Home  |  About JAPTR |  Editorial board  |  Search |  Ahead of print  |  Current issue  |  Archives |  Submit article  |  Instructions  |  Subscribe  |  Advertise  |  Contacts  |Login 
Users Online: 172   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size

 Table of Contents  
Year : 2010  |  Volume : 1  |  Issue : 4  |  Page : 381-387  

Mucoadhesive drug delivery system: An overview

1 Department of Pharmaceutics, Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh - 508 001, India
2 Faculty of Technology, Osmania University, Hyderabad, Andhra Pradesh - 500 013, India

Date of Web Publication3-Feb-2011

Correspondence Address:
Bindu M Boddupalli
Department of Pharmaceutics, Nalanda College of Pharmacy, Cherlapalli, Nalgonda, Andhra Pradesh - 508 001
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0110-5558.76436

Rights and Permissions

Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or those which have maximum absorption in gastrointestinal tract (GIT) require increased duration of stay in GIT. Thus, mucoadhesive dosage forms are advantageous in increasing the drug plasma concentrations and also therapeutic activity. In this regard, this review covers the areas of mechanisms and theories of mucoadhesion, factors influencing the mucoadhesive devices and also various mucoadhesive dosage forms.

Keywords: Mucoadhesion, theories, mucoadhesive dosage forms

How to cite this article:
Boddupalli BM, Mohammed ZN, Nath RA, Banji D. Mucoadhesive drug delivery system: An overview. J Adv Pharm Technol Res 2010;1:381-7

How to cite this URL:
Boddupalli BM, Mohammed ZN, Nath RA, Banji D. Mucoadhesive drug delivery system: An overview. J Adv Pharm Technol Res [serial online] 2010 [cited 2023 Feb 2];1:381-7. Available from: https://www.japtr.org/text.asp?2010/1/4/381/76436

   Introduction Top

Since the early 1980s, the concept of mucoadhesion has gained considerable interest in pharmaceutical technology. [1] Adhesion can be defined as the bond produced by contact between a pressure sensitive adhesive and a surface. The American Society of Testing and Materials has defined it as the state in which two surfaces are held together by interfacial forces, which may consist of valence forces, interlocking action or both. Mucoadhesive drug delivery systems prolong the residence time of the dosage form at the site of application or absorption. They facilitate an intimate contact of the dosage form with the underlying absorption surface and thus improve the therapeutic performance of the drug. In recent years, many such mucoadhesive drug delivery systems have been developed for oral, buccal, nasal, rectal and vaginal routes for both systemic and local effects. [2]

Dosage forms designed for mucoadhesive drug delivery should be small and flexible enough to be acceptable for patients and should not cause irritation. Other desired characteristics of a mucoadhesive dosage form include high drug loading capacity, controlled drug release (preferably unidirectional release), good mucoadhesive properties, smooth surface, tastelessness, and convenient application. Erodible formulations can be beneficial because they do not require system retrieval at the end of desired dosing interval. A number of relevant mucoadhesive dosage forms have been developed for a variety of drugs. Several peptides, including thyrotropin-releasing hormone (TRH), insulin, octreotide, leuprolide, and oxytocin, have been delivered via the mucosal route, albeit with relatively low bioavailability (0.1-5%), [3] owing to their hydrophilicity and large molecular weight, as well as the inherent permeation and enzymatic barriers of the mucosa.

The development of sustain release dosage form can achieve the aim of releasing the drug slowly for a long period but this is not sufficient to get sustained therapeutic effect. They may be cleared from the site of absorption before emptying the drug content. Instead, the mucoadhesive dosage form will serve both the purposes of sustain release and presence of dosage form at the site of absorption. In this regard, our review is high lighting few aspects of mucoadhesive drug delivery systems.

   Advantages of Mucoadhesive Drug Delivery System Top

Mucoadhesive delivery systems offer several advantages over other oral controlled release systems by virtue of prolongation of residence time of drug in gastrointestinal tract (GIT).

  • Targeting and localization of the dosage form at a specific site.
  • Also, the mucoadhesive systems are known to provide intimate contact between dosage form and the absorptive mucosa, resulting in high drug flux at the absorbing tissue. [4]

Mucus Membranes

Mucus membranes (mucosae) [Figure 1] are the moist surfaces lining the walls of various body cavities such as the gastrointestinal and respiratory tracts. They consist of a connective tissue layer (the lamina propria) above which is an epithelial layer, the surface of which is made moist usually by the presence of a mucus layer. The epithelia may be either single layered (e.g. the stomach, small and large intestines and bronchi) or multilayered/stratified (e.g. in the esophagus, vagina and cornea). The former contain goblet cells which secrete mucus directly onto the epithelial surfaces; the latter contain, or are adjacent to tissues containing, specialized glands such as salivary glands that secrete mucus onto the epithelial surface. Mucus is present either as a gel layer adherent to the mucosal surface or as a luminal soluble or suspended form. The major components of all mucus gels are mucin glycoproteins, lipids, inorganic salts and water, the latter accounting for more than 95% of their weight, making them a highly hydrated system. [5] The major functions of mucus are that of protection and lubrication.
Figure 1 :Mucus membrane structure

Click here to view

Mechanisms of Mucoadhesion

The mechanism of mucoadhesion is generally divided into two steps: the contact stage and the consolidation stage [Figure 2]. The first stage is characterized by the contact between the mucoadhesive and the mucus membrane, with spreading and swelling of the formulation, initiating its deep contact with the mucus layer. [6]

In the consolidation step [Figure 2], the mucoadhesive materials are activated by the presence of moisture. Moisture plasticizes the system, allowing the mucoadhesive molecules to break free and to link up by weak van der Waals and hydrogen bonds. Essentially, there are two theories explaining the consolidation step: the diffusion theory and the dehydration theory. According to the diffusion theory, the mucoadhesive molecules and the glycoproteins of the mucus mutually interact by means of interpenetration of their chains and the building of secondary bonds. For this to take place, the mucoadhesive device has features favoring both chemical and mechanical interactions. For example, molecules with hydrogen bond building groups (-OH, -COOH), an anionic surface charge, high molecular weight, flexible chains and surface-active properties, which help in spreading throughout the mucus layer, can present mucoadhesive properties. [6]
Figure 2 :The process of contact and consolidation

Click here to view

Mucoadhesion Theories

Mucoadhesion is a complex process and numerous theories have been proposed to explain the mechanisms involved. These theories include mechanical interlocking, electrostatic, diffusion interpenetration, adsorption and fracture processes.

Wetting theory

The wetting theory applies to liquid systems which present affinity to the surface in order to spread over it. This affinity can be found by using measuring techniques such as the contact angle. The general rule states that the lower the contact angle, the greater is the affinity [Figure 3]. The contact angle should be equal or close to zero to provide adequate spreadability. The spreadability coefficient, S AB0, can be calculated from the difference between the surface energies γB and γA and the interfacial energy γAB, as indicated in the equation given below. [5] This theory explains the importance of contact angle and reduction of surface and interfacial energies to achieve good amount of mucoadhesion.
Figure 3 :Influence of contact angle on mucoadhesion

Click here to view

S AB = γB - γA - γAB

Diffusion theory

Diffusion theory describes the interpenetration of both polymer and mucin chains to a sufficient depth to create a semi-permanent adhesive bond [Figure 4]. It is believed that the adhesion force increases with the degree of penetration of the polymer chains. This penetration rate depends on the diffusion coefficient, flexibility and nature of the mucoadhesive chains, mobility and contact time. According to the literature, the depth of interpenetration required to produce an efficient bioadhesive bond lies in the range 0.2-0.5 μm. This interpenetration depth of polymer and mucin chains can be estimated by the following equation: [5]
Figure 4 :Secondary interaction between mucoadhesive device and of mucus

Click here to view

l = (tD b)½

where t is the contact time and D b is the diffusion coefficient of the mucoadhesive material in the mucus. The adhesion strength for a polymer is reached when the depth of penetration is approximately equivalent to the polymer chain size. In order for diffusion to occur, it is important that the components involved have good mutual solubility, that is, both the bioadhesive and the mucus have similar chemical structures. The greater the structural similarity, the better is the mucoadhesive bond. [5]

Fracture theory

This is perhaps the most used theory in studies on the mechanical measurement of mucoadhesion. It analyzes the force required to separate two surfaces after adhesion is established. This force, s m, is frequently calculated in tests of resistance to rupture by the ratio of the maximal detachment force, F m, and the total surface area, A0 , involved in the adhesive interaction

Since the fracture theory [Figure 5] is concerned only with the force required to separate the parts, it does not take into account the interpenetration or diffusion of polymer chains. Consequently, it is appropriate for use in the calculations for rigid or semi-rigid bioadhesive materials, in which the polymer chains do not penetrate into the mucus layer. [5],[6]
Figure 5 :Fractures occurring for mucoadhesion

Click here to view

The electronic theory

This theory describes adhesion occurring by means of electron transfer between the mucus and the mucoadhesive system, arising through differences in their electronic structures. The electron transfer between the mucus and the mucoadhesive results in the formation of double layer of electrical charges at the mucus and mucoadhesive interface. The net result of such a process is the formation of attractive forces within this double layer. [7]

The adsorption theory

In this instance, adhesion is the result of various surface interactions (primary and secondary bonding) between the adhesive polymer and mucus substrate. Primary bonds due to chemisorptions result in adhesion due to ionic, covalent and metallic bonding, which is generally undesirable due to their permanency. [8] Secondary bonds arise mainly due to van der Waals forces, hydrophobic interactions and hydrogen bonding. Whilst these interactions require less energy to "break", they are the most prominent form of surface interaction in mucoadhesion processes as they have the advantage of being semi-permanent bonds. [9]

All these numerous theories should be considered as supplementary processes involved in the different stages of the mucus/substrate interaction, rather than individual and alternative theories. Each and every theory is equally important to describe the mucoadhesion process. There is a possibility that there will be initial wetting of the mucin, and then diffusion of the polymer into mucin layer, thus causing the fracture in the layers to effect the adhesion or electronic transfer or simple adsorption phenomenon that finally leads to the perfect mucoadhesion. The mechanism by which a mucoadhesive bond is formed will depend on the nature of the mucus membrane and mucoadhesive material, the type of formulation, the attachment process and the subsequent environment of the bond. It is apparent that a single mechanism for mucoadhesion proposed in many texts is unlikely for all the different occasions when adhesion occurs.

Factors Affecting Mucoadhesion

Molecular weight

The mucoadhesive strength of a polymer increases with molecular weights above 100,000. Direct correlation between the mucoadhesive strength of polyoxyethylene polymers and their molecular weights lies in the range of 200,000-7,000,000. [10]


Mucoadhesion starts with the diffusion of the polymer chains in the interfacial region. Therefore, it is important that the polymer chains contain a substantial degree of flexibility in order to achieve the desired entanglement with the mucus. [11] The increased chain interpenetration was attributed to the increased structural flexibility of the polymer upon incorporation of polyethylene glycol. In general, mobility and flexibility of polymers can be related to their viscosities and diffusion coefficients, as higher flexibility of a polymer causes greater diffusion into the mucus network. [12]

Cross-linking density

The average pore size, the number and average molecular weight of the cross-linked polymers, and the density of cross-linking are three important and inter-related structural parameters of a polymer network. Therefore, it seems reasonable that with increasing density of cross-linking, diffusion of water into the polymer network occurs at a lower rate which, in turn, causes an insufficient swelling of the polymer and a decreased rate of interpenetration between polymer and mucin. [12]

Hydrogen bonding capacity

Hydrogen bonding is another important factor in mucoadhesion of a polymer. Desired polymers must have functional groups that are able to form hydrogen bonds, and flexibility of the polymer is important to improve this hydrogen bonding potential. [12] Polymers such as poly(vinyl alcohol), hydroxylated methacrylate, and poly(methacrylic acid), as well as all their copolymers, have good hydrogen bonding capacity. [13]


Hydration is required for a mucoadhesive polymer to expand and create a proper macromolecular mes of sufficient size, and also to induce mobility in the polymer chains in order to enhance the interpenetration process between polymer and mucin. Polymer swelling permits a mechanical entanglement by exposing the bioadhesive sites for hydrogen bonding and/or electrostatic interaction between the polymer and the mucus network. [12] However, a critical degree of hydration of the mucoadhesive polymer exists where optimum swelling and mucoadhesion occurs. [13]


Some generalizations about the charge of bioadhesive polymers have been made previously, where nonionic polymers appear to undergo a smaller degree of adhesion compared to anionic polymers. Strong anionic charge on the polymer is one of the required characteristics for mucoadhesion. [13] Some cationic polymers are likely to demonstrate superior mucoadhesive properties, especially in a neutral or slightly alkaline medium. [14] Additionally, some cationic high-molecular-weight polymers, such as chitosan, have shown to possess good adhesive properties. [15] There is no significant literature about the influence of the charge of the membrane on the mucoadhesion but the pH of the membrane affects the mucoadhesion as it can influence the ionized or un-ionized forms of the polymers. [16]


The importance of this factor lies in the development of a strong adhesive bond with the mucus, and can be explained by the polymer chain length available for penetration into the mucus layer. When the concentration of the polymer is too low, the number of penetrating polymer chains per unit volume of the mucus is small and the interaction between polymer and mucus is unstable. In general, the more concentrated polymer would result in a longer penetrating chain length and better adhesion. However, for each polymer, there is a critical concentration, above which the polymer produces an "unperturbed" state due to a significantly coiled structure. As a result, the accessibility of the solvent to the polymer decreases, and chain penetration of the polymer is drastically reduced. Therefore, higher concentrations of polymers do not necessarily improve and, in some cases, actually diminish mucoadhesive properties. One of the studies addressing this factor demonstrated that high concentrations of flexible polymeric films based on polyvinylpyrrolidone or poly(vinyl alcohol) as film-forming polymers did not further enhance the mucoadhesive properties of the polymer. [17]

Sites for Mucoadhesive Drug Delivery Systems

The common sites of application where mucoadhesive polymers have the ability to deliver pharmacologically active agents include oral cavity, eye conjunctiva, vagina, nasal cavity and GIT.

