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Year : 2010  |  Volume : 1  |  Issue : 4  |  Page : 406-414

Detachment and recovery index: A new parameter measuring powder compressibility

Department of Research and Development, Chemical Industries Development (CID), Assiut Branch, Assiut, Egypt

Correspondence Address:
Department of Pharmaceutics and Pharmceutical Technology, College of Pharmacy, Al-Jouf University, Sakaka, Al-Jouf, Kingdom of Saudi Arabia

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0110-5558.76440

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This investigation introduces a simple and reliable approach to measure the compressibility of some direct compression excipients in tablet systems made from compressible components. The claim made here is that: the total reduction, ΔL T , in the thickness of a tablet batch due to compression at a confined machine settings is the integral sum of small reductions generated by the compressible components in the batch. The reduction value, ΔL E , generated by a single or a blend of excipients in a batch could be calculated and was found to correlate to its concentration, C, by the relation: ΔL E =A E.C x. The constants AE and x concern the reduction tendency, RT, of the excipient particles due to compression, and detachment and recovery index (DRI), respectively. Some physicomechanical parameters characterizing the compression behavior of an excipient in a tablet batch could be determined and were found to be functions of the determine DRI of the excipient in the batch.

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