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EDITORIAL
Year : 2014  |  Volume : 5  |  Issue : 3  |  Page : 105-106  

Nanotechnology: The vision of 2025


Organizing Secretary, SPER 3rd Annual Conference Editor, Journal of Advanced Pharmaceutical Technology and Research (JAPTR), Editor-in- Chief, SPER Times Secretary, Society of Pharmaceutical Education and Research, 22-C, Jawahar Colony, Gwalior - 474 001, M.P., India

Date of Web Publication23-Jul-2014

Correspondence Address:
Upendra Nagaich
Organizing Secretary, SPER 3rd Annual Conference Editor, Journal of Advanced Pharmaceutical Technology and Research (JAPTR), Editor-in- Chief, SPER Times Secretary, Society of Pharmaceutical Education and Research, 22-C, Jawahar Colony, Gwalior - 474 001, M.P.
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-4040.137382

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How to cite this article:
Nagaich U. Nanotechnology: The vision of 2025. J Adv Pharm Technol Res 2014;5:105-6

How to cite this URL:
Nagaich U. Nanotechnology: The vision of 2025. J Adv Pharm Technol Res [serial online] 2014 [cited 2019 Oct 21];5:105-6. Available from: http://www.japtr.org/text.asp?2014/5/3/105/137382

Dear Friends,

Increasing susceptibility of patients toward chronic diseases such as cardiovascular, neurological, oncology, and respiratory diseases coupled with increasing R and D spending opening new application avenues is expected to drive market growth over the next 6 years. Nano-based approaches or nanotechnology is to delivery of the various drugs on crossing a physical barrier, such as the blood-brain barrier, or acceptable routes for the delivery of a new generation produced protein-based active medicaments other than via the git, where degradation is more prone to occur. Nanoscience associated with nanotechnology is thus the basis for the innovative delivery techniques that offer potential benefits to patients and new markets for pharmaceutical companies. Nanotechnology, reduction of the size of dimensions between 1 and 100 nm (0.001-0.1 μm), where specific techniques are required to characterize and evaluate the nanoscale materials.

The global market for health care, nanotechnology is expected to reach USD 196.02 billion by 2020 growing at a CAGR of 12.1%, according to a new study by the Grand View Research, Inc. As the field of nanotechnology advances we anticipate that the use of nano-based formulations should be in accordance with the three final guidelines and one-draft guidelines issued by the US Food and Drug Administration (FDA), providing greater regulatory clarity for industry on the use of nanotechnology. FDA helps them to identify and understand potential issues related to safety and regulatory status of medicines concerning to the disease. One final guideline illustrates the industrial overall approach for all formulations and development, while other the two final guidelines and the new draft guideline provide specific guidance for the production of medicines and their formulations, respectively.
"Our goal remains to ensure transparent and predictable regulatory pathways, grounded in the best available science, in support of the responsible development of nanotechnology products," said FDA Commissioner Margaret A. Hamburg. When nanotechnology became mainstream in 2004-2005, many companies used this as an opportunity to incorporate the word nanotechnology into their company name or products, in particular over-the-counter companies such as JMAR, Biophan, US Global Nanospace, Industrial Nanotech, Natural Nano, mPhase, etc.

Clinical oncology nanotechnology applications dominated the overall market in 2013, accounting for 35% of total market revenue. Higher efficacy of nanomaterials and the ability of engineered nanoparticles to cross through the blood-brain barrier provide a platform for groundbreaking innovations through R and D in the field of cancer therapy and serves this market as a high-impact rendering driver. Like:

Johnson and Johnson revealed that Elan's nanocrystal technology in a phase III clinical trial for an injectable formulation of Paliperidone palmitate, a drug for schizophrenia, which overcomes the insolubility, by reducing the particle size to under 200 nm.

Germany's NanoPharm have developed systems capable of reaching the brain for dalargin (anesthesia), cancer drugs, etc.

In 2003 Novavax successfully developed two hormone replacement therapies, called Estrasorb and Androsorb.

Kala Pharmaceuticals Inc. a leading developer of innovative ophthalmic products based on the company's proprietary mucus penetrating particle (MPP) platform today announced the initiation of two clinical trials with its nanotechnology-based loteprednol etabonate-MPP (LE-MPP) program KPI-121.

mPhase Technologies Inc. (XDSL), a 2013 is pioneering a revolutionary Smart surface technology enabled by breakthroughs in nanotechnology, microelectromechanical systems processing and microfluidics. Smart Surface technology has potential applications within drug delivery systems, lab-on-a-chip analytic systems, self-cleaning systems, liquid and chemical sensor systems, and filtration systems.

The combination of nanotechnology along with medicine has potential for the pharma industry, which is set to introduce momentous innovations in the fight against different diseases. The two concepts of therapeutic nanocarriers - liposomes and albumin nanoparticles are gaining prominence rapidly and would soon become well-established in the market across the globe.

In addition, a significant growth of this field would mostly depend on the strong establishment of a toxicology database which would support the safety determinations and risk assessments. This could possibly include toxicity, material, size, shape, cell type or animal, duration of exposure and the methods, which are used to assay toxicity. Also, needs to be a mechanism, wherein the scaling up of production levels of drug particles is enabled. The use of such a compact database would help the pharma industry to translate biomedical nanotechnology from the laboratory to the general public at ease.

 
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