The buccal cavity has a very limited surface area of around 50 cm 2 but the easy access to the site makes it a preferred location for delivering active agents. The site provides an opportunity to deliver pharmacologically active agents systemically by avoiding hepatic first-pass metabolism in addition to the local treatment of the oral lesions.

The sublingual mucosa is relatively more permeable than the buccal mucosa due to the presence of large number of smooth muscle and immobile mucosa. Hence, formulations for sublingual delivery are designed to release the active agent quickly while mucoadhesive formulation is of importance for the delivery of active agents to the buccal mucosa, where the active agent has to be released in a controlled manner. This makes the buccal cavity more suitable for mucoadhesive drug delivery. [18] The various mucoadhesive polymers used for the development of buccal delivery systems include cyanoacrylates, polyacrylic acid, sodium carboxymethylcellulose, hyaluronic acid, hydroxypropylcellulose, polycarbophil, chitosan and gellan. The delivery systems are generally coated with a drug and water impermeable film so as to prevent the washing of the active agent by the saliva. [19]

Like buccal cavity, nasal cavity also provides a potential site for the development of formulations where mucoadhesive polymers can play an important role. The nasal mucosal layer has a surface area of around 150-200 cm 2 . The residence time of a particulate matter in the nasal mucosa varies between 15 and 30 min, which has been attributed to the increased activity of the mucociliary layer in the presence of foreign particulate matter. The polymers used in the development of formulations for the development of nasal delivery system include copolymer of methyl vinyl ether, hydroxypropylmethylcellulose (HPMC), sodium carboxymethylcellulose, carbopol-934P and Eudragit RL-100. [20],[21]

Due to the continuous formation of tears and blinking of eye lids, there is a rapid removal of the active medicament from the ocular cavity, which results in the poor bioavailability of the active agents. This can be minimized by delivering the drugs using ocular insert or patches. The mucoadhesive polymers used for the ocular delivery include thiolated poly(acrylic acid), poloxamer, celluloseacetophthalate, methyl cellulose, hydroxy ethyl cellulose, poly(amidoamine) dendrimers, poly(dimethyl siloxane) and poly(vinyl pyrrolidone). [22],[23]

The vaginal and the rectal lumen have also been explored for the delivery of the active agents both systemically and locally. The active agents meant for the systemic delivery by this route of administration bypass the hepatic first-pass metabolism. Quite often, the delivery systems suffer from migration within the vaginal/rectal lumen, which might affect the delivery of the active agent to the specific location. The use of mucoadhesive polymers for the development of delivery system helps in reducing the migration of the same, thereby promoting better therapeutic efficacy. The polymers used in the development of vaginal and rectal delivery systems include mucin, gelatin, polycarbophil and poloxamer. [24],[25],[26]

GIT is also a potential site which has been explored for a long time for the development of mucoadhesive based formulations. The modulation of the transit time of the delivery systems in a particular location of the gastrointestinal system by using mucoadhesive polymers has generated much interest among researchers around the world. The various mucoadhesive polymers which have been used for the development of oral delivery systems include chitosan, poly(acrylic acid), alginate, poly(methacrylic acid) and sodium carboxymethyl cellulose. [27]

Each site of mucoadhesion has its own advantages and disadvantages along with the basic property of prolonged residence of dosage form at that particular site. In buccal and sublingual sites, there is an advantage of fast onset along with bypassing the first-pass metabolism, but these sites suffer from inconvenience because of taste and intake of food. In GIT, there is a chance for improved amount of absorption because of microvilli, but it has a drawback of acid instability and first-pass effects. Rectal and vaginal sites are the best ones for the local action of the drug but they suffer from inconvenience of administration. Nasal and ophthalmic routes have another drawback of mucociliary drainage that would clear the dosage form from the site.

Mucoadhesive Dosage Forms


Tablets are small, flat, and oval, with a diameter of approximately 5-8 mm. [28] Unlike the conventional tablets, mucoadhesive tablets allow for drinking and speaking without major discomfort. They soften, adhere to the mucosa, and are retained in position until dissolution and/or release is complete. Mucoadhesive tablets, in general, have the potential to be used for controlled release drug delivery, but coupling of mucoadhesive properties to tablet has additional advantages, for example, it offers efficient absorption and enhanced bioavailability of the drugs due to a high surface to volume ratio and facilitates a much more intimate contact with the mucus layer. Mucoadhesive tablets can be tailored to adhere to any mucosal tissue including those found in stomach, thus offering the possibilities of localized as well as systemic controlled release of drugs. The application of mucoadhesive tablets to the mucosal tissues of gastric epithelium is used for administration of drugs for localized action. Mucoadhesive tablets are widely used because they release the drug for a prolonged period, reduce frequency of drug administration and improve the patient compliance. The major drawback of mucoadhesive tablets is their lack of physical flexibility, leading to poor patient compliance for long-term and repeated use. [29],[30],[31]


Mucoadhesive films may be preferred over adhesive tablets in terms of flexibility and comfort. In addition, they can circumvent the relatively short residence time of oral gels on the mucosa, which are easily washed away and removed by saliva. Moreover, in the case of local delivery for oral diseases, the films also help protect the wound surface, thus helping to reduce pain, and treat the disease more effectively. An ideal film should be flexible, elastic, and soft, yet adequately strong to withstand breakage due to stress from mouth movements. It must also possess good mucoadhesive strength in order to be retained in the mouth for the desired duration of action. Swelling of film, if it occurs, should not be too extensive in order to prevent discomfort. [32]


Patches are laminates consisting of an impermeable backing layer, a drug-containing reservoir layer from which the drug is released in a controlled manner, and a mucoadhesive surface for mucosal attachment. Patch systems are similar to those used in transdermal drug delivery. Two methods used to prepare adhesive patches include solvent casting and direct milling. In the solvent casting method, the intermediate sheet from which patches are punched is prepared by casting the solution of the drug and polymer(s) onto a backing layer sheet, and subsequently allowing the solvent(s) to evaporate. In the direct milling method, formulation constituents are homogeneously mixed and compressed to the desired thickness, and patches of predetermined size and shape are then cut or punched out. An impermeable backing layer may also be applied to control the direction of drug release, prevent drug loss, and minimize deformation and disintegration of the device during the application period. [33],[34]

Gels and ointments

Semisolid dosage forms, such as gels and ointments, have the advantage of easy dispersion throughout the oral mucosa. However, drug dosing from semisolid dosage forms may not be as accurate as from tablets, patches, or films. Poor retention of the gels at the site of application has been overcome by using mucoadhesive formulations. Certain mucoadhesive polymers, for example, sodium carboxymethylcellulose, [35] carbopol, [36] hyaluronic acid, [37] and xanthan gum, [38] undergo a phase change from liquid to semisolid. This change enhances the viscosity, which results in sustained and controlled release of drugs. Hydrogels are also a promising dosage form for buccal drug delivery. They are formed from polymers that are hydrated in an aqueous environment and physically entrap drug molecules for subsequent slow release by diffusion or erosion. [39] The application of mucoadhesive gels provides an extended retention time in the oral cavity, adequate drug penetration, as well as high efficacy and patient acceptability. A major application of adhesive gels is the local delivery of medicinal agents for the treatment of periodontitis, which is an inflammatory and infectious disease that causes formation of pockets between the gum and the tooth, and can eventually cause loss of teeth. It has been suggested that mucoadhesive polymers might be useful for periodontitis therapy when incorporated in antimicrobial-containing formulations that are easily introduced into the periodontal pocket with a syringe. [40],[41],[42] HPMC has been used as an adhesive ointment ingredient. Additionally, a highly viscous gel was developed from carbopal and hydroxypropylcellulose for ointment dosage forms that could be maintained on the tissue for up to 8 hours. [2]

   Conclusion Top

This overview about the mucoadhesive dosage forms might be a useful tool for the efficient design of novel mucoadhesive drug delivery systems. Mucoadhesive drug delivery systems have applications from different angles, including development of novel mucoadhesives, design of the device, mechanisms of mucoadhesion and permeation enhancement. With the influx of a large number of new drug molecules due to drug discovery, mucoadhesive drug delivery will play an even more important role in delivering these molecules.

   Acknowledgments Top

The authors wish to thank the Management and HOD, Department of Pharmaceutics, Nalanda College of Pharmacy, Nalgonda, AP, India, and also Faculty of Pharmacy, Osmania University, for providing facilities to carry out this review work.

