nanoparticles for Treatment of Inflammatory Disorders of Anterior and Posterior Segments of the Eye
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International Journal of Pharmaceutics. 2018;
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247 Carcinoembryonic antigen-targeted nanoparticles potentiate the delivery of anticancer drugs to colorectal cancer cells
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248 Nanosuspension of quercetin: preparation, characterization and effects against Aedes aegypti larvae
Leticie Zulmira da Silva Pessoa,Jonatas Lobato Duarte,Ricardo Marcelo dos Anjos Ferreira,Anna Eliza Maciel de Faria Motta Oliveira,Rodrigo Alves Soares Cruz,Silvia Maria Mathes Faustino,José Carlos Tavares Carvalho,Caio Pinho Fernandes,Raimundo Nonato Picanço Souto,Raquel Silva Araújo
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249 Release kinetics and cell viability of ibuprofen nanocrystals produced by melt-emulsification
A.R. Fernandes,J. Dias-Ferreira,C. Cabral,M.L. Garcia,E.B. Souto
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250 GABA B receptor ligand-directed trimethyl chitosan/tripolyphosphate nanoparticles and their pMDI formulation for survivin siRNA pulmonary delivery
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251 Effects of different emulsifiers on the bonding performance, freeze-thaw stability and retrogradation behavior of the resulting high amylose starch-based wood adhesive
Zia-ud- Din,Hanguo Xiong,Zhenjiong Wang,Lei Chen,Ikram Ullah,Peng Fei,Naveed Ahmad
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252 Influencing factors on the stabilization of colloid biliquid aphrons and its effectiveness used for density modification of DNAPLs in subsurface environment
Chaoge Yang,Jun Dong,Liming Ren,Ye Fan,Bowen Li,Wenhua Hu
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253 Zeaxanthin nanoencapsulation with Opuntia monacantha mucilage as structuring material: Characterization and stability evaluation under different temperatures
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254 Enhancing the recovery of oilseed rape seed oil bodies (oleosomes) using bicarbonate-based soaking and grinding media
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Food Chemistry. 2018; 241: 419
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255 Design and characterization of loratadine nanosuspension prepared by ultrasonic-assisted precipitation
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European Journal of Pharmaceutical Sciences. 2018;
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256 Octacosanol educes physico-chemical attributes, release and bioavailability as modified nanocrystals
Surashree Sen Gupta,Mahua Ghosh
European Journal of Pharmaceutics and Biopharmaceutics. 2017; 119: 201
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257 Encapsulation of E. coli in biomimetic and Fe3O4-doped hydrogel: structural and viability analyses
Sabella Jelimo Kiprono,Muhammad Wajid Ullah,Guang Yang
Applied Microbiology and Biotechnology. 2017;
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258 Effects of different combinations of nanocrystallization technologies on avanafil nanoparticles: in vitro, in vivo and stability evaluation
Kareem AbuBakr Soliman,Howida Kamal Ibrahim,Mahmoud Mohammed Ghorab
International Journal of Pharmaceutics. 2017; 517(1-2): 148
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259 Nanosystem trends in drug delivery using quality-by-design concept
Jing Li,Yanjiang Qiao,Zhisheng Wu
Journal of Controlled Release. 2017; 256: 9
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260 Role of enzymatic free radical scavengers in management of oxidative stress in autoimmune disorders
Shikha Srivastava,Deependra Singh,Satish Patel,Manju R. Singh
International Journal of Biological Macromolecules. 2017; 101: 502
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261 Preparation and evaluation of BSA-based hydrosol nanoparticles cross-linked with genipin for oral administration of poorly water-soluble curcumin
Narges Shahgholian,Ghadir Rajabzadeh,Bizhan Malaekeh-Nikouei
International Journal of Biological Macromolecules. 2017;
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262 Genotoxic effects in transformed and non-transformed human breast cell lines after exposure to silver nanoparticles in combination with aluminium chloride, butylparaben or di- n -butylphthalate
