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REVIEW ARTICLE
Year : 2010  |  Volume : 1  |  Issue : 3  |  Page : 291-296

Ocular inserts - Advancement in therapy of eye diseases


Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Baghpat Bypass Crossing, Delhi- Haridwar Highway, NH-58, Meerut-250005 (UP), India

Correspondence Address:
Anita Kumari
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Baghpat Bypass Crossing, Delhi - Haridwar Highway, NH-58, Meerut - 250 005 (UP)
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0110-5558.72419

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The ocular insert represents a significant advancement in the therapy of eye disease. Ocular inserts are defined as sterile, thin, multilayered, drug-impregnated, solid or semisolid consistency devices placed into the cul-de-sac or conjuctival sac, whose size and shape are especially designed for ophthalmic application. They are composed of a polymeric support that may or may not contain a drug. The drug can later be incorporated as dispersion or a solution in the polymeric support. They offer several advantages as increased ocular residence and sustained release of medication into the eye. The insert includes a body portion sized to position within a lachrymal canaliculus of the eyelid. The inserts are classified according to their solubility as insoluble, soluble, or bioerodible inserts. The release of drug from the insert depends upon the diffusion, osmosis, and bioerosion of the drug, and this article is an attempt to present a brief about this newer drug delivery system.


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