Journal of Advanced Pharmaceutical Technology & Research

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 7  |  Issue : 3  |  Page : 87--90

Effects of Cr3+ ions on electrophysiological parameters of isolated skin of toad Pleurodema thaul


Luis Guzman Jofre1, Ricardo I Castro Cepeda2 
1 Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, University of Talca, Talca, Chile
2 Institute of Chemistry and Natural Resources, University of Talca, Talca, Chile

Correspondence Address:
Ricardo I Castro Cepeda
Institute of Chemistry and Natural Resources, Universidad de Talca, Talca
Chile

In view of the toxicity of chromium (Cr3+) ions, it was explored the damaging effects that this ion could induce in cell membranes. The measurement of the effects induced by Cr3+ ions on electrophysiological parameters of short-circuit current and on the potential difference were investigated using the outer side (mucosal) and the inner side (serosal) of toad Pleurodema thaul skin. The results showed a decreased on electrophysiological parameters when it were administered concentrations of 33, 100 and 200 μM of Cr3+, the results also suggest that the administration of Cr3+ inhibits the ion transport in toad skin by the interaction of Cr3+ with lipid bilayers or protein constituents of membrane, and not by an inhibition of the active transport of ions across Na+ channels.


How to cite this article:
Jofre LG, Castro Cepeda RI. Effects of Cr3+ ions on electrophysiological parameters of isolated skin of toad Pleurodema thaul.J Adv Pharm Technol Res 2016;7:87-90


How to cite this URL:
Jofre LG, Castro Cepeda RI. Effects of Cr3+ ions on electrophysiological parameters of isolated skin of toad Pleurodema thaul. J Adv Pharm Technol Res [serial online] 2016 [cited 2020 Aug 11 ];7:87-90
Available from: http://www.japtr.org/article.asp?issn=2231-4040;year=2016;volume=7;issue=3;spage=87;epage=90;aulast=Jofre;type=0