   References Top

1.Chickering DE III, Mathiowitz E. Fundamentals of bioadhesion. In: Lehr CM, editor. Bioadhesive drug delivery systems-Fundamentals, Novel Approaches and Development. New York: Marcel Dekker; 1999. p. 1-85.  Back to cited text no. 1
2.Ahuja A, Khar RK, Ali J. Mucoadhesive drug delivery systems. Drug Dev Ind Pharm 1997;23:489-515.  Back to cited text no. 2
3.Veuillez F, Kalia YN, Jacques Y, Deshusses J, Buri P. Factors and strategies for improving buccal absorption of peptides. Eur J Pharm Biopharm 2001;51:93-109.  Back to cited text no. 3
4.Punitha S, Girish Y. Polymers in mucoadhesive buccal drug delivery system: A review. Int J Res Pharm Sci 2010;1:170-86.  Back to cited text no. 4
5.Smart JD. The basics and underlying mechanisms of mucoadhesion. Adv Drug Deliv Rev 2005;57:1556-68.  Back to cited text no. 5
6.Hδgerstrφm H, Edsman K, Strψmme M. Low-frequency dielectric spectroscopy as a tool for studying the compatibility between pharmaceutical gels and mucus tissue. J Pharm Sci 2003;92:1869-81.  Back to cited text no. 6
7.Dodou D, Breedveld P, Wieringa P. Mucoadhesives in the gastrointestinal tract: Revisiting the literature for novel applications. Eur J Pharm Biopharm 2005;60:1-16.  Back to cited text no. 7
8.Kinloch AJ. The science of adhesion. J Mater Sci 1980;15:2141-66.  Back to cited text no. 8
9.Jimιnez-Castellanos MR, Zia H, Rhodes CT. Mucoadhe-sive drug delivery systems. Drug Dev Ind Pharm 1993;19:143-94.  Back to cited text no. 9
10.Tiwari D, Goldman D, Sause R, Madan PL. Evaluation of polyoxyethylene homopolymers for buccal bioadhesive drug delivery device formulations. AAPS Pharm Sci 1999;1:13-21.  Back to cited text no. 10
11.Huang Y, Leobandung W, Foss A, Peppas NA. Molecular aspects of muco- and bioadhesion: Tethered structures and site-specific surfaces. J Control Release 2000;65:63-71.  Back to cited text no. 11
12.Gu JM, Robinson JR, Leung SH. Binding of acrylic polymers to mucin/epithelial surfaces: Structure-property relationships. Crit Rev Ther Drug Carrier Syst 1998;5:21-67.  Back to cited text no. 12
13.Peppas NA, Buri PA. Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues. J Control Release 1985;2:257-75.  Back to cited text no. 13
14.Park H, Amiji M, Park K. Mucoadhesive hydrogels effective at neutral pH. Proc Int Symp Control Release Bioact Mater 1989;16:217-8.  Back to cited text no. 14
15.Lehr CM, Bouwstra JA, Schacht EH, Junginger HE. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int J Pharm 1992;78:43-8.  Back to cited text no. 15
16.Smart JD, Mortazavi SA. An investigation of the pH within the hydrating gel layer of a poly(acylic acid) compact. J Pharm Pharmacol 1995;47:1099.  Back to cited text no. 16
17.Solomonidou D, Cremer K, Krumme M, Kreuter J. Effect of carbomer concentration and degree of neutralization on the mucoadhesive properties of polymer films. J Biomater Sci Polym Ed 2001;12:1191-205.  Back to cited text no. 17
18.Shojaei AH. Buccal mucosa as a route for systemic drug delivery: A review. J Pharm Pharm Sci 1998;1:15-30.   Back to cited text no. 18
19.Remuραn-Lσpez C, Portero A, Vila-Jato JL, Alonso MJ. Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. J Control Release 1998;55:143-52.   Back to cited text no. 19
20.Semalty M, Semalty A, Kumar G. Formulation and characterization of mucoadhesive buccal films of glipizide. Indian J Pharm Sci 2008;70:43-8.   Back to cited text no. 20
[PUBMED]  Medknow Journal  
21.Hornof M, Weyenberg W, Ludwig A, Bernkop SA. Mucoadhesive ocular insert based on thiolated poly (acrylic acid): Development and in vivo evaluation in humans. J Control Release 2003;89:419-28.   Back to cited text no. 21
22.Sultana Y, Aqil M, Ali A. Ocular inserts for controlled delivery of pefloxacin mesylate: Preparation and evaluation. Acta Pharm 2005;55:305-14.  Back to cited text no. 22
23.Wagh VD, Inamdar B, Samanta MK. Polymers used in ocular dosage form and drug delivery systems. Asian J Pharmaceutics 2008;2:12-7.   Back to cited text no. 23
24.Elhadi SS, Mortada ND, Awad GA, Zaki NM, Taha RA. Development of in situ gelling and mucoadhesive mebeverine hydrochloride solution for rectal administration. Saudi Pharm J 2003;11:150-71.   Back to cited text no. 24
25.Neves JD, Amaral MH, Bahia MF. Vaginal drug delivery. In: Gad SC, editor. Pharmaceutical Manufacturing Handbook. NJ: John Willey and Sons Inc; 2007. p. 809-78.   Back to cited text no. 25
26.Choi HG, Kim CK. In situ gelling and mucoadhesive liquid suppository containing acetaminophen: Enhanced bioavailability. Int J Pharm 1998;165:23-32.   Back to cited text no. 26
27.Asane GS. Mucoadhesive gastro intestinal drug delivery system: An overview. Pharmainfo.net 2007;5:1-5.   Back to cited text no. 27
28.Schnόrch AB. Mucoadhesive systems in oral drug delivery. Drug Discov Today Technol 2005;2:83-7.   Back to cited text no. 28
29.Rathbone MJ, Drummond BK, Tucker G. The oral cavity as a site for systemic drug delivery. Adv Drug Deliv Rev 1994;13:1-22.  Back to cited text no. 29
30.Rajput GC, Majmudar FD, Patel JK, Patel KN, Thakor RS, Patel BP, et al. Stomach specific mucoadhesive tablets as controlled drug delivery system: A review work. Int J Pharm Biol Res 2010;1:30-41.  Back to cited text no. 30
31.Remeth D, Sfurti S, Kailas M. In-vitro absorption studies of mucoadhesive tablets of acyclovir. Indian J Pharm Educ Res 2010;44:183-8.  Back to cited text no. 31
32.Shah D, Gaud RS, Misra AN, Parikh R. Formulation of a water soluble mucoadhesive film of lycopene for treatment of leukoplakia. Int J Pharm Sci Rev Res 2010;12:6-11.  Back to cited text no. 32
33.Biswajit B, Kevin G, Thimmasetty J. Formulation and evaluation of pimozide buccal mucoadhesive patches. Int J Pharm Sci Nanotechnol 2010;2:32-41.  Back to cited text no. 33
34.Wong CF, Yuen KH, Peh KK. Formulation and evaluation of controlled release Eudragit buccal patches. Int J Pharm 1999;178:11-22.  Back to cited text no. 34
35.Kumar S, Haglund BO, Himmelstein KJ. In situ-forming gels for ophthalmic drug delivery. J Ocul Pharmacol 1994;10:47-56.  Back to cited text no. 35
36.Ishida M, Nambu N, Nagai T. Highly viscous gel ointment containing carbopol for application to the oral mucosa. Chem Pharm Bull 1983;31:4561-4.  Back to cited text no. 36
37.Gurny R, Ryser JE, Tabatabay C, Martenet M, Edman P, Camber O. Precorneal residence time in humans of sodium hyaluronate as measured by gamma scintigraphy. Graefes Arch Clin Exp Ophthalmol 1990;228:510-2.  Back to cited text no. 37
38.Meseguer G, Gurny R, Buri P. Gamma scintigraphic evaluation of precorneal clearance in human volunteers and in rabbits. Eur J Drug Metab Pharmacokinet 1993;18:190-4.  Back to cited text no. 38
39.Martin L, Wilson CG, Koosha F, Uchegbu IF. Sustained buccal delivery of the hydrophobic drug denbufylline using physically cross-linked palmitoyl glycol chitosan hydrogels. Eur J Pharm Biopharm 2003;55:35-45.  Back to cited text no. 39
40.Jones DS, Woolfson AD, Brown AF, Coulter WA, McClelland C, Irwin CR. Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease. J Control Release 2000;67:357-68.  Back to cited text no. 40
41.Vinholis AH, De Figueiredo LC, Marcantonio E, Marcantonio RA, Salvador SL, Goissis G. Subgingival utilization of a 1% chlorhexidine collagen gel for the treatment of periodontal pockets. A clinical and microbiological study. Braz Dent J 2001;12:209-13.  Back to cited text no. 41
42.Ikinci G, Kenel SS, AkVncVbay H, Kas S, Ercis S, Wilson CG, et al. Effect of chitosan on a periodontal pathogen Porphyromonas gingivalis. Int J Pharm 2002;235:121-7.  Back to cited text no. 42


  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]

