Home  |  About JAPTR |  Editorial board  |  Search |  Ahead of print  |  Current issue  |  Archives |  Submit article  |  Instructions  |  Subscribe  |  Advertise  |  Contacts  |Login 
Users Online: 580   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
     
ORIGINAL ARTICLE
Year : 2010  |  Volume : 1  |  Issue : 3  |  Page : 342-347

Synthesis, characterization, and analgesic activity of novel schiff base of isatin derivatives


1 Department of Pharmaceutical Chemistry, D.C.R.M. Pharmacy College, Inkollu - 523 167 (A.P), India
2 Kamalakshi Pandurangan College of Pharmacy, Ayyampalayam, Thiruvannamalai, (T.N), India
3 Department of Medicinal Chemistry, Medicinal Chemistry Research Laboratory, Bapatla College of Pharmacy, Bapatla - 522 101, (A.P), India

Correspondence Address:
Rajaram Prakash Chinnasamy
Department of Pharmaceutical Chemistry, D.C.R.M. Pharmacy College, Inkollu - 523 167, (A.P)
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0110-5558.72428

Rights and Permissions

In the present study, a series of novel Schiff bases of isatin [5a-5l] were synthesized by condensation of imesatin with different aromatic aldehydes. The imesatins were synthesized by the reaction of isatin with p-phenylenediamine. The chemical structures of the synthesized compounds were confirmed by means of Infrared (IR), Mass spectroscopy, and Elemental analysis. These compounds were screened for the analgesic activity by the tail-immersion method at a dose of 200 mg/kg body weight. Among the tested compounds 3-(4-(4-hydroxy-3-methoxylbenzylideneamino) phenylimino) indoline-2-one (5i) exhibited better analgesic activity when compared to standard pentazocine. From the above-mentioned results it may be concluded that compounds containing electron-donating groups exhibit better analgesic activity than the electron-withdrawing groups.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed7009    
    Printed243    
    Emailed2    
    PDF Downloaded1122    
    Comments [Add]    
    Cited by others 40    

Recommend this journal