Home  |  About JAPTR |  Editorial board  |  Search |  Ahead of print  |  Current issue  |  Archives |  Submit article  |  Instructions  |  Subscribe  |  Advertise  |  Contacts  |Login 
Users Online: 114   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
     
ORIGINAL ARTICLE
Year : 2012  |  Volume : 3  |  Issue : 2  |  Page : 106-111

Development and evaluation of antimicrobial herbal formulations containing the methanolic extract of Samadera indica for skin diseases


1 Department of Pharmacology, Amrita School of Pharmacy, AIMS Health Science Campus, Kochi, Kerala and Research Scholar, Vinayaka Mission's College of Pharmacy, Salem, India
2 Department of Pharmacology, Pusphagiri College of Pharmacy, Thiruvalla, Kerala, India
3 Department of Pharmacology, Vinayaka Mission's College of Pharmacy, Salem, Tamil Nadu, India
4 Department of Pharmacology, Amrita School of Pharmacy, AIMS Health Science Campus, Kochi, Kerala, India

Correspondence Address:
Vidya Viswanad
Assistant Professor, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham University, AIMS Health Science Campus, AIMS, Ponekkara P.O. Kochi-Kerala - 682 041
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-4040.97285

Rights and Permissions

Samadera indica Gaetrn (Simaroubaceae) is claimed to possess various pharmacological activities like antioxidant, antifungal, antitumor, antiviral, and so on, but its taste is bitter. The aim of the present study is to investigate the toxicity of the methanolic extract and to develop suitable herbal formulations of the methanolic extract of Samadera indica, having efficient antimicrobial activity. The methanolic extract prepared from the dried leaves of Samadera indica by continuous hot percolation, were used to examine the toxicity, according to the OECD 423 guidelines, in Swiss Albino mice. Topical formulations were prepared by incorporating Samadera indica (5% w / w) in an emulsifying ointment and a carbopol gel base and evaluated for physical parameters and in-vitro antimicrobial activity (S. aureus, P. aeruginosa and C. albicans). The study reveals that no animals under the study showed any clinical signs of toxicity or mortality when administered a dose of 5 - 2000 mg / kg body weight. Therefore, the maximum tolerated dose of the methanolic extract of Samadera indica was above 2000 mg / kg body weight. The formulated ointment and gel had acceptable physical parameters that showed that they were compatible with the skin, and in addition to this, these formulations passed the short-term stability studies. The in-vitro antimicrobial activity studies showed that the formulated ointment showed significantly strong (p < 0.05) activity against S. aureus, P. aeruginosa and C. albicans than the formulated gel. Thus, the present study concludes that the formulated ointment and gel are safe and efficient antimicrobial formulations for the topical delivery of the methanolic extract of Samadera indica.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4250    
    Printed139    
    Emailed2    
    PDF Downloaded502    
    Comments [Add]    
    Cited by others 1    

Recommend this journal