This article has been cited by
1 Thiolated pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer
Theodore Ebenezer Leonard, Alvaro Filbert Liko, Marsia Gustiananda, Agus Budiawan Naro Putra, Ario Betha Juanssilfero, Pietradewi Hartrianti
International Journal of Biological Macromolecules. 2023; 225: 1
[Pubmed] | [DOI]
International Journal of Applied Pharmaceutics. 2023; : 44
[Pubmed] | [DOI]
3 The Spray-Dried Alginate/Gelatin Microparticles with Luliconazole as Mucoadhesive Drug Delivery System
Marta Szekalska, Magdalena Wróblewska, Anna Czajkowska-Kosnik, Katarzyna Sosnowska, Pawel Misiak, Agnieszka Zofia Wilczewska, Katarzyna Winnicka
Materials. 2023; 16(1): 403
[Pubmed] | [DOI]
4 Nanoparticles for Inducing Antigen-Specific T Cell Tolerance in Autoimmune Diseases
Naomi Benne, Daniëlle ter Braake, Arie Jan Stoppelenburg, Femke Broere
Frontiers in Immunology. 2022; 13
[Pubmed] | [DOI]
5 Nanocarriers-Assisted Needle-Free Vaccine Delivery Through Oral and Intranasal Transmucosal Routes: A Novel Therapeutic Conduit
Bharti Mangla, Shamama Javed, Muhammad H. Sultan, Waquar Ahsan, Geeta Aggarwal, Kanchan Kohli
Frontiers in Pharmacology. 2022; 12
[Pubmed] | [DOI]
6 Cyclodextrin Stabilized Freeze-Dried Silica/Chitosan Nanoparticles for Improved Terconazole Ocular Bioavailability
Nada Zaghloul, Nada M. El Hoffy, Azza A. Mahmoud, Nermeen A. Elkasabgy
Pharmaceutics. 2022; 14(3): 470
[Pubmed] | [DOI]
7 Efficacy of Polymer-Based Nanomedicine for the Treatment of Brain Cancer
Tobeka Naki, Blessing A. Aderibigbe
Pharmaceutics. 2022; 14(5): 1048
[Pubmed] | [DOI]
8 Vaginal Nanoformulations for the Management of Preterm Birth
Asad Mir, Richa V. Vartak, Ketan Patel, Steven M. Yellon, Sandra E. Reznik
Pharmaceutics. 2022; 14(10): 2019
[Pubmed] | [DOI]
9 Bio-Inspired Muco-Adhesive Polymers for Drug Delivery Applications
Zina Jawadi, Christine Yang, Ziyad S. Haidar, Peter L. Santa Maria, Solange Massa
Polymers. 2022; 14(24): 5459
[Pubmed] | [DOI]
10 A comparative physicochemical and pharmacological evaluation of dexamethasone sodium phosphate and betamethasone sodium phosphate mucoadhesive gels for the treatment of oral submucous fibrosis in rats
Vijaybhaskar Desai, Sidramappa Shirsand, Gurunath Surampalli
Brazilian Journal of Pharmaceutical Sciences. 2022; 58
[Pubmed] | [DOI]
11 Development, in vitro Evaluation, and in vivo Study of Adhesive Buccal Films for the Treatment of Diabetic Pediatrics via Trans Mucosal Delivery of Gliclazide
Dalia A Gaber, Abeer I Alburaykan, Lama M Alruthea, Njoud S Aldohan, Raneem F Alharbi, Alhanoof R Aljohani, Helah M Albilaihi, Somaiah S Adogim
Drug Design, Development and Therapy. 2022; Volume 16: 4235
[Pubmed] | [DOI]
12 Vaccines, adjuvants and key factors for mucosal immune response
Victor Araujo Correa, Amanda Izeli Portilho, Elizabeth De Gaspari
Immunology. 2022;
[Pubmed] | [DOI]
13 Advancement of Nanofibrous Mats and Common Useful Drug Delivery Applications
Hamza Abu Owida, Jamal I. Al-Nabulsi, Feras Alnaimat, Ashraf Al Sharah, Muhammad Al-Ayyad, Nidal M. Turab, Mustafa Abdullah, Jirapornchai Suksaeree
Advances in Pharmacological and Pharmaceutical Sciences. 2022; 2022: 1
[Pubmed] | [DOI]
14 Pharmaceutical nanotechnology: from the bench to the market
Zaed M. Mazayen, Amira M. Ghoneim, Rasha S. Elbatanony, Emad B. Basalious, Ehab R. Bendas
Future Journal of Pharmaceutical Sciences. 2022; 8(1)
[Pubmed] | [DOI]
15 Exploiting Polymeric Films as a Multipurpose Drug Delivery System: a Review
Bruno Vincenzo Fiod Riccio, Amanda Letícia Polli Silvestre, Andreia Bagliotti Meneguin, Tais de Cassia Ribeiro, Ana Beatriz Klosowski, Priscileila Colerato Ferrari, Marlus Chorilli
AAPS PharmSciTech. 2022; 23(7)
[Pubmed] | [DOI]
16 Potential of naturally occurring Mucoadhesive polymer in Vaginal infection
Ishwar Singh, Jatin Sharma, Inder Kumar, Shivali Singla, Amit Chaudhary, Sunny Dhiman
Asian Journal of Pharmacy and Technology. 2022; : 251
[Pubmed] | [DOI]
17 Effects of Mucoadhesive Gel Containing Propolis on Some Biochemical and Hematologic Parameters in Rats With Experimental Periodontitis
Ömer EBREM, Pinar Alkim ULUTAS
Animal Health Production and Hygiene. 2022;
[Pubmed] | [DOI]
18 New hope for preventing preterm birth: The promise of vaginal nanoformulations
Sandra Reznik
Placenta and Reproductive Medicine. 2022; 1
[Pubmed] | [DOI]
19 An overview of oral insulin delivery strategies (OIDS)
Gayatri Iyer, Sathish Dyawanapelly, Ratnesh Jain, Prajakta Dandekar
International Journal of Biological Macromolecules. 2022;
[Pubmed] | [DOI]
20 Design, Characterization and In Vivo Performance of Solid Lipid Nanoparticles (SLNs)-Loaded Mucoadhesive Buccal Tablets for Efficient Delivery of Lornoxicam in Experimental Inflammation
Moataz B. Zewail, Gihan F.Asaad, Salma M. Swellam, Sama M. Abd-allah, Sahar K.Hosny, Salma K. Sallah, Jehan E.Eissa, Salma S.Mohamed, Walaa A. El-Dakroury
International Journal of Pharmaceutics. 2022; : 122006
[Pubmed] | [DOI]
21 Water-soluble chitosan eases development of mucoadhesive buccal films and wafers for children
Karin Korelc, Bjarke Strøm Larsen, Mirjana Gašperlin, Ingunn Tho
International Journal of Pharmaceutics. 2022; : 122544
[Pubmed] | [DOI]
22 Oromucosal delivery of macromolecules: Challenges and recent developments to improve bioavailability
Mutasem Rawas-Qalaji, Hnin Ei Thu, Zahid Hussain
Journal of Controlled Release. 2022; 352: 726
[Pubmed] | [DOI]
23 Engineering drug delivery systems to overcome the vaginal mucosal barrier: Current understanding and research agenda of mucoadhesive formulations of vaginal delivery
Bhavana Valamla, Pradip Thakor, Rashmi Phuse, Mayuri Dalvi, Pratik Kharat, Ankaj Kumar, Dilip Panwar, Shashi Bala Singh, Pastorin Giorgia, Neelesh Kumar Mehra
Journal of Drug Delivery Science and Technology. 2022; : 103162
[Pubmed] | [DOI]
24 Analysis of interactions between polymeric gel and esophageal mucosae by a multivariate experimental approach
Aimee Accarini Oteiro, Lariani Aparecida Delboni, Luis Alexandre Pedro de Freitas, Marilisa Guimarães Lara
Journal of Drug Delivery Science and Technology. 2022; : 103413
[Pubmed] | [DOI]
25 Formulation of metoclopramide HCl gastroretentive film and In vitro- In silico prediction using Gastroplus® PBPK software
Dalia Safaa Hamdi, Masar Basim Mohsin Mohamed
Saudi Pharmaceutical Journal. 2022;
[Pubmed] | [DOI]
26 Clotrimazole-incorporated fatty acid-based in situ forming film containing pressure sensitive adhesive
Ei Mon Khaing, Prapansak Toungsuwan, Takron Chantadee, Sai Myo Thu Rein, Thawatchai Phaechamud, Juree Charoenteeraboon, Jongjan Mahadlek
Materials Today: Proceedings. 2022;
[Pubmed] | [DOI]
27 Natural rubber-based pressure sensitive adhesive as a drug carrier
Napaphol Puyathorn, Sasiprapa Limsirilak, Wiwat Pichayakorn, Ekwipoo Kalkornsurapranee, Thawatchai Phaechamud
Materials Today: Proceedings. 2022;
[Pubmed] | [DOI]
28 Nanocellulose as sustainable biomaterials for drug delivery
Sudipta Das, Baishali Ghosh, Keya Sarkar
Sensors International. 2022; 3: 100135
[Pubmed] | [DOI]
29 From Static to Dynamic: A Review on the Role of Mucus Heterogeneity in Particle and Microbial Transport
Dipesh Dinanath Pednekar, Madison A. Liguori, Claudia N. H. Marques, Teng Zhang, Nan Zhang, Zejian Zhou, Kagya Amoako, Huan Gu
ACS Biomaterials Science & Engineering. 2022;
[Pubmed] | [DOI]
30 Surface Modification of Lipid-Based Nanoparticles
Yining Xu, Thibaut Fourniols, Yasmine Labrak, Véronique Préat, Ana Beloqui, Anne des Rieux
ACS Nano. 2022;
[Pubmed] | [DOI]
31 Nanotherapeutic Intervention in Photodynamic Therapy for Cancer
Asif Mohd Itoo, Milan Paul, Sri Ganga Padaga, Balaram Ghosh, Swati Biswas
ACS Omega. 2022;
[Pubmed] | [DOI]
32 Hijacking the intrinsic vitamin B12 pathway for the oral delivery of nanoparticles, resulting in enhanced in vivo anti-leishmanial activity
Aakriti Singh, Ganesh Yadagiri, Aaqib Javaid, Krishna Kumar Sharma, Anurag Verma, Om Prakash Singh, Shyam Sundar, Shyam Lal Mudavath
Biomaterials Science. 2022;
[Pubmed] | [DOI]
33 Structure, controlled release mechanisms and health benefits of pectins as an encapsulation material for bioactive food components
Rocío Morales-Medina, Stephan Drusch, Francisca Acevedo, Alejandro Castro-Alvarez, Astrid Benie, Denis Poncelet, Marijana M. Dragosavac, María Victoria Defain Tesoriero, Patricia Löwenstein, Verónica Yonaha, Ramiro Iturralde, Regina Gauna Peter, Paul de Vos
Food & Function. 2022;
[Pubmed] | [DOI]
34 Thermomechanical Soft Actuator for Targeted Delivery of Anchoring Drug Deposits to the GI Tract
Joshua A. Levy, Michael A. Straker, Justin M. Stine, Luke A. Beardslee, Vivian Borbash, Reza Ghodssi
Advanced Materials Technologies. 2022; : 2201365
[Pubmed] | [DOI]
35 SNAC for Enhanced Oral Bioavailability: An Updated Review
Nagavendra Kommineni, Vaskuri G S Sainaga Jyothi, Arun Butreddy, Saka Raju, Tovi Shapira, Wahid Khan, Pavimol Angsantikul, Abraham J. Domb
Pharmaceutical Research. 2022;
[Pubmed] | [DOI]
36 Tailoring the properties of chitosan by grafting with 2-mercaptobenzoic acid to improve mucoadhesion: in silico studies, synthesis and characterization
Tejinder K. Marwaha, Ashwini Madgulkar, Mangesh Bhalekar, Kalyani Asgaonkar, Rajesh Gachche, Pallavi Shewale
Progress in Biomaterials. 2022;
[Pubmed] | [DOI]
37 Fabrication and characterization of a myrrh hydrocolloid dressing for dermal wound healing
Olatunji Ajiteru, Ok Joo Lee, Jung-Ho Kim, Young Jin Lee, Ji Seung Lee, Hanna Lee, Md. Tipu Sultan, Chan Hum Park
Colloid and Interface Science Communications. 2022; 48: 100617
[Pubmed] | [DOI]
38 The effect of polyacid on the physical and biological properties of chitosan based layer-by-layer films
Nihan Saracogullari,Dilara Gundogdu,Fatma Neslihan Ozdemir,Yesim Soyer,Irem Erel-Goktepe
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2021; 617: 126313
[Pubmed] | [DOI]
39 Oral care product formulations, properties and challenges
Sam R. Aspinall,Jane K. Parker,Vitaliy V. Khutoryanskiy
Colloids and Surfaces B: Biointerfaces. 2021; : 111567
[Pubmed] | [DOI]
40 Role of mucoadhesive polymers in retention of toothpaste in the oral cavity
Sam R. Aspinall,Jane K. Parker,Vitaliy V. Khutoryanskiy
Colloids and Surfaces B: Biointerfaces. 2021; : 112104
[Pubmed] | [DOI]
41 Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac
Santosh Koirala,Prabin Nepal,Govinda Ghimire,Rojina Basnet,Ishwori Rawat,Aashma Dahal,Jitendra Pandey,Kalpana Parajuli-Baral
Heliyon. 2021; 7(3): e06439
[Pubmed] | [DOI]
42 Mucoadhesive Biopolymer Nanoparticles for Encapsulation of Lipophilic Nutrients With Enhanced Bioactivity
Erika Fleming,Zhen Jia,Manyun Yang,Qiaobin Hu,Jingyi Xue,Boce Zhang,Yangchao Luo
Food Biophysics. 2021;
[Pubmed] | [DOI]
43 Design of ophthalmic micelles loaded with diclofenac sodium: effect of chitosan and temperature on the block-copolymer micellization behaviour
Sarra Aicha Koummich,Ikram Mustapha Zoukh,Filip Gorachinov,Nikola Geskovski,Petre Makreski,Marija Glavas Dodov,Katerina Goracinova
Drug Delivery and Translational Research. 2021;
[Pubmed] | [DOI]
44 Fabrication of multifunctional mucoadhesive buccal patch for drug delivery applications
Anahita Rohani Shirvan,Nahid Hemmatinejad,S. Hajir Bahrami,Azadeh Bashari
Journal of Biomedical Materials Research Part A. 2021;
[Pubmed] | [DOI]
45 Chemically and Biologically Engineered Bacteria-Based Delivery Systems for Emerging Diagnosis and Advanced Therapy
Zhaoting Li,Yixin Wang,Jun Liu,Piper Rawding,Jiyoon Bu,Seungpyo Hong,Quanyin Hu
Advanced Materials. 2021; : 2102580
[Pubmed] | [DOI]
46 Design and Testing of Efficient Mucus-Penetrating Nanogels—Pitfalls of Preclinical Testing and Lessons Learned
Rawan Charbaji,Mrityunjoy Kar,Loryn E. Theune,Julián Bergueiro,Anne Eichhorst,Lucila Navarro,Patrick Graff,Friederike Stumpff,Marcelo Calderón,Sarah Hedtrich
Small. 2021; : 2007963
[Pubmed] | [DOI]
47 Influence of Plasticizers on the pH-Dependent Drug Release and Cellular Interactions of Hydroxypropyl Methylcellulose/Zein Vaginal Anti-HIV Films Containing Tenofovir
Fernando Notario-Pérez,Raúl Cazorla-Luna,Araceli Martín-Illana,Joana Galante,Roberto Ruiz-Caro,Bruno Sarmento,José das Neves,María-Dolores Veiga
Biomacromolecules. 2021;
[Pubmed] | [DOI]
48 Development of purified cashew gum mucoadhesive buccal tablets containing nystatin for treatment of oral candidiasis
Ana Paula de Sá Pinto Abrahão Magalhães,Helena Keiko Toma,Flávia Almada do Carmo,Claudia Regina Elias Mansur
Drug Development and Industrial Pharmacy. 2021; : 1
[Pubmed] | [DOI]
49 Significant biopolymers and their applications in buccal mediated drug delivery
Rajat Anand,Awanish Kumar
Journal of Biomaterials Science, Polymer Edition. 2021; : 1
[Pubmed] | [DOI]
50 Brain targeting of agomelatine egg lecithin based chitosan coated nanoemulsion
Marwa Hassan Shukr,Omar A. Ahmed Farid
Pharmaceutical Development and Technology. 2021; : 1
[Pubmed] | [DOI]
51 Development of thermostable vaccine adjuvants
Yizhi Qi,Christopher B. Fox
Expert Review of Vaccines. 2021;
[Pubmed] | [DOI]
52 Polydopamine nanoparticles and hyaluronic acid hydrogels for mussel-inspired tissue adhesive nanocomposites
Nikhil Pandey, Luis Soto-Garcia, Serkan Yaman, Aneetta Kuriakose, Andres Urias Rivera, Valinda Jones, Jun Liao, Philippe Zimmern, Kytai T. Nguyen, Yi Hong
Materials Science and Engineering: C. 2021; : 112589
[Pubmed] | [DOI]
53 In vitro evaluation of mucoadhesive in situ nanogel of celecoxib for buccal delivery
R. Reddy HV,S. Bhattacharyya
Annales Pharmaceutiques Françaises. 2021;
[Pubmed] | [DOI]
54 Role of physicochemical properties of some grades of hydroxypropyl methylcellulose on in vitro mucoadhesion
Qing Zhang, Xiaoling Li, Bhaskara R. Jasti
International Journal of Pharmaceutics. 2021; 609: 121218
[Pubmed] | [DOI]
55 Recent Trends in Design and Evaluation of Chitosan-based Colon Targeted Drug Delivery Systems: Update 2020
Mallesh Kurakula,Shashank Gorityala,Keshav Moharir
Journal of Drug Delivery Science and Technology. 2021; : 102579
[Pubmed] | [DOI]
56 Micellar buccal film for safe and effective control of seizures: Preparation, in vitro characterization, ex vivo permeation studies and in vivo assessment
Alaa H. Salama,Mona Basha,Abeer A.A. Salama
European Journal of Pharmaceutical Sciences. 2021; : 105978
[Pubmed] | [DOI]
57 Development and characterization of sublingual films for enhanced bioavailability of selegiline hydrochloride
Sara Salatin,Raziyeh Asadi,Mitra Jelvehgari
Therapeutic Delivery. 2021;
[Pubmed] | [DOI]
58 Gastro Retentive Dosage Forms: An excellent carrier system for treatment of Peptic Ulcer
P S Goudanavar,B. Ramesh,S. R. Fattepur
Research Journal of Pharmacy and Technology. 2021; : 2316
[Pubmed] | [DOI]
59 Effect of various Polymers on Drug Release from Mucoadhesive Tablets of Cefixime Trihydrate
Kumara Swamy Samanthula,Agaiah Goud Bairi,Shobha Rani Satla,Mahendra Kumar CB
Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; : 167
[Pubmed] | [DOI]
60 Biological evaluation of Safrole oil and Safrole oil Nanoemulgel as antioxidant, antidiabetic, antibacterial, antifungal and anticancer
Ahmad M. Eid,Mohammed Hawash
BMC Complementary Medicine and Therapies. 2021; 21(1)
[Pubmed] | [DOI]
61 Review of Approaches for Increasing Ophthalmic Bioavailability for Eye Drop Formulations
Olivia L. Lanier,Miranda G. Manfre,Claire Bailey,Zhen Liu,Zachary Sparks,Sandesh Kulkarni,Anuj Chauhan
AAPS PharmSciTech. 2021; 22(3)
[Pubmed] | [DOI]
62 Development of Coriandrum sativum Oil Nanoemulgel and Evaluation of Its Antimicrobial and Anticancer Activity
Ahmad M. Eid,Linda Issa,Omamah Al-kharouf,Raghad Jaber,Fatima Hreash,José L. Campos
BioMed Research International. 2021; 2021: 1
[Pubmed] | [DOI]
63 Polysaccharide-Based Micro- and Nanosized Drug Delivery Systems for Potential Application in the Pediatric Dentistry
Plamen Katsarov,Maria Shindova,Paolina Lukova,Ani Belcheva,Cédric Delattre,Bissera Pilicheva
Polymers. 2021; 13(19): 3342
[Pubmed] | [DOI]
64 Determination of Oxaliplatin by a UHPLC-MS/MS Method: Application to Pharmacokinetics and Tongue Tissue Distribution Studies in Rats
Xiuqing Gao, Robert Y. L. Tsai, Jing Ma, Yang Wang, Xiaohua Liu, Dong Liang, Huan Xie
Pharmaceuticals. 2021; 15(1): 52
[Pubmed] | [DOI]
65 Mussel Inspired Chemistry and Bacteria Derived Polymers for Oral Mucosal Adhesion and Drug Delivery
Nazanin Owji,Nandin Mandakhbayar,David A. Gregory,Elena Marcello,Hae-won Kim,Ipsita Roy,Jonathan C. Knowles
Frontiers in Bioengineering and Biotechnology. 2021; 9
[Pubmed] | [DOI]
66 Keratin-Based Nanoparticles as Drug Delivery Carriers
Claudia Ferroni,Greta Varchi
Applied Sciences. 2021; 11(20): 9417
[Pubmed] | [DOI]
67 Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis
Ine Suharyani,Ahmed Fouad Abdelwahab Mohammed,Muchtaridi Muchtaridi,Nasrul Wathoni,Marline Abdassah
Drug Design, Development and Therapy. 2021; Volume 15: 4071
[Pubmed] | [DOI]
68 Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats
Ana Brotons-Canto,Carlos J. González-Navarro,Ana Gloria Gil,Eduardo Asin-Prieto,María José Saiz,Josep Manuel Llabrés
Pharmaceutics. 2021; 13(3): 361
[Pubmed] | [DOI]
69 Synthesis and In Vivo Evaluation of Insulin-Loaded Whey Beads as an Oral Peptide Delivery System
Joanne Heade,Fiona McCartney,Miguel Chenlo,Olga Moreno Marro,Maja Severic,Robert Kent,Sinead B. Bleiel,Clara V. Alvarez,Brendan T. Griffin,David J. Brayden
Pharmaceutics. 2021; 13(5): 656
[Pubmed] | [DOI]
70 Intranasal Administration for Pain: Oxytocin and Other Polypeptides
Vimala N. Bharadwaj,Alexander Z. Tzabazis,Michael Klukinov,Neil A. Manering,David C. Yeomans
Pharmaceutics. 2021; 13(7): 1088
[Pubmed] | [DOI]
71 Nanoparticulate Drug Delivery Strategies to Address Intestinal Cytochrome P450 CYP3A4 Metabolism towards Personalized Medicine
Rui Xue Zhang,Ken Dong,Zhigao Wang,Ruimin Miao,Weijia Lu,Xiao Yu Wu
Pharmaceutics. 2021; 13(8): 1261
[Pubmed] | [DOI]
72 Mangiferin-Loaded Smart Gels for HSV-1 Treatment
Mariaconcetta Sicurella,Maddalena Sguizzato,Rita Cortesi,Nicolas Huang,Fanny Simelière,Leda Montesi,Peggy Marconi,Elisabetta Esposito
Pharmaceutics. 2021; 13(9): 1323
[Pubmed] | [DOI]
73 Development and Evaluation of Tannic Acid-Coated Nanosuspension for Enhancing Oral Bioavailability of Curcumin
Hyeonmin Lee,Jun-Bae Bang,Young-Guk Na,Jae-Young Lee,Cheong-Weon Cho,Jong-Suep Baek,Hong-Ki Lee
Pharmaceutics. 2021; 13(9): 1460
[Pubmed] | [DOI]
74 3D-Printed Mucoadhesive Collagen Scaffolds as a Local Tetrahydrocurcumin Delivery System
Mireia Andonegi, Teresa Carranza, Alaitz Etxabide, Koro de la Caba, Pedro Guerrero
Pharmaceutics. 2021; 13(10): 1697
[Pubmed] | [DOI]
75 Oromucosal Alginate Films with Zein Nanoparticles as a Novel Delivery System for Digoxin
Daniela A. Rodrigues, Sónia P. Miguel, Jorge Loureiro, Maximiano Ribeiro, Fátima Roque, Paula Coutinho
Pharmaceutics. 2021; 13(12): 2030
[Pubmed] | [DOI]
76 The Influence of pH Values on the Rheological, Textural and Release Properties of Carbomer Polacril® 40P-Based Dental Gel Formulation with Plant-Derived and Synthetic Active Components
Yuliia Maslii,Olena Ruban,Giedre Kasparaviciene,Zenona Kalveniene,Anna Materiienko,Liudas Ivanauskas,Agne Mazurkeviciute,Dalia M. Kopustinskiene,Jurga Bernatoniene
Molecules. 2020; 25(21): 5018
[Pubmed] | [DOI]
77 Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal Administration of Poorly Water-Soluble and Biological Drugs
Wai-Houng Chou,Ariel Galaz,Miguel O. Jara,Alexander Gamboa,Javier O. Morales
Pharmaceutics. 2020; 12(12): 1168
[Pubmed] | [DOI]
78 Nanocellulose in Drug Delivery and Antimicrobially Active Materials
Kaja Kupnik,Mateja Primožic,Vanja Kokol,Maja Leitgeb
Polymers. 2020; 12(12): 2825
[Pubmed] | [DOI]
79 Synthesis and characterization of thiol modified beta cyclodextrin, its biocompatible analysis and application as a modified release carrier of ticagrelor
Muhammad Zaman,Rabia Imtiaz Bajwa,Sadaf Saeed,Muhammad Ajaz Hussain,Muhammad Hanif
Biomedical Materials. 2020; 16(1): 015023
[Pubmed] | [DOI]
80 Airway epithelial-targeted nanoparticles for asthma therapy
Stanislav Kan,Dewi Melani Hariyadi,Christopher Grainge,Darryl A. Knight,Nathan W Bartlett,Mingtao Liang
American Journal of Physiology-Lung Cellular and Molecular Physiology. 2020;
[Pubmed] | [DOI]
81 The effect of topical chamomile in the prevention of chemotherapy-induced oral mucositis: A randomized clinical trial
Mahmoud Ahmed Elhadad,Ehsan El-Negoumy,Maha R. Taalab,Reham S. Ibrahim,Rasha O. Elsaka
Oral Diseases. 2020;
[Pubmed] | [DOI]
O. ?. Hrudnytska,Yu. S. Maslii,G. V. Zaychenko,O. A. Ruban
???????? ????????? ? ????????????????? ????????. 2020; (3): 13
[Pubmed] | [DOI]
83 Formulating SLN and NLC as Innovative Drug Delivery Systems for Non-Invasive Routes of Drug Administration
Bruno Fonseca-Santos,Patrícia Bento Silva,Roberta Balansin Rigon,Mariana Rillo Sato,Marlus Chorilli
Current Medicinal Chemistry. 2020; 27(22): 3623
[Pubmed] | [DOI]
84 Development of Mucoadhesive Buccal Drug Delivery System of Propranolol Hydrochloride Using Aster ericoides Mucilage
Ankaj Kaundal,Pravin Kumar,Rajendra Awasthi,Giriraj T. Kulkarni
Drug Delivery Letters. 2020; 10(2): 133
[Pubmed] | [DOI]
85 Features of the Hydrolysis Kinetics of Micrococcus lysodeikticus by Immobilized Lysozyme
Oleg Sevastyanov,Iryna Romanovska,Svetlana Dekina
Innovative Biosystems and Bioengineering. 2020; 4(1): 45
[Pubmed] | [DOI]
86 Technological development of mucoadhesive film containing poloxamer 407, polyvinyl alcohol and polyvinylpyrrolidone for buccal metronidazole delivery
Camila Felix Vecchi,Rafaela Said dos Santos,Marcos Luciano Bruschi
Therapeutic Delivery. 2020;
[Pubmed] | [DOI]
87 Characterization of Rheological Property of Mucoadhesive Polymeric Sol-Gel in the Presence of Black Ginger Kaempferia parviflora Extract
Siriporn Taokaew,Nattanich Wattanaphraya,Worawut Kriangkrai
Key Engineering Materials. 2020; 859: 81
[Pubmed] | [DOI]
88 Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems
Maurício Palmeira Chaves de Souza,Rafael Miguel Sábio,Taís de Cássia Ribeiro,Aline Martins dos Santos,Andréia Bagliotti Meneguin,Marlus Chorilli
International Journal of Biological Macromolecules. 2020;
[Pubmed] | [DOI]
89 Fabrication of chitosan/polyvinylpyrrolidone hydrogel scaffolds containing PLGA microparticles loaded with dexamethasone for biomedical applications
Sadaf Saeedi Garakani,Seyed Mohammad Davachi,Zohreh Bagher,Anahita Heraji Esfahani,Niki Jenabi,Zhaleh Atoufi,Mehdi Khanmohammadi,Alireza Abbaspourrad,Hamid Rashedi,Maryam Jalessi
International Journal of Biological Macromolecules. 2020; 164: 356
[Pubmed] | [DOI]
90 Optimization and evaluation of chitosan buccal films containing tenoxicam for treating chronic periodontitis: In vitro and in vivo studies
Lubna Y. Ashri,Amal El Sayeh F. Abou El Ela,Mohamed Abbas Ibrahim,Doaa Hasan Alshora,Marianne j. Naguib
Journal of Drug Delivery Science and Technology. 2020; : 101720
[Pubmed] | [DOI]
91 Hypromellose – A traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery
Eliška Mašková,Katerina Kubová,Bahijja T. Raimi-Abraham,Driton Vllasaliu,Eva Vohlídalová,Jaroslav Turánek,Josef Mašek
Journal of Controlled Release. 2020;
[Pubmed] | [DOI]
92 Zero-order drug delivery: State of the art and future prospects
Mei-Li Laracuente,Marina H. Yu,Kevin J. McHugh
Journal of Controlled Release. 2020;
[Pubmed] | [DOI]
93 Ondansetron buccal administration for paediatric use: a comparison between films and wafers
Barbara Giordani,Angela Abruzzo,Cecilia Prata,Fiore Pasquale Nicoletta,Francesco Dalena,Teresa Cerchiara,Barbara Luppi,Federica Bigucci
International Journal of Pharmaceutics. 2020; : 119228
[Pubmed] | [DOI]
94 Synthesis and in vitro characterization of a preactivated thiolated acrylic acid/acrylamide-methylpropane sulfonic acid copolymer as a mucoadhesive sprayable polymer
Felix Prüfert,Ulrike Hering,Sergey Zaichik,Nguyet-Minh Nguyen Le,Andreas Bernkop-Schnürch
International Journal of Pharmaceutics. 2020; 583: 119371
[Pubmed] | [DOI]
95 Nanotechnology based blended chitosan-pectin hybrid for safe and efficient consolidative antiemetic and neuro-protective effect of meclizine hydrochloride in chemotherapy induced emesis
Alaa H. Salama,Heba Elmotasem,Abeer A.A. Salama
International Journal of Pharmaceutics. 2020; 584: 119411
[Pubmed] | [DOI]
96 Nanosponges as protein delivery systems: Insulin, a case study
Silvia Lucia Appleton,Maria Tannous,Monica Argenziano,Elisabetta Muntoni,Arianna Carolina Rosa,Davide Rossi,Fabrizio Caldera,Anna Scomparin,Francesco Trotta,Roberta Cavalli
International Journal of Pharmaceutics. 2020; 590: 119888
[Pubmed] | [DOI]
97 Electrospun nanofiber for the delivery of active drugs through nasal, oral and vaginal mucosal: Current status and future perspectives
Hasham S. Sofi,Abdalla Abdal-hay,Saso Ivanovski,Yu Shrike Zhang,Faheem A. Sheikh
Materials Science and Engineering: C. 2020; : 110756
[Pubmed] | [DOI]
98 Ciprofloxacin-intercalated layered double hydroxide-in-hybrid films as composite dressings for controlled antimicrobial topical delivery
Yadira Salguero,Laura Valenti,Ricardo Rojas,Mónica C. García
Materials Science and Engineering: C. 2020; : 110859
[Pubmed] | [DOI]
99 Intestinal permeation enhancers to improve oral bioavailability of macromolecules: Reasons for low efficacy in humans
Sam Maher,Caroline Geoghegan,David J. Brayden
Expert Opinion on Drug Delivery. 2020;
[Pubmed] | [DOI]
100 The gamut of perspectives, challenges, and recent trends for in situ hydrogels: a smart ophthalmic drug delivery vehicle
Beauty Das,Dipankar Chattopadhyay,Dipak Rana
Biomaterials Science. 2020; 8(17): 4665
[Pubmed] | [DOI]
101 Nano and microscale delivery platforms for enhanced oral peptide/protein bioavailability
Tong Tong,Liying Wang,Xinru You,Jun Wu
Biomaterials Science. 2020;
[Pubmed] | [DOI]
102 Harnessing emerging paradigms in chemical engineering to accelerate the development of pharmaceutical products
Adhithi R. Raghavan,Vikramaditya G. Yadav
The Canadian Journal of Chemical Engineering. 2020;
[Pubmed] | [DOI]
103 Polymeric Films for the Encapsulation, Storage, and Tunable Release of Therapeutic Microbes
Kunyu Qiu,Isabella Young,Blaide M. Woodburn,Yirui Huang,Aaron C. Anselmo
Advanced Healthcare Materials. 2020; : 1901643
[Pubmed] | [DOI]
104 Genetically Programmable Self-Regenerating Bacterial Hydrogels
Anna M. Duraj-Thatte,Noémie-Manuelle Dorval Courchesne,Pichet Praveschotinunt,Jarod Rutledge,Yuhan Lee,Jeffrey M. Karp,Neel S. Joshi
Advanced Materials. 2019; : 1901826
[Pubmed] | [DOI]
105 Design, Formulation, and Evaluation of Novel Dissolving Microarray Patches Containing Rilpivirine for Intravaginal Delivery
Maelíosa T. C. Mc Crudden,Eneko Larrañeta,Annie Clark,Courtney Jarrahian,Annie Rein-Weston,Benjamin Creelman,Yolanda Moyo,Sophie Lachau-Durand,Nico Niemeijer,Peter Williams,Helen O. McCarthy,Darin Zehrung,Ryan F. Donnelly
Advanced Healthcare Materials. 2019; : 1801510
[Pubmed] | [DOI]
106 Hydrogel Adhesion: A Supramolecular Synergy of Chemistry, Topology, and Mechanics
Jiawei Yang,Ruobing Bai,Baohong Chen,Zhigang Suo
Advanced Functional Materials. 2019; : 1901693
[Pubmed] | [DOI]
107 Review of recently used techniques and materials to improve the efficiency of orally administered proteins/peptides
Yousif H-E. Y. Ibrahim,Géza Regdon,Elnazeer I. Hamedelniel,Tamás Sovány
DARU Journal of Pharmaceutical Sciences. 2019;
[Pubmed] | [DOI]
108 Courier properties of modified citrus pectinate-chitosan nanoparticles in colon delivery of curcumin
Rayan Sabra,Clive J. Roberts,Nashiru Billa
Colloid and Interface Science Communications. 2019; 32: 100192
[Pubmed] | [DOI]
109 Evaluation of the mucoadhesive strengths of Abelmoschus esculentus and Irvingia gabonensis gums for possible application in veterinary vaccine delivery: the effect of extraction methods
Chukwunonso Kenechukwu Ezeasor,Benjamin Obukowho Emikpe,Michael. O. Odeniyi,Shodeinde Vincent Shoyinka
Journal of Immunoassay and Immunochemistry. 2019; : 1
[Pubmed] | [DOI]
110 Mannosylated Nanoparticles for Oral Immunotherapy in a Murine Model of Peanut Allergy
Ana Brotons-Canto,Carlos Gamazo,Nekane Martín-Arbella,Muthanna Abdulkarim,Mark Gumbleton,Gemma Quincoces,Ivan Peñuelas,Juan M. Irache
Journal of Pharmaceutical Sciences. 2019;
[Pubmed] | [DOI]
111 Development of Rectodispersible Tablets and Granulate Capsules for the Treatment of Serious Neonatal Sepsis in Developing Countries
Tina Kauss,Marie-Hélène Langlois,Alice Guyonnet-Dupérat,Thida Phoeung,Xiao Yu Xie,Anthony Cartwright,Nicholas White,Melba Gomes,Karen Gaudin
Journal of Pharmaceutical Sciences. 2019;
[Pubmed] | [DOI]
112 Mucoadhesive Hybrid Polymer/Liposome Pastes Based on Modified Polysaccharides
Yarden Shtenberg,Mor Goldfeder,Hodaya Prinz,Janna Shainsky,Yasmen Ghantous,Imad Abu El-Naaj,Avi Schroeder,Havazelet Bianco-Peled
Journal of Pharmaceutical Sciences. 2019;
[Pubmed] | [DOI]
113 Targeted drug delivery to the brain via intranasal nanoemulsion: Available proof of concept and existing challenges
Bappaditya Chatterjee,Bapi Gorain,Keithanchali Mohananaidu,Pinaki Sengupta,Uttam Kumar Mandal,Hira Choudhury
International Journal of Pharmaceutics. 2019; 565: 258
[Pubmed] | [DOI]
114 Optimization and in vivo evaluation of duloxetine hydrochloride buccoadhesive lyophilized tablets
Ahmed Hassen Elshafeey,Marwa Hassan Shukr,Amr Mostafa Elsharawy
Journal of Drug Delivery Science and Technology. 2019;
[Pubmed] | [DOI]
115 Mucoadhesive approach for buccal application: Preactivated chitosan
Flavia Laffleur,Sonja Röttges
European Polymer Journal. 2019; 113: 60
[Pubmed] | [DOI]
116 New Insight into the Fabrication of Smart Mucoadhesive Buccal Patches as a Novel Controlled-Drug Delivery System
Anahita Rohani Shirvan,Azadeh Bashari,Nahid Hemmatinejad
European Polymer Journal. 2019;
[Pubmed] | [DOI]
117 Intestinal permeability enhancement of benzopyran HP1-loaded nanoemulsions
Gabriela C. Meirelles,Cassiana Mendes,Thiago Caon,Helder F. Teixeira,Gilsane von Poser,Gilles Ponchel
European Journal of Pharmaceutical Sciences. 2019; 127: 115
[Pubmed] | [DOI]
118 Buccal adhesive chitosan conjugate comprising pilocarpine for xerostomia
Flavia Laffleur,Sonja Röttges
International Journal of Biological Macromolecules. 2019;
[Pubmed] | [DOI]
119 Furcellaran-Coated Microcapsules as Carriers of Cyprinus carpio Skin-Derived Antioxidant Hydrolysate: An In Vitro and In Vivo Study
Joanna Tkaczewska,Ewelina Jamróz,Ewa Piatkowska,Barbara Borczak,Joanna Kapusta-Duch,Malgorzata Morawska
Nutrients. 2019; 11(10): 2502
[Pubmed] | [DOI]
120 Mucoadhesive Hydrogel Nanoparticles as Smart Biomedical Drug Delivery System
Nemany Hanafy,Stefano Leporatti,Maged El-Kemary
Applied Sciences. 2019; 9(5): 825
[Pubmed] | [DOI]
121 Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers
Ameya Sharma,Vivek Puri,Vandita Kakkar,Inderbir Singh
Journal of Functional Biomaterials. 2018; 9(3): 52
[Pubmed] | [DOI]
122 Calcium Chloride Modified Alginate Microparticles Formulated by the Spray Drying Process: A Strategy to Prolong the Release of Freely Soluble Drugs
Marta Szekalska,Katarzyna Sosnowska,Anna Czajkowska-Kosnik,Katarzyna Winnicka
Materials. 2018; 11(9): 1522
[Pubmed] | [DOI]
123 Production and Characterization of a Clotrimazole Liposphere Gel for Candidiasis Treatment
Elisabetta Esposito,Maddalena Sguizzato,Christian Bories,Claudio Nastruzzi,Rita Cortesi
Polymers. 2018; 10(2): 160
[Pubmed] | [DOI]
124 Strategies for Improving Ocular Drug Bioavailability and Corneal Wound Healing with Chitosan-Based Delivery Systems
Teodora Irimia,Mihaela Ghica,Lacramioara Popa,Valentina Anuta,Andreea-Letitia Arsene,Cristina-Elena Dinu-Pîrvu
Polymers. 2018; 10(11): 1221
[Pubmed] | [DOI]
125 Chitosan Glutamate-Coated Niosomes: A Proposal for Nose-to-Brain Delivery
Federica Rinaldi,Patrizia Hanieh,Lik Chan,Livia Angeloni,Daniele Passeri,Marco Rossi,Julie Wang,Anna Imbriano,Maria Carafa,Carlotta Marianecci
Pharmaceutics. 2018; 10(2): 38
[Pubmed] | [DOI]
126 Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview
Elena Giuliano,Donatella Paolino,Massimo Fresta,Donato Cosco
Pharmaceutics. 2018; 10(3): 159
[Pubmed] | [DOI]
127 Recent Advances in Drug Delivery System for Bioactive Glycosides from Traditional Chinese Medicine
Lei Li,Yi Feng,Yanlong Hong,Xiao Lin,Lan Shen
The American Journal of Chinese Medicine. 2018; : 1
[Pubmed] | [DOI]
128 Hydrogels based on poly(methyl vinyl ether-co-maleic acid) and Tween 85 for sustained delivery of hydrophobic drugs
Eneko Larrañeta,Laura Barturen,Michael Ervine,Ryan F. Donnelly
International Journal of Pharmaceutics. 2018; 538(1-2): 147
[Pubmed] | [DOI]
129 Oral insulin delivery, the challenge to increase insulin bioavailability: Influence of surface charge in nanoparticle system
Elodie Czuba,Mouhamadou Diop,Carole Mura,Anais Schaschkow,Allan Langlois,William Bietiger,Romain Neidl,Aurélien Virciglio,Nathalie Auberval,Diane Julien-David,Elisa Maillard,Yves Frere,Eric Marchioni,Michel Pinget,Séverine Sigrist
International Journal of Pharmaceutics. 2018; 542(1-2): 47
[Pubmed] | [DOI]
130 Physicochemical and rheo-mechanical characterization of titanium dioxide reinforced sage seed gum nanohybrid hydrogel
Seyed Amir Oleyaei,Seyed Mohammad Ali Razavi,Kirsi S. Mikkonen
International Journal of Biological Macromolecules. 2018;
[Pubmed] | [DOI]
131 Evaluation of the mucoadhesive properties of chitosan nanoparticles prepared using different chitosan to tripolyphosphate (CS:TPP) ratios
Ezzeddin M.A. Hejjaji,Alan M. Smith,Gordon A. Morris
International Journal of Biological Macromolecules. 2018; 120: 1610
[Pubmed] | [DOI]
132 Non-invasive delivery strategies for biologics
Aaron C. Anselmo,Yatin Gokarn,Samir Mitragotri
Nature Reviews Drug Discovery. 2018;
[Pubmed] | [DOI]
133 Development of (Acrylic acid/ Polyethylene glycol)-Zinc oxide mucoadhesive nanocomposites for buccal administration of Propranolol HCl
Ghada A. Mahmoud,Amr El-Hag Ali,Amany I. Raafat,Nagwa A. Badawy,Mai. F. Elshahawy
Radiation Physics and Chemistry. 2018;
[Pubmed] | [DOI]
134 Mucoadhesive assessment of different antifungal nanoformulations
L Roque,J Alopaeus,Claudia Reis,P Rijo,J Molpeceres,E Hagesaether,I Tho,Catarina Reis
Bioinspiration & Biomimetics. 2018; 13(5): 055001
[Pubmed] | [DOI]
135 Design, Characterization, and Biopharmaceutical Behavior of Nanoparticles Loaded with an HIV-1 Fusion Inhibitor Peptide
Martha Ariza-Sáenz,Marta Espina,Ana Calpena,María J. Gómara,Ignacio Pérez-Pomeda,Isabel Haro,María Luisa García
Molecular Pharmaceutics. 2018;
[Pubmed] | [DOI]
136 Cyclodextrin based nanosponge of norfloxacin: Intestinal permeation enhancement and improved antibacterial activity
Cassiana Mendes,Gabriela C. Meirelles,Clarissa Germano Barp,Jamil Assreuy,Marcos A.S. Silva,Gilles Ponchel
Carbohydrate Polymers. 2018; 195: 586
[Pubmed] | [DOI]
137 Polymer adhesion predictions for oral dosage forms to enhance drug administration safety. Part 1: In vitro approach using particle interaction methods
Nélio Drumond,Sven Stegemann
Colloids and Surfaces B: Biointerfaces. 2018; 165: 9
[Pubmed] | [DOI]
138 Preclinical pharmacokinetics of benznidazole-loaded interpolyelectrolyte complex-based delivery systems
Mónica Cristina García,María Laura Guzman,Martín A. Himelfarb,Nicolás J. Litterio,María Eugenia Olivera,Alvaro Jimenez-Kairuz
European Journal of Pharmaceutical Sciences. 2018; 122: 281
[Pubmed] | [DOI]
139 Mucoadhesive nanofibrous membrane with anti-inflammatory activity
Simzar Hosseinzadeh,Shokouhsadat Hamedi,Elaheh Esmaeili,Mahboubeh Kabiri,Ali Babaie,Masoud Soleimani,Abdolreza Ardeshirylajimi
Polymer Bulletin. 2018;
[Pubmed] | [DOI]
140 Efficient Mucosal Immunization by Mucoadhesive and pH-Sensitive Polymeric Vaccine Delivery System
Lei Xing,Tian-Jiao Zhou,Ya-Tong Fan,Yu-jing He,Tao Pang,Ki-Hyun Cho,Jin-Jian Lu,Hu-Lin Jiang,Chong-Su Cho
Macromolecular Research. 2018;
[Pubmed] | [DOI]
141 Covalently mucoadhesive amphiphilic prodrug of 5-fluorouracil for enhanced permeation and improved oral absorption
Yan Liu,Dongyang Zhao,Mengchi Sun,Wei Wei,Yingli Wang,Jiahua Zhou,Ruoshi Zhang,Jian Wang,Haotian Zhang,Zhonggui He,Qiming Kan,Jin Sun
Drug Delivery and Translational Research. 2018;
[Pubmed] | [DOI]
142 A stimulus-responsive, in situ-forming, nanoparticle-laden hydrogel for ocular drug delivery
Maryam Kabiri,Syed H. Kamal,Sandip V. Pawar,Protiva R. Roy,Maziar Derakhshandeh,Ujendra Kumar,Savvas G. Hatzikiriakos,Sazzad Hossain,Vikramaditya G. Yadav
Drug Delivery and Translational Research. 2018;
[Pubmed] | [DOI]
143 Comparative mucoadhesive study of hyaluronic acid-based conjugates on different mucosae
Flavia Laffleur
Journal of Applied Polymer Science. 2017; : 46071
[Pubmed] | [DOI]
144 The wettability and swelling of selected mucoadhesive polymers in simulated saliva and vaginal fluids
M. Rojewska,M. Olejniczak-Rabinek,A. Bartkowiak,A. Snela,K. Prochaska,J. Lulek
Colloids and Surfaces B: Biointerfaces. 2017; 156: 366
[Pubmed] | [DOI]
145 Novel ex vivo protocol using porcine vagina to assess drug permeation from mucoadhesive and colloidal pharmaceutical systems
Maíra N. Pereira,Thaiene A. Reis,Breno N. Matos,Marcílio Cunha-Filho,Taís Gratieri,Guilherme M. Gelfuso
Colloids and Surfaces B: Biointerfaces. 2017; 158: 222
[Pubmed] | [DOI]
146 Self-emulsifying drug delivery systems (SEDDS): Proof-of-concept how to make them mucoadhesive
Gintare Leonaviciute,Nada Trivic Adamovic,Hung Thanh Lam,Julia Rohrer,Alexandra Partenhauser,Andreas Bernkop-Schnürch
European Journal of Pharmaceutics and Biopharmaceutics. 2017; 112: 51
[Pubmed] | [DOI]
147 An overview of intestinal wafers for oral drug delivery
Kirsten Kirsch,Ulrike Hanke,Werner Weitschies
European Journal of Pharmaceutics and Biopharmaceutics. 2017;
[Pubmed] | [DOI]
148 Enhancing the efficiency of thiomers: Utilizing a highly mucoadhesive polymer as backbone for thiolation and preactivation
Felix Prüfert,Sonja Bonengel,Claudia Menzel,Andreas Bernkop-Schnürch
European Journal of Pharmaceutical Sciences. 2017; 96: 309
[Pubmed] | [DOI]
149 Formulation, functional evaluation and ex vivo performance of thermoresponsive soluble gels - A platform for therapeutic delivery to mucosal sinus tissue
Preeti Pandey,Peter J. Cabot,Benjamin Wallwork,Benedict J. Panizza,Harendra S. Parekh
European Journal of Pharmaceutical Sciences. 2017; 96: 499
[Pubmed] | [DOI]
150 Controlled-release biodegradable nanoparticles: From preparation to vaginal applications
Beatriz Martínez-Pérez,David Quintanar-Guerrero,Melina Tapia-Tapia,Ricardo Cisneros-Tamayo,María L. Zambrano-Zaragoza,Sergio Alcalá-Alcalá,Néstor Mendoza-Muñoz,Elizabeth Piñón-Segundo
European Journal of Pharmaceutical Sciences. 2017;
[Pubmed] | [DOI]
151 Surface properties and surface free energy of cellulosic etc mucoadhesive polymers
M. Rojewska,A. Bartkowiak,B. Strzemiecka,A. Jamrozik,A Voelkel,K. Prochaska
Carbohydrate Polymers. 2017; 171: 152
[Pubmed] | [DOI]
152 Bioadhesive and biocompatible films as wound dressing materials based on a novel dendronized chitosan loaded with ciprofloxacin
Mónica C. García,Ana A. Aldana,Luis I. Tártara,Fabiana Alovero,Miriam C. Strumia,Rubén H. Manzo,Marisa Martinelli,Alvaro F. Jimenez-Kairuz
Carbohydrate Polymers. 2017;
[Pubmed] | [DOI]
153 Molecular and biopharmaceutical investigation of alginate–inulin synbiotic coencapsulation of probiotic to target the colon
Abdelbasset Atia,Ahmed I. Gomma,Ismail Fliss,Eric Beyssac,Ghislain Garrait,Muriel Subirade
Journal of Microencapsulation. 2017; : 1
[Pubmed] | [DOI]
154 Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation
Amr Mostafa El Sharawy,Marwa Hassan Shukr,Ahmed Hassen Elshafeey
Drug Delivery. 2017; 24(1): 1762
[Pubmed] | [DOI]
155 A critical review about methodologies for the analysis of mucoadhesive properties of drug delivery systems
Jéssica Bassi da Silva,Sabrina Barbosa de Souza Ferreira,Osvaldo de Freitas,Marcos Luciano Bruschi
Drug Development and Industrial Pharmacy. 2017; 43(7): 1053
[Pubmed] | [DOI]
156 Evaluation of polyvinyl alcohols as mucoadhesive polymers for mucoadhesive buccal tablets prepared by direct compression
Yuri Ikeuchi-Takahashi,Chizuko Ishihara,Hiraku Onishi
Drug Development and Industrial Pharmacy. 2017; 43(9): 1489
[Pubmed] | [DOI]
157 A novel pH-responsive hydrogel-based on calcium alginate engineered by the previous formation of polyelectrolyte complexes (PECs) intended to vaginal administration
Natália Noronha Ferreira,Taciane Alvarenga Perez,Liliane Neves Pedreiro,Fabíola Garavello Prezotti,Fernanda Isadora Boni,Valéria Maria de Oliveira Cardoso,Tiago Venâncio,Maria Palmira Daflon Gremião
Drug Development and Industrial Pharmacy. 2017; : 1
[Pubmed] | [DOI]
158 Modified xanthan gum for buccal delivery—A promising approach in treating sialorrhea
Flavia Laffleur,Martina Michalek
International Journal of Biological Macromolecules. 2017; 102: 1250
[Pubmed] | [DOI]
159 Recent advances in nanoparticle-mediated drug delivery
Bipul Kumar,Kanika Jalodia,Pradeep Kumar,Hemant K. Gautam
Journal of Drug Delivery Science and Technology. 2017; 41: 260
[Pubmed] | [DOI]
160 Preparation and characterization of gastrointestinal wafer formulations
Kirsten Kirsch,Ulrike Hanke,Werner Weitschies
International Journal of Pharmaceutics. 2017;
[Pubmed] | [DOI]
161 Evolution of the scientific literature on drug delivery: A 1974–2015 bibliometric study
C. Robert,C.S. Wilson,A. Venuta,M. Ferrari,C.-D. Arreto
Journal of Controlled Release. 2017; 260: 226
[Pubmed] | [DOI]
162 Development and in�vitro evaluation of mucoadhesive patches of methotrexate for targeted delivery in oral cancer
Bao-Zhong Jin,Xiao-Qi Dong,Xin Xu,Feng-He Zhang
Oncology Letters. 2017;
[Pubmed] | [DOI]
163 The Influence of Chitosan Cross-linking on the Properties of Alginate Microparticles with Metformin Hydrochloride—In Vitro and In Vivo Evaluation
Marta Szekalska,Katarzyna Sosnowska,Agnieszka Zakrzeska,Irena Kasacka,Alicja Lewandowska,Katarzyna Winnicka
Molecules. 2017; 22(1): 182
[Pubmed] | [DOI]
164 Tailored Hydrogel Microbeads of Sodium Carboxymethylcellulose as a Carrier to Deliver Mefenamic Acid: Transmucosal Administration
Babak Shirizadeh,Maryam Maghsoodi,Mitra Alami-Milani,Sara Salatin,Mitra Jelvehgari
Jundishapur Journal of Natural Pharmaceutical Products. 2017; In Press(In Press)
[Pubmed] | [DOI]
165 Design and evaluation of buccal-adhesive system made of modified xanthan
Flavia Laffleur,Martina Michalek,Wongsakorn Suchaoin,Muhammad Ijaz
Therapeutic Delivery. 2016; 7(7): 423
[Pubmed] | [DOI]
166 Development of mucoadhesive thio-carboxymethyl cellulose for application in buccal delivery of drugs
Flavia Laffleur,Alexie Messirek
Therapeutic Delivery. 2016; 7(2): 63
[Pubmed] | [DOI]
167 Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review
Giovana Calixto,Jéssica Bernegossi,Laura de Freitas,Carla Fontana,Marlus Chorilli
Molecules. 2016; 21(3): 342
[Pubmed] | [DOI]
168 Treatment of Radiation-Induced Oral Mucositis Using a Novel Accepted Taste of Prolonged Release Mucoadhesive Bi-medicated Double-Layer Buccal Films
Hadel A. Abo Enin,Nagla Ahmed El Nabarawy,Rehab A. Abd Elmonem
AAPS PharmSciTech. 2016;
[Pubmed] | [DOI]
169 Evaluation of the Safety, Cell Migration, and Mucoadhesive Properties of a Mucoadhesive Polymer Blend in Human Oral Mucosa
Guiyun Song,Daniel Banov,August S. Bassani,Benigno C. Valdez
AAPS PharmSciTech. 2016;
[Pubmed] | [DOI]
170 Gastroretentive systems – a proposed strategy to modulate anthocyanin release and absorption for the management of diabetes
Giovana Bonat Celli,Wilhelmina Kalt,Marianne Su-Ling Brooks
Drug Delivery. 2016; : 1
[Pubmed] | [DOI]
171 Preactivated thiolated nanoparticles: A novel mucoadhesive dosage form
Claudia Menzel,Sonja Bonengel,Irene Pereira de Sousa,Flavia Laffleur,Felix Prüfert,Andreas Bernkop-Schnürch
International Journal of Pharmaceutics. 2016; 497(1-2): 123
[Pubmed] | [DOI]
172 Functional physico-chemical, ex vivo permeation and cell viability characterization of omeprazole loaded buccal films for paediatric drug delivery
Sajjad Khan,Vivek Trivedi,Joshua Boateng
International Journal of Pharmaceutics. 2016; 500(1-2): 217
[Pubmed] | [DOI]
173 Mucoadhesive nanostructured lipid carriers (NLCs) as potential carriers for improving oral delivery of curcumin
Sanipon Chanburee,Waree Tiyaboonchai
Drug Development and Industrial Pharmacy. 2016; : 1
[Pubmed] | [DOI]
174 Gelatin/hydroxypropyl methylcellulose matrices — Polymer interactions approach for oral disintegrating films
Marcela P. Tedesco,Carla A. Monaco-Lourenço,Rosemary A. Carvalho
Materials Science and Engineering: C. 2016; 69: 668
[Pubmed] | [DOI]
175 Maleimide-bearing nanogels as novel mucoadhesive materials for drug delivery
Prasopchai Tonglairoum,Ruairí P. Brannigan,Praneet Opanasopit,Vitaliy V. Khutoryanskiy
J. Mater. Chem. B. 2016; 4(40): 6581
[Pubmed] | [DOI]
176 Filmes bucais mucoadesivos de tramadol para o controle eficaz da dor
Xiao-Qin Li,Zhao-Ming Ye,Jian-Bing Wang,Cai-Rong Fan,Ai-Wu Pan,Cong Li,Ren-Bing Zhang
Brazilian Journal of Anesthesiology. 2016;
[Pubmed] | [DOI]
177 Mucoadhesive buccal films of tramadol for effective pain management
Xiao-Qin Li,Zhao-Ming Ye,Jian-Bing Wang,Cai-Rong Fan,Ai-Wu Pan,Cong Li,Ren-Bing Zhang
Brazilian Journal of Anesthesiology (English Edition). 2016;
[Pubmed] | [DOI]
178 Thermosensitive chitosan-based hydrogels for sustained release of ferulic acid on corneal wound healing
Ching-Yao Tsai,Lin-Chung Woung,Jiin-Cherng Yen,Po-Chen Tseng,Shih-Hwa Chiou,Yen-Jen Sung,Kuan-Ting Liu,Yung-Hsin Cheng
Carbohydrate Polymers. 2016; 135: 308
[Pubmed] | [DOI]
179 Association of Lactobacillus crispatus with fructo-oligosaccharides and ascorbic acid in hydroxypropyl methylcellulose vaginal insert
Beatrice Vitali,Angela Abruzzo,Carola Parolin,Rogers Alberto Ñahui Palomino,Francesco Dalena,Federica Bigucci,Teresa Cerchiara,Barbara Luppi
Carbohydrate Polymers. 2016; 136: 1161
[Pubmed] | [DOI]
180 Mucoadhesive chitosan hydrogels as rectal drug delivery vessels to treat ulcerative colitis
Jinke Xu,Mifong Tam,Sepideh Samaei,Sophie Lerouge,Jake Barralet,Mary M. Stevenson,Marta Cerruti
Acta Biomaterialia. 2016;
[Pubmed] | [DOI]
181 Thin films as an emerging platform for drug delivery
Sandeep Karki,Hyeongmin Kim,Seon-Jeong Na,Dohyun Shin,Kanghee Jo,Jaehwi Lee
Asian Journal of Pharmaceutical Sciences. 2016;
[Pubmed] | [DOI]
182 Response surface based co-optimization of release kinetics and mucoadhesive strength for an oral mucoadhesive tablet of cefixime trihydrate
Jagdish Manwar,Dipak D. Kumbhar,Ravindra Bakal,Swati Baviskar,Rahul Manmode
Bulletin of Faculty of Pharmacy, Cairo University. 2016;
[Pubmed] | [DOI]
183 Mucoadhesive acrylated block copolymers micelles for the delivery of hydrophobic drugs
Tal Eshel-Green,Havazelet Bianco-Peled
Colloids and Surfaces B: Biointerfaces. 2016; 139: 42
[Pubmed] | [DOI]
184 Modulation of bovine whey protein digestion in gastrointestinal tract: A comprehensive review
B.N.P. Sah,A.J. McAinch,T. Vasiljevic
International Dairy Journal. 2016;
[Pubmed] | [DOI]
185 Phosphorylation of psyllium seed polysaccharide and its characterization
Monica R.P. Rao,Deepa U. Warrier,Snehal R. Gaikwad,Prachi M. Shevate
International Journal of Biological Macromolecules. 2016; 85: 317
[Pubmed] | [DOI]
186 Lecithin, gelatin and hydrolyzed collagen orally disintegrating films: functional properties
J.G. Borges,A.G. Silva,C.M. Bitencourt,F.M. Vanin,R.A. Carvalho
International Journal of Biological Macromolecules. 2016;
[Pubmed] | [DOI]
187 Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy
Obinna C. Okeke,Joshua S. Boateng
International Journal of Biological Macromolecules. 2016;
[Pubmed] | [DOI]
188 Intestinal mucoadhesive devices for oral delivery of insulin
Amrita Banerjee,JooHee Lee,Samir Mitragotri
Bioengineering & Translational Medicine. 2016;
[Pubmed] | [DOI]
189 A Janus Mucoadhesive and Omniphobic Device for Gastrointestinal Retention
Young-Ah Lucy Lee,Shiyi Zhang,Jiaqi Lin,Robert Langer,Giovanni Traverso
Advanced Healthcare Materials. 2016;
[Pubmed] | [DOI]
190 Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery
Sara Salatin,Jaleh Barar,Mohammad Barzegar-Jalali,Khosro Adibkia,Mitra Alami Milani,Mitra Jelvehgari
Archives of Pharmacal Research. 2016;
[Pubmed] | [DOI]
191 Drug delivery techniques for buccal route: formulation strategies and recent advances in dosage form design
Sonia Barua,Hyeongmin Kim,Kanghee Jo,Chang Won Seo,Tae Jun Park,Kyung Bin Lee,Gyiae Yun,Kyungsoo Oh,Jaehwi Lee
Journal of Pharmaceutical Investigation. 2016; 46(7): 593
[Pubmed] | [DOI]
192 Orally Disintegrating Films Containing Propolis: Properties and Release Profile
Josiane Gonçalves Borges,Rosemary Aparecida De Carvalho
Journal of Pharmaceutical Sciences. 2015; : n/a
[Pubmed] | [DOI]
193 Mucoadhesive Buccal Tablets Based on Chitosan/Gelatin Microparticles for Delivery of Propranolol Hydrochloride
Angela Abruzzo,Teresa Cerchiara,Federica Bigucci,Maria Caterina Gallucci,Barbara Luppi
Journal of Pharmaceutical Sciences. 2015; 104(12): 4365
[Pubmed] | [DOI]
194 Regional Morphology and Transport of PAMAM Dendrimers Across Isolated Rat Intestinal Tissue
Dallin Hubbard,Tanner Bond,Hamidreza Ghandehari
Macromolecular Bioscience. 2015; 15(12): 1735
[Pubmed] | [DOI]
195 Gastrointestinal Mucosa: The Target Site of Mucoadhesive Microspheres, A Review
Advances in Polymer Technology. 2015; : n/a
[Pubmed] | [DOI]
196 Chitosan-catechol: A polymer with long-lasting mucoadhesive properties
Kyuri Kim,Keumyeon Kim,Ji Hyun Ryu,Haeshin Lee
Biomaterials. 2015; 52: 161
[Pubmed] | [DOI]
197 Mucoadhesive and thermogelling systems for vaginal drug delivery
Carla M. Caramella,Silvia Rossi,Franca Ferrari,Maria Cristina Bonferoni,Giuseppina Sandri
Advanced Drug Delivery Reviews. 2015;
[Pubmed] | [DOI]
198 Evaluation of functional characteristics of preactivated thiolated chitosan as potential therapeutic agent for dry mouth syndrome
Flavia Laffleur,Alexander Fischer,Matthias Schmutzler,Fabian Hintzen,Andreas Bernkop-Schnürch
Acta Biomaterialia. 2015;
[Pubmed] | [DOI]
199 New equipment for measurement of the force of adhesion of mucoadhesive films
András Kelemen,Mihály Gottnek,Géza Regdon,Klára Pintye-Hódi
Journal of Adhesion Science and Technology. 2015; 29(13): 1360
[Pubmed] | [DOI]
200 Polymeric nanoparticle drug delivery technologies for oral delivery applications
Eric M Pridgen,Frank Alexis,Omid C Farokhzad
Expert Opinion on Drug Delivery. 2015; : 1
[Pubmed] | [DOI]
201 Eye gels for ophthalmic delivery
Barbara McKenzie,Graeme Kay
Expert Review of Ophthalmology. 2015; : 1
[Pubmed] | [DOI]
202 Mucoadhesive drug carrier based on functional-modified cellulose as poorly water-soluble drug delivery system
Kultida Songsurang,Krisana Siraleartmukul,Nongnuj Muangsin
Journal of Microencapsulation. 2015; 32(5): 450
[Pubmed] | [DOI]
203 Formulation and evaluation of floating mucoadhesive alginate beads for targetingHelicobacter?pylori
Adeola O. Adebisi,Peter R. Laity,Barbara R. Conway
Journal of Pharmacy and Pharmacology. 2015; : n/a
[Pubmed] | [DOI]
204 Effect of Molar Mass and Water Solubility of Incorporated Molecules on the Degradation Profile of the Triblock Copolymer Delivery System
Mayura Oak,Rhishikesh Mandke,Sushant Lakkadwala,Lindsey Lipp,Jagdish Singh
Polymers. 2015; 7(8): 1510
[Pubmed] | [DOI]
205 The Effect of ß-Glycerophosphate Crosslinking on Chitosan Cytotoxicity and Properties of Hydrogels for Vaginal Application
Emilia Szyma?ska,Katarzyna Sosnowska,Wojciech Miltyk,Malgorzata Rusak,Anna Basa,Katarzyna Winnicka
Polymers. 2015; 7(11): 2223
[Pubmed] | [DOI]
206 Bilayer mucoadhesive microparticles for the delivery of metoprolol succinate: Formulation and evaluation
Krishan Kumar,Neha Dhawan,Harshita Sharma,Pramod S. Patwal,Shubha Vaidya,Bhuvaneshwar Vaidya
Artificial Cells, Nanomedicine, and Biotechnology. 2014; : 1
[Pubmed] | [DOI]
207 Development and Statistical Optimisation of Buspirone Hydrochloride Buccoadhesive Films
Upendra Nagaich,Vandana Chaudhary,Jaya Nagaich
International Scholarly Research Notices. 2014; 2014: 1
[Pubmed] | [DOI]
208 Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study
Rishikesh Gupta,Sunil Kumar Prajapati,Snigdha Pattnaik,Peeyush Bhardwaj
Asian Pacific Journal of Tropical Biomedicine. 2014; 4(9): 729
[Pubmed] | [DOI]
209 Design andin vitrocharacterization of buccoadhesive tablets of timolol maleate
Sachin S. Gaikwad,Shital K. Thombre,Yogesh K. Kale,Sheetal B. Gondkar,Avinash B. Darekar
Drug Development and Industrial Pharmacy. 2014; : 1
[Pubmed] | [DOI]
210 Mucoadhesive polymers for buccal drug delivery
Flavia Laffleur
Drug Development and Industrial Pharmacy. 2014; : 1
[Pubmed] | [DOI]
211 In vivoevaluation of a mucoadhesive polymeric caplet for intravaginal anti-HIV-1 delivery and development of a molecular mechanistic model for thermochemical characterization
Valence M. K. Ndesendo,Yahya E. Choonara,Leith C. R. Meyer,Pradeep Kumar,Lomas K. Tomar,Charu Tyagi,Lisa C. du Toit,Viness Pillay
Drug Development and Industrial Pharmacy. 2014; : 1
[Pubmed] | [DOI]
212 Oro-dental mucoadhesive proniosomal gel formulation loaded with lornoxicam for management of dental pain
Ghada Ahmed Abdelbary,Mona Hassan Aburahma
Journal of Liposome Research. 2014; : 1
[Pubmed] | [DOI]
213 Advances in ophthalmic drug delivery
Peter WJ Morrison,Vitaliy V Khutoryanskiy
Therapeutic Delivery. 2014; 5(12): 1297
[Pubmed] | [DOI]
214 Lectin-conjugated microspheres for eradication of Helicobacter pylori infection and interaction with mucus
Adeola O. Adebisi,Barbara R. Conway
International Journal of Pharmaceutics. 2014;
[Pubmed] | [DOI]
215 Mucins; A Biologically Relevant Glycan Barrier in Mucosal Protection
Anthony P. Corfield
Biochimica et Biophysica Acta (BBA) - General Subjects. 2014;
[Pubmed] | [DOI]
216 Crosslinked thiolated starch coated Fe3O4magnetic nanoparticles: Effect of montmorillonite and crosslinking density on drug delivery properties
Chinmayee Saikia,Anowar Hussain,Anand Ramteke,Hemanta K. Sharma,Tarun K. Maji
Starch - Stärke. 2014; 66(7-8): 760
[Pubmed] | [DOI]
217 Overview on buccal drug delivery systems
Raghavendra Rao NG, Shravani B, Srikanth Reddy M.
Journal of Pharmaceutical Sciences and Research. 2013; 5(4): 80-88
218 Design, synthesis and in vitro evaluation of mucoadhesive p-coumarate-thiolated-chitosan as a hydrophobic drug carriers
Thatthai Pengpong,Polkit Sangvanich,Krisana Sirilertmukul,Nongnuj Muangsin
European Journal of Pharmaceutics and Biopharmaceutics. 2013;
[Pubmed] | [DOI]
219 Perceptive solutions to anti-filarial chemotherapy of lymphatic filariasis from the plethora of nanomedical sciences
Mohammad Ali,Mohammad Afzal,Ujjwal Kaushik,Shailja Mishra Bhattacharya,Farhan Jalees Ahmad,Amit Kumar Dinda
Journal of Drug Targeting. 2013; : 1
[Pubmed] | [DOI]
220 Pressure-sensitive mucoadhesive polymer-based dental patches to treat periodontal diseases: anin vitrostudy
R. Manasadeepa,Paramita Paul,Biswajit Mukherjee
Drug Delivery. 2013; 20(6): 258
[Pubmed] | [DOI]
221 Bioadhesive polymers: Novel tool for drug delivery
Krishan Kumar,Neha Dhawan,Harshita Sharma,Shubha Vaidya,Bhuvaneshwar Vaidya
Artificial Cells, Nanomedicine, and Biotechnology. 2013; : 1
[Pubmed] | [DOI]
222 Drug delivery systems with modified release for systemic and biophase bioavailability
Leucuta SE.
Current Clinical Pharmacology. 2012; 7(4): 282-317
223 Mucoadhesive microspheres: A short review
Garg A, Upadhyay P.
Asian Journal of Pharmaceutical and Clinical Research. 2012; 5((Suppl 3)): 24-27
224 Design and evaluation of buccal tablets of lisinopri
Biradar somnath manohar 
225 Qualitative analysis of controlled release ciprofloxacin/carbopol 934 mucoadhesive suspension
Sahoo S, Chakraborti CK, Mishra SC
J Adv Pharm Tech Res. 2011; 2: 195-204
226 Study on effect of alginate and mucoadhesive polymers on drug release from nateglinide loaded mucoadhesive microcapsules
Mankala SK, Korla AC, Gade S
Journal of Pharmacy Research. 2011; 4(8): 2732-2740
227 Development and evaluation of aceclofenac-loaded mucoadhesive microcapsules
Mankala, S. and Korla, A. and Gade, S.
Journal of Advanced Pharmaceutical Technology and Research. 2011; 2(4): 245-254


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
    Advantages of Mu...
    Article Figures

 Article Access Statistics
    PDF Downloaded4937    
    Comments [Add]    
    Cited by others 227    

Recommend this journal