Home  |  About JAPTR |  Editorial board  |  Search |  Ahead of print  |  Current issue  |  Archives |  Submit article  |  Instructions  |  Subscribe  |  Advertise  |  Contacts  |Login 
Users Online: 327   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
     
ORIGINAL ARTICLE
Year : 2010  |  Volume : 1  |  Issue : 4  |  Page : 396-400

Synthesis and biological evaluation of formazan derivatives


1 Department of Medicinal Chemistry, Himalayan Pharmacy Institute, E. Sikkim, India
2 Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Correspondence Address:
Gurusamy Mariappan
Department of Medicinal Chemistry, Himalayan Pharmacy Institute, E. Sikkim-737136
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0110-5558.76438

Rights and Permissions

The formazan derivatives (FM1-FM5) were synthesized by the reaction of benzaldehyde phenylhydrazone with substituted aromatic and hetero aromatic amines. The structures of the synthesized compounds were then elucidated using UV, IR, 1 H NMR and mass spectral data. The synthesized derivatives were screened for anticonvulsant, antibacterial and antiviral activities. All the compounds showed remarkable antibacterial activity at 250 μg/ml, but FM4 and FM3 did not show any inhibition on Staphylococcus aureus and Vibriocholera, respectively. All the compounds showed significant anticonvulsant effect at 100 mg/kg p.o. and the experimental data were statistically significant at P<0.001 level. But none of the compounds was effective against Japanese encephalitis virus.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed6800    
    Printed276    
    Emailed0    
    PDF Downloaded566    
    Comments [Add]    
    Cited by others 33    

Recommend this journal