J. Roszak,K. Domeradzka-Gajda,A. Smok-Pieniazek,A. Kozajda,S. Spryszynska,J. Grobelny,E. Tomaszewska,K. Ranoszek-Soliwoda,M. Cieslak,D. Puchowicz,M. Stepnik
Toxicology in Vitro. 2017; 45: 181
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263 Palmitoylethanolamide sub-micronization using fast precipitation followed by supercritical fluids extraction
R. Campardelli,E. Oleandro,M. Scognamiglio,G. Della Porta,E. Reverchon
Powder Technology. 2017; 305: 217
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264 Reducible PEG-POD/DNA Nanoparticles for Gene Transfer In Vitro and In Vivo: Application in a Mouse Model of Age-Related Macular Degeneration
Bhanu Chandar Dasari,Siobhan M. Cashman,Rajendra Kumar-Singh
Molecular Therapy - Nucleic Acids. 2017; 8: 77
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265 Novel technologies to enhance solubility of food-derived bioactive compounds: A review
Neeraja Recharla,Muhammad Riaz,Sanghoon Ko,Sungkwon Park
Journal of Functional Foods. 2017; 39: 63
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266 Maintaining Supersaturation of Active Pharmaceutical Ingredient Solutions with Biologically Relevant Bile Salts
Jennifer Lu,James D. Ormes,Michael Lowinger,Amanda K. P. Mann,Wei Xu,James D. Litster,Lynne S. Taylor
Crystal Growth & Design. 2017; 17(5): 2782
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267 Dispersion enhancing effect of sonochemically functionalized graphene oxide for catalysing antioxidant efficacy of curcumin
Shrikant S. Maktedar,Parth Malik,Gopal Avashthi,Man Singh
Ultrasonics Sonochemistry. 2017; 39: 208
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268 Design and Synthesis of ?- and d-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity
Jennifer E. Davoren,Michelle Garnsey,Betty Pettersen,Michael A. Brodney,Jeremy R. Edgerton,Jean Philippe Fortin,Sarah Grimwood,Antony R. Harris,Stephen Jenkinson,Terry P. Kenakin,John T. Lazzaro,Che-Wah Lee,Susan M. Lotarski,Lisa Nottebaum,Steven V. OæNeil,Michael Popiolek,Simeon Ramsey,Stefanus J. Steyn,Catherine A. Thorn,Lei Zhang,Damien Webb
Journal of Medicinal Chemistry. 2017;
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269 Silver nanoparticles from Prosopis glandulosa and their potential application as biocontrol of Acinetobacter calcoaceticus and Bacillus cereus
Ali Abdelmoteleb,Benjamín Valdez-Salas,Carlos Ceceña-Duran,Olivia Tzintzun-Camacho,Federico Gutiérrez-Miceli,Onecimo Grimaldo-Juarez,Daniel González-Mendoza
Chemical Speciation & Bioavailability. 2017; 29(1): 1
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270 High drug payload curcumin nanosuspensions stabilized by mPEG-DSPE and SPC: in vitro and in vivo evaluation
Jingyi Hong,Yingying Liu,Yao Xiao,Xiaofeng Yang,Wenjing Su,Mingzhu Zhang,Yonghong Liao,Haixue Kuang,Xiangtao Wang
Drug Delivery. 2017; 24(1): 109
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271 Nano-formulations for Ophthalmic Treatments
Rajesh N
Archives of Pharmacy and Pharmaceutical Sciences. 2017; 1(1): 028
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272 Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules
Sonam Choudhary,Lokesh Gupta,Sarita Rani,Kaushalkumar Dave,Umesh Gupta
Frontiers in Pharmacology. 2017; 8
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273 Modeling the Viscosity of Concentrated Nanoemulsions and Nanosuspensions
Rajinder Pal
Fluids. 2016; 1(2): 11
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274 A recent trend of drug-nanoparticles in suspension for the application in drug delivery
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Nanomedicine. 2016;
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275 Comparison of Different Nanosuspensions as Potential Ophthalmic Delivery Systems for Ketotifen Fumarate
Saieede Soltani,Parvin Zakeri-Milani,Mohammad Barzegar-Jalali,Mitra Jelvehgari
Advanced Pharmaceutical Bulletin. 2016; 6(3): 345
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276 Size and Charge Stability of Oil Bodies from Peanut
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Journal of Chemistry. 2016; 2016: 1
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277 Nanoencapsulation, Nano-guard for Pesticides: A New Window for Safe Application
Md. Nuruzzaman,Mohammad Mahmudur Rahman,Yanju Liu,Ravi Naidu
Journal of Agricultural and Food Chemistry. 2016;
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278 DLS and zeta potential – What they are and what they are not?
