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ORIGINAL ARTICLE
Year : 2010  |  Volume : 1  |  Issue : 4  |  Page : 415-418

Analgesic and antipyretic activities of Momordica charantia linn. fruits


Shree Leuva Patel Trust Pharmacy Mahila College, Amreli, Gujarat, India

Correspondence Address:
Roshan Patel
Department of Pharmacognosy, Shree Leuva Patel Trust Pharmacy Mahila College, Patel Sankul, Chakkargadh Road, Amreli - 365 601, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0110-5558.76441

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Plant Momordica charantia Linn. belongs to family Cucurbitaceae. It is known as bitter gourd in English and karela in Hindi. Earlier claims show that the plant is used in stomachic ailments as a carminative tonic; as an antipyretic and antidiabetic agent; and in rheumatoid arthritis and gout. The fruit has been claimed to contain charantin, steroidal saponin, momordium, carbohydrates, mineral matters, ascorbic acid, alkaloids, glucosides, etc. The ethanolic extract of the fruit showed the presence of alkaloids, tannins, glycosides, steroids, proteins, and carbohydrates. The present study was carried out using acetic acid-induced writhing and tail-immersion tests in mice, while yeast-induced pyrexia in rats. The ethanolic extracts (250 and 500 mg/kg, po.) showed an analgesic and antipyretic effect, which was significantly higher than that in the control rats. The observed pharmacological activities provide the scientific basis to support traditional claims as well as explore some new and promising leads.


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