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ORIGINAL ARTICLE
Year : 2010  |  Volume : 1  |  Issue : 3  |  Page : 330-333

Assessment of the antidiabetic potential of Cassia grandis using an in vivo model


1 Department of Pharmaceutical Chemistry, Maliba Pharmacy College, Gopal Vidyanagar, Tarsadi, Gujarat, India
2 Department of Pharmaceutical Chemistry, Modern College of Pharmacy (for ladies), Moshi, Pune, Maharashtra, India

Correspondence Address:
Sandesh R Lodha
Maliba Pharmacy College, Gopal Vidyanagar, Tarsadi - 394 350, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0110-5558.72429

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The aqueous and ethanolic extracts of C. grandis (Family: Leguminosae) were evaluated for antidiabetic activity by a glucose tolerance test, in normal rats and alloxan-induced diabetic rats. The aqueous and ethanolic extracts showed that they significantly lowered the blood glucose levels to normal in the glucose tolerance test. In alloxan-induced diabetic rats the maximum reduction in blood glucose was observed after three hours, at a dose level of 150 mg/kg of body weight. The percentage of protection given by the aqueous and ethanolic extracts was 32.72 and 46.42%, respectively. In the long-term treatment of alloxan-induced diabetic rats, the degree of protection was determined by measuring the blood glucose, cholesterol, and triglycerides on the tenth day. Both the extracts showed a significant antidiabetic activity comparable to that of glibenclamide. These results showed that the Cassia grandis possessed significant antidiabetic activity.


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