Sourav Bhattacharjee
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279 Green Synthesis of Silver Nanoparticles Using Pluchea sericea a Native Plants from Baja California, Mexico and their Potential Application as Antimicrobials
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Iranian Journal of Science and Technology, Transactions A: Science. 2016;
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280 Water soluble nanocurcumin extracted from turmeric challenging the microflora from human oral cavity
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Food Chemistry. 2016; 211: 903
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281 Fine-tuned PEGylation of chitosan to maintain optimal siRNA-nanoplex bioactivity
Andra Gutoaia,Liane Schuster,Simona Margutti,Stefan Laufer,Burkhard Schlosshauer,Rumen Krastev,Dieter Stoll,Hanna Hartmann
Carbohydrate Polymers. 2016; 143: 25
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282 Particle size control and the interactions between drug and stabilizers in an amorphous nanosuspension system
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283 Preparation and in vitro–in vivo evaluation of teniposide nanosuspensions
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284 Novel self-nanoemulsifying self-nanosuspension (SNESNS) for enhancing oral bioavailability of diacerein: Simultaneous portal blood absorption and lymphatic delivery
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International Journal of Pharmaceutics. 2015; 490(1-2): 146
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285 Impact of Surfactants on the Crystallization of Aqueous Suspensions of Celecoxib Amorphous Solid Dispersion Spray Dried Particles
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286 Optimization of Cefixime Nanosuspension to Improve Drug Dissolution
Elham Ghasemian,Behnaz Rezaeian,Samaneh Alaei,Alireza Vatanara,Vahid Ramezani
Pharmaceutical Sciences. 2015; 21(3): 136
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287 Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats
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288 Amorphous isradipine nanosuspension by the sonoprecipitation method
Thao Truong-Dinh Tran,Phuong Ha-Lien Tran,Minh Ngoc Uyen Nguyen,Khanh Thi My Tran,Minh Nguyet Pham,Phuc Cao Tran,Toi Van Vo
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289 Investigation of a nanosuspension stabilized by Soluplus® to improve bioavailability
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International Journal of Pharmaceutics. 2014;
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290 a-Tocopherol nanosuspensions produced using a supercritical assisted process
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291 Fabrication of spontaneous emulsifying powders for improved dissolution of poorly water-soluble drugs
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Powder Technology. 2014;
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292 A high-drug-loading self-assembled nanoemulsion enhances the oral absorption of probucol in rats
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Journal of Pharmaceutical Sciences. 2013; 102(4): 1301
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293 Advances in nanotechnology for diagnosis and treatment of tuberculosis
Shelza Banyal,Parth Malik,Hardeep S. Tuli,Tapan K. Mukherjee
Current Opinion in Pulmonary Medicine. 2013; 19(3): 289
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294 Transition from Planar to Nonplanar Hydrogen Bond Networks in the Solvation of Aromatic Dimers: Propofol2-(H2O)2–4
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295 Hollow superparamagnetic iron oxide nanoshells as a hydrophobic anticancer drug carrier: intracelluar pH-dependent drug release and enhanced cytotoxicity
Xiao-Ming Zhu,Jing Yuan,Ken Cham-Fai Leung,Siu-Fung Lee,Kathy W. Y. Sham,Christopher H. K. Cheng,Doris W. T. Au,Gao-Jun Teng,Anil T. Ahuja,Yi-Xiang J. Wang
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296 Hollow superparamagnetic iron oxide nanoshells as a hydrophobic anticancer drug carrier: intracelluar pH-dependent drug release and enhanced cytotoxicity
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Journal Cover:Nanoscale, 2012, Advance Article Nanoscale. 2012;
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297 NANOTECHNOLOGY: A NEW APPROACH FOR OCULAR DRUG DELIVERY SYSTEM
MEETALI MUDGIL, NIDHI GUPTA, MANJU NAGPAL, PRAVIN PAWAR
International Journal of Pharmacy and Pharmaceutical Sciences. 2012; 4(2)
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