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ORIGINAL ARTICLE
Year : 2020  |  Volume : 11  |  Issue : 1  |  Page : 36-43

Polymeric worm-like nanomicellar system for accelerated wound healing


1 Amity Institute of Click Chemistry Research and Studies, Amity University, Noida, Uttar Pradesh, India
2 All India Institute of Medical Sciences, New Delhi, India
3 Amity Institute of Click Chemistry Research and Studies; Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India
4 Amity Institute of Click Chemistry Research and Studies; Amity Institute of Nanotechnology, Amity University, Noida, Uttar Pradesh, India
5 Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India

Correspondence Address:
Dr. Monalisa Mukherjee
Amity Institute of Click Chemistry Research and Studies, J3 Block, Lab 103, Amity University, Noida, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/japtr.JAPTR_153_19

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Self-assembly is an unparalleled step in designing macromolecular analogs of nature's simple amphiphiles. Tailoring hydrogel systems – a material with ample potential for wound healing applications – to simultaneously alleviate infection and prompt wound closure is vastly appealing. The poly (DEAEMA-co-AAc) (PDEA) is examined with a cutaneous excisional wound model alterations in wound size, and histological assessments revealed a higher wound healing rate, including dermis proliferation, re-epithelialization, reduced scar formation, and anti-inflammatory properties. Moreover, a mechanism for the formation of spherical and worm-like micelles (WLMs) is delineated using a suite of characterizations. The excellent porosity and ability to absorb exudates impart the PDEA with reliable wound healing. Altogether, this system demonstrates exceptional promise as an infection-mitigating, cell-stimulating, homeostasis-maintaining dressing for accelerated wound healing. The aim and objective of this study is to understand the mechanism of self-assembly in synthesized WLMs from PDEA and their application in wound